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Gene: Apoe (apolipoprotein E) Rattus norvegicus
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Symbol: Apoe
Name: apolipoprotein E
Description: Exhibits several functions, including amyloid-beta binding activity; hydroxyapatite binding activity; and phospholipid binding activity. Involved in several processes, including cellular response to alcohol; neurogenesis; and regulation of lipid metabolic process. Localizes to several cellular components, including the cytoplasm; nuclear envelope; and triglyceride-rich plasma lipoprotein particle. Colocalizes with the early endosome and microtubule. Used to study artery disease (multiple); familial hyperlipidemia; fatty liver disease (multiple); and glomerulosclerosis. Biomarker of several diseases, including glomerulonephritis (multiple); hyperhomocysteinemia; hypothyroidism; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); familial hyperlipidemia (multiple); and neurodegenerative disease (multiple). Orthologous to human APOE (apolipoprotein E); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; Alzheimer's disease pathway; INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apo-E; APOEA
Orthologs:
Homo sapiens (human) : APOE (apolipoprotein E)  HGNC  Alliance
Mus musculus (house mouse) : Apoe (apolipoprotein E)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apoe (apolipoprotein E)
Pan paniscus (bonobo/pygmy chimpanzee) : APOE (apolipoprotein E)
Canis lupus familiaris (dog) : APOE (apolipoprotein E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apoe (apolipoprotein E)
Sus scrofa (pig) : APOE (apolipoprotein E)
more info ...
Allele / Splice: Apoeem8Mcwi   Apoeem7Mcwi   Apoeem9Mcwi   Apoeem1Sage  
Genetic Models: SD-Apoeem1Sage SS-Apoeem9Mcwi SS-Apoeem8Mcwi SS-Apoeem7Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0180,612,894 - 80,616,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0181,878,372 - 81,882,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,003,634 - 79,006,387 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1179,081,854 - 79,083,684 (-)NCBI
Celera173,813,122 - 73,817,046 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

Comparative Map Data
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QTLs in Region (Rnor_6.0)
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Sequence

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Strain Variation

Strain Sequence Variants (Rnor 5.0)