RUVBL2 (RuvB like AAA ATPase 2) - Rat Genome Database

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Gene: RUVBL2 (RuvB like AAA ATPase 2) Canis lupus familiaris
Analyze
Symbol: RUVBL2
Name: RuvB like AAA ATPase 2
RGD ID: 12175919
Description: ENCODES a protein that exhibits ADP binding (inferred); ATP binding (inferred); ATP hydrolysis activity (inferred); INVOLVED IN telomerase RNA localization to Cajal body (ortholog); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; ASSOCIATED WITH progressive familial heart block type IB (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: RuvB-like 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,384,328 - 107,400,849 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,384,342 - 107,400,505 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,910,707 - 106,923,430 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,908,904 - 107,925,482 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,908,893 - 107,925,182 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,576,740 - 107,593,066 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,222,909 - 107,239,405 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,058,521 - 108,075,019 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202   PMID:30404858  


Genomics

Comparative Map Data
RUVBL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,384,328 - 107,400,849 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,384,342 - 107,400,505 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,910,707 - 106,923,430 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,908,904 - 107,925,482 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,908,893 - 107,925,182 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,576,740 - 107,593,066 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,222,909 - 107,239,405 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,058,521 - 108,075,019 (-)NCBIUU_Cfam_GSD_1.0
RUVBL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,993,448 - 49,015,995 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,993,562 - 49,015,970 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,496,705 - 49,519,252 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,188,968 - 54,210,994 (+)NCBINCBI36Build 36hg18NCBI36
Build 341954,188,967 - 54,210,994NCBI
Celera1946,364,487 - 46,386,389 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,873,862 - 45,895,902 (+)NCBIHuRef
CHM1_11949,499,385 - 49,521,406 (+)NCBICHM1_1
T2T-CHM13v2.01951,988,347 - 52,010,769 (+)NCBIT2T-CHM13v2.0
Ruvbl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,071,320 - 45,084,817 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,071,184 - 45,087,520 (-)EnsemblGRCm39 Ensembl
GRCm38745,421,896 - 45,436,171 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,421,760 - 45,438,096 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,677,268 - 52,689,834 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,290,000 - 45,302,337 (-)NCBIMGSCv36mm8
Celera740,877,932 - 40,890,498 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.3NCBI
Ruvbl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,038,487 - 105,051,851 (-)NCBIGRCr8
mRatBN7.2195,902,014 - 95,915,247 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,901,701 - 95,915,342 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,287,438 - 101,300,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,760,116 - 109,773,349 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,050,515 - 103,063,748 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,413,766 - 101,426,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,413,766 - 101,426,852 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,493,176 - 102,506,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,894,029 - 95,906,885 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,972,140 - 95,985,010 (-)NCBI
Celera190,157,605 - 90,170,691 (-)NCBICelera
Cytogenetic Map1q22NCBI
Ruvbl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,654,059 - 1,674,272 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,657,241 - 1,674,272 (-)NCBIChiLan1.0ChiLan1.0
RUVBL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,099,261 - 55,121,683 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,025,412 - 57,047,842 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,995,394 - 46,017,835 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,739,474 - 54,761,407 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,739,474 - 54,761,407 (-)Ensemblpanpan1.1panPan2
Ruvbl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,377,118 - 21,392,373 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,995,213 - 3,010,853 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,995,212 - 3,010,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RUVBL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,250,515 - 54,266,893 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,250,494 - 54,263,492 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,065,154 - 50,078,153 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RUVBL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,227,982 - 42,247,204 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,227,821 - 42,249,707 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,110,661 - 22,134,370 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ruvbl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,014,484 - 5,028,885 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,014,484 - 5,028,868 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RUVBL2
240 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000006198   ⟹   ENSCAFP00000005741
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1107,384,342 - 107,400,505 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845000699   ⟹   ENSCAFP00845000507
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1107,908,893 - 107,925,182 (-)Ensembl
RefSeq Acc Id: XM_038467599   ⟹   XP_038323527
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11107,576,740 - 107,593,066 (-)NCBI
RefSeq Acc Id: XM_038528303   ⟹   XP_038384231
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01108,058,521 - 108,075,019 (-)NCBI
RefSeq Acc Id: XM_038592593   ⟹   XP_038448521
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01107,222,909 - 107,239,405 (-)NCBI
RefSeq Acc Id: XM_038656384   ⟹   XP_038512312
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01107,908,904 - 107,925,482 (-)NCBI
RefSeq Acc Id: XM_038676711   ⟹   XP_038532639
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1106,910,707 - 106,923,430 (-)NCBI
Ensembl Acc Id: ENSCAFP00000005741   ⟸   ENSCAFT00000006198
RefSeq Acc Id: XP_038323527   ⟸   XM_038467599
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038448521   ⟸   XM_038592593
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038512312   ⟸   XM_038656384
- Peptide Label: isoform X1
- UniProtKB: A0A8C0Q285 (UniProtKB/TrEMBL),   A0A8I3MBF5 (UniProtKB/TrEMBL),   A0A8C0NK68 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038532639   ⟸   XM_038676711
- Peptide Label: isoform X2
- UniProtKB: A0A8P0N6P2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038384231   ⟸   XM_038528303
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NK68 (UniProtKB/TrEMBL),   A0A8C0Q285 (UniProtKB/TrEMBL),   A0A8I3MBF5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845000507   ⟸   ENSCAFT00845000699
Protein Domains
AAA+ ATPase

Promoters
RGD ID:13682204
Promoter ID:EPDNEW_C272
Type:multiple initiation site
Name:RUVBL2_1
Description:RuvB like AAA ATPase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11107,400,525 - 107,400,585EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003844 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030014635 UniProtKB/TrEMBL
  ENSCAFG00040000535 UniProtKB/TrEMBL
  ENSCAFG00845000439 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006198.5 UniProtKB/TrEMBL
  ENSCAFT00000106107.1 UniProtKB/TrEMBL
  ENSCAFT00030027015.1 UniProtKB/TrEMBL
  ENSCAFT00030027141.1 UniProtKB/TrEMBL
  ENSCAFT00040000939.1 UniProtKB/TrEMBL
  ENSCAFT00845000699 ENTREZGENE
  ENSCAFT00845000699.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/TrEMBL
  2.40.50.360 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RuvB-like UniProtKB/TrEMBL
  RuvB-like_C UniProtKB/TrEMBL
  RuvBL1/2_DNA/RNA_bd_dom UniProtKB/TrEMBL
  TIP49_P-loop UniProtKB/TrEMBL
NCBI Gene RUVBL2 ENTREZGENE
PANTHER PTHR11093 UniProtKB/TrEMBL
  PTHR11093:SF2 UniProtKB/TrEMBL
Pfam TIP49 UniProtKB/TrEMBL
  TIP49_C UniProtKB/TrEMBL
PRINTS DNAREPAIRADA UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP Nucleic acid-binding proteins UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8C0NK68 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q285 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MBF5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N6P2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TLE8_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:45812 ENTREZGENE