APOE (apolipoprotein E) - Rat Genome Database

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Gene: APOE (apolipoprotein E) Canis lupus familiaris
Analyze
Symbol: APOE
Name: apolipoprotein E
RGD ID: 12307590
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); heparan sulfate proteoglycan binding (ortholog); heparin binding (ortholog); INVOLVED IN aging (ortholog); AMPA glutamate receptor clustering (ortholog); artery morphogenesis (ortholog); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); adenocarcinoma (ortholog); age related macular degeneration 1 (ortholog); FOUND IN cell surface (ortholog); chylomicron (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Apo-E; apolipoprotein E4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,525,717 - 110,528,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,525,722 - 110,528,440 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,006,660 - 110,009,463 (-)NCBI
ROS_Cfam_1.01111,055,483 - 111,058,288 (-)NCBI
ROS_Cfam_1.0 Ensembl1111,055,483 - 111,058,228 (-)Ensembl
UMICH_Zoey_3.11110,730,139 - 110,732,942 (-)NCBI
UNSW_CanFamBas_1.01110,365,616 - 110,368,413 (-)NCBI
UU_Cfam_GSD_1.01111,234,400 - 111,237,204 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
adenocarcinoma  (ISO)
age related macular degeneration 1  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 2  (ISO)
Alzheimer's disease 3  (ISO)
Alzheimer's disease 4  (ISO)
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Apraxia  (ISO)
amyloidosis  (ISO)
amyotrophic lateral sclerosis  (ISO)
angle-closure glaucoma  (ISO)
anxiety disorder  (ISO)
aortic atherosclerosis  (ISO)
Apolipoprotein E, Deficiency or Defect of  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
beta thalassemia  (ISO)
bile duct cancer  (ISO)
breast cancer  (ISO)
Broad-Betalipoproteinemia  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
cerebral amyloid angiopathy  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholelithiasis  (ISO)
cholestasis  (ISO)
Chronic Brain Injury  (ISO)
Chronic Cerebral Hypoperfusion  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
Cognitive Dysfunction  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Coumarin Sensitivity  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
Dysbetalipoproteinemia due to Defect in Apolipoprotein E-d  (ISO)
Dyslipidemias  (ISO)
Emphysema  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial combined hyperlipidemia  (ISO)
Familial Hyperbeta- and Prebetalipoproteinemia  (ISO)
familial hypercholesterolemia  (ISO)
familial hyperlipidemia  (ISO)
fatty liver disease  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
Floating-Betalipoproteinemia  (ISO)
gallbladder cancer  (ISO)
Genetic Translocation  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
Habitual Abortions  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
Hypercholesterolemia  (ISO)
hyperhomocysteinemia  (ISO)
Hyperlipemia with Familial Hypercholesterolemic Xanthomatosis  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hyperlipoproteinemia type III  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hyperuricemia  (ISO)
hypothyroidism  (ISO)
kidney failure  (ISO)
Klebsiella Infections  (ISO)
Kuhnt-Junius degeneration  (ISO)
Lewy body dementia  (ISO)
Lipoprotein Glomerulopathy  (ISO)
low tension glaucoma  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
macular degeneration  (ISO)
malaria  (ISO)
Mammary Neoplasms, Experimental  (ISO)
membranous glomerulonephritis  (ISO)
Memory Disorders  (ISO)
Mercury Poisoning  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
Neurobehavioral Manifestations  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
open-angle glaucoma  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
Peripheral Nerve Injuries  (ISO)
Plaque, Atherosclerotic  (ISO)
Pregnancy Complications, Infectious  (ISO)
Presenile and Senile Dementia  (ISO)
primary cutaneous amyloidosis  (ISO)
primary open angle glaucoma  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
retinal disease  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
sea-blue histiocytosis  (ISO)
sensorineural hearing loss  (ISO)
Sjogren's syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
Spontaneous Abortions  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Vascular System Injuries  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Left  (ISO)
visual epilepsy  (ISO)
warfarin resistance  (ISO)
warfarin sensitivity  (ISO)
Wilson disease  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
AMPA glutamate receptor clustering  (IEA,ISO)
amyloid precursor protein metabolic process  (IEA)
artery morphogenesis  (IEA,ISO)
axon regeneration  (ISO)
cellular calcium ion homeostasis  (IEA,ISO)
cellular oxidant detoxification  (IEA)
cellular response to cholesterol  (ISO)
cellular response to ethanol  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cGMP-mediated signaling  (IEA)
cholesterol catabolic process  (IBA,IEA,ISO)
cholesterol efflux  (IEA,ISO,ISS)
cholesterol homeostasis  (IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
chylomicron remnant clearance  (IEA,ISS)
circulatory system development  (IEA,ISO)
fatty acid homeostasis  (IEA)
G protein-coupled receptor signaling pathway  (IEA)
gene expression  (IEA,ISO)
high-density lipoprotein particle assembly  (IEA,ISS)
high-density lipoprotein particle clearance  (IEA)
high-density lipoprotein particle remodeling  (IEA)
intermediate-density lipoprotein particle clearance  (IEA,ISS)
intermembrane lipid transfer  (IEA)
lipid homeostasis  (IEA,ISO)
lipid metabolic process  (IEA,ISO)
lipid transport  (IEA,ISO)
lipid transport involved in lipid storage  (IEA)
lipoprotein biosynthetic process  (IEA,ISO,ISS)
lipoprotein catabolic process  (IBA,IEA,ISO)
lipoprotein metabolic process  (IEA,ISO)
locomotory exploration behavior  (IEA)
long-chain fatty acid transport  (IEA)
long-term memory  (IEA)
low-density lipoprotein particle remodeling  (IEA)
maintenance of location in cell  (IEA,ISO)
negative regulation of amyloid fibril formation  (IEA,ISS)
negative regulation of amyloid-beta formation  (IEA)
negative regulation of blood coagulation  (IEA)
negative regulation of blood vessel endothelial cell migration  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cholesterol biosynthetic process  (IEA,ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of dendritic spine development  (ISO)
negative regulation of dendritic spine maintenance  (ISO)
negative regulation of endothelial cell migration  (IEA)
negative regulation of endothelial cell proliferation  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of inflammatory response  (IEA)
negative regulation of lipid biosynthetic process  (ISO)
negative regulation of lipid transport across blood-brain barrier  (ISO)
negative regulation of long-term synaptic potentiation  (IEA)
negative regulation of MAP kinase activity  (IEA)
negative regulation of neuron apoptotic process  (IBA,ISO)
negative regulation of neuron death  (ISO)
negative regulation of neuron projection development  (IEA)
negative regulation of phospholipid efflux  (ISO)
negative regulation of platelet activation  (IEA)
negative regulation of postsynaptic membrane organization  (ISO)
negative regulation of protein metabolic process  (IEA)
negative regulation of protein secretion  (IEA)
negative regulation of smooth muscle cell proliferation  (IEA,ISO)
negative regulation of triglyceride metabolic process  (IEA,ISO)
neuron projection development  (IEA)
nitric oxide mediated signal transduction  (IEA)
NMDA glutamate receptor clustering  (IEA,ISO)
oligodendrocyte differentiation  (ISO)
peripheral nervous system axon regeneration  (ISO)
phospholipid efflux  (IEA)
positive regulation by host of viral process  (IEA)
positive regulation of amyloid-beta clearance  (IEA,ISS)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cholesterol efflux  (IEA)
positive regulation of cholesterol esterification  (IEA)
positive regulation of cholesterol metabolic process  (IEA)
positive regulation of CoA-transferase activity  (IEA)
positive regulation of dendritic spine development  (IEA,ISO)
positive regulation of dendritic spine maintenance  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of endocytosis  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of heparan sulfate binding  (IEA)
positive regulation of heparan sulfate proteoglycan binding  (IEA)
positive regulation of lipid biosynthetic process  (IEA)
positive regulation of lipid transport across blood-brain barrier  (IEA)
positive regulation of low-density lipoprotein particle receptor catabolic process  (IEA)
positive regulation of membrane protein ectodomain proteolysis  (IEA)
positive regulation of neurofibrillary tangle assembly  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neuron projection development  (IEA)
positive regulation of nitric-oxide synthase activity  (IBA,IEA)
positive regulation of phospholipid efflux  (IEA)
positive regulation of presynaptic membrane organization  (ISO)
protein import  (IEA)
protein localization  (ISO)
receptor-mediated endocytosis  (IEA)
regulation of amyloid fibril formation  (IEA)
regulation of amyloid precursor protein catabolic process  (IEA)
regulation of amyloid-beta clearance  (IBA,IEA)
regulation of apoptotic process  (IEA)
regulation of behavioral fear response  (IEA)
regulation of Cdc42 protein signal transduction  (IEA)
regulation of cellular response to very-low-density lipoprotein particle stimulus  (IEA)
regulation of cholesterol metabolic process  (IEA)
regulation of gene expression  (IEA,ISO)
regulation of innate immune response  (IEA)
regulation of neuron death  (ISO)
regulation of plasma lipoprotein particle levels  (IEA)
regulation of proteasomal protein catabolic process  (IEA)
regulation of protein metabolic process  (IEA)
regulation of protein-containing complex assembly  (IEA)
regulation of synapse organization  (IEA)
regulation of tau-protein kinase activity  (ISO)
regulation of triglyceride metabolic process  (ISO)
response to caloric restriction  (IEA)
response to D-galactosamine  (ISO)
response to dietary excess  (IEA,ISO)
response to ethanol  (ISO)
response to insulin  (ISO)
response to oxidative stress  (IEA,ISO)
response to retinoic acid  (ISO)
response to tumor necrosis factor  (ISO)
response to zinc ion  (ISO)
reverse cholesterol transport  (IEA)
triglyceride homeostasis  (IEA)
triglyceride metabolic process  (IEA)
triglyceride-rich lipoprotein particle clearance  (IEA,ISS)
vasodilation  (IEA,ISO)
very-low-density lipoprotein particle clearance  (IEA,ISS)
very-low-density lipoprotein particle remodeling  (IEA)
virion assembly  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:2515239   PMID:20875843   PMID:29396142  


Genomics

Comparative Map Data
APOE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,525,717 - 110,528,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,525,722 - 110,528,440 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,006,660 - 110,009,463 (-)NCBI
ROS_Cfam_1.01111,055,483 - 111,058,288 (-)NCBI
ROS_Cfam_1.0 Ensembl1111,055,483 - 111,058,228 (-)Ensembl
UMICH_Zoey_3.11110,730,139 - 110,732,942 (-)NCBI
UNSW_CanFamBas_1.01110,365,616 - 110,368,413 (-)NCBI
UU_Cfam_GSD_1.01111,234,400 - 111,237,204 (-)NCBI
APOE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,905,796 - 44,909,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1944,905,791 - 44,909,393 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,409,053 - 45,412,650 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,100,879 - 50,104,490 (+)NCBINCBI36hg18NCBI36
Build 341950,100,878 - 50,104,489NCBI
Celera1942,213,361 - 42,216,972 (+)NCBI
Cytogenetic Map19q13.32NCBI
HuRef1941,839,825 - 41,843,436 (+)NCBIHuRef
CHM1_11945,411,793 - 45,415,404 (+)NCBICHM1_1
T2T-CHM13v2.01947,730,492 - 47,734,089 (+)NCBI
Apoe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,430,169 - 19,434,326 (-)NCBIGRCm39mm39
GRCm39 Ensembl719,430,034 - 19,433,113 (-)Ensembl
GRCm38719,696,244 - 19,701,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,696,109 - 19,699,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv37720,281,593 - 20,284,515 (-)NCBIGRCm37mm9NCBIm37
MGSCv36718,854,794 - 18,857,554 (-)NCBImm8
Celera717,102,329 - 17,105,251 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
Apoe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,353,924 - 79,357,852 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl179,353,916 - 79,357,932 (-)Ensembl
Rnor_6.0180,612,894 - 80,616,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,612,895 - 80,617,057 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,878,372 - 81,882,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,003,634 - 79,006,387 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1179,081,854 - 79,083,684 (-)NCBI
Celera173,813,122 - 73,817,046 (-)NCBICelera
Cytogenetic Map1q21NCBI
Apoe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,999,711 - 2,001,888 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555551,998,170 - 2,002,003 (+)NCBIChiLan1.0ChiLan1.0
APOE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11950,459,906 - 50,463,490 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,459,906 - 50,463,490 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01941,853,669 - 41,857,252 (+)NCBIMhudiblu_PPA_v0panPan3
Apoe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,165,062 - 17,169,462 (+)NCBI
SpeTri2.0NW_0049367061,512,438 - 1,516,805 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,372,259 - 51,377,794 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,373,113 - 51,375,333 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,269,973 - 47,272,195 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q1.2-q2.12NCBI
APOE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,377,154 - 38,381,219 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl638,376,887 - 38,381,438 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607317,947,315 - 17,951,250 (+)NCBIVero_WHO_p1.0
Apoe
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249071,752,322 - 1,755,308 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 11 6 6 6 5 6
Medium 5 5 11 6 6 6 6 8 5
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005616460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022425020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_533644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_860950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY926587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ948095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ948096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ948102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000007432   ⟹   ENSCAFP00000006888
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1110,525,844 - 110,528,440 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000092662   ⟹   ENSCAFP00000057461
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1110,525,722 - 110,528,440 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845011898   ⟹   ENSCAFP00845009282
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1111,055,483 - 111,058,228 (-)Ensembl
RefSeq Acc Id: XM_005616460   ⟹   XP_005616517
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11110,525,717 - 110,528,510 (-)NCBI
Dog10K_Boxer_Tasha1110,006,660 - 110,009,445 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022425020   ⟹   XP_022280728
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11110,525,717 - 110,528,443 (-)NCBI
Dog10K_Boxer_Tasha1110,006,660 - 110,009,409 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038467899   ⟹   XP_038323827
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11110,730,139 - 110,732,924 (-)NCBI
RefSeq Acc Id: XM_038467900   ⟹   XP_038323828
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11110,730,139 - 110,732,942 (-)NCBI
RefSeq Acc Id: XM_038467901   ⟹   XP_038323829
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11110,730,139 - 110,732,897 (-)NCBI
RefSeq Acc Id: XM_038467902   ⟹   XP_038323830
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11110,730,139 - 110,732,888 (-)NCBI
RefSeq Acc Id: XM_038528613   ⟹   XP_038384541
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01111,234,400 - 111,237,186 (-)NCBI
RefSeq Acc Id: XM_038528614   ⟹   XP_038384542
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01111,234,400 - 111,237,204 (-)NCBI
RefSeq Acc Id: XM_038528615   ⟹   XP_038384543
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01111,234,400 - 111,237,159 (-)NCBI
RefSeq Acc Id: XM_038528616   ⟹   XP_038384544
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01111,234,400 - 111,237,150 (-)NCBI
RefSeq Acc Id: XM_038592897   ⟹   XP_038448825
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01110,365,616 - 110,368,395 (-)NCBI
RefSeq Acc Id: XM_038592898   ⟹   XP_038448826
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01110,365,616 - 110,368,413 (-)NCBI
RefSeq Acc Id: XM_038592899   ⟹   XP_038448827
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01110,365,616 - 110,368,368 (-)NCBI
RefSeq Acc Id: XM_038592900   ⟹   XP_038448828
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01110,365,616 - 110,368,359 (-)NCBI
RefSeq Acc Id: XM_038656703   ⟹   XP_038512631
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01111,055,483 - 111,058,270 (-)NCBI
RefSeq Acc Id: XM_038656704   ⟹   XP_038512632
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01111,055,483 - 111,058,288 (-)NCBI
RefSeq Acc Id: XM_038656705   ⟹   XP_038512633
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01111,055,483 - 111,058,243 (-)NCBI
RefSeq Acc Id: XM_038656706   ⟹   XP_038512634
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01111,055,483 - 111,058,234 (-)NCBI
RefSeq Acc Id: XM_533644   ⟹   XP_533644
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11110,525,717 - 110,528,534 (-)NCBI
Dog10K_Boxer_Tasha1110,006,660 - 110,009,463 (-)NCBI
Sequence:
RefSeq Acc Id: XM_860950   ⟹   XP_866043
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11110,525,717 - 110,528,482 (-)NCBI
Dog10K_Boxer_Tasha1110,006,660 - 110,009,418 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005616517   ⟸   XM_005616460
- UniProtKB: F1PJ74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_533644   ⟸   XM_533644
- UniProtKB: F1PJ74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_866043   ⟸   XM_860950
- UniProtKB: F1PJ74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022280728   ⟸   XM_022425020
- Sequence:
RefSeq Acc Id: ENSCAFP00000057461   ⟸   ENSCAFT00000092662
RefSeq Acc Id: ENSCAFP00000006888   ⟸   ENSCAFT00000007432
RefSeq Acc Id: XP_038323828   ⟸   XM_038467900
RefSeq Acc Id: XP_038323827   ⟸   XM_038467899
RefSeq Acc Id: XP_038323829   ⟸   XM_038467901
RefSeq Acc Id: XP_038323830   ⟸   XM_038467902
RefSeq Acc Id: XP_038448826   ⟸   XM_038592898
RefSeq Acc Id: XP_038448825   ⟸   XM_038592897
RefSeq Acc Id: XP_038448827   ⟸   XM_038592899
RefSeq Acc Id: XP_038448828   ⟸   XM_038592900
RefSeq Acc Id: XP_038512632   ⟸   XM_038656704
RefSeq Acc Id: XP_038512631   ⟸   XM_038656703
RefSeq Acc Id: XP_038512633   ⟸   XM_038656705
RefSeq Acc Id: XP_038512634   ⟸   XM_038656706
RefSeq Acc Id: XP_038384542   ⟸   XM_038528614
RefSeq Acc Id: XP_038384541   ⟸   XM_038528613
RefSeq Acc Id: XP_038384543   ⟸   XM_038528615
RefSeq Acc Id: XP_038384544   ⟸   XM_038528616
RefSeq Acc Id: ENSCAFP00845009282   ⟸   ENSCAFT00845011898

Promoters
RGD ID:13682256
Promoter ID:EPDNEW_C324
Type:multiple initiation site
Name:APOE_1
Description:apolipoprotein E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11110,527,673 - 110,527,733EPDNEW
Damaging Variants


Assembly: CanFam3.1
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 110526284 110526285 C A snv German Shepherd/Mixed breed (DS032)
1 110526380 110526381 T A snv Doberman Pinscher (DO159), Lagotto Romagnolo (LR390)
1 110526506 110526507 A G snv Lagotto Romagnolo (LR390), Lagotto Romagnolo (LR1030)
1 110526560 110526561 T C snv Lagotto Romagnolo (LR753), Poodle (PL116)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004617 Ensembl, UniProtKB/Swiss-Prot
  ENSCAFG00845006705 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSCAFP00000057461 UniProtKB/Swiss-Prot
  ENSCAFP00845009282 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000092662 UniProtKB/Swiss-Prot
  ENSCAFT00845011898 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro ApoA_E UniProtKB/Swiss-Prot
KEGG Report cfa:476438 UniProtKB/Swiss-Prot
NCBI Gene APOE ENTREZGENE
Pfam Apolipoprotein UniProtKB/Swiss-Prot
UniProt APOE_CANLF UniProtKB/Swiss-Prot
  F1PJ74 ENTREZGENE
  P18649 ENTREZGENE
UniProt Secondary F1PJ74 UniProtKB/Swiss-Prot
VGNC ID VGNC:38002 ENTREZGENE