Snrnp70 (small nuclear ribonucleoprotein U1 subunit 70) - Rat Genome Database

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Gene: Snrnp70 (small nuclear ribonucleoprotein U1 subunit 70) Rattus norvegicus
Analyze
Symbol: Snrnp70
Name: small nuclear ribonucleoprotein U1 subunit 70
RGD ID: 1307120
Description: Enables U1 snRNP binding activity. Involved in cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; and cellular response to tumor necrosis factor. Part of U1 snRNP. Human ortholog(s) of this gene implicated in disease of mental health and systemic lupus erythematosus. Orthologous to human SNRNP70 (small nuclear ribonucleoprotein U1 subunit 70); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC361574; small nuclear ribonucleoprotein 70 (U1); Snrp70; U1 small nuclear ribonucleoprotein 70 kDa; U1 small nuclear ribonucleoprotein polypeptide A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,992,518 - 105,012,851 (-)NCBIGRCr8
mRatBN7.2195,856,038 - 95,876,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,856,036 - 95,876,392 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,241,472 - 101,261,800 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,714,149 - 109,734,477 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,004,549 - 103,024,877 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,367,470 - 101,388,153 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,367,471 - 101,388,129 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,431,122 - 102,468,602 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,853,923 - 95,868,393 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,925,963 - 95,946,503 (-)NCBI
Celera190,118,420 - 90,132,674 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-bromohexadecanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
bathocuproine disulfonic acid  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
decabromodiphenyl ether  (ISO)
diuron  (EXP)
enzyme inhibitor  (ISO)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gamma-hexachlorocyclohexane  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
hydralazine  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
menadione  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
pyrrolidine dithiocarbamate  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease. Bai B, etal., Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16562-7. doi: 10.1073/pnas.1310249110. Epub 2013 Sep 10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective study. Katsumata Y, etal., Mod Rheumatol. 2013 Jan;23(1):71-80. doi: 10.1007/s10165-012-0624-y. Epub 2012 Mar 28.
5. Dual posttranscriptional targets of retinoic acid-induced gene expression. Manji SS, etal., J Cell Biochem. 1999 Mar 1;72(3):411-22.
6. B and T cell immune response to small nuclear ribonucleoprotein particles in lupus mice: autoreactive CD4(+) T cells recognize a T cell epitope located within the RNP80 motif of the 70K protein. Monneaux F, etal., Eur J Immunol. 2000 Aug;30(8):2191-200.
7. Separation of nuclear protein complexes by blue native polyacrylamide gel electrophoresis. Novakova Z, etal., Electrophoresis. 2006 Apr;27(7):1277-87.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Structural analyses of the pre-mRNA splicing machinery. Zhang L, etal., Protein Sci. 2013 Jun;22(6):677-92. doi: 10.1002/pro.2266. Epub 2013 May 8.
Additional References at PubMed
PMID:2467746   PMID:9531537   PMID:9731529   PMID:12477932   PMID:17656373   PMID:18559850   PMID:21113136   PMID:22658674   PMID:22681889   PMID:23636947   PMID:23793891   PMID:25555158  
PMID:30361391   PMID:31505169  


Genomics

Comparative Map Data
Snrnp70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,992,518 - 105,012,851 (-)NCBIGRCr8
mRatBN7.2195,856,038 - 95,876,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,856,036 - 95,876,392 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,241,472 - 101,261,800 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,714,149 - 109,734,477 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,004,549 - 103,024,877 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,367,470 - 101,388,153 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,367,471 - 101,388,129 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,431,122 - 102,468,602 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,853,923 - 95,868,393 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,925,963 - 95,946,503 (-)NCBI
Celera190,118,420 - 90,132,674 (-)NCBICelera
Cytogenetic Map1q22NCBI
SNRNP70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,085,451 - 49,108,604 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,085,419 - 49,108,605 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,588,708 - 49,611,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,280,277 - 54,303,682 (+)NCBINCBI36Build 36hg18NCBI36
Build 341954,280,276 - 54,303,681NCBI
Celera1946,455,683 - 46,479,094 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,964,935 - 45,988,033 (+)NCBIHuRef
CHM1_11949,590,572 - 49,613,985 (+)NCBICHM1_1
T2T-CHM13v2.01952,080,187 - 52,103,340 (+)NCBIT2T-CHM13v2.0
Snrnp70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,025,878 - 45,045,177 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,025,877 - 45,045,166 (-)EnsemblGRCm39 Ensembl
GRCm38745,376,454 - 45,395,742 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,376,453 - 45,395,742 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,631,824 - 52,651,017 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,244,496 - 45,263,689 (-)NCBIMGSCv36mm8
Celera740,832,480 - 40,851,675 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.28NCBI
Snrnp70
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,614,039 - 1,634,142 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,618,246 - 1,634,144 (-)NCBIChiLan1.0ChiLan1.0
SNRNP70
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,199,729 - 55,221,922 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,118,085 - 57,141,420 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,094,679 - 46,118,022 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,021,402 - 55,044,351 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,021,402 - 55,046,281 (+)Ensemblpanpan1.1panPan2
SNRNP70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,340,484 - 107,356,280 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,113,974 - 107,356,241 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01107,865,353 - 107,881,109 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,865,361 - 107,881,086 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,533,257 - 107,549,010 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,179,479 - 107,195,244 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,015,085 - 108,030,850 (-)NCBIUU_Cfam_GSD_1.0
Snrnp70
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,417,537 - 21,436,387 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366643,035,679 - 3,054,577 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNRNP70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,288,397 - 54,304,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,288,354 - 54,304,272 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,024,183 - 50,040,138 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SNRNP70
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,305,961 - 42,329,289 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,305,687 - 42,330,332 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,196,694 - 22,220,757 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snrnp70
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248324,973,251 - 4,988,679 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Snrnp70
60 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:107
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000028176, ENSRNOT00000049957
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat

Markers in Region
BE114951  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,856,123 - 95,856,280 (+)MAPPERmRatBN7.2
Rnor_6.01101,367,549 - 101,367,705NCBIRnor6.0
Rnor_5.01102,431,201 - 102,431,357UniSTSRnor5.0
RGSC_v3.4195,847,934 - 95,848,090UniSTSRGSC3.4
Celera190,112,425 - 90,112,581UniSTS
RH 3.4 Map1909.3UniSTS
Cytogenetic Map1q22UniSTS
AI325098  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,875,364 - 95,875,458 (+)MAPPERmRatBN7.2
Rnor_6.01101,387,119 - 101,387,212NCBIRnor6.0
Rnor_5.01102,467,572 - 102,467,665UniSTSRnor5.0
RGSC_v3.4195,867,383 - 95,867,476UniSTSRGSC3.4
Celera190,131,664 - 90,131,757UniSTS
Cytogenetic Map1q22UniSTS
RH141656  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,870,668 - 95,870,879 (+)MAPPERmRatBN7.2
Rnor_6.01101,382,425 - 101,382,635NCBIRnor6.0
Rnor_5.01102,462,878 - 102,463,088UniSTSRnor5.0
RGSC_v3.4195,862,689 - 95,862,899UniSTSRGSC3.4
Celera190,126,970 - 90,127,180UniSTS
RH 3.4 Map1909.6UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000028176   ⟹   ENSRNOP00000028176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,856,038 - 95,876,392 (-)Ensembl
Rnor_6.0 Ensembl1101,367,471 - 101,388,125 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000049957   ⟹   ENSRNOP00000043074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,862,117 - 95,876,375 (-)Ensembl
Rnor_6.0 Ensembl1101,373,539 - 101,388,129 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098428   ⟹   ENSRNOP00000083303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,872,318 - 95,876,375 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118005   ⟹   ENSRNOP00000079909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,856,036 - 95,876,392 (-)Ensembl
RefSeq Acc Id: NM_001399641   ⟹   NP_001386570
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,992,518 - 105,012,851 (-)NCBI
mRatBN7.2195,856,038 - 95,876,375 (-)NCBI
RefSeq Acc Id: XM_006229102   ⟹   XP_006229164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,992,527 - 105,012,578 (-)NCBI
mRatBN7.2195,856,039 - 95,875,904 (-)NCBI
Rnor_6.01101,367,470 - 101,387,658 (-)NCBI
Rnor_5.01102,431,122 - 102,468,602 (-)NCBI
Sequence:
RefSeq Acc Id: XP_006229164   ⟸   XM_006229102
- Peptide Label: isoform X1
- UniProtKB: B2RZ74 (UniProtKB/TrEMBL),   F7FIU1 (UniProtKB/TrEMBL),   A0A8I6G5W4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028176   ⟸   ENSRNOT00000028176
Ensembl Acc Id: ENSRNOP00000043074   ⟸   ENSRNOT00000049957
Ensembl Acc Id: ENSRNOP00000083303   ⟸   ENSRNOT00000098428
Ensembl Acc Id: ENSRNOP00000079909   ⟸   ENSRNOT00000118005
RefSeq Acc Id: NP_001386570   ⟸   NM_001399641
- UniProtKB: B2RZ74 (UniProtKB/TrEMBL),   F7FIU1 (UniProtKB/TrEMBL)
Protein Domains
RRM   U1 small nuclear ribonucleoprotein of 70kDa N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RZ74-F1-model_v2 AlphaFold B2RZ74 1-451 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690035
Promoter ID:EPDNEW_R560
Type:initiation region
Name:Snrnp70_1
Description:small nuclear ribonucleoprotein U1 subunit 70
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,388,135 - 101,388,195EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307120 AgrOrtholog
BioCyc Gene G2FUF-59689 BioCyc
Ensembl Genes ENSRNOG00000020763 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028176.7 UniProtKB/TrEMBL
  ENSRNOT00000049957.5 UniProtKB/TrEMBL
  ENSRNOT00000098428.1 UniProtKB/TrEMBL
  ENSRNOT00000118005.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9089731 IMAGE-MGC_LOAD
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_RNP1 UniProtKB/TrEMBL
  snRNP70_RRM UniProtKB/TrEMBL
  U1_U11-U12_snRNP_70-35kDa UniProtKB/TrEMBL
  U1snRNP70_N UniProtKB/TrEMBL
MGC_CLONE MGC:189347 IMAGE-MGC_LOAD
NCBI Gene 361574 ENTREZGENE
PANTHER U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD UniProtKB/TrEMBL
  U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
  U1snRNP70_N UniProtKB/TrEMBL
PhenoGen Snrnp70 PhenoGen
PROSITE RRM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020763 RatGTEx
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A8I5ZV69_RAT UniProtKB/TrEMBL
  A0A8I6G5W4 ENTREZGENE, UniProtKB/TrEMBL
  B2RZ74 ENTREZGENE, UniProtKB/TrEMBL
  D3Z8H0_RAT UniProtKB/TrEMBL
  F7FIU1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-15 Snrnp70  small nuclear ribonucleoprotein U1 subunit 70  Snrnp70  small nuclear ribonucleoprotein 70 (U1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-22 Snrnp70  small nuclear ribonucleoprotein 70 (U1)  Snrp70  U1 small nuclear ribonucleoprotein polypeptide A   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Snrp70  U1 small nuclear ribonucleoprotein polypeptide A   Snrp70_predicted  U1 small nuclear ribonucleoprotein polypeptide A (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Snrp70_predicted  U1 small nuclear ribonucleoprotein polypeptide A (predicted)      Symbol and Name status set to approved 70820 APPROVED