Dbp (D-box binding PAR bZIP transcription factor) - Rat Genome Database

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Gene: Dbp (D-box binding PAR bZIP transcription factor) Rattus norvegicus
Analyze
Symbol: Dbp
Name: D-box binding PAR bZIP transcription factor
RGD ID: 2491
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in liver development and positive regulation of transcription by RNA polymerase II. Predicted to be located in membrane. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human DBP (D-box binding PAR bZIP transcription factor); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: albumin D box-binding protein; albumin D-element-binding protein; D site albumin promoter binding protein; d site albumin promoter-binding protein 1; D site of albumin promoter (albumin D-box) binding protein; D site-binding protein; MGC105474
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,312,256 - 105,317,205 (+)NCBIGRCr8
mRatBN7.2196,175,796 - 96,180,745 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,175,440 - 96,180,745 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,561,232 - 101,566,181 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,033,930 - 110,038,879 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,324,307 - 103,329,256 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,687,896 - 101,692,845 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,687,855 - 101,692,846 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,766,762 - 102,771,674 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,173,573 - 96,178,485 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,251,683 - 96,256,595 (+)NCBI
Celera190,428,995 - 90,433,944 (+)NCBICelera
RH 3.4 Map1909.3RGD
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
osteoporosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
avobenzone  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromobenzene  (EXP)
C60 fullerene  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
chrysene  (ISO)
clofibrate  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzofurans  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diethyl maleate  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
folpet  (ISO)
FR900359  (ISO)
fructose  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (EXP,ISO)
graphene oxide  (ISO)
imidacloprid  (EXP)
isoprenaline  (ISO)
lead(0)  (ISO)
levetiracetam  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
mercury dichloride  (EXP)
metacetamol  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP)
milrinone  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
nevirapine  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
raloxifene  (EXP)
ritodrine  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
SCH-351591  (EXP)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
styrene  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
Trapidil  (EXP)
triadimefon  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Rhythms of mammalian body temperature can sustain peripheral circadian clocks. Brown SA, etal., Curr Biol 2002 Sep 17;12(18):1574-83.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally. Mueller CR, etal., Cell 1990 Apr 20;61(2):279-91.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. Xiong DH, etal., J Bone Miner Res. 2006 Nov;21(11):1678-95.
Additional References at PubMed
PMID:10508692   PMID:12477932   PMID:15489334   PMID:15792371   PMID:16257226   PMID:18583459   PMID:19387896   PMID:20093779   PMID:21458520   PMID:21635892   PMID:23738784   PMID:25068868  
PMID:31759405  


Genomics

Comparative Map Data
Dbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,312,256 - 105,317,205 (+)NCBIGRCr8
mRatBN7.2196,175,796 - 96,180,745 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,175,440 - 96,180,745 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,561,232 - 101,566,181 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,033,930 - 110,038,879 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,324,307 - 103,329,256 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,687,896 - 101,692,845 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,687,855 - 101,692,846 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,766,762 - 102,771,674 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,173,573 - 96,178,485 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,251,683 - 96,256,595 (+)NCBI
Celera190,428,995 - 90,433,944 (+)NCBICelera
RH 3.4 Map1909.3RGD
Cytogenetic Map1q22NCBI
DBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,630,030 - 48,637,379 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,630,030 - 48,637,379 (-)EnsemblGRCh38hg38GRCh38
GRCh371949,133,287 - 49,140,636 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,825,754 - 53,832,400 (-)NCBINCBI36Build 36hg18NCBI36
Build 341953,825,758 - 53,832,400NCBI
Celera1945,998,682 - 46,005,504 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,513,353 - 45,520,093 (-)NCBIHuRef
CHM1_11949,135,691 - 49,142,513 (-)NCBICHM1_1
T2T-CHM13v2.01951,624,512 - 51,631,860 (-)NCBIT2T-CHM13v2.0
Dbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,354,658 - 45,359,579 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,354,512 - 45,359,627 (+)EnsemblGRCm39 Ensembl
GRCm38745,705,100 - 45,710,203 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,705,088 - 45,710,203 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,960,617 - 52,965,573 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,573,274 - 45,578,193 (+)NCBIMGSCv36mm8
Celera741,167,804 - 41,172,760 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.45NCBI
Dbp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,916,018 - 1,921,075 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,915,424 - 1,921,322 (+)NCBIChiLan1.0ChiLan1.0
DBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22054,735,623 - 54,742,640 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,661,959 - 56,668,982 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,631,939 - 45,638,962 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,224,188 - 54,231,331 (-)NCBIpanpan1.1PanPan1.1panPan2
DBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,675,138 - 107,681,246 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,675,477 - 107,681,204 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,196,619 - 107,202,740 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01108,199,175 - 108,205,291 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,199,346 - 108,205,288 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,865,726 - 107,871,840 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,513,020 - 107,519,141 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,348,719 - 108,354,835 (+)NCBIUU_Cfam_GSD_1.0
Dbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,058,564 - 21,064,165 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,676,754 - 2,682,425 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,676,754 - 2,682,425 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,986,959 - 53,993,020 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,986,955 - 53,993,044 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,734,283 - 49,740,214 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,882,042 - 41,889,311 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl641,882,317 - 41,889,200 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607321,749,902 - 21,757,502 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dbp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,240,365 - 5,246,185 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,240,338 - 5,246,185 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dbp
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:44
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000028546
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat

Markers in Region
RH94402  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,180,566 - 96,180,725 (+)MAPPERmRatBN7.2
Rnor_6.01101,692,667 - 101,692,825NCBIRnor6.0
Rnor_5.01102,771,499 - 102,771,657UniSTSRnor5.0
RGSC_v3.4196,178,310 - 96,178,468UniSTSRGSC3.4
Celera190,433,766 - 90,433,924UniSTS
RH 3.4 Map1909.3UniSTS
Cytogenetic Map1q22UniSTS
RH141779  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,180,413 - 96,180,594 (+)MAPPERmRatBN7.2
Rnor_6.01101,692,514 - 101,692,694NCBIRnor6.0
Rnor_5.01102,771,346 - 102,771,526UniSTSRnor5.0
RGSC_v3.4196,178,157 - 96,178,337UniSTSRGSC3.4
Celera190,433,613 - 90,433,793UniSTS
RH 3.4 Map1909.49UniSTS
Cytogenetic Map1q22UniSTS
RH129117  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,180,923 - 96,181,112 (+)MAPPERmRatBN7.2
Rnor_6.01101,693,024 - 101,693,212NCBIRnor6.0
Rnor_5.01102,771,856 - 102,772,044UniSTSRnor5.0
RGSC_v3.4196,178,667 - 96,178,855UniSTSRGSC3.4
Celera190,434,123 - 90,434,311UniSTS
RH 3.4 Map1907.59UniSTS
Cytogenetic Map1q22UniSTS
RH131462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,174,812 - 96,175,026 (+)MAPPERmRatBN7.2
Rnor_6.01101,686,913 - 101,687,126NCBIRnor6.0
Rnor_5.01102,765,745 - 102,765,958UniSTSRnor5.0
RGSC_v3.4196,172,556 - 96,172,769UniSTSRGSC3.4
Celera190,428,012 - 90,428,225UniSTS
RH 3.4 Map1909.1UniSTS
Cytogenetic Map1q22UniSTS
D1Bda18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,180,282 - 96,180,544 (+)MAPPERmRatBN7.2
Rnor_6.01101,692,383 - 101,692,644NCBIRnor6.0
Rnor_5.01102,771,215 - 102,771,476UniSTSRnor5.0
RGSC_v3.4196,178,026 - 96,178,287UniSTSRGSC3.4
Celera190,433,482 - 90,433,743UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000028546   ⟹   ENSRNOP00000028547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,175,796 - 96,180,745 (+)Ensembl
Rnor_6.0 Ensembl1101,687,855 - 101,692,846 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091597   ⟹   ENSRNOP00000068721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,175,440 - 96,180,745 (+)Ensembl
Rnor_6.0 Ensembl1101,687,896 - 101,692,845 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091606   ⟹   ENSRNOP00000073424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1101,688,297 - 101,692,804 (+)Ensembl
RefSeq Acc Id: NM_001289982   ⟹   NP_001276911
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,312,256 - 105,317,205 (+)NCBI
mRatBN7.2196,175,796 - 96,180,745 (+)NCBI
Rnor_6.01101,687,896 - 101,692,845 (+)NCBI
Celera190,428,995 - 90,433,944 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001289983   ⟹   NP_001276912
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,312,256 - 105,317,205 (+)NCBI
mRatBN7.2196,175,796 - 96,180,745 (+)NCBI
Rnor_6.01101,687,896 - 101,692,845 (+)NCBI
Celera190,428,995 - 90,433,944 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012543   ⟹   NP_036675
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,312,256 - 105,317,205 (+)NCBI
mRatBN7.2196,175,796 - 96,180,745 (+)NCBI
Rnor_6.01101,687,896 - 101,692,845 (+)NCBI
Rnor_5.01102,766,762 - 102,771,674 (+)NCBI
RGSC_v3.4196,173,573 - 96,178,485 (+)RGD
Celera190,428,995 - 90,433,944 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063280571   ⟹   XP_063136641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,314,069 - 105,317,205 (+)NCBI
RefSeq Acc Id: XM_063280574   ⟹   XP_063136644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,314,865 - 105,317,205 (+)NCBI
RefSeq Acc Id: XM_063280595   ⟹   XP_063136665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,314,931 - 105,317,205 (+)NCBI
RefSeq Acc Id: NP_036675   ⟸   NM_012543
- Peptide Label: isoform 1
- UniProtKB: P16443 (UniProtKB/Swiss-Prot),   A6JB71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276911   ⟸   NM_001289982
- Peptide Label: isoform 2
- UniProtKB: Q6R2I3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276912   ⟸   NM_001289983
- Peptide Label: isoform 3
- UniProtKB: Q6R2I2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028547   ⟸   ENSRNOT00000028546
Ensembl Acc Id: ENSRNOP00000073424   ⟸   ENSRNOT00000091606
Ensembl Acc Id: ENSRNOP00000068721   ⟸   ENSRNOT00000091597
RefSeq Acc Id: XP_063136641   ⟸   XM_063280571
- Peptide Label: isoform X1
- UniProtKB: A6JB72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136644   ⟸   XM_063280574
- Peptide Label: isoform X1
- UniProtKB: A6JB72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136665   ⟸   XM_063280595
- Peptide Label: isoform X1
- UniProtKB: A6JB72 (UniProtKB/TrEMBL)
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16443-F1-model_v2 AlphaFold P16443 1-325 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690050
Promoter ID:EPDNEW_R574
Type:initiation region
Name:Dbp_1
Description:D-box binding PAR bZIP transcription factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,687,917 - 101,687,977EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2491 AgrOrtholog
BioCyc Gene G2FUF-59655 BioCyc
Ensembl Genes ENSRNOG00000021027 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006654 UniProtKB/Swiss-Prot
  ENSRNOG00060010607 UniProtKB/Swiss-Prot
  ENSRNOG00065031277 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028546.6 UniProtKB/Swiss-Prot
  ENSRNOT00000091597.2 UniProtKB/TrEMBL
  ENSRNOT00055010850 UniProtKB/Swiss-Prot
  ENSRNOT00060017975 UniProtKB/Swiss-Prot
  ENSRNOT00065053978 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7317132 IMAGE-MGC_LOAD
InterPro bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAR_bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24309 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105474 IMAGE-MGC_LOAD
NCBI Gene 24309 ENTREZGENE
PANTHER PTHR11988 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11988:SF7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dbp PhenoGen
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021027 RatGTEx
  ENSRNOG00055006654 RatGTEx
  ENSRNOG00060010607 RatGTEx
  ENSRNOG00065031277 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229305
UniProt A0A0G2JTI1_RAT UniProtKB/TrEMBL
  A6JB71 ENTREZGENE, UniProtKB/TrEMBL
  A6JB72 ENTREZGENE, UniProtKB/TrEMBL
  DBP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6R2I1_RAT UniProtKB/TrEMBL
  Q6R2I2 ENTREZGENE, UniProtKB/TrEMBL
  Q6R2I3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Dbp  D-box binding PAR bZIP transcription factor  Dbp  D site of albumin promoter (albumin D-box) binding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Dbp  D site of albumin promoter (albumin D-box) binding protein  Dbp  D site albumin promoter binding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Dbp  D site albumin promoter binding protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is downregulated during chemically induced liver regeneration, suggesting a role in regulating cell proliferation 727680