 Gene-Chemical Interaction Annotations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations |
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Analyze GeneStrainQTL List |
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Gene Annotator (Annotation Comparison) |
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MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology AnnotationsBiological Process
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Cellular Component
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Molecular Function
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Molecular Pathway AnnotationsReferences - curated| 1. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 2. | KEGG |
| 3. | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 4. | Pipeline to import KEGG annotations from KEGG into RGD |
| 5. | RGD automated data pipeline |
| 6. | RGD automated import pipeline for gene-chemical interactions |
| 7. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 8. | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 9. | Tsuji S, etal., Proc Natl Acad Sci U S A 1994 Sep 27;91(20):9392-6. |
References - uncuratedGenomics
Comparative Map Data| Ldhc (Rattus norvegicus - Norway rat) |
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| LDHC (Homo sapiens - human) |
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| Ldhc (Mus musculus - house mouse) |
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| LOC102020557 (Chinchilla lanigera - long-tailed chinchilla) |
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| LDHC (Pan paniscus - bonobo/pygmy chimpanzee) |
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| LDHC (Canis lupus familiaris - dog) |
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| LOC101970352 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| LDHC (Sus scrofa - pig) |
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| LDHC (Chlorocebus sabaeus - African green monkey) |
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| LOC101715932 (Heterocephalus glaber - naked mole-rat) |
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Position Markers| BE120592 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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Expression
RNA-SEQ ExpressionHigh: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM
| alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
| High | |||||||||||||
| Medium | 7 | ||||||||||||
| Low | 17 | 6 | 13 | 6 | 2 | 2 | 1 | 21 | 15 | 11 | 2 | ||
| Below cutoff | 2 | 11 | 31 | 26 | 5 | 26 | 6 | 9 | 18 | 12 | 10 | 6 |
View RNA-SEQ Expression Data
Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_017266 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_006229233 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_008759344 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_008759345 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017589062 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017589063 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AAHX01005085 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AAHX01005086 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AC099150 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| BC078862 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473979 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| JQ173138 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| JQ173139 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| JQ173140 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| JQ173141 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| JQ409364 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| JQ409365 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| JQ409366 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| JQ409367 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| JQ409368 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| JQ409369 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| U07177 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | ENSRNOT00000017851 ⟹ ENSRNOP00000017851 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | ENSRNOT00000079440 ⟹ ENSRNOP00000069268 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | ENSRNOT00000082718 ⟹ ENSRNOP00000071562 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | ENSRNOT00000083079 ⟹ ENSRNOP00000070991 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | ENSRNOT00000088892 ⟹ ENSRNOP00000073654 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | ENSRNOT00000090520 ⟹ ENSRNOP00000075021 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | ENSRNOT00000092180 ⟹ ENSRNOP00000072576 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | NM_017266 ⟹ NP_058962 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Position: |
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| Sequence: |
CCTGGGCCTAACGGTCATCCTTGTTTCTTAACTGCTGCGGGGTGTGTTTTCGACATCCTTTGAGhide sequence |
| RefSeq Acc Id: | XM_006229233 ⟹ XP_006229295 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
GGGAGGGAGGAGCCTAAAGGGAGGGAGGGGCCTGTGGCCACAAGTCATCCTTTGCCTCCTTGGGhide sequence |
| RefSeq Acc Id: | XM_008759344 ⟹ XP_008757566 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| Sequence: |
GCCCCCAACTCTCAGTGCCTACAAACAGATGTAAGGTATGCTCCTCAAACTCTGCATTTCCTCAhide sequence |
| RefSeq Acc Id: | XM_008759345 ⟹ XP_008757567 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| Sequence: |
CGCGCCCCCAACTCTCAGTGCCTACAAACAGATGTAAGGTATGCTCCTCAAACTCTGCATTTCChide sequence |
| RefSeq Acc Id: | XM_017589062 ⟹ XP_017444551 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| Sequence: |
CTGTTGGCTCCTGGGCCTAACGGTCATCCTTGTTTCTTAACTGCTGCGGGGTGTGTTTTCGACAhide sequence |
| RefSeq Acc Id: | XM_017589063 ⟹ XP_017444552 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| Sequence: |
ATGTCCACTGTCAAGGAGCAGCTAATTCAGAACCTAGCTCCAGATGAAAAACAATCCCGGTGTAhide sequence |
Protein Sequences| Protein RefSeqs | NP_058962 | (Get FASTA) | NCBI Sequence Viewer |
| XP_006229295 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_008757566 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_008757567 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017444551 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017444552 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | AAA50435 | (Get FASTA) | NCBI Sequence Viewer |
| AAH78862 | (Get FASTA) | NCBI Sequence Viewer | |
| AFF19212 | (Get FASTA) | NCBI Sequence Viewer | |
| AFI54976 | (Get FASTA) | NCBI Sequence Viewer | |
| AFI54977 | (Get FASTA) | NCBI Sequence Viewer | |
| AFI54978 | (Get FASTA) | NCBI Sequence Viewer | |
| AFI54979 | (Get FASTA) | NCBI Sequence Viewer | |
| AFI54980 | (Get FASTA) | NCBI Sequence Viewer | |
| AFI54981 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM07248 | (Get FASTA) | NCBI Sequence Viewer | |
| P19629 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_058962 ⟸ NM_017266 |
| - UniProtKB: | Q6AYX2 (UniProtKB/TrEMBL) |
| - Sequence: |
MSTVKEQLIQNLAPDEKQSRCKITVVGVGNVGMACAISILLKGLADELALVDADENKLKGEALDhide sequence |
| RefSeq Acc Id: | XP_006229295 ⟸ XM_006229233 |
| - Peptide Label: | isoform X2 |
| - UniProtKB: | Q6AYX2 (UniProtKB/TrEMBL) |
| - Sequence: |
MSTVKEQLIQNLAPDEKQSRCKITVVGVGNVGMACAISILLKGLADELALVDADENKLKGEALDhide sequence |
| RefSeq Acc Id: | XP_008757566 ⟸ XM_008759344 |
| - Peptide Label: | isoform X1 |
| - Sequence: |
MRLNMSTVKEQLIQNLAPDEKQSRCKITVVGVGNVGMACAISILLKGLADELALVDADENKLKGhide sequence |
| RefSeq Acc Id: | XP_008757567 ⟸ XM_008759345 |
| - Peptide Label: | isoform X4 |
| - Sequence: |
MRLNMSTVKEQLIQNLAPDEKQSRCKITVVGVGNVGMACAISILLKGLADELALVDADENKLKGhide sequence |
| RefSeq Acc Id: | XP_017444551 ⟸ XM_017589062 |
| - Peptide Label: | isoform X2 |
| - UniProtKB: | Q6AYX2 (UniProtKB/TrEMBL) |
| - Sequence: |
MSTVKEQLIQNLAPDEKQSRCKITVVGVGNVGMACAISILLKGLADELALVDADENKLKGEALDhide sequence |
| RefSeq Acc Id: | XP_017444552 ⟸ XM_017589063 |
| - Peptide Label: | isoform X3 |
| - Sequence: |
MAAFSSALQKSSLEKRPKAWNPLDLKLGSQQLWVLRTELGFILKSNYSVSANSKLVIITAGARMhide sequence |
| RefSeq Acc Id: | ENSRNOP00000069268 ⟸ ENSRNOT00000079440 |
| RefSeq Acc Id: | ENSRNOP00000071562 ⟸ ENSRNOT00000082718 |
| RefSeq Acc Id: | ENSRNOP00000072576 ⟸ ENSRNOT00000092180 |
| RefSeq Acc Id: | ENSRNOP00000070991 ⟸ ENSRNOT00000083079 |
| RefSeq Acc Id: | ENSRNOP00000075021 ⟸ ENSRNOT00000090520 |
| RefSeq Acc Id: | ENSRNOP00000073654 ⟸ ENSRNOT00000088892 |
| RefSeq Acc Id: | ENSRNOP00000017851 ⟸ ENSRNOT00000017851 |
Protein Domains
Ldh_1_C Ldh_1_N
TranscriptomePromoters| RGD ID: | 13690069 | ||||||||
| Promoter ID: | EPDNEW_R593 | ||||||||
| Type: | initiation region | ||||||||
| Name: | Ldhc_1 | ||||||||
| Description: | lactate dehydrogenase C | ||||||||
| SO ACC ID: | SO:0000170 | ||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
| Alternative Promoters: | null; see alsoEPDNEW_R594 | ||||||||
| Experiment Methods: | Single-end sequencing. | ||||||||
| Position: |
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| RGD ID: | 13690072 | ||||||||
| Promoter ID: | EPDNEW_R594 | ||||||||
| Type: | single initiation site | ||||||||
| Name: | Ldhc_2 | ||||||||
| Description: | lactate dehydrogenase C | ||||||||
| SO ACC ID: | SO:0000170 | ||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
| Alternative Promoters: | null; see alsoEPDNEW_R593 | ||||||||
| Experiment Methods: | Single-end sequencing. | ||||||||
| Position: |
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Strain Variation
Strain Sequence Variants (Rnor 6.0)
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Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:69366 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000013103 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000017851 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000069268 | ENTREZGENE, UniProtKB/TrEMBL | |
| ENSRNOP00000070991 | UniProtKB/TrEMBL | |
| ENSRNOP00000071562 | UniProtKB/TrEMBL | |
| ENSRNOP00000072576 | UniProtKB/TrEMBL | |
| ENSRNOP00000073654 | UniProtKB/TrEMBL | |
| ENSRNOP00000075021 | UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000017851 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000079440 | ENTREZGENE, UniProtKB/TrEMBL | |
| ENSRNOT00000082718 | UniProtKB/TrEMBL | |
| ENSRNOT00000083079 | UniProtKB/TrEMBL | |
| ENSRNOT00000088892 | UniProtKB/TrEMBL | |
| ENSRNOT00000090520 | UniProtKB/TrEMBL | |
| ENSRNOT00000092180 | UniProtKB/TrEMBL | |
| Gene3D-CATH | 3.90.110.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| IMAGE_CLONE | IMAGE:7131609 | IMAGE-MGC_LOAD |
| InterPro | L-lactate/malate_DH | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| L-lactate_DH | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| L-lactate_DH_AS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| Lactate/malate_DH_C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| Lactate/malate_DH_N | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| Lactate_DH/Glyco_Ohase_4_C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| NAD(P)-bd_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| KEGG Report | rno:29634 | UniProtKB/TrEMBL |
| MGC_CLONE | MGC:93523 | IMAGE-MGC_LOAD |
| NCBI Gene | 29634 | ENTREZGENE |
| Pfam | Ldh_1_C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| Ldh_1_N | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| PhenoGen | Ldhc | PhenoGen |
| PIRSF | Lac_mal_DH | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| PRINTS | LLDHDRGNASE | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| PROSITE | L_LDH | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| Superfamily-SCOP | SSF51735 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| SSF56327 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| TIGR | TC234106 | |
| TIGRFAMs | L-LDH-NAD | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| UniGene | Rn.9984 | ENTREZGENE |
| UniProt | A0A0G2K3B9_RAT | UniProtKB/TrEMBL |
| H9N9H4_RAT | UniProtKB/TrEMBL | |
| I1VWM9_RAT | UniProtKB/TrEMBL | |
| I1VWN0_RAT | UniProtKB/TrEMBL | |
| I1VWN1_RAT | UniProtKB/TrEMBL | |
| LDHC_RAT | UniProtKB/Swiss-Prot, ENTREZGENE | |
| Q6AYX2 | ENTREZGENE, UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2006-03-30 | Ldhc | lactate dehydrogenase C | lactate dehydrogenase 3, C chain | Name updated | 1299863 | APPROVED | |
| 2002-06-10 | Ldhc | lactate dehydrogenase 3, C chain | Name updated | 70584 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | expressed in testis | 68808 |
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| More on Ldhc | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 69366 |
| Created: | 2001-11-14 |
| Species: | Rattus norvegicus |
| Last Modified: | 2020-08-20 |
| Status: | ACTIVE |
