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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of RUVBL2 mRNA] | CTD | PMID:31150632 | (1->4)-beta-D-glucan | multiple interactions | ISO | RGD:1315166 | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of RUVBL2 mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | increases expression | ISO | RGD:1315166 | 6480464 | 1, 2-Dimethylhydrazine results in increased expression of RUVBL2 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1315166 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RUVBL2 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:1315166 | 6480464 | Ethinyl Estradiol results in increased expression of RUVBL2 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:1315166 | 6480464 | Ethinyl Estradiol affects the expression of RUVBL2 mRNA | CTD | PMID:17555576 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of RUVBL2 mRNA | CTD | PMID:32145629 | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | multiple interactions | ISO | RGD:1315165 | 6480464 | Metribolone promotes the reaction [NDRG1 protein binds to RUVBL2 protein] | CTD | PMID:17220478 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | RGD:1315166 | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1315166 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RUVBL2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of RUVBL2 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1315166 | 6480464 | Tetrachlorodibenzodioxin affects the expression of RUVBL2 mRNA | CTD | PMID:21570461, PMID:24680724 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of RUVBL2 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RUVBL2 mRNA | CTD | PMID:21215274 | 2,3-dimethoxynaphthalene-1,4-dione | increases expression | ISO | RGD:1315165 | 6480464 | 2 more ... | CTD | PMID:19031421 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2, 4-dinitrotoluene affects the expression of RUVBL2 mRNA | CTD | PMID:21346803 | 3,3'-Dichlorobenzidine | affects expression | ISO | RGD:1315165 | 6480464 | 3, 3'-Dichlorobenzidine affects the expression of RUVBL2 protein | CTD | PMID:24604609 | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2, 6-dinitrotoluene affects the expression of RUVBL2 mRNA | CTD | PMID:21346803 | acrolein | multiple interactions | ISO | RGD:1315165 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of RUVBL2 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of RUVBL2 mRNA | CTD | PMID:32699268 | aflatoxin B1 | increases methylation | ISO | RGD:1315165 | 6480464 | Aflatoxin B1 results in increased methylation of RUVBL2 gene | CTD | PMID:27153756 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1315165 | 6480464 | Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of RUVBL2 mRNA] | CTD | PMID:16140955 | all-trans-retinoic acid | decreases expression | ISO | RGD:1315165 | 6480464 | Tretinoin results in decreased expression of RUVBL2 mRNA | CTD | PMID:16140955, PMID:23724009 | alpha-pinene | multiple interactions | ISO | RGD:1315165 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of RUVBL2 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of RUVBL2 mRNA | CTD | PMID:32699268 | arsenite(3-) | multiple interactions | ISO | RGD:1315165 | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to RUVBL2 protein] | CTD | PMID:32406909 | arsenous acid | multiple interactions | ISO | RGD:1315165 | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to RUVBL2 protein] | CTD | PMID:26598702 | atrazine | increases expression | ISO | RGD:1315165 | 6480464 | Atrazine results in increased expression of RUVBL2 mRNA | CTD | PMID:22378314 | benzatropine | increases expression | ISO | RGD:1315165 | 6480464 | Benztropine results in increased expression of RUVBL2 protein | CTD | PMID:34122009 | benzo[a]pyrene | increases methylation | ISO | RGD:1315166 | 6480464 | Benzo(a)pyrene results in increased methylation of RUVBL2 exon, Benzo(a)pyrene results in increased methylation of RUVBL2 intron | CTD | PMID:27901495 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of RUVBL2 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | RGD:1315165 | 6480464 | bisphenol A results in decreased expression of RUVBL2 mRNA, bisphenol A results in decreased expression of RUVBL2 protein | CTD | PMID:29275510, PMID:31675489 | cadmium atom | multiple interactions | ISO | RGD:1315165 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of RUVBL2 protein | CTD | PMID:33040242 | cadmium dichloride | multiple interactions | ISO | RGD:1315165 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of RUVBL2 protein | CTD | PMID:33040242 | caffeine | decreases phosphorylation | ISO | RGD:1315165 | 6480464 | Caffeine results in decreased phosphorylation of RUVBL2 protein | CTD | PMID:35688186 | CGP 52608 | multiple interactions | ISO | RGD:1315165 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to RUVBL2 gene] | CTD | PMID:28238834 | cisplatin | increases expression | ISO | RGD:1315165 | 6480464 | Cisplatin results in increased expression of RUVBL2 protein | CTD | PMID:20540955 | clobetasol | increases expression | ISO | RGD:1315166 | 6480464 | Clobetasol results in increased expression of RUVBL2 mRNA | CTD | PMID:27462272 | cobalt dichloride | decreases expression | ISO | RGD:1315165 | 6480464 | cobaltous chloride results in decreased expression of RUVBL2 mRNA | CTD | PMID:19376846 | copper atom | multiple interactions | ISO | RGD:1315165 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of RUVBL2 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RGD:1315165 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of RUVBL2 mRNA | CTD | PMID:20971185 | coumestrol | increases expression | ISO | RGD:1315165 | 6480464 | Coumestrol results in increased expression of RUVBL2 mRNA | CTD | PMID:19167446 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of RUVBL2 mRNA | CTD | PMID:26577399 | deoxynivalenol | increases expression | ISO | RGD:1315165 | 6480464 | deoxynivalenol results in increased expression of RUVBL2 mRNA | CTD | PMID:31863870 | diarsenic trioxide | multiple interactions | ISO | RGD:1315165 | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to RUVBL2 protein] | CTD | PMID:26598702 | dibutyl phthalate | decreases expression | ISO | RGD:1315166 | 6480464 | Dibutyl Phthalate results in decreased expression of RUVBL2 mRNA | CTD | PMID:17361019, PMID:21266533 | elemental selenium | increases expression | ISO | RGD:1315165 | 6480464 | Selenium results in increased expression of RUVBL2 mRNA | CTD | PMID:19244175 | epoxiconazole | decreases expression | ISO | RGD:1315166 | 6480464 | epoxiconazole results in decreased expression of RUVBL2 mRNA | CTD | PMID:35436446 | fenthion | increases expression | ISO | RGD:1315166 | 6480464 | Fenthion results in increased expression of RUVBL2 mRNA | CTD | PMID:34813904 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of RUVBL2 mRNA | CTD | PMID:24136188 | geraniol | decreases expression | ISO | RGD:1315165 | 6480464 | geraniol results in decreased expression of RUVBL2 mRNA | CTD | PMID:27683099 | glyphosate | increases methylation | EXP | | 6480464 | glyphosate results in increased methylation of RUVBL2 gene | CTD | PMID:31011160 | hydrogen peroxide | affects expression | ISO | RGD:1315165 | 6480464 | Hydrogen Peroxide affects the expression of RUVBL2 mRNA | CTD | PMID:20044591 | hypochlorous acid | decreases expression | ISO | RGD:1315166 | 6480464 | Hypochlorous Acid results in decreased expression of RUVBL2 mRNA | CTD | PMID:19376150 | imiquimod | decreases expression | ISO | RGD:1315166 | 6480464 | imiquimod results in decreased expression of RUVBL2 mRNA | CTD | PMID:21878529 | ivermectin | decreases expression | ISO | RGD:1315165 | 6480464 | Ivermectin results in decreased expression of RUVBL2 protein | CTD | PMID:32959892 | lead(0) | decreases expression | ISO | RGD:1315165 | 6480464 | Lead results in decreased expression of RUVBL2 mRNA | CTD | PMID:19921347 | linalool | decreases expression | ISO | RGD:1315165 | 6480464 | linalool results in decreased expression of RUVBL2 mRNA | CTD | PMID:27683099 | lovastatin | decreases expression | ISO | RGD:1315166 | 6480464 | Lovastatin results in decreased expression of RUVBL2 mRNA | CTD | PMID:20493250 | methidathion | increases expression | ISO | RGD:1315166 | 6480464 | methidathion results in increased expression of RUVBL2 mRNA | CTD | PMID:34813904 | N-methyl-4-phenylpyridinium | increases expression | ISO | RGD:1315166 | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of RUVBL2 protein | CTD | PMID:26558463 | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of RUVBL2 mRNA | CTD | PMID:24136188 | ozone | multiple interactions | ISO | RGD:1315165 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of RUVBL2 mRNA more ... | CTD | PMID:32699268 | ozone | multiple interactions | ISO | RGD:1315166 | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of RUVBL2 mRNA | CTD | PMID:34911549 | paclitaxel | decreases expression | ISO | RGD:1315165 | 6480464 | Paclitaxel results in decreased expression of RUVBL2 protein | CTD | PMID:15907983 | paracetamol | affects expression | ISO | RGD:1315166 | 6480464 | Acetaminophen affects the expression of RUVBL2 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:1315165 | 6480464 | Acetaminophen results in increased expression of RUVBL2 mRNA | CTD | PMID:22230336 | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of RUVBL2 mRNA | CTD | PMID:32680482 | perfluorooctane-1-sulfonic acid | increases expression | ISO | RGD:1315165 | 6480464 | perfluorooctane sulfonic acid results in increased expression of RUVBL2 mRNA | CTD | PMID:27153767 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | RGD:1315166 | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of RUVBL2 mRNA | CTD | PMID:36331819 | phenobarbital | affects expression | ISO | RGD:1315166 | 6480464 | Phenobarbital affects the expression of RUVBL2 mRNA | CTD | PMID:23091169 | pirinixic acid | multiple interactions | ISO | RGD:1315166 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RUVBL2 mRNA | CTD | PMID:19710929 | quercetin | affects binding | ISO | RGD:1315165 | 6480464 | Quercetin analog binds to RUVBL2 protein | CTD | PMID:21798748 | selenium atom | increases expression | ISO | RGD:1315165 | 6480464 | Selenium results in increased expression of RUVBL2 mRNA | CTD | PMID:19244175 | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of RUVBL2 protein | CTD | PMID:29459688 | sodium arsenite | increases expression | ISO | RGD:1315165 | 6480464 | sodium arsenite results in increased expression of RUVBL2 mRNA | CTD | PMID:34032870 | sunitinib | decreases expression | ISO | RGD:1315165 | 6480464 | Sunitinib results in decreased expression of RUVBL2 mRNA | CTD | PMID:31533062 | T-2 toxin | affects expression | EXP | | 6480464 | T-2 Toxin affects the expression of RUVBL2 protein | CTD | PMID:26141394 | T-2 toxin | increases expression | ISO | RGD:1315165 | 6480464 | T-2 Toxin results in increased expression of RUVBL2 mRNA | CTD | PMID:31863870 | tamoxifen | affects expression | ISO | RGD:1315166 | 6480464 | Tamoxifen affects the expression of RUVBL2 mRNA | CTD | PMID:17555576 | temozolomide | increases expression | ISO | RGD:1315165 | 6480464 | Temozolomide results in increased expression of RUVBL2 mRNA | CTD | PMID:31758290 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of RUVBL2 mRNA | CTD | PMID:31150632 | tetrachloromethane | increases expression | ISO | RGD:1315166 | 6480464 | Carbon Tetrachloride results in increased expression of RUVBL2 mRNA | CTD | PMID:31919559 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of RUVBL2 mRNA] | CTD | PMID:31150632 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of RUVBL2 mRNA | CTD | PMID:23411599, PMID:34492290 | thiophenes | multiple interactions | ISO | RGD:1315165 | 6480464 | Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of RUVBL2 mRNA] | CTD | PMID:16140955 | titanium dioxide | increases expression | ISO | RGD:1315165 | 6480464 | titanium dioxide results in increased expression of RUVBL2 protein | CTD | PMID:30910687 | triptonide | decreases expression | ISO | RGD:1315166 | 6480464 | triptonide results in decreased expression of RUVBL2 mRNA | CTD | PMID:33045310 | valproic acid | increases methylation | ISO | RGD:1315165 | 6480464 | Valproic Acid results in increased methylation of RUVBL2 gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | RGD:1315165 | 6480464 | Valproic Acid results in increased expression of RUVBL2 mRNA | CTD | PMID:23179753, PMID:29154799 | valproic acid | affects expression | ISO | RGD:1315165 | 6480464 | Valproic Acid affects the expression of RUVBL2 mRNA | CTD | PMID:25979313 | warfarin | decreases expression | ISO | RGD:1315166 | 6480464 | Warfarin results in decreased expression of RUVBL2 mRNA | CTD | PMID:20493250 | |