APOE (apolipoprotein E) - Rat Genome Database

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Gene: APOE (apolipoprotein E) Pan paniscus
Analyze
Symbol: APOE
Name: apolipoprotein E
RGD ID: 11785447
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); hydroxyapatite binding (ortholog); lipid transporter activity (ortholog); INVOLVED IN aging (ortholog); AMPA glutamate receptor clustering (ortholog); artery morphogenesis (ortholog); PARTICIPATES IN altered lipoprotein metabolic pathway; lipoprotein metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); adenocarcinoma (ortholog); age related macular degeneration 1 (ortholog); FOUND IN cell surface (ortholog); chylomicron (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11950,459,906 - 50,463,490 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,459,906 - 50,463,490 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01941,853,669 - 41,857,252 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
adenocarcinoma  (ISO)
age related macular degeneration 1  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 2  (ISO)
Alzheimer's disease 3  (ISO)
Alzheimer's disease 4  (ISO)
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Apraxia  (ISO)
amyloidosis  (ISO)
amyotrophic lateral sclerosis  (ISO)
angle-closure glaucoma  (ISO)
anxiety disorder  (ISO)
aortic atherosclerosis  (ISO)
Apolipoprotein E, Deficiency or Defect of  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
beta thalassemia  (ISO)
bile duct cancer  (ISO)
breast cancer  (ISO)
Broad-Betalipoproteinemia  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
cerebral amyloid angiopathy  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholelithiasis  (ISO)
cholestasis  (ISO)
Chronic Brain Injury  (ISO)
Chronic Cerebral Hypoperfusion  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
Cognitive Dysfunction  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Coumarin Sensitivity  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
Dysbetalipoproteinemia due to Defect in Apolipoprotein E-d  (ISO)
Dyslipidemias  (ISO)
Emphysema  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial combined hyperlipidemia  (ISO)
Familial Hyperbeta- and Prebetalipoproteinemia  (ISO)
familial hypercholesterolemia  (ISO)
familial hyperlipidemia  (ISO)
fatty liver disease  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
Floating-Betalipoproteinemia  (ISO)
gallbladder cancer  (ISO)
Genetic Translocation  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
Habitual Abortions  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
Hypercholesterolemia  (ISO)
hyperhomocysteinemia  (ISO)
Hyperlipemia with Familial Hypercholesterolemic Xanthomatosis  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hyperlipoproteinemia type III  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hyperuricemia  (ISO)
hypothyroidism  (ISO)
kidney failure  (ISO)
Klebsiella Infections  (ISO)
Kuhnt-Junius degeneration  (ISO)
Lewy body dementia  (ISO)
Lipoprotein Glomerulopathy  (ISO)
low tension glaucoma  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
macular degeneration  (ISO)
malaria  (ISO)
membranous glomerulonephritis  (ISO)
Memory Disorders  (ISO)
Mercury Poisoning  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
Neurobehavioral Manifestations  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
open-angle glaucoma  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
Peripheral Nerve Injuries  (ISO)
Plaque, Atherosclerotic  (ISO)
Pregnancy Complications, Infectious  (ISO)
Presenile and Senile Dementia  (ISO)
primary cutaneous amyloidosis  (ISO)
primary open angle glaucoma  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
retinal disease  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
sea-blue histiocytosis  (ISO)
sensorineural hearing loss  (ISO)
Sjogren's syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
Spontaneous Abortions  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Vascular System Injuries  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Left  (ISO)
visual epilepsy  (ISO)
warfarin resistance  (ISO)
warfarin sensitivity  (ISO)
Wilson disease  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
AMPA glutamate receptor clustering  (IEA,ISO)
amyloid precursor protein metabolic process  (IEA)
artery morphogenesis  (IEA,ISO)
axon regeneration  (ISO)
cellular calcium ion homeostasis  (IEA,ISO)
cellular oxidant detoxification  (IEA)
cellular response to cholesterol  (ISO)
cellular response to ethanol  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cGMP-mediated signaling  (IEA)
cholesterol catabolic process  (IEA,ISO)
cholesterol efflux  (IEA,ISO)
cholesterol homeostasis  (IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
chylomicron remnant clearance  (IEA)
circulatory system development  (IEA,ISO)
fatty acid homeostasis  (IEA)
G protein-coupled receptor signaling pathway  (IEA)
gene expression  (IEA,ISO)
high-density lipoprotein particle assembly  (IEA)
high-density lipoprotein particle clearance  (IEA)
high-density lipoprotein particle remodeling  (IEA)
intermediate-density lipoprotein particle clearance  (IEA)
intermembrane lipid transfer  (IEA)
lipid homeostasis  (IEA,ISO)
lipid metabolic process  (IEA,ISO)
lipid transport  (IEA,ISO)
lipid transport involved in lipid storage  (IEA)
lipoprotein biosynthetic process  (IEA,ISO)
lipoprotein catabolic process  (IEA,ISO)
lipoprotein metabolic process  (IEA,ISO)
locomotory exploration behavior  (IEA)
long-chain fatty acid transport  (IEA)
long-term memory  (IEA)
low-density lipoprotein particle remodeling  (IEA)
maintenance of location in cell  (IEA,ISO)
melanosome organization  (IEA)
negative regulation of amyloid fibril formation  (IEA)
negative regulation of amyloid-beta formation  (IEA)
negative regulation of blood coagulation  (IEA)
negative regulation of blood vessel endothelial cell migration  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cholesterol biosynthetic process  (IEA,ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of dendritic spine development  (ISO)
negative regulation of dendritic spine maintenance  (ISO)
negative regulation of endothelial cell migration  (IEA)
negative regulation of endothelial cell proliferation  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of inflammatory response  (IEA)
negative regulation of lipid biosynthetic process  (ISO)
negative regulation of lipid transport across blood-brain barrier  (ISO)
negative regulation of long-term synaptic potentiation  (IEA)
negative regulation of MAP kinase activity  (IEA)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of neuron projection development  (IEA)
negative regulation of phospholipid efflux  (ISO)
negative regulation of platelet activation  (IEA)
negative regulation of postsynaptic membrane organization  (ISO)
negative regulation of protein metabolic process  (IEA)
negative regulation of protein secretion  (IEA)
negative regulation of smooth muscle cell proliferation  (IEA,ISO)
negative regulation of triglyceride metabolic process  (IEA,ISO)
neuron projection development  (IEA)
nitric oxide mediated signal transduction  (IEA)
NMDA glutamate receptor clustering  (IEA,ISO)
obsolete positive regulation of cholesterol esterification  (ISO)
oligodendrocyte differentiation  (ISO)
peripheral nervous system axon regeneration  (ISO)
phospholipid efflux  (IEA)
positive regulation by host of viral process  (IEA)
positive regulation of amyloid-beta clearance  (IEA)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cholesterol efflux  (IEA)
positive regulation of cholesterol metabolic process  (IEA)
positive regulation of CoA-transferase activity  (IEA)
positive regulation of dendritic spine development  (IEA,ISO)
positive regulation of dendritic spine maintenance  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of endocytosis  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of heparan sulfate binding  (IEA)
positive regulation of heparan sulfate proteoglycan binding  (IEA)
positive regulation of lipid biosynthetic process  (IEA)
positive regulation of lipid transport across blood-brain barrier  (IEA)
positive regulation of low-density lipoprotein particle receptor catabolic process  (IEA)
positive regulation of membrane protein ectodomain proteolysis  (IEA)
positive regulation of neurofibrillary tangle assembly  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neuron projection development  (IEA)
positive regulation of nitric-oxide synthase activity  (IEA)
positive regulation of phospholipid efflux  (IEA)
positive regulation of presynaptic membrane organization  (ISO)
protein import  (IEA)
protein localization  (ISO)
receptor-mediated endocytosis  (IEA)
regulation of amyloid fibril formation  (IEA)
regulation of amyloid precursor protein catabolic process  (IEA)
regulation of amyloid-beta clearance  (IEA)
regulation of apoptotic process  (IEA)
regulation of behavioral fear response  (IEA)
regulation of Cdc42 protein signal transduction  (IEA)
regulation of cellular response to very-low-density lipoprotein particle stimulus  (IEA)
regulation of cholesterol metabolic process  (IEA)
regulation of gene expression  (IEA,ISO)
regulation of innate immune response  (IEA)
regulation of neuron death  (ISO)
regulation of plasma lipoprotein particle levels  (IEA)
regulation of proteasomal protein catabolic process  (IEA)
regulation of protein metabolic process  (IEA)
regulation of protein-containing complex assembly  (IEA)
regulation of synapse organization  (IEA)
regulation of tau-protein kinase activity  (ISO)
regulation of triglyceride metabolic process  (ISO)
response to caloric restriction  (IEA)
response to D-galactosamine  (ISO)
response to dietary excess  (IEA,ISO)
response to ethanol  (ISO)
response to insulin  (ISO)
response to oxidative stress  (IEA,ISO)
response to retinoic acid  (ISO)
response to tumor necrosis factor  (ISO)
response to zinc ion  (ISO)
reverse cholesterol transport  (IEA)
triglyceride homeostasis  (IEA)
triglyceride metabolic process  (IEA)
triglyceride-rich lipoprotein particle clearance  (IEA)
vasodilation  (IEA,ISO)
very-low-density lipoprotein particle clearance  (IEA)
very-low-density lipoprotein particle remodeling  (IEA)
virion assembly  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
APOE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11950,459,906 - 50,463,490 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,459,906 - 50,463,490 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01941,853,669 - 41,857,252 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
APOE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,905,796 - 44,909,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1944,905,791 - 44,909,393 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,409,053 - 45,412,650 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,100,879 - 50,104,490 (+)NCBINCBI36Build 36hg18NCBI36
Build 341950,100,878 - 50,104,489NCBI
Celera1942,213,361 - 42,216,972 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,839,825 - 41,843,436 (+)NCBIHuRef
CHM1_11945,411,793 - 45,415,404 (+)NCBICHM1_1
T2T-CHM13v2.01947,730,492 - 47,734,089 (+)NCBIT2T-CHM13v2.0
Apoe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,430,169 - 19,434,326 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,430,034 - 19,433,113 (-)EnsemblGRCm39 Ensembl
GRCm38719,696,244 - 19,701,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,696,109 - 19,699,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv37720,281,593 - 20,284,515 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,854,794 - 18,857,554 (-)NCBIMGSCv36mm8
Celera717,102,329 - 17,105,251 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
Apoe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,353,924 - 79,357,852 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,353,916 - 79,357,932 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,748,825 - 84,752,747 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0193,300,176 - 93,304,099 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0186,503,931 - 86,507,854 (-)NCBIRnor_WKY
Rnor_6.0180,612,894 - 80,616,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,612,895 - 80,617,057 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,878,372 - 81,882,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,003,634 - 79,006,387 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1179,081,854 - 79,083,684 (-)NCBI
Celera173,813,122 - 73,817,046 (-)NCBICelera
Cytogenetic Map1q21NCBI
Apoe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,999,711 - 2,001,888 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555551,998,170 - 2,002,003 (+)NCBIChiLan1.0ChiLan1.0
APOE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,525,717 - 110,528,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,525,722 - 110,528,440 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,006,660 - 110,009,463 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01111,055,483 - 111,058,288 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,055,483 - 111,058,228 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,730,139 - 110,732,942 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,365,616 - 110,368,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,234,400 - 111,237,204 (-)NCBIUU_Cfam_GSD_1.0
Apoe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,165,062 - 17,169,462 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367061,512,438 - 1,516,805 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,372,292 - 51,375,330 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,373,113 - 51,375,333 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,269,973 - 47,272,195 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q1.2-q2.12NCBI
APOE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,377,154 - 38,381,219 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,376,887 - 38,381,438 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607317,947,315 - 17,951,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoe
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249071,752,322 - 1,755,308 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008970765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000045576   ⟹   ENSPPAP00000022762
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1950,459,906 - 50,463,490 (+)Ensembl
RefSeq Acc Id: XM_008970765   ⟹   XP_008969013
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11950,459,906 - 50,463,490 (+)NCBI
Mhudiblu_PPA_v01941,853,669 - 41,857,252 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008969013 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008969013   ⟸   XM_008970765
- Sequence:
RefSeq Acc Id: ENSPPAP00000022762   ⟸   ENSPPAT00000045576


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034562 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000022762 ENTREZGENE
  ENSPPAP00000022762.1 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000045576.1 UniProtKB/TrEMBL
InterPro ApoA_E UniProtKB/TrEMBL
NCBI Gene APOE ENTREZGENE
Pfam Apolipoprotein UniProtKB/TrEMBL
UniProt A0A2R9B3N2_PANPA UniProtKB/TrEMBL