Ifnl1 (interferon, lambda 1) - Rat Genome Database

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Gene: Ifnl1 (interferon, lambda 1) Rattus norvegicus
Symbol: Ifnl1
Name: interferon, lambda 1
RGD ID: 6493686
Description: Predicted to enable interleukin-28 receptor binding activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of immune response; and regulation of gene expression. Predicted to be located in extracellular region. Predicted to be part of interleukin-28 receptor complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; cryoglobulinemia; dengue hemorrhagic fever; hepatitis C; and liver disease (multiple). Orthologous to several human genes including IFNL2 (interferon lambda 2) and IFNL3 (interferon lambda 3); INTERACTS WITH N,N-diethyl-m-toluamide; permethrin; benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: If1ia2; interferon 1ia2; interferon lambda-2-like; interleukin-28A-like; LOC100911249
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2183,798,651 - 83,800,297 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,798,703 - 83,800,235 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0185,252,103 - 85,253,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,252,103 - 85,253,635 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,468,148 - 86,469,680 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Interferon lambda 1 is associated with dengue severity in Thailand. Arayasongsak U, etal., Int J Infect Dis. 2020 Apr;93:121-125. doi: 10.1016/j.ijid.2020.01.026. Epub 2020 Jan 22.
2. IL28B, IL29 and micro-RNA 548 in subacute sclerosing panencephalitis as a rare disease. Cakmak Genc G, etal., Gene. 2018 Dec 15;678:73-78. doi: 10.1016/j.gene.2018.07.062. Epub 2018 Aug 2.
3. Dendritic cells-derived interferon-λ1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis. Chen Y, etal., Cell Death Dis. 2020 Jun 2;11(6):414. doi: 10.1038/s41419-020-2612-z.
4. A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures. Dinnon KH, etal., Nature. 2020 Oct;586(7830):560-566. doi: 10.1038/s41586-020-2708-8. Epub 2020 Aug 27.
5. Type III interferons, IL-28 and IL-29, are increased in chronic HCV infection and induce myeloid dendritic cell-mediated FoxP3+ regulatory T cells. Dolganiuc A, etal., PLoS One. 2012;7(10):e44915. doi: 10.1371/journal.pone.0044915. Epub 2012 Oct 10.
6. Peripheral blood and hepatic Toll-like receptor 7 expression and interferon lambda 1 levels in chronic hepatitis C: Relation to virus replication and liver injury. El Aggan H, etal., Microb Pathog. 2019 Jun;131:65-74. doi: 10.1016/j.micpath.2019.03.032. Epub 2019 Mar 26.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. IL-28 and IL-29 as protective markers in subject with dengue fever. Hung CH, etal., Med Microbiol Immunol. 2017 Jun;206(3):217-223. doi: 10.1007/s00430-017-0498-x. Epub 2017 Feb 25.
9. Interferon-lambda serum levels in hepatitis C. Langhans B, etal., J Hepatol. 2011 May;54(5):859-65. doi: 10.1016/j.jhep.2010.08.020. Epub 2010 Oct 23.
10. A mechanistic role for type III IFN-λ1 in asthma exacerbations mediated by human rhinoviruses. Miller EK, etal., Am J Respir Crit Care Med. 2012 Mar 1;185(5):508-16. doi: 10.1164/rccm.201108-1462OC. Epub 2011 Dec 1.
11. Interferon Lambda Family along with HTLV-1 Proviral Load, Tax, and HBZ Implicated in the Pathogenesis of Myelopathy/Tropical Spastic Paraparesis. Mozhgani SH, etal., Neurodegener Dis. 2018;18(2-3):150-155. doi: 10.1159/000490058. Epub 2018 Jul 10.
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Severity of virus-induced asthma symptoms is inversely related to resolution IFN-λ expression. Schwantes EA, etal., J Allergy Clin Immunol. 2015 Jun;135(6):1656-9. doi: 10.1016/j.jaci.2015.01.038. Epub 2015 Mar 14.
14. Interferon lambda 1-3 expression in infants hospitalized for RSV or HRV associated bronchiolitis. Selvaggi C, etal., J Infect. 2014 May;68(5):467-77. doi: 10.1016/j.jinf.2013.12.010. Epub 2014 Jan 2.
15. Suppression of hepatocellular carcinoma proliferation and hepatitis B surface antigen secretion with interferon-λ1 or PEG-interferon-λ1. Tian S, etal., FASEB J. 2014 Aug;28(8):3528-39. doi: 10.1096/fj.14-250704. Epub 2014 Apr 25.
16. Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, IL-29, IL-8, and cyclooxygenase-2. Yu Y, etal., J Immunol. 2011 Nov 1;187(9):4844-60. doi: 10.4049/jimmunol.1100998. Epub 2011 Sep 28.
17. Genetic polymorphisms of the IFNλ genes are associated with biochemical features in Han Chinese with HCV infection from Yunnan Province, China. Zhang AM, etal., Infect Genet Evol. 2014 Jan;21:161-5. doi: 10.1016/j.meegid.2013.11.013. Epub 2013 Nov 21.
Additional References at PubMed
PMID:12469119   PMID:12483210   PMID:15166220   PMID:15899585   PMID:19346497   PMID:24950142  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2183,798,651 - 83,800,297 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,798,703 - 83,800,235 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0185,252,103 - 85,253,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,252,103 - 85,253,635 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,468,148 - 86,469,680 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map1q21NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381939,296,407 - 39,298,673 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1939,296,407 - 39,298,673 (+)EnsemblGRCh38hg38GRCh38
GRCh371939,787,047 - 39,789,313 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,478,805 - 44,481,152 (+)NCBINCBI36Build 36hg18NCBI36
Build 341944,478,804 - 44,481,152NCBI
Celera1936,588,638 - 36,590,984 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,233,484 - 36,235,831 (+)NCBIHuRef
CHM1_11939,787,771 - 39,790,118 (+)NCBICHM1_1
T2T-CHM13v2.01942,100,680 - 42,102,942 (+)NCBIT2T-CHM13v2.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11944,942,186 - 44,944,519 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,942,186 - 44,944,519 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01936,394,462 - 36,397,363 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12436,440,445 - 36,441,017 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,440,445 - 36,441,017 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2435,681,783 - 35,682,355 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02437,144,224 - 37,144,796 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2437,144,224 - 37,144,796 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12436,385,609 - 36,386,181 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02436,518,941 - 36,519,513 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02437,062,250 - 37,062,822 (+)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1751,484,658 - 51,485,233 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,484,658 - 51,485,233 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1633,901,382 - 33,904,356 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,901,801 - 33,903,894 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607311,921,937 - 11,924,341 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Variants in Ifnl1
9 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,798,362 - 83,798,460 (-)MAPPERmRatBN7.2
mRatBN7.2183,798,362 - 83,798,460 (+)MAPPERmRatBN7.2
mRatBN7.2183,816,338 - 83,816,436 (-)MAPPERmRatBN7.2
mRatBN7.2183,816,338 - 83,816,436 (+)MAPPERmRatBN7.2
Rnor_6.0185,235,903 - 85,236,000NCBIRnor6.0
Rnor_6.0185,253,878 - 85,253,975NCBIRnor6.0
Rnor_5.0186,469,923 - 86,470,020UniSTSRnor5.0
Rnor_5.0186,450,491 - 86,450,588UniSTSRnor5.0
RGSC_v3.4183,617,468 - 83,617,565UniSTSRGSC3.4
Celera178,211,121 - 78,211,218UniSTS
Cytogenetic Map1q21UniSTS



Reference Sequences
RefSeq Acc Id: ENSRNOT00000080740   ⟹   ENSRNOP00000069941
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,798,703 - 83,800,235 (-)Ensembl
Rnor_6.0 Ensembl185,252,103 - 85,253,635 (+)Ensembl
RefSeq Acc Id: XM_008759287   ⟹   XP_008757509
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2183,798,651 - 83,800,297 (-)NCBI
Rnor_6.0185,252,103 - 85,253,635 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008757509 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAB0000200 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008757509   ⟸   XM_008759287
- UniProtKB: A0A0G2JWM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069941   ⟸   ENSRNOT00000080740

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JWM7-F1-model_v2 AlphaFold A0A0G2JWM7 1-192 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6493686 AgrOrtholog
BioCyc Gene G2FUF-60239 BioCyc
Ensembl Genes ENSRNOG00000056251 Ensembl
  ENSRNOG00000063917 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000069941 ENTREZGENE
  ENSRNOP00000069941.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080740 ENTREZGENE
  ENSRNOT00000080740.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.60 UniProtKB/TrEMBL
InterPro IFN-lambda_sf UniProtKB/TrEMBL
  INF_lambda UniProtKB/TrEMBL
KEGG Report rno:100911249 UniProtKB/TrEMBL
Pfam IL28A UniProtKB/TrEMBL
PhenoGen Ifnl1 PhenoGen

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Ifnl1  interferon, lambda 1  Ifnl1  interferon, lambda 1  Data Merged 737654 PROVISIONAL
2021-08-09 Ifnl1  interferon, lambda 1      Symbol and Name status set to provisional 45752 PROVISIONAL
2016-06-15 Ifnl1  interferon, lambda 1  LOC100911249  interleukin-28A-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911249  interleukin-28A-like      Symbol and Name status set to provisional 70820 PROVISIONAL