APOE (apolipoprotein E) - Rat Genome Database

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Gene: APOE (apolipoprotein E) Canis lupus familiaris
Analyze
Symbol: APOE
Name: apolipoprotein E
RGD ID: 12307590
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); heparan sulfate proteoglycan binding (ortholog); heparin binding (ortholog); INVOLVED IN axon regeneration (ortholog); cellular response to amyloid-beta (ortholog); cellular response to cholesterol (ortholog); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); adenocarcinoma (ortholog); age related macular degeneration 1 (ortholog); FOUND IN cell surface (ortholog); chylomicron (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Apo-E; apolipoprotein E4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,525,717 - 110,528,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,525,722 - 110,528,440 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,006,660 - 110,009,463 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01111,055,483 - 111,058,288 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,055,483 - 111,058,228 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,730,139 - 110,732,942 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,365,616 - 110,368,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,234,400 - 111,237,204 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
adenocarcinoma  (ISO)
age related macular degeneration 1  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 2  (ISO)
Alzheimer's disease 3  (ISO)
Alzheimer's disease 4  (ISO)
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Apraxia  (ISO)
amyloidosis  (ISO)
amyotrophic lateral sclerosis  (ISO)
angle-closure glaucoma  (ISO)
anxiety disorder  (ISO)
aortic atherosclerosis  (ISO)
Apolipoprotein E, Deficiency or Defect of  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
beta thalassemia  (ISO)
bile duct cancer  (ISO)
breast cancer  (ISO)
Broad-Betalipoproteinemia  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
cerebral amyloid angiopathy  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholelithiasis  (ISO)
cholestasis  (ISO)
Chronic Brain Injury  (ISO)
Chronic Cerebral Hypoperfusion  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
Cognitive Dysfunction  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Coumarin Sensitivity  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
Dysbetalipoproteinemia due to Defect in Apolipoprotein E-d  (ISO)
Dyslipidemias  (ISO)
Emphysema  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial combined hyperlipidemia  (ISO)
Familial Hyperbeta- and Prebetalipoproteinemia  (ISO)
familial hypercholesterolemia  (ISO)
familial hyperlipidemia  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
Floating-Betalipoproteinemia  (ISO)
gallbladder cancer  (ISO)
Genetic Translocation  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
Habitual Abortions  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
Hypercholesterolemia  (ISO)
hyperhomocysteinemia  (ISO)
Hyperlipemia with Familial Hypercholesterolemic Xanthomatosis  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hyperlipoproteinemia type III  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hyperuricemia  (ISO)
hypothyroidism  (ISO)
kidney failure  (ISO)
Klebsiella Infections  (ISO)
Kuhnt-Junius degeneration  (ISO)
Lewy body dementia  (ISO)
Lipoprotein Glomerulopathy  (ISO)
low tension glaucoma  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
macular degeneration  (ISO)
malaria  (ISO)
membranous glomerulonephritis  (ISO)
Memory Disorders  (ISO)
Mercury Poisoning  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
open-angle glaucoma  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
Peripheral Nerve Injuries  (ISO)
Plaque, Atherosclerotic  (ISO)
Pregnancy Complications, Infectious  (ISO)
Presenile and Senile Dementia  (ISO)
primary cutaneous amyloidosis  (ISO)
primary open angle glaucoma  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
retinal disease  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
sea-blue histiocytosis  (ISO)
sensorineural hearing loss  (ISO)
Sjogren's syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
Spontaneous Abortions  (ISO)
steatotic liver disease  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Vascular System Injuries  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Left  (ISO)
warfarin resistance  (ISO)
warfarin sensitivity  (ISO)
Wilson disease  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
AMPA glutamate receptor clustering  (IEA)
amyloid precursor protein metabolic process  (IEA)
artery development  (IEA)
artery morphogenesis  (IEA)
axon regeneration  (ISO)
cellular oxidant detoxification  (IEA)
cellular response to amyloid-beta  (ISO)
cellular response to cholesterol  (ISO)
cellular response to ethanol  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipoprotein particle stimulus  (IEA,ISO)
cholesterol catabolic process  (IEA)
cholesterol efflux  (IEA,ISS)
cholesterol homeostasis  (IEA)
cholesterol metabolic process  (IEA)
chylomicron remnant clearance  (IEA,ISS)
circulatory system development  (IEA)
fatty acid homeostasis  (IEA)
G protein-coupled receptor signaling pathway  (IEA)
gene expression  (IEA)
high-density lipoprotein particle assembly  (IEA,ISS)
high-density lipoprotein particle clearance  (IEA)
high-density lipoprotein particle remodeling  (IEA)
intermediate-density lipoprotein particle clearance  (IEA,ISS)
intracellular calcium ion homeostasis  (IEA)
lipid homeostasis  (IEA)
lipid metabolic process  (IEA)
lipid transport  (IEA,ISO)
lipid transport involved in lipid storage  (IEA)
lipoprotein biosynthetic process  (IEA,ISS)
lipoprotein catabolic process  (IEA)
lipoprotein metabolic process  (IEA,ISO)
locomotory exploration behavior  (IEA)
long-chain fatty acid transport  (IEA)
long-term memory  (IEA)
low-density lipoprotein particle remodeling  (IEA)
maintenance of location in cell  (IEA)
melanosome organization  (IEA,ISS)
negative regulation of amyloid fibril formation  (IEA,ISS)
negative regulation of amyloid-beta formation  (IEA)
negative regulation of blood coagulation  (IEA)
negative regulation of blood vessel endothelial cell migration  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cholesterol biosynthetic process  (IEA,ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of dendritic spine development  (ISO)
negative regulation of dendritic spine maintenance  (ISO)
negative regulation of endothelial cell migration  (IEA)
negative regulation of endothelial cell proliferation  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of inflammatory response  (IEA)
negative regulation of lipid biosynthetic process  (ISO)
negative regulation of lipid transport across blood-brain barrier  (ISO)
negative regulation of long-term synaptic potentiation  (IEA)
negative regulation of MAPK cascade  (IEA)
negative regulation of neuron projection development  (IEA)
negative regulation of phospholipid efflux  (ISO)
negative regulation of platelet activation  (IEA)
negative regulation of platelet-derived growth factor receptor signaling pathway  (IEA)
negative regulation of postsynaptic membrane organization  (ISO)
negative regulation of protein metabolic process  (IEA)
negative regulation of protein secretion  (IEA)
negative regulation of smooth muscle cell proliferation  (IEA)
negative regulation of triglyceride metabolic process  (IEA)
neuron projection development  (IEA)
nitric oxide-cGMP-mediated signaling  (IEA)
NMDA glutamate receptor clustering  (IEA)
obsolete positive regulation of CoA-transferase activity  (ISO)
oligodendrocyte differentiation  (ISO)
peripheral nervous system axon regeneration  (ISO)
phospholipid efflux  (IEA)
positive regulation by host of viral process  (IEA)
positive regulation of amyloid-beta clearance  (IEA,ISS)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cholesterol efflux  (IEA)
positive regulation of cholesterol metabolic process  (IEA)
positive regulation of dendritic spine development  (IEA)
positive regulation of dendritic spine maintenance  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of endocytosis  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of lipid biosynthetic process  (IEA)
positive regulation of lipid transport across blood-brain barrier  (IEA)
positive regulation of lipoprotein transport  (IEA)
positive regulation of low-density lipoprotein particle receptor catabolic process  (IEA)
positive regulation of membrane protein ectodomain proteolysis  (IEA)
positive regulation of neurofibrillary tangle assembly  (ISO)
positive regulation of neuron projection development  (IEA)
positive regulation of nitric oxide biosynthetic process  (IEA)
positive regulation of phospholipid efflux  (IEA)
positive regulation of presynaptic membrane organization  (ISO)
protein import  (IEA)
protein localization  (ISO)
receptor-mediated endocytosis  (IEA)
regulation of amyloid fibril formation  (IEA)
regulation of amyloid precursor protein catabolic process  (IEA)
regulation of amyloid-beta clearance  (IEA)
regulation of apoptotic process  (IEA)
regulation of behavioral fear response  (IEA)
regulation of Cdc42 protein signal transduction  (IEA)
regulation of cellular response to very-low-density lipoprotein particle stimulus  (IEA)
regulation of cholesterol metabolic process  (IEA)
regulation of gene expression  (IEA)
regulation of innate immune response  (IEA)
regulation of plasma lipoprotein particle levels  (IEA)
regulation of proteasomal protein catabolic process  (IEA)
regulation of protein metabolic process  (IEA)
regulation of protein-containing complex assembly  (IEA)
regulation of synapse organization  (IEA)
regulation of triglyceride metabolic process  (ISO)
response to caloric restriction  (IEA)
response to D-galactosamine  (ISO)
response to dietary excess  (IEA)
response to ethanol  (ISO)
response to insulin  (ISO)
response to oxidative stress  (IEA)
response to retinoic acid  (ISO)
response to tumor necrosis factor  (ISO)
response to zinc ion  (ISO)
reverse cholesterol transport  (IEA)
triglyceride homeostasis  (IEA)
triglyceride metabolic process  (IEA)
triglyceride-rich lipoprotein particle clearance  (IEA,ISS)
vasodilation  (IEA)
very-low-density lipoprotein particle clearance  (IEA,ISS)
very-low-density lipoprotein particle remodeling  (IEA)
virion assembly  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:2515239   PMID:20875843   PMID:22301074   PMID:29396142   PMID:30032202   PMID:34705220  


Genomics

Comparative Map Data
APOE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,525,717 - 110,528,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,525,722 - 110,528,440 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,006,660 - 110,009,463 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01111,055,483 - 111,058,288 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,055,483 - 111,058,228 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,730,139 - 110,732,942 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,365,616 - 110,368,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,234,400 - 111,237,204 (-)NCBIUU_Cfam_GSD_1.0
APOE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,905,796 - 44,909,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1944,905,791 - 44,909,393 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,409,053 - 45,412,650 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,100,879 - 50,104,490 (+)NCBINCBI36Build 36hg18NCBI36
Build 341950,100,878 - 50,104,489NCBI
Celera1942,213,361 - 42,216,972 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,839,825 - 41,843,436 (+)NCBIHuRef
CHM1_11945,411,793 - 45,415,404 (+)NCBICHM1_1
T2T-CHM13v2.01947,730,492 - 47,734,089 (+)NCBIT2T-CHM13v2.0
Apoe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,430,169 - 19,434,326 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,430,034 - 19,433,113 (-)EnsemblGRCm39 Ensembl
GRCm38719,696,244 - 19,701,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,696,109 - 19,699,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv37720,281,593 - 20,284,515 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,854,794 - 18,857,554 (-)NCBIMGSCv36mm8
Celera717,102,329 - 17,105,251 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
Apoe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,481,889 - 88,485,816 (-)NCBIGRCr8
GRCr8 Ensembl188,481,385 - 88,485,855 (-)EnsemblGRCr8 Ensembl
mRatBN7.2179,353,924 - 79,357,852 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,353,916 - 79,357,932 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,748,825 - 84,752,747 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,300,176 - 93,304,099 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,503,931 - 86,507,854 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,612,894 - 80,616,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,612,895 - 80,617,057 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,878,372 - 81,882,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,003,634 - 79,006,387 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera173,813,122 - 73,817,046 (-)NCBICelera
RGSC_v3.1179,081,854 - 79,083,684 (-)NCBI
Cytogenetic Map1q21NCBI
Apoe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,999,711 - 2,001,888 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555551,998,170 - 2,002,003 (+)NCBIChiLan1.0ChiLan1.0
APOE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,065,455 - 51,069,038 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11952,937,264 - 52,940,847 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,853,669 - 41,857,252 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,459,906 - 50,463,490 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,459,906 - 50,463,490 (+)Ensemblpanpan1.1panPan2
Apoe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,165,062 - 17,169,462 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367061,512,438 - 1,516,805 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,372,292 - 51,375,330 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,373,113 - 51,375,333 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,269,973 - 47,272,195 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q1.2-q2.12NCBI
APOE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,377,154 - 38,381,219 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,376,887 - 38,381,438 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607317,947,315 - 17,951,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoe
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249071,752,322 - 1,755,308 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in APOE
70 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005616460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022425020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_533644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_860950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY926587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ948095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ948096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ948102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000007432   ⟹   ENSCAFP00000006888
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1110,525,844 - 110,528,440 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000092662   ⟹   ENSCAFP00000057461
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1110,525,722 - 110,528,440 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845011898   ⟹   ENSCAFP00845009282
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1111,055,483 - 111,058,228 (-)Ensembl
RefSeq Acc Id: XM_005616460   ⟹   XP_005616517
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11110,525,717 - 110,528,510 (-)NCBI
Dog10K_Boxer_Tasha1110,006,660 - 110,009,445 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022425020   ⟹   XP_022280728
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11110,525,717 - 110,528,443 (-)NCBI
Dog10K_Boxer_Tasha1110,006,660 - 110,009,409 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038467899   ⟹   XP_038323827
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11110,730,139 - 110,732,924 (-)NCBI
RefSeq Acc Id: XM_038467900   ⟹   XP_038323828
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11110,730,139 - 110,732,942 (-)NCBI
RefSeq Acc Id: XM_038467901   ⟹   XP_038323829
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11110,730,139 - 110,732,897 (-)NCBI
RefSeq Acc Id: XM_038467902   ⟹   XP_038323830
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11110,730,139 - 110,732,888 (-)NCBI
RefSeq Acc Id: XM_038528613   ⟹   XP_038384541
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01111,234,400 - 111,237,186 (-)NCBI
RefSeq Acc Id: XM_038528614   ⟹   XP_038384542
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01111,234,400 - 111,237,204 (-)NCBI
RefSeq Acc Id: XM_038528615   ⟹   XP_038384543
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01111,234,400 - 111,237,159 (-)NCBI
RefSeq Acc Id: XM_038528616   ⟹   XP_038384544
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01111,234,400 - 111,237,150 (-)NCBI
RefSeq Acc Id: XM_038592897   ⟹   XP_038448825
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01110,365,616 - 110,368,395 (-)NCBI
RefSeq Acc Id: XM_038592898   ⟹   XP_038448826
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01110,365,616 - 110,368,413 (-)NCBI
RefSeq Acc Id: XM_038592899   ⟹   XP_038448827
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01110,365,616 - 110,368,368 (-)NCBI
RefSeq Acc Id: XM_038592900   ⟹   XP_038448828
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01110,365,616 - 110,368,359 (-)NCBI
RefSeq Acc Id: XM_038656703   ⟹   XP_038512631
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01111,055,483 - 111,058,270 (-)NCBI
RefSeq Acc Id: XM_038656704   ⟹   XP_038512632
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01111,055,483 - 111,058,288 (-)NCBI
RefSeq Acc Id: XM_038656705   ⟹   XP_038512633
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01111,055,483 - 111,058,243 (-)NCBI
RefSeq Acc Id: XM_038656706   ⟹   XP_038512634
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01111,055,483 - 111,058,234 (-)NCBI
RefSeq Acc Id: XM_533644   ⟹   XP_533644
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11110,525,717 - 110,528,534 (-)NCBI
Dog10K_Boxer_Tasha1110,006,660 - 110,009,463 (-)NCBI
Sequence:
RefSeq Acc Id: XM_860950   ⟹   XP_866043
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11110,525,717 - 110,528,482 (-)NCBI
Dog10K_Boxer_Tasha1110,006,660 - 110,009,418 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005616517 (Get FASTA)   NCBI Sequence Viewer  
  XP_022280728 (Get FASTA)   NCBI Sequence Viewer  
  XP_038323827 (Get FASTA)   NCBI Sequence Viewer  
  XP_038323828 (Get FASTA)   NCBI Sequence Viewer  
  XP_038323829 (Get FASTA)   NCBI Sequence Viewer  
  XP_038323830 (Get FASTA)   NCBI Sequence Viewer  
  XP_038384541 (Get FASTA)   NCBI Sequence Viewer  
  XP_038384542 (Get FASTA)   NCBI Sequence Viewer  
  XP_038384543 (Get FASTA)   NCBI Sequence Viewer  
  XP_038384544 (Get FASTA)   NCBI Sequence Viewer  
  XP_038448825 (Get FASTA)   NCBI Sequence Viewer  
  XP_038448826 (Get FASTA)   NCBI Sequence Viewer  
  XP_038448827 (Get FASTA)   NCBI Sequence Viewer  
  XP_038448828 (Get FASTA)   NCBI Sequence Viewer  
  XP_038512631 (Get FASTA)   NCBI Sequence Viewer  
  XP_038512632 (Get FASTA)   NCBI Sequence Viewer  
  XP_038512633 (Get FASTA)   NCBI Sequence Viewer  
  XP_038512634 (Get FASTA)   NCBI Sequence Viewer  
  XP_533644 (Get FASTA)   NCBI Sequence Viewer  
  XP_866043 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAX81916 (Get FASTA)   NCBI Sequence Viewer  
  ADB55604 (Get FASTA)   NCBI Sequence Viewer  
  ADB55605 (Get FASTA)   NCBI Sequence Viewer  
  ADB55611 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000057461.2
  ENSCAFP00845009282
  ENSCAFP00845009282.1
GenBank Protein P18649 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005616517   ⟸   XM_005616460
- UniProtKB: P18649 (UniProtKB/Swiss-Prot),   F1PJ74 (UniProtKB/TrEMBL),   A0A8C0KEX2 (UniProtKB/TrEMBL),   A0A8C0M3L6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_533644   ⟸   XM_533644
- UniProtKB: P18649 (UniProtKB/Swiss-Prot),   F1PJ74 (UniProtKB/TrEMBL),   A0A8C0KEX2 (UniProtKB/TrEMBL),   A0A8C0M3L6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_866043   ⟸   XM_860950
- UniProtKB: P18649 (UniProtKB/Swiss-Prot),   F1PJ74 (UniProtKB/TrEMBL),   A0A8C0KEX2 (UniProtKB/TrEMBL),   A0A8C0M3L6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022280728   ⟸   XM_022425020
- UniProtKB: P18649 (UniProtKB/Swiss-Prot),   F1PJ74 (UniProtKB/Swiss-Prot),   A0A8C0KEX2 (UniProtKB/TrEMBL),   A0A8C0M3L6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000057461   ⟸   ENSCAFT00000092662
Ensembl Acc Id: ENSCAFP00000006888   ⟸   ENSCAFT00000007432
RefSeq Acc Id: XP_038323828   ⟸   XM_038467900
RefSeq Acc Id: XP_038323827   ⟸   XM_038467899
RefSeq Acc Id: XP_038323829   ⟸   XM_038467901
RefSeq Acc Id: XP_038323830   ⟸   XM_038467902
RefSeq Acc Id: XP_038448826   ⟸   XM_038592898
RefSeq Acc Id: XP_038448825   ⟸   XM_038592897
RefSeq Acc Id: XP_038448827   ⟸   XM_038592899
RefSeq Acc Id: XP_038448828   ⟸   XM_038592900
RefSeq Acc Id: XP_038512632   ⟸   XM_038656704
- UniProtKB: P18649 (UniProtKB/Swiss-Prot),   F1PJ74 (UniProtKB/Swiss-Prot),   A0A8C0KEX2 (UniProtKB/TrEMBL),   A0A8C0M3L6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038512631   ⟸   XM_038656703
- UniProtKB: P18649 (UniProtKB/Swiss-Prot),   F1PJ74 (UniProtKB/Swiss-Prot),   A0A8C0KEX2 (UniProtKB/TrEMBL),   A0A8C0M3L6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038512633   ⟸   XM_038656705
- UniProtKB: P18649 (UniProtKB/Swiss-Prot),   F1PJ74 (UniProtKB/Swiss-Prot),   A0A8C0KEX2 (UniProtKB/TrEMBL),   A0A8C0M3L6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038512634   ⟸   XM_038656706
- UniProtKB: P18649 (UniProtKB/Swiss-Prot),   F1PJ74 (UniProtKB/Swiss-Prot),   A0A8C0KEX2 (UniProtKB/TrEMBL),   A0A8C0M3L6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038384542   ⟸   XM_038528614
- UniProtKB: P18649 (UniProtKB/Swiss-Prot),   F1PJ74 (UniProtKB/Swiss-Prot),   A0A8C0KEX2 (UniProtKB/TrEMBL),   A0A8C0M3L6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038384541   ⟸   XM_038528613
- UniProtKB: P18649 (UniProtKB/Swiss-Prot),   F1PJ74 (UniProtKB/Swiss-Prot),   A0A8C0KEX2 (UniProtKB/TrEMBL),   A0A8C0M3L6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038384543   ⟸   XM_038528615
- UniProtKB: P18649 (UniProtKB/Swiss-Prot),   F1PJ74 (UniProtKB/Swiss-Prot),   A0A8C0KEX2 (UniProtKB/TrEMBL),   A0A8C0M3L6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038384544   ⟸   XM_038528616
- UniProtKB: P18649 (UniProtKB/Swiss-Prot),   F1PJ74 (UniProtKB/Swiss-Prot),   A0A8C0KEX2 (UniProtKB/TrEMBL),   A0A8C0M3L6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845009282   ⟸   ENSCAFT00845011898

Promoters
RGD ID:13682256
Promoter ID:EPDNEW_C324
Type:multiple initiation site
Name:APOE_1
Description:apolipoprotein E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11110,527,673 - 110,527,733EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004617 Ensembl, UniProtKB/Swiss-Prot
  ENSCAFG00845006705 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000092662.2 UniProtKB/Swiss-Prot
  ENSCAFT00845011898 ENTREZGENE
  ENSCAFT00845011898.1 UniProtKB/Swiss-Prot
Gene3D-CATH Apolipoprotein UniProtKB/Swiss-Prot
InterPro ApoA_E UniProtKB/Swiss-Prot
  Apolipoprotein_A1/A4/E UniProtKB/Swiss-Prot
KEGG Report cfa:476438 UniProtKB/Swiss-Prot
NCBI Gene APOE ENTREZGENE
PANTHER APOLIPOPROTEIN UniProtKB/Swiss-Prot
  APOLIPOPROTEIN E UniProtKB/Swiss-Prot
Pfam Apolipoprotein UniProtKB/Swiss-Prot
Superfamily-SCOP Apolipoprotein A-I UniProtKB/Swiss-Prot
UniProt A0A8C0KEX2 ENTREZGENE
  A0A8C0M3L6 ENTREZGENE, UniProtKB/TrEMBL
  APOE_CANLF UniProtKB/Swiss-Prot
  F1PJ74 ENTREZGENE
  P18649 ENTREZGENE
UniProt Secondary F1PJ74 UniProtKB/Swiss-Prot
VGNC ID VGNC:38002 ENTREZGENE