Apoe (apolipoprotein E) - Rat Genome Database

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Gene: Apoe (apolipoprotein E) Mus musculus
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Symbol: Apoe
Name: apolipoprotein E
RGD ID: 733604
MGI Page MGI
Description: Enables several functions, including cholesterol transfer activity; heparan sulfate proteoglycan binding activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Involved in several processes, including negative regulation of macromolecule metabolic process; plasma lipoprotein particle remodeling; and regulation of defense response. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including cholesterol catabolic process; cholesterol efflux; and lipoprotein metabolic process. Located in extracellular space. Part of low-density lipoprotein particle. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; liver and biliary system; nervous system; and sensory organ. Used to study Alzheimer's disease; age related macular degeneration 1; and homocystinuria. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A; AI255918; apo-E
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,430,169 - 19,434,326 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,430,034 - 19,433,113 (-)EnsemblGRCm39 Ensembl
GRCm38719,696,244 - 19,701,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,696,109 - 19,699,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv37720,281,593 - 20,284,515 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,854,794 - 18,857,554 (-)NCBIMGSCv36mm8
Celera717,102,329 - 17,105,251 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IMP,ISO)
adenocarcinoma  (ISO)
age related macular degeneration 1  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 2  (ISO)
Alzheimer's disease 3  (ISO)
Alzheimer's disease 4  (ISO)
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Apraxia  (ISO)
amyloidosis  (ISO)
amyotrophic lateral sclerosis  (ISO)
angle-closure glaucoma  (ISO)
anxiety disorder  (ISO)
aortic atherosclerosis  (ISO)
Apolipoprotein E, Deficiency or Defect of  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (IMP,ISO)
atopic dermatitis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
beta thalassemia  (ISO)
bile duct cancer  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Broad-Betalipoproteinemia  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
cerebral amyloid angiopathy  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholelithiasis  (ISO)
cholestasis  (ISO)
Chronic Brain Injury  (ISO)
Chronic Cerebral Hypoperfusion  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
Cognitive Dysfunction  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Coumarin Sensitivity  (ISO)
dementia  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IMP,ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
Dysbetalipoproteinemia due to Defect in Apolipoprotein E-d  (ISO)
Dyslipidemias  (ISO)
Emphysema  (ISO)
end stage renal disease  (IMP,ISO)
Endotoxemia  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (IMP)
familial combined hyperlipidemia  (ISO)
Familial Hyperbeta- and Prebetalipoproteinemia  (ISO)
familial hypercholesterolemia  (ISO)
familial hyperlipidemia  (ISO)
fetal alcohol spectrum disorder  (IMP)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
Floating-Betalipoproteinemia  (ISO)
gallbladder cancer  (ISO)
Genetic Translocation  (ISO)
glaucoma  (ISO)
glomerulonephritis  (IMP)
glomerulosclerosis  (ISO)
Habitual Abortions  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (IEP)
herpes simplex  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
Hypercholesterolemia  (IMP,ISO)
hyperhomocysteinemia  (ISO)
Hyperlipemia with Familial Hypercholesterolemic Xanthomatosis  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hyperlipoproteinemia type III  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hyperuricemia  (ISO)
hypothyroidism  (ISO)
kidney failure  (ISO)
Klebsiella Infections  (IMP)
Kuhnt-Junius degeneration  (ISO)
Lewy body dementia  (ISO)
Lipoprotein Glomerulopathy  (ISO)
low tension glaucoma  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
macular degeneration  (ISO)
malaria  (ISO)
membranous glomerulonephritis  (ISO)
Memory Disorders  (IMP,ISO)
Mercury Poisoning  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (IMP)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (IMP,ISO)
open-angle glaucoma  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
Peripheral Nerve Injuries  (ISO)
Plaque, Atherosclerotic  (ISO)
Pregnancy Complications, Infectious  (ISO)
Presenile and Senile Dementia  (ISO)
primary cutaneous amyloidosis  (ISO)
primary open angle glaucoma  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
retinal disease  (ISO)
schizophrenia  (IEA,ISO)
sciatic neuropathy  (ISO)
sea-blue histiocytosis  (ISO)
sensorineural hearing loss  (ISO)
Sjogren's syndrome  (ISO)
sleep apnea  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
Spontaneous Abortions  (ISO)
steatotic liver disease  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Vascular System Injuries  (IMP,ISO)
Venous Thrombosis  (IMP)
Ventricular Dysfunction, Left  (ISO)
warfarin resistance  (ISO)
warfarin sensitivity  (ISO)
Wilson disease  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-schisandrin B  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-nicotine  (EXP)
1,1-dichloroethene  (EXP)
11-dehydro-thromboxane B2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-arachidonoylglycerol  (EXP)
2-butoxyethanol  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-Nitrobenzanthrone  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxy-TEMPO  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-oxoprostaglandin F1alpha  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
8-epi-prostaglandin F2alpha  (EXP)
Abemaciclib  (ISO)
acenocoumarol  (ISO)
acetamide  (ISO)
acetylcholine  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
arachidonic acid  (EXP,ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (EXP)
bezafibrate  (ISO)
bifenthrin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
BQ 123  (EXP)
Brodifacoum  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
capsaicin  (EXP)
captan  (EXP)
carbon nanotube  (EXP)
carnosic acid  (EXP)
cerium trichloride  (ISO)
cetirizine  (EXP)
cetrorelix  (ISO)
chlordecone  (EXP)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
clotrimazole  (ISO)
cobalt atom  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
cordycepin  (EXP)
corosolic acid  (ISO)
curcumin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (EXP,ISO)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (ISO)
desogestrel  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinic acid  (EXP)
dimethylarsinous acid  (EXP)
dipyridamole  (ISO)
diquat  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP,ISO)
enalapril  (EXP,ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
erianin  (EXP)
ethanol  (EXP,ISO)
ethanolamine  (ISO)
Evodiamine  (EXP)
felodipine  (EXP)
fenvalerate  (ISO)
Fexofenadine hydrochloride  (EXP)
flusilazole  (EXP)
flutamide  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
fructose  (EXP)
furan  (ISO)
Ganoderic acid A  (ISO)
gemfibrozil  (ISO)
genistein  (EXP)
gentamycin  (ISO)
gingerol  (EXP)
ginkgolide B  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP)
glycidol  (ISO)
glyphosate  (EXP)
GW 3965  (EXP,ISO)
GW 4064  (EXP,ISO)
GW 7647  (ISO)
hexadecanoic acid  (EXP)
high-density lipoprotein cholesterol  (EXP,ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
imisopasem manganese  (EXP)
indometacin  (EXP)
iron atom  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
isotretinoin  (ISO)
ivabradine  (EXP)
ivermectin  (ISO)
kaempferol  (EXP)
kainic acid  (EXP)
ketamine  (ISO)
ketoconazole  (ISO)
kuwanone G  (EXP)
L-ascorbic acid  (ISO)
lansoprazole  (EXP,ISO)
lanthanum trichloride  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP)
lovastatin  (EXP)
mechlorethamine  (ISO)
menadione  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (ISO)
methyl beta-cyclodextrin  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monosodium L-glutamate  (EXP,ISO)
morphine  (ISO)
Morroniside  (EXP)
myricitrin  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nimesulide  (EXP)
nitric oxide  (EXP)
nitrofen  (ISO)
Nivalenol  (ISO)
NONOate(1-)  (EXP)
notoginsenoside R1  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
oxaliplatin  (ISO)
oxybenzone  (EXP)
ozone  (EXP)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (EXP,ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
Phenelzine  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenytoin  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phytosterols  (EXP)
pirinixic acid  (ISO)
potassium chloride  (ISO)
probucol  (EXP)
propamocarb  (EXP)
propanal  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (EXP,ISO)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
rotenone  (EXP)
Salvianolic acid A  (EXP)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (EXP,ISO)
sevoflurane  (EXP,ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
streptozocin  (EXP,ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
superoxide  (EXP)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
taurocholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
theaflavin  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
Trihexyphenidyl  (ISO)
trimellitic anhydride  (EXP)
triolein  (ISO)
triphenyl phosphate  (EXP)
triptonide  (EXP)
troglitazone  (ISO)
Tropicamide  (ISO)
trovafloxacin  (EXP)
Tungsten carbide  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vanadyl sulfate  (ISO)
varenicline  (EXP)
vitamin E  (EXP)
vitamin K  (ISO)
vitexin  (EXP)
warfarin  (EXP,ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc sulfate  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acylglycerol homeostasis  (IBA)
AMPA glutamate receptor clustering  (ISO)
amyloid precursor protein metabolic process  (IEA,ISO)
artery development  (IGI)
artery morphogenesis  (IGI)
axon regeneration  (IGI)
cellular oxidant detoxification  (IEA)
cellular response to amyloid-beta  (ISO)
cellular response to cholesterol  (ISO)
cellular response to ethanol  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipoprotein particle stimulus  (IEA,ISO)
cholesterol catabolic process  (IMP)
cholesterol efflux  (IBA,IDA,IEA,IMP,ISO)
cholesterol homeostasis  (IEA,IGI,IMP,ISO)
cholesterol metabolic process  (IBA,IEA,IMP,ISO)
chylomicron remnant clearance  (IEA,ISO,ISS)
circulatory system development  (IMP)
fatty acid homeostasis  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
gene expression  (IGI)
high-density lipoprotein particle assembly  (IEA,ISO,ISS)
high-density lipoprotein particle clearance  (IEA,ISO)
high-density lipoprotein particle remodeling  (IEA,ISO)
host-mediated activation of viral process  (IEA,ISO)
intermediate-density lipoprotein particle clearance  (IEA,ISO,ISS)
intracellular calcium ion homeostasis  (IDA)
intracellular protein localization  (IMP)
lipid homeostasis  (IMP)
lipid metabolic process  (IGI)
lipid transport  (IEA,ISO)
lipid transport involved in lipid storage  (IMP)
lipoprotein biosynthetic process  (IEA,IGI,ISO,ISS)
lipoprotein catabolic process  (IMP)
lipoprotein metabolic process  (IEA,IGI,IMP,ISO)
locomotory exploration behavior  (IEA,ISO)
long-chain fatty acid transport  (IEA,ISO)
long-term memory  (IEA,ISO)
low-density lipoprotein particle remodeling  (IMP)
maintenance of location in cell  (IMP)
melanosome organization  (IEA,IMP,ISO)
negative regulation of amyloid fibril formation  (IMP)
negative regulation of amyloid-beta formation  (IEA,ISO)
negative regulation of blood coagulation  (IEA,ISO)
negative regulation of blood vessel endothelial cell migration  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cholesterol biosynthetic process  (IEA,ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of dendritic spine development  (ISO)
negative regulation of dendritic spine maintenance  (ISO)
negative regulation of endothelial cell migration  (IEA,ISO)
negative regulation of endothelial cell proliferation  (IEA,ISO)
negative regulation of gene expression  (IMP)
negative regulation of inflammatory response  (IEA,IGI,ISO)
negative regulation of lipid biosynthetic process  (ISO)
negative regulation of lipid metabolic process  (IEA)
negative regulation of lipid transport across blood-brain barrier  (ISO)
negative regulation of long-term synaptic potentiation  (IEA,ISO)
negative regulation of MAPK cascade  (IEA,ISO)
negative regulation of neuron projection development  (IEA,ISO)
negative regulation of phospholipid efflux  (ISO)
negative regulation of platelet activation  (IEA,ISO)
negative regulation of platelet-derived growth factor receptor signaling pathway  (IEA,ISO)
negative regulation of postsynaptic membrane organization  (ISO)
negative regulation of protein metabolic process  (IEA,ISO)
negative regulation of protein secretion  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (IGI)
negative regulation of triglyceride metabolic process  (IGI)
neuron projection development  (IEA,ISO)
nitric oxide-cGMP-mediated signaling  (IEA,ISO)
NMDA glutamate receptor clustering  (ISO)
oligodendrocyte differentiation  (ISO)
peripheral nervous system axon regeneration  (ISO)
phospholipid efflux  (IBA,IEA,ISO)
positive regulation of amyloid-beta clearance  (IMP)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cholesterol efflux  (IEA,IMP,ISO)
positive regulation of cholesterol metabolic process  (IEA,IMP,ISO)
positive regulation of dendritic spine development  (IEA,ISO)
positive regulation of dendritic spine maintenance  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of endocytosis  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of lipid biosynthetic process  (IEA,ISO)
positive regulation of lipid transport across blood-brain barrier  (IEA,ISO)
positive regulation of lipoprotein transport  (IEA,ISO)
positive regulation of low-density lipoprotein particle receptor catabolic process  (IEA,ISO)
positive regulation of membrane protein ectodomain proteolysis  (IEA,ISO)
positive regulation of neurofibrillary tangle assembly  (ISO)
positive regulation of neuron projection development  (IEA,IMP,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of phospholipid efflux  (IEA,ISO)
positive regulation of presynaptic membrane organization  (ISO)
protein import  (ISO)
receptor-mediated endocytosis  (IEA,ISO)
regulation of amyloid fibril formation  (IEA,ISO)
regulation of amyloid precursor protein catabolic process  (IEA,ISO)
regulation of amyloid-beta clearance  (IEA,ISO)
regulation of apoptotic process  (IMP)
regulation of behavioral fear response  (IEA,ISO)
regulation of Cdc42 protein signal transduction  (IEA,ISO)
regulation of cellular response to very-low-density lipoprotein particle stimulus  (IEA,ISO)
regulation of cholesterol metabolic process  (IEA,ISO)
regulation of gene expression  (IMP)
regulation of innate immune response  (IMP)
regulation of plasma lipoprotein particle levels  (IMP)
regulation of proteasomal protein catabolic process  (IEA,ISO)
regulation of protein metabolic process  (IEA,ISO)
regulation of protein-containing complex assembly  (IEA,ISO)
regulation of synapse organization  (IDA,IMP)
regulation of triglyceride metabolic process  (IEA,ISO)
response to caloric restriction  (IEA,ISO)
response to D-galactosamine  (ISO)
response to dietary excess  (IMP)
response to ethanol  (ISO)
response to insulin  (ISO)
response to oxidative stress  (IMP)
response to retinoic acid  (ISO)
response to tumor necrosis factor  (ISO)
response to zinc ion  (ISO)
reverse cholesterol transport  (IEA,ISO)
triglyceride homeostasis  (IMP)
triglyceride metabolic process  (IEA,ISO)
triglyceride-rich lipoprotein particle clearance  (IEA,IMP,ISO,ISS)
vasodilation  (IMP)
very-low-density lipoprotein particle clearance  (IEA,ISO,ISS)
very-low-density lipoprotein particle remodeling  (IEA,IMP,ISO)
virion assembly  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adrenal cortex morphology  (IAGP)
abnormal adrenal gland morphology  (IAGP)
abnormal adrenal medulla morphology  (IAGP)
abnormal aorta bulb morphology  (IAGP)
abnormal aorta elastic tissue morphology  (IAGP)
abnormal aorta endothelium morphology  (IAGP)
abnormal aorta morphology  (IAGP)
abnormal aorta tunica media morphology  (IAGP)
abnormal aorta wall morphology  (IAGP)
abnormal aortic arch morphology  (IAGP)
abnormal apolipoprotein level  (IAGP)
abnormal arterial thrombosis  (IAGP)
abnormal artery morphology  (IAGP)
abnormal astrocyte morphology  (IAGP)
abnormal astrocyte physiology  (IAGP)
abnormal axon extension  (IAGP)
abnormal B cell activation  (IAGP)
abnormal basilar membrane morphology  (IAGP)
abnormal bile salt homeostasis  (IAGP)
abnormal blood coagulation  (IAGP)
abnormal blood flow velocity  (IAGP)
abnormal blood vessel physiology  (IAGP)
abnormal body weight  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal bone structure  (IAGP)
abnormal brachiocephalic trunk morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal Bruch membrane morphology  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal CD4-positive, alpha-beta T cell number  (IAGP)
abnormal cell-mediated immunity  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal cerebrospinal fluid amyloid beta 40 isoform level  (IAGP)
abnormal cerebrospinal fluid amyloid beta 42 isoform level  (IAGP)
abnormal cholesterol homeostasis  (IAGP)
abnormal cholesterol level  (IAGP)
abnormal circulating apolipoprotein E level  (IAGP)
abnormal circulating cholesterol level  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal circulating enzyme level  (IAGP)
abnormal circulating LDL cholesterol level  (IAGP)
abnormal circulating lipid level  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal coat appearance  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal coronary artery morphology  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal descending thoracic aorta morphology  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal enzyme/coenzyme level  (IAGP)
abnormal epididymal fat pad morphology  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal fat cell morphology  (IAGP)
abnormal fear/anxiety-related behavior  (IAGP)
abnormal gland physiology  (IAGP)
abnormal glomerular capillary thrombosis  (IAGP)
abnormal glomerular mesangium morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal gonadal fat pad morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hematopoietic system physiology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal immune serum protein physiology  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal impulse conducting system conduction  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal kidney arterial blood vessel morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kindling response  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal lipid level  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal lung hysteresivity  (IAGP)
abnormal lung volume  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal lymphocyte physiology  (IAGP)
abnormal macrophage chemotaxis  (IAGP)
abnormal macrophage derived foam cell morphology  (IAGP)
abnormal macrophage morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal mononuclear phagocyte morphology  (IAGP)
abnormal myelin sheath morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal nitric oxide homeostasis  (IAGP)
abnormal nucleotide metabolism  (IAGP)
abnormal nursing  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal phospholipid level  (IAGP)
abnormal plasma membrane morphology  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal response to CNS ischemic injury  (IAGP)
abnormal response to infection  (IAGP)
abnormal response to new environment  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal retina inner nuclear layer morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal skin condition  (IAGP)
abnormal skin morphology  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spatial reference memory  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal spiral modiolar artery morphology  (IAGP)
abnormal ST segment  (IAGP)
abnormal stationary movement  (IAGP)
abnormal stria vascularis morphology  (IAGP)
abnormal susceptibility to atherosclerosis  (IAGP)
abnormal synapse morphology  (IAGP)
abnormal synaptic vesicle morphology  (IAGP)
abnormal T cell number  (IAGP)
abnormal tectorial membrane morphology  (IAGP)
abnormal thermal nociception  (IAGP)
abnormal thrombosis  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal triglyceride level  (IAGP)
abnormal urine nucleoside level  (IAGP)
abnormal vascular endothelial cell morphology  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
abnormal vascular wound healing  (IAGP)
abnormal vasodilation  (IAGP)
abnormal vitamin E level  (IAGP)
albuminuria  (IAGP)
alopecia  (IAGP)
alveolitis  (IAGP)
amyloid beta deposits  (IAGP)
amyloidosis  (IAGP)
anemia  (IAGP)
aortic aneurysm  (IAGP)
aortic dissection  (IAGP)
aortic elastic tissue lesions  (IAGP)
aortic sinus aneurysm  (IAGP)
arteriosclerosis  (IAGP)
artery occlusion  (IAGP)
atherosclerotic lesions  (IAGP)
blood vessel inflammation  (IAGP)
calcified artery  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cerebral amyloid angiopathy  (IAGP)
cochlear ganglion degeneration  (IAGP)
cochlear inner hair cell degeneration  (IAGP)
cochlear outer hair cell degeneration  (IAGP)
cornea opacity  (IAGP)
deafness  (IAGP)
decreased acute inflammation  (IAGP)
decreased autoantibody level  (IAGP)
decreased body length  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone mineral density of femur  (IAGP)
decreased bone mineral density of vertebrae  (IAGP)
decreased bone trabecula number  (IAGP)
decreased brain cholesterol level  (IAGP)
decreased brown adipose tissue mass  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cardiac muscle triglyceride level  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cerebral infarct size  (IAGP)
decreased cholesterol level  (IAGP)
decreased circulating adiponectin level  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating homocysteine level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased circulating LDL cholesterol level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating serum amyloid protein level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased circulating troponin level  (IAGP)
decreased circulating VLDL cholesterol level  (IAGP)
decreased circulating VLDL triglyceride level  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased exploration in new environment  (IAGP)
decreased follicular B cell number  (IAGP)
decreased hair follicle number  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased inflammatory response  (IEA)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased kidney weight  (IAGP)
decreased liver cholesterol level  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased macrophage cell number  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased monocyte cell number  (IAGP)
decreased myocardial infarct size  (IAGP)
decreased skeletal muscle triglyceride level  (IAGP)
decreased startle reflex  (IAGP)
decreased susceptibility to atherosclerosis  (IAGP)
decreased susceptibility to diet-induced aortic fatty streak lesions  (IEA)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased susceptibility to hyperlipidemia  (IAGP)
decreased susceptibility to induced aneurysm formation  (IAGP)
decreased susceptibility to induced morbidity/mortality  (IAGP)
decreased susceptibility to type IV hypersensitivity reaction  (IAGP)
decreased systemic arterial blood pressure  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased systemic vascular resistance  (IAGP)
decreased T cell number  (IAGP)
decreased trabecular bone connectivity density  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased trabecular bone volume  (IAGP)
decreased triglyceride level  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
decreased vasodilation  (IAGP)
decreased vertical activity  (IAGP)
decreased white fat cell lipid droplet size  (IAGP)
decreased white fat cell size  (IAGP)
delayed cellular replicative senescence  (IAGP)
dilated aorta  (IAGP)
dilated glomerular capillary  (IAGP)
dilated heart left ventricle  (IAGP)
dry eyes  (IAGP)
echinocytosis  (IAGP)
enhanced coordination  (IAGP)
enlarged heart  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
enlarged thymus  (IAGP)
expanded mesangial matrix  (IAGP)
gliosis  (IAGP)
glomerulonephritis  (IAGP)
glomerulosclerosis  (IAGP)
heart inflammation  (IAGP)
hematoma  (IAGP)
hyperglycemia  (IAGP)
hyperkeratosis  (IAGP)
hyperlipidemia  (IAGP)
hypersecretion of corticosterone  (IAGP)
hypertension  (IAGP)
hypochromic macrocytic anemia  (IAGP)
hypopituitarism  (IAGP)
impaired blood-brain barrier function  (IAGP)
impaired glucose tolerance  (IAGP)
impaired lipolysis  (IAGP)
impaired macrophage chemotaxis  (IAGP)
impaired macrophage phagocytosis  (IAGP)
impaired muscle relaxation  (IAGP)
impaired olfaction  (IAGP)
impaired spatial learning  (IAGP)
impaired spatial working memory  (IAGP)
improved glucose tolerance  (IAGP)
increased airway resistance  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased anxiety-related response  (IAGP)
increased apoptosis  (IAGP)
increased autoantibody level  (IAGP)
increased B cell number  (IAGP)
increased body weight  (IAGP)
increased bone mineral density of vertebrae  (IAGP)
increased bone trabecula number  (IAGP)
increased bone volume  (IAGP)
increased cardiac output  (IAGP)
increased cardiac stroke volume  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased cellular sensitivity to hydrogen peroxide  (IAGP)
increased cerebral infarct size  (IAGP)
increased cerebrospinal fluid amyloid beta 40 isoform level  (IAGP)
increased cerebrospinal fluid amyloid beta 42 isoform level  (IAGP)
increased chemokine level  (IAGP)
increased cholesterol efflux  (IAGP)
increased cholesterol level  (IAGP)
increased circulating C-reactive protein level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating factor VIII level  (IAGP)
increased circulating free fatty acids level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating HDL cholesterol level  (IAGP)
increased circulating homocysteine level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-10 level  (IAGP)
increased circulating interleukin-12 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating methionine level  (IAGP)
increased circulating phospholipid level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased circulating VLDL cholesterol level  (IAGP)
increased circulating VLDL triglyceride level  (IAGP)
increased circulating von Willebrand factor level  (IAGP)
increased collagen level  (IAGP)
increased compact bone thickness  (IAGP)
increased exploration in new environment  (IAGP)
increased fat cell size  (IAGP)
increased fluid intake  (IAGP)
increased food intake  (IAGP)
increased growth rate  (IAGP)
increased heart left ventricle posterior wall thickness  (IAGP)
increased heart rate  (IAGP)
increased heart weight  (IAGP)
increased IgG level  (IAGP)
increased IgM level  (IAGP)
increased immunoglobulin level  (IAGP)
increased insulin sensitivity  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-10 secretion  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased kidney apoptosis  (IAGP)
increased lipoprotein lipase activity  (IAGP)
increased liver weight  (IAGP)
increased lung compliance  (IAGP)
increased Ly6C high monocyte number  (IAGP)
increased macrophage apoptosis  (IAGP)
increased macrophage cell number  (IAGP)
increased macrophage derived foam cell number  (IAGP)
increased marginal zone B cell number  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased monocyte cell number  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased phosphatidylcholine-sterol O-acyltransferase activity  (IAGP)
increased prostaglandin level  (IAGP)
increased renal glomerulus lobularity  (IAGP)
increased renal tubule apoptosis  (IAGP)
increased spleen weight  (IAGP)
increased startle reflex  (IAGP)
increased susceptibility to age-related hepatic steatosis  (IAGP)
increased susceptibility to atherosclerosis  (IAGP)
increased susceptibility to induced aneurysm formation  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to induced thrombosis  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to systemic lupus erythematosus  (IAGP)
increased susceptibility to weight gain  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased T cell number  (IAGP)
increased T-helper 2 cell number  (IAGP)
increased thigmotaxis  (IAGP)
increased trabecular bone volume  (IAGP)
increased triglyceride level  (IAGP)
increased triglyceride lipase activity  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
increased urine protein level  (IAGP)
increased uterus weight  (IAGP)
increased vascular smooth muscle cell proliferation  (IAGP)
increased vasoconstriction  (IAGP)
increased vasodilation  (IAGP)
insulin resistance  (IAGP)
kidney inflammation  (IAGP)
kidney microaneurysm  (IAGP)
lung inflammation  (IAGP)
macrocytosis  (IAGP)
Meibomian gland atrophy  (IAGP)
mesangiolysis  (IAGP)
mixed cellular infiltration to dermis  (IAGP)
neurodegeneration  (IAGP)
obese  (IAGP)
organ of Corti degeneration  (IAGP)
oxidative stress  (IAGP)
poikilocytosis  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
renal glomerular immunoglobulin deposits  (IAGP)
renal glomerulus hypertrophy  (IAGP)
renal glomerulus lipidosis  (IAGP)
reticulocytosis  (IAGP)
retina degeneration  (IAGP)
retina neovascularization  (IAGP)
retina pigment epithelium atrophy  (IAGP)
skin fibrosis  (IAGP)
skin inflammation  (IAGP)
skin lesions  (IAGP)
sparse hair  (IAGP)
spiral modiolar artery stenosis  (IAGP)
thick dermal layer  (IAGP)
thick interventricular septum  (IAGP)
thick skin  (IAGP)
thin retina inner nuclear layer  (IAGP)
thin retina outer nuclear layer  (IAGP)
thoracic aorta aneurysm  (IAGP)
uterus atrophy  (IAGP)
vascular smooth muscle hyperplasia  (IAGP)
vascular smooth muscle hypoplasia  (IAGP)
vascular stenosis  (IAGP)
xanthoma  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice. null
2. Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model. Alikhani N, etal., Oncogene. 2013 Feb 21;32(8):961-7. doi: 10.1038/onc.2012.113. Epub 2012 Apr 2.
3. Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China. Andreotti G, etal., Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):525-34. Epub 2008 Feb 22.
4. Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex. Arold S, etal., Acta Neuropathol. 2012 Jan;123(1):39-52. Epub 2011 Oct 22.
5. Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein E-deficient mice: a model linking hyperlipidemia and renal disease. Bagavant H, etal., Am J Pathol. 2011 Aug;179(2):651-60. Epub 2011 Jun 14.
6. APOE and APOC1 genetic polymorphisms in age-associated memory impairment. Bartres-Faz D, etal., Neurogenetics. 2001 Oct;3(4):215-9.
7. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
8. Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice. Bellosta S, etal., J Clin Invest. 1995 Nov;96(5):2170-9.
9. Effective treatment of ocular HSK with a human apolipoprotein E mimetic peptide in a mouse eye model. Bhattacharjee PS, etal., Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4263-8. doi: 10.1167/iovs.08-2077. Epub 2008 May 30.
10. Fetal adrenal gland alterations in a rat model of adverse intrauterine environment. Bibeau K, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R899-911. Epub 2009 Nov 18.
11. Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction. Bleumink GS, etal., Am Heart J. 2004 Apr;147(4):685-9.
12. A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. Boyles JK, etal., J Clin Invest. 1989 Mar;83(3):1015-31.
13. Protective peptides that are orally active and mechanistically nonchiral. Brenneman DE, etal., J Pharmacol Exp Ther. 2004 Jun;309(3):1190-7. Epub 2004 Mar 8.
14. Studies of familial type III hyperlipoproteinemia using as a genetic marker the apoE phenotype E2/2. Breslow JL, etal., J Lipid Res. 1982 Nov;23(8):1224-35.
15. Chronic renal failure alters endothelial function in cerebral circulation in mice. Bugnicourt JM, etal., Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H1143-52. Epub 2011 Jun 24.
16. Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin. Campalani E, etal., Br J Dermatol. 2006 Feb;154(2):345-52.
17. The apolipoprotein E genotype predicts postprandial hypertriglyceridemia in patients with the metabolic syndrome. Cardona F, etal., J Clin Endocrinol Metab. 2005 May;90(5):2972-5. Epub 2005 Feb 15.
18. Characterizations and proteome analysis of platelet-free plasma-derived microparticles in beta-thalassemia/hemoglobin E patients. Chaichompoo P, etal., J Proteomics. 2012 Dec 5;76 Spec No.:239-50. doi: 10.1016/j.jprot.2012.06.004. Epub 2012 Jun 15.
19. Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan. Chang NW, etal., Breast Cancer Res Treat. 2005 Apr;90(3):257-61.
20. Association between the apolipoprotein E genotypes and breast cancer patients in Taiwanese. Chang SJ, etal., Breast Cancer Res Treat. 2006 Jul;98(1):109-13. Epub 2006 Jun 5.
21. The effects of berberine on hyperhomocysteinemia and hyperlipidemia in rats fed with a long-term high-fat diet. Chang XX, etal., Lipids Health Dis. 2012 Jul 4;11(1):86.
22. APOE polymorphism and angiographic coronary artery disease severity in the Women's Ischemia Syndrome Evaluation (WISE) study. Chen Q, etal., Atherosclerosis. 2003 Jul;169(1):159-67.
23. Low cholesterol in dialysis patients--causal factor for mortality or an effect of confounding? Chmielewski M, etal., Nephrol Dial Transplant. 2011 Oct;26(10):3325-31. Epub 2011 Feb 28.
24. SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors. Corella D and Ordovas JM, Annu Rev Nutr. 2005;25:341-90.
25. [Comparative plasma proteomic analysis of patients with multiple myeloma treated with bortezomib-based regimens]. Cumova J, etal., Klin Onkol. 2012;25(1):17-25.
26. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. Daugherty A, etal., J Clin Invest. 2000 Jun;105(11):1605-12.
27. Apolipoprotein E-deficient mice have an impaired immune response to Klebsiella pneumoniae. de Bont N, etal., Eur J Clin Invest. 2000 Sep;30(9):818-22.
28. Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis. Diaz JA, etal., J Vasc Surg. 2012 Mar;55(3):815-22. Epub 2011 Nov 25.
29. Magnesium sulfate reduces bacterial LPS-induced inflammation at the maternal-fetal interface. Dowling O, etal., Placenta. 2012 May;33(5):392-8. doi: 10.1016/j.placenta.2012.01.013. Epub 2012 Feb 16.
30. Apolipoprotein E epsilon4 allele as a genetic risk factor for left ventricular failure in homozygous beta-thalassemia. Economou-Petersen E, etal., Blood. 1998 Nov 1;92(9):3455-9.
31. Effect of polymorphisms of the MTHFR and APOE genes on susceptibility to diabetes and severity of diabetic retinopathy in Brazilian patients. Errera FI, etal., Braz J Med Biol Res. 2006 Jul;39(7):883-8.
32. Severe type III hyperlipoproteinemia associated with unusual apolipoprotein E1 phenotype and epsilon 1/'null' genotype. Feussner G, etal., Eur J Clin Invest. 1992 Sep;22(9):599-608.
33. Subsets of SNPs define rare genotype classes that predict ischemic heart disease. Frikke-Schmidt R, etal., Hum Genet. 2007 Feb;120(6):865-877. Epub 2006 Sep 28.
34. Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene. Fritsche LG, etal., Hum Mutat. 2009 Jul;30(7):1048-53. doi: 10.1002/humu.20957.
35. Apolipoprotein E is present in primary localized cutaneous amyloidosis. Furumoto H, etal., J Invest Dermatol. 1998 Sep;111(3):417-21.
36. Involvement of apolipoprotein E in excess fat accumulation and insulin resistance. Gao J, etal., Diabetes. 2007 Jan;56(1):24-33.
37. Establishment of a rat model with diet-induced coronary atherosclerosis. Gao M, etal., J Biomed Res. 2016 Oct 17;31(1):47-55. doi: 10.7555/JBR.31.20160020.
38. Apolipoprotein E genotype is associated with differential expansion rates of small abdominal aortic aneurysms. Gerdes LU, etal., Br J Surg. 2000 Jun;87(6):760-5.
39. The association of Apoprotein E polymorphisms with recurrent pregnancy loss. Goodman C, etal., Am J Reprod Immunol. 2009 Jan;61(1):34-8. doi: 10.1111/j.1600-0897.2008.00659.x.
40. Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Gronborg M, etal., Mol Cell Proteomics. 2006 Jan;5(1):157-71. Epub 2005 Oct 8.
41. Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors. Hirashiki A, etal., J Am Coll Cardiol. 2003 Oct 15;42(8):1429-37.
42. The apolipoprotein E epsilon4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities. Hogh P, etal., Acta Neurol Scand. 2007 Apr;115(4):248-53.
43. Proteomic identification of biomarkers of vascular injury. Huang NF, etal., Am J Transl Res. 2011 Feb;3(2):139-48. Epub 2010 Nov 21.
44. Expression of apolipoprotein E during nerve degeneration and regeneration. Ignatius MJ, etal., Proc Natl Acad Sci U S A. 1986 Feb;83(4):1125-9.
45. Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males. Inbal A, etal., Blood. 1999 Apr 1;93(7):2186-90.
46. Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice. Ishigaki Y, etal., J Biol Chem. 2000 Oct 6;275(40):31269-73.
47. Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans. James ML, etal., J Stroke Cerebrovasc Dis. 2009 Mar-Apr;18(2):144-9.
48. Apolipoprotein E epsilon4 allele and outcomes of traumatic spinal cord injury. Jha A, etal., J Spinal Cord Med. 2008;31(2):171-6.
49. Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing. Jordan BD, etal., JAMA. 1997 Jul 9;278(2):136-40.
50. Abnormalities of lipoprotein metabolism in patients with the nephrotic syndrome. Joven J, etal., N Engl J Med. 1990 Aug 30;323(9):579-84.
51. Is the ApoE polymorphism associated with dilated cardiomyopathy? Jurkovicova D, etal., Gen Physiol Biophys. 2006 Mar;25(1):3-10.
52. Apolipoprotein E gene polymorphism in psoriasis. Karpouzis A, etal., Arch Dermatol Res. 2009 Jul;301(6):405-10. doi: 10.1007/s00403-009-0968-0. Epub 2009 Jun 5.
53. Effect of fungal polysaccharides on the modulation of plasma proteins in streptozotocin-induced diabetic rats. Kim SW, etal., Proteomics. 2006 Oct;6(19):5291-302.
54. Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers. Kim WK, etal., Exp Mol Med. 2008 Dec 31;40(6):677-85.
55. Association of apolipoprotein E polymorphisms with normal tension glaucoma in a Chinese population. Lam CY, etal., J Glaucoma. 2006 Jun;15(3):218-22.
56. Expression profiles of cholesterol metabolism-related genes are altered during development of experimental autoimmune encephalomyelitis in the rat spinal cord. Lavrnja I, etal., Sci Rep. 2017 Jun 2;7(1):2702. doi: 10.1038/s41598-017-02638-8.
57. Red mold rice promotes neuroprotective sAPPalpha secretion instead of Alzheimer's risk factors and amyloid beta expression in hyperlipidemic Abeta40-infused rats. Lee CL, etal., J Agric Food Chem. 2010 Feb 24;58(4):2230-8. doi: 10.1021/jf904027y.
58. Knockout rat models mimicking human atherosclerosis created by Cpf1-mediated gene targeting. Lee JG, etal., Sci Rep. 2019 Feb 22;9(1):2628. doi: 10.1038/s41598-019-38732-2.
59. An apolipoprotein E-mimetic stimulates axonal regeneration and remyelination after peripheral nerve injury. Li FQ, etal., J Pharmacol Exp Ther. 2010 Jul;334(1):106-15. Epub 2010 Apr 20.
60. Glucose concentration in the dialysate does not contribute to lipid profiles in patients undergoing CAPD. Li Z and Fengxian H, Ren Fail. 2011;33(2):124-30.
61. Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study. Liew G, etal., Arch Ophthalmol. 2007 Jun;125(6):813-8.
62. Herpes simplex encephalitis: involvement of apolipoprotein E genotype. Lin WR, etal., J Neurol Neurosurg Psychiatry. 2001 Jan;70(1):117-9.
63. Fcgamma receptor deficiency attenuates diabetic nephropathy. Lopez-Parra V, etal., J Am Soc Nephrol. 2012 Sep;23(9):1518-27. Epub 2012 Aug 2.
64. Apolipoprotein E promoter polymorphisms (-491A/T and -427T/C) and Alzheimer's disease: no evidence of association in the Irish population. Lynch CA, etal., Ir J Med Sci. 2008 Mar;177(1):29-33. Epub 2007 Dec 5.
65. The apolipoprotein E gene polymorphism is associated with open angle glaucoma in the Japanese population. Mabuchi F, etal., Mol Vis. 2005 Aug 12;11:609-12.
66. Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Malek G, etal., Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11900-5. Epub 2005 Aug 3.
67. Meta-analysis of genome-wide gene expression differences in onset and maintenance phases of genetic hypertension. Marques FZ, etal., Hypertension. 2010 Aug;56(2):319-24. Epub 2010 Jun 28.
68. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
69. MGDs mouse GO annotations MGD data from the GO Consortium
70. MGD IEA MGD IEA
71. Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Miklossy J, etal., Neurobiol Aging. 2008 Oct 23.
72. Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency. Miller RM and Federoff HJ, Neurobiol Aging. 2008 Jan;29(1):71-7. Epub 2006 Nov 13.
73. Genetic associations in diabetic nephropathy: a meta-analysis. Mooyaart AL, etal., Diabetologia. 2011 Mar;54(3):544-53. Epub 2010 Dec 3.
74. Apolipoprotein E genotyping in sporadic amyotrophic lateral sclerosis: evidence for a major influence on the clinical presentation and prognosis. Moulard B, etal., J Neurol Sci. 1996 Aug;139 Suppl:34-7.
75. Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats. Nakano T, etal., J Hepatol. 2011 Aug;55(2):415-25. Epub 2010 Dec 22.
76. Apolipoprotein E alleles and sensorineural hearing loss. O'Grady G, etal., Int J Audiol. 2007 Apr;46(4):183-6.
77. Apolipoprotein E Sendai (arginine 145-->proline): a new variant associated with lipoprotein glomerulopathy. Oikawa S, etal., J Am Soc Nephrol. 1997 May;8(5):820-3.
78. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
79. Combined germline variations of thrombophilic genes promote genesis of lung cancer. Ozen F, etal., Asian Pac J Cancer Prev. 2013;14(9):5449-54.
80. Regulation of apolipoprotein A-1 and E gene expression in liver and intestine of nephrotic and pair-fed rats. Panduro A, etal., Nephron. 1993;65(1):100-7.
81. The apolipoprotein E epsilon4 allele is unlikely to be a major risk factor of age-related macular degeneration in Chinese. Pang CP, etal., Ophthalmologica. 2000;214(4):289-91.
82. Apolipoprotein E polymorphism influences lipid phenotypes in Chinese families with familial combined hyperlipidemia. Pei WD, etal., Circ J. 2006 Dec;70(12):1606-10.
83. Presence of apolipoprotein E epsilon4 allele predisposes to early onset of primary Sjogren's syndrome. Pertovaara M, etal., Rheumatology (Oxford). 2004 Dec;43(12):1484-7. Epub 2004 Aug 24.
84. Angiotensin II Infusion Does Not Cause Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Rats. Phillips EH, etal., J Vasc Res. 2018;55(1):1-12. doi: 10.1159/000484086. Epub 2017 Nov 23.
85. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
86. Early hypercholesterolemia contributes to vasomotor dysfunction and injury associated atherogenesis that can be inhibited by nitric oxide. Raman KG, etal., J Vasc Surg. 2011 Mar;53(3):754-63. Epub 2010 Dec 15.
87. Postprandial triglyceride levels in familial combined hyperlipidemia. The role of apolipoprotein E and lipoprotein lipase polymorphisms. Reiber I, etal., J Nutr Biochem. 2003 Jul;14(7):394-400.
88. Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats In vivo. Rensen PC, etal., J Clin Invest. 1997 May 15;99(10):2438-45.
89. Apolipoprotein E promoter polymorphisms do not have a major influence on the risk of developing primary open angle glaucoma. Ressiniotis T, etal., Mol Vis. 2004 Oct 28;10:805-7.
90. Mouse MP Annotation Import Pipeline RGD automated import pipeline
91. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
92. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
93. Combined serum and tissue proteomic study applied to a c-Myc transgenic mouse model of hepatocellular carcinoma identified novel disease regulated proteins suitable for diagnosis and therapeutic intervention strategies. Ritorto MS and Borlak J, J Proteome Res. 2011 Jul 1;10(7):3012-30. Epub 2011 Jun 6.
94. Epistatic Interactions between apolipoprotein E and hemoglobin S Genes in regulation of malaria parasitemia. Rougeron V, etal., PLoS One. 2013 Oct 8;8(10):e76924. doi: 10.1371/journal.pone.0076924. eCollection 2013.
95. Enriched environment reduces apolipoprotein E (ApoE) in reactive astrocytes and attenuates inflammation of the peri-infarct tissue after experimental stroke. Ruscher K, etal., J Cereb Blood Flow Metab. 2009 Nov;29(11):1796-805. Epub 2009 Jul 22.
96. Plasma levels of apolipoprotein E and genetic markers in elderly patients with Alzheimer's disease. Scacchi R, etal., Neurosci Lett. 1999 Jan 4;259(1):33-6.
97. A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy. Schmidt S, etal., Ophthalmic Genet. 2002 Dec;23(4):209-23.
98. Robust association of the APOE epsilon4 allele with premature myocardial infarction especially in patients without hypercholesterolaemia: the Aachen study. Schmitz F, etal., Eur J Clin Invest. 2007 Feb;37(2):106-8.
99. Apolipoprotein E gene polymorphism is not a strong risk factor for diabetic nephropathy and retinopathy in Type I diabetes: case-control study. Shcherbak NS BMC Med Genet. 2001;2:8. Epub 2001 Jul 24.
100. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. Shulman JM, etal., PLoS One. 2010 Jun 21;5(6):e11244. doi: 10.1371/journal.pone.0011244.
101. A discovery-phase urine proteomics investigation in type 1 diabetes. Soggiu A, etal., Acta Diabetol. 2012 Jun 8.
102. The epsilon4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration. Souied EH, etal., Am J Ophthalmol. 1998 Mar;125(3):353-9.
103. The usefulness of measuring body fat deposition for detecting obesity and atherogenesity in Japanese school children. Takahashi H, etal., Acta Paediatr Jpn. 1996 Dec;38(6):634-9.
104. Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man. Utermann G, etal., Nature. 1977 Oct 13;269(5629):604-7.
105. Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease. Viitanen L, etal., J Mol Med. 2001 Dec;79(12):732-7. Epub 2001 Jul 25.
106. Chronic Cerebral Hypoperfusion Induced Synaptic Proteome Changes in the rat Cerebral Cortex. Völgyi K, etal., Mol Neurobiol. 2018 May;55(5):4253-4266. doi: 10.1007/s12035-017-0641-0. Epub 2017 Jun 15.
107. Proteinuria decreases tissue lipoprotein receptor levels resulting in altered lipoprotein structure and increasing lipid levels. Wang L, etal., Kidney Int. 2012 Jul 11. doi: 10.1038/ki.2012.244.
108. Olfactory identification and apolipoprotein E epsilon 4 allele in mild cognitive impairment. Wang QS, etal., Brain Res. 2002 Sep 27;951(1):77-81.
109. Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Warden CH, etal., Genomics 1993 Nov;18(2):295-307.
110. Apolipoprotein E genotype as a determinant of survival in chronic lymphocytic leukemia. Weinberg JB, etal., Leukemia. 2008 Dec;22(12):2184-92. doi: 10.1038/leu.2008.241. Epub 2008 Sep 11.
111. Effects of triiodothyronine and propylthiouracil on plasma lipoproteins in male rats. Wilcox HG, etal., J Lipid Res. 1982 Nov;23(8):1159-66.
112. Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis. Wilhelmus MM, etal., Am J Pathol. 2011 Nov;179(5):2152-6. doi: 10.1016/j.ajpath.2011.07.021. Epub 2011 Sep 9.
113. Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus. Wozniak MA, etal., Hepatology. 2002 Aug;36(2):456-63.
114. Genetic risk for coronary artery disease in individuals with or without type 2 diabetes. Yamada Y, etal., Mol Genet Metab. 2004 Apr;81(4):282-90.
115. Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis. Yamaguchi S, etal., Int J Mol Med. 2006 Nov;18(5):871-83.
116. Confounding effect of obstructive jaundice in the interpretation of proteomic plasma profiling data for pancreatic cancer. Yan L, etal., J Proteome Res. 2009 Jan;8(1):142-8.
117. Effects of apolipoprotein E genotypes on the development of exfoliation syndrome. Yilmaz A, etal., Exp Eye Res. 2005 Jun;80(6):871-5.
118. Investigation of the relationship between apolipoprotein E gene polymorphisms and hepatitis B virus infection in northern China. Yin Z, etal., Clin Chem Lab Med. 2010 Dec;48(12):1803-7. doi: 10.1515/CCLM.2010.354. Epub 2010 Oct 20.
119. [A study on the association of apolipoprotein E genotypes with primary open-angle glaucoma and primary angle-closure glaucoma in northeast of China]. Yuan HP, etal., Zhonghua Yan Ke Za Zhi. 2007 May;43(5):416-20.
120. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Zhang SH, etal., Science 1992 Oct 16;258(5081):468-71.
121. Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats. Zhao Y, etal., Atherosclerosis. 2018 Apr;271:26-35. doi: 10.1016/j.atherosclerosis.2018.02.015. Epub 2018 Feb 12.
122. Identification of differentially expressed proteins in rats with spinal cord injury during the transitional phase using an iTRAQ-based quantitative analysis. Zhou H, etal., Gene. 2018 Jul 20. pii: S0378-1119(18)30820-5. doi: 10.1016/j.gene.2018.07.050.
123. Less gelatinases is associated with apolipoprotein E accumulation in glomerulosclerosis rats. Zhou TB, etal., Histol Histopathol. 2012 Feb;27(2):249-56.
124. All-trans retinoic acid can regulate the expressions of gelatinases and apolipoprotein E in glomerulosclerosis rats. Zhou TB, etal., Vascul Pharmacol. 2011 Nov-Dec;55(5-6):169-77. Epub 2011 Sep 2.
Additional References at PubMed
PMID:1423598   PMID:1423604   PMID:1584779   PMID:1638085   PMID:1733675   PMID:1870200   PMID:1981054   PMID:2307474   PMID:2499515   PMID:2550421   PMID:2706836   PMID:2842249  
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PMID:7671812   PMID:7729619   PMID:7741021   PMID:7749859   PMID:7772082   PMID:7798236   PMID:7798939   PMID:7802634   PMID:7803821   PMID:7829881   PMID:7840811   PMID:7860728  
PMID:7916738   PMID:7937814   PMID:7948005   PMID:8024602   PMID:8040345   PMID:8068611   PMID:8083379   PMID:8088778   PMID:8104872   PMID:8105016   PMID:8183926   PMID:8185566  
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PMID:8618929   PMID:8647961   PMID:8656070   PMID:8660658   PMID:8686767   PMID:8692825   PMID:8696940   PMID:8701976   PMID:8707269   PMID:8710189   PMID:8747158   PMID:8757019  
PMID:8773783   PMID:8798405   PMID:8798769   PMID:8816744   PMID:8827514   PMID:8833906   PMID:8889548   PMID:8910571   PMID:8932523   PMID:8940032   PMID:8962133   PMID:8976376  
PMID:8980023   PMID:9069289   PMID:9077551   PMID:9106456   PMID:9136933   PMID:9137093   PMID:9153204   PMID:9169497   PMID:9169506   PMID:9185508   PMID:9186920   PMID:9202070  
PMID:9218423   PMID:9240444   PMID:9245700   PMID:9254055   PMID:9261817   PMID:9265639   PMID:9266610   PMID:9294126   PMID:9294211   PMID:9300780   PMID:9302276   PMID:9303078  
PMID:9325076   PMID:9326295   PMID:9327723   PMID:9354781   PMID:9358763   PMID:9398846   PMID:9407129   PMID:9409199   PMID:9409242   PMID:9409260   PMID:9416903   PMID:9446609  
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PMID:9607706   PMID:9628766   PMID:9649566   PMID:9651338   PMID:9664079   PMID:9682019   PMID:9682819   PMID:9724804   PMID:9727059   PMID:9732872   PMID:9743578   PMID:9756870  
PMID:9788969   PMID:9826706   PMID:9861024   PMID:9862272   PMID:9928488   PMID:10037478   PMID:10049716   PMID:10069791   PMID:10073953   PMID:10073981   PMID:10075730   PMID:10079115  
PMID:10086392   PMID:10087291   PMID:10092072   PMID:10094927   PMID:10192911   PMID:10195908   PMID:10195942   PMID:10208497   PMID:10208557   PMID:10221153   PMID:10224148   PMID:10224149  
PMID:10336088   PMID:10349636   PMID:10353889   PMID:10359567   PMID:10359569   PMID:10359814   PMID:10364560   PMID:10366621   PMID:10377084   PMID:10391478   PMID:10393696   PMID:10404048  
PMID:10407491   PMID:10426483   PMID:10428071   PMID:10428991   PMID:10430768   PMID:10430941   PMID:10435780   PMID:10441168   PMID:10441734   PMID:10446078   PMID:10448437   PMID:10477299  
PMID:10479659   PMID:10482304   PMID:10484545   PMID:10484615   PMID:10486514   PMID:10487844   PMID:10488949   PMID:10501533   PMID:10511293   PMID:10514484   PMID:10516643   PMID:10521365  
PMID:10521366   PMID:10529267   PMID:10532681   PMID:10546000   PMID:10559023   PMID:10585451   PMID:10591674   PMID:10611368   PMID:10613521   PMID:10614672   PMID:10620617   PMID:10632725  
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PMID:11095717   PMID:11106557   PMID:11110693   PMID:11116057   PMID:11116059   PMID:11116064   PMID:11120597   PMID:11120757   PMID:11120928   PMID:11122341   PMID:11138930   PMID:11154223  
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PMID:11606480   PMID:11606787   PMID:11682116   PMID:11692031   PMID:11701467   PMID:11701621   PMID:11705813   PMID:11705823   PMID:11707081   PMID:11709540   PMID:11714743   PMID:11719520  
PMID:11722612   PMID:11726538   PMID:11726660   PMID:11739102   PMID:11752403   PMID:11772998   PMID:11792702   PMID:11809774   PMID:11834721   PMID:11844581   PMID:11844869   PMID:11854327  
PMID:11861300   PMID:11861652   PMID:11861662   PMID:11866033   PMID:11884291   PMID:11884297   PMID:11893779   PMID:11893784   PMID:11901183   PMID:11902115   PMID:11909955   PMID:11912196  
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PMID:12044962   PMID:12054745   PMID:12056591   PMID:12067910   PMID:12077215   PMID:12093886   PMID:12097330   PMID:12105225   PMID:12105373   PMID:12135350   PMID:12163452   PMID:12171793  
PMID:12177238   PMID:12182886   PMID:12193651   PMID:12213722   PMID:12220566   PMID:12235184   PMID:12364322   PMID:12364544   PMID:12368212   PMID:12368657   PMID:12370251   PMID:12374623  
PMID:12377750   PMID:12388474   PMID:12401887   PMID:12401891   PMID:12414984   PMID:12419536   PMID:12431986   PMID:12446574   PMID:12451108   PMID:12454276   PMID:12457735   PMID:12466851  
PMID:12477932   PMID:12483207   PMID:12486146   PMID:12490540   PMID:12493565   PMID:12501252   PMID:12506016   PMID:12507771   PMID:12509421   PMID:12524433   PMID:12526030   PMID:12538437  
PMID:12538731   PMID:12538880   PMID:12551940   PMID:12559836   PMID:12562870   PMID:12569158   PMID:12576523   PMID:12598230   PMID:12600880   PMID:12600915   PMID:12609489   PMID:12615667  
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PMID:37595268   PMID:37620511   PMID:37629052   PMID:37650329   PMID:37651538   PMID:37652021   PMID:37659412   PMID:37668005   PMID:37731512   PMID:37739965   PMID:37749326   PMID:37767704  
PMID:37768825   PMID:37777633   PMID:37791598   PMID:37805344   PMID:37824329   PMID:37827334   PMID:37852961   PMID:37857162   PMID:37857825   PMID:37863057   PMID:37866313   PMID:37894941  
PMID:37900572   PMID:37922574   PMID:37944881   PMID:37947205   PMID:37957317   PMID:37988162   PMID:37995600   PMID:37995685   PMID:37998401   PMID:38020764   PMID:38026185   PMID:38034389  
PMID:38036784   PMID:38054039   PMID:38055674   PMID:38075287   PMID:38084147   PMID:38159571   PMID:38175709   PMID:38184021   PMID:38194294   PMID:38201205   PMID:38206365   PMID:38217595  
PMID:38259450   PMID:38279355   PMID:38285461   PMID:38301863   PMID:38306049   PMID:38348753   PMID:38348876   PMID:38355793   PMID:38390337   PMID:38416841   PMID:38421303   PMID:38439966  
PMID:38468308   PMID:38476659   PMID:38480892   PMID:38498570   PMID:38521811   PMID:38563353   PMID:38581737   PMID:38583587   PMID:38635560   PMID:38671323   PMID:38676929   PMID:38687251  
PMID:38713704   PMID:38733581   PMID:38735056   PMID:38748407   PMID:38777335   PMID:38783058   PMID:38797271   PMID:38818612   PMID:38830896   PMID:38838211   PMID:38841495   PMID:38860377  
PMID:38867189   PMID:38868202   PMID:38870781   PMID:38883832   PMID:38891121   PMID:38891996   PMID:38892314   PMID:38904030   PMID:38956041   PMID:38961225   PMID:38972156   PMID:38982113  
PMID:38982272   PMID:38996716   PMID:39109174   PMID:39112593   PMID:39112714   PMID:39126769   PMID:39128931   PMID:39138561   PMID:39156133   PMID:39187565   PMID:39241778   PMID:39260002  
PMID:39419029   PMID:39424784   PMID:39466775   PMID:39532095   PMID:39615283   PMID:39678689   PMID:39731355   PMID:39744521   PMID:39769453   PMID:39813317   PMID:39844286   PMID:39854369  
PMID:40003949   PMID:40056905   PMID:40075551   PMID:40093319   PMID:40121230   PMID:40159437   PMID:40362477  


Genomics

Comparative Map Data
Apoe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,430,169 - 19,434,326 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,430,034 - 19,433,113 (-)EnsemblGRCm39 Ensembl
GRCm38719,696,244 - 19,701,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,696,109 - 19,699,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv37720,281,593 - 20,284,515 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,854,794 - 18,857,554 (-)NCBIMGSCv36mm8
Celera717,102,329 - 17,105,251 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
APOE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,905,796 - 44,909,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1944,905,791 - 44,909,393 (+)EnsemblGRCh38hg38GRCh38
GRCh371945,409,053 - 45,412,650 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,100,879 - 50,104,490 (+)NCBINCBI36Build 36hg18NCBI36
Build 341950,100,878 - 50,104,489NCBI
Celera1942,213,361 - 42,216,972 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1941,839,825 - 41,843,436 (+)NCBIHuRef
CHM1_11945,411,793 - 45,415,404 (+)NCBICHM1_1
T2T-CHM13v2.01947,730,492 - 47,734,089 (+)NCBIT2T-CHM13v2.0
Apoe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,481,889 - 88,485,816 (-)NCBIGRCr8
GRCr8 Ensembl188,481,385 - 88,485,855 (-)EnsemblGRCr8 Ensembl
mRatBN7.2179,353,924 - 79,357,852 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,353,916 - 79,357,932 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,748,825 - 84,752,747 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,300,176 - 93,304,099 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,503,931 - 86,507,854 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,612,894 - 80,616,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,612,895 - 80,617,057 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,878,372 - 81,882,298 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,003,634 - 79,006,387 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera173,813,122 - 73,817,046 (-)NCBICelera
RGSC_v3.1179,081,854 - 79,083,684 (-)NCBI
Cytogenetic Map1q21NCBI
Apoe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,999,711 - 2,001,888 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555551,998,170 - 2,002,003 (+)NCBIChiLan1.0ChiLan1.0
APOE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,065,455 - 51,069,038 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11952,937,264 - 52,940,847 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,853,669 - 41,857,252 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,459,906 - 50,463,490 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,459,906 - 50,463,490 (+)Ensemblpanpan1.1panPan2
APOE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,525,717 - 110,528,534 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,525,722 - 110,528,440 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,006,660 - 110,009,463 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01111,055,483 - 111,058,288 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,055,483 - 111,058,228 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,730,139 - 110,732,942 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,365,616 - 110,368,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,234,400 - 111,237,204 (-)NCBIUU_Cfam_GSD_1.0
Apoe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,165,062 - 17,169,462 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367061,512,438 - 1,516,805 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,372,292 - 51,375,330 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,373,113 - 51,375,333 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,269,973 - 47,272,195 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q1.2-q2.12NCBI
APOE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,377,154 - 38,381,219 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,376,887 - 38,381,438 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607317,947,315 - 17,951,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoe
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249071,752,322 - 1,755,308 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apoe
187 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1680
Count of miRNA genes:482
Interacting mature miRNAs:582
Transcripts:ENSMUST00000003066, ENSMUST00000167646, ENSMUST00000172808, ENSMUST00000172983, ENSMUST00000173739, ENSMUST00000174064, ENSMUST00000174144, ENSMUST00000174191, ENSMUST00000174355, ENSMUST00000174710
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
12904941Edlmmq6_mextensor digitorum longus muscle mass QTL 6 (mouse)7121821047Mouse
1301177Vent3_mventricular size 3 (mouse)Not determined7120511925Mouse
10054067Sle20_msystematic lupus erythematosus susceptibility 20 (mouse)Not determined7120511925Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
12904948Tammq5_mtibialis anterior muscle mass QTL 5 (mouse)7121821047Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
12904953Gmmq5_mgastrocnemius muscle mass QTL 5 (mouse)7121821047Mouse
1302188Lxw6_mlupus BXSB x NZW 6 (mouse)Not determined7121698146Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse

Markers in Region
AI255918  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38719,696,285 - 19,696,374UniSTSGRCm38
MGSCv37720,281,634 - 20,281,723UniSTSGRCm37
Celera717,102,370 - 17,102,459UniSTS
Cytogenetic Map7A3UniSTS
cM Map74.0UniSTS
Whitehead/MRC_RH7264.79UniSTS
D7Mit57  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38719,697,771 - 19,697,919UniSTSGRCm38
MGSCv37720,283,120 - 20,283,268UniSTSGRCm37
Celera717,103,856 - 17,104,004UniSTS
Cytogenetic Map7A3UniSTS
cM Map74.0UniSTS
Whitehead Genetic74.4UniSTS
Whitehead/MRC_RH7263.38UniSTS
Apoe  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38719,697,072 - 19,697,512UniSTSGRCm38
MGSCv37720,281,663 - 20,281,892UniSTSGRCm37
MGSCv37720,281,636 - 20,281,844UniSTSGRCm37
Celera717,103,157 - 17,103,597UniSTS
Cytogenetic Map7A3UniSTS
cM Map74.0UniSTS
cM Map74.0UniSTS
PMC186328P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38719,696,953 - 19,697,649UniSTSGRCm38
MGSCv37720,282,302 - 20,282,998UniSTSGRCm37
Celera717,103,038 - 17,103,734UniSTS
Cytogenetic Map7A3UniSTS
cM Map74.0UniSTS
Apoe  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38719,696,314 - 19,696,543UniSTSGRCm38
MGSCv37720,281,663 - 20,281,892UniSTSGRCm37
Celera717,102,399 - 17,102,628UniSTS
Cytogenetic Map7A3UniSTS
cM Map74.0UniSTS
Apoe  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38719,696,287 - 19,696,495UniSTSGRCm38
MGSCv37720,281,636 - 20,281,844UniSTSGRCm37
Celera717,102,372 - 17,102,580UniSTS
Cytogenetic Map7A3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001305819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001305843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001305844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030242015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC149282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI836733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK019319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY313639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY772289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN173921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ299295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M12414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M73490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000003066   ⟹   ENSMUSP00000003066
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,430,197 - 19,432,977 (-)Ensembl
GRCm38.p6 Ensembl719,696,272 - 19,699,052 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167646
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,430,192 - 19,432,977 (-)Ensembl
GRCm38.p6 Ensembl719,696,267 - 19,699,052 (-)Ensembl
Ensembl Acc Id: ENSMUST00000172808   ⟹   ENSMUSP00000134558
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,430,769 - 19,432,172 (-)Ensembl
GRCm38.p6 Ensembl719,696,844 - 19,698,247 (-)Ensembl
Ensembl Acc Id: ENSMUST00000172983   ⟹   ENSMUSP00000133359
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,430,545 - 19,432,963 (-)Ensembl
GRCm38.p6 Ensembl719,696,620 - 19,699,038 (-)Ensembl
Ensembl Acc Id: ENSMUST00000173739   ⟹   ENSMUSP00000133371
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,430,197 - 19,432,332 (-)Ensembl
GRCm38.p6 Ensembl719,696,272 - 19,698,407 (-)Ensembl
Ensembl Acc Id: ENSMUST00000174064   ⟹   ENSMUSP00000133302
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,430,034 - 19,433,113 (-)Ensembl
GRCm38.p6 Ensembl719,696,109 - 19,699,188 (-)Ensembl
Ensembl Acc Id: ENSMUST00000174144   ⟹   ENSMUSP00000134622
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,430,546 - 19,432,546 (-)Ensembl
GRCm38.p6 Ensembl719,696,621 - 19,698,621 (-)Ensembl
Ensembl Acc Id: ENSMUST00000174191   ⟹   ENSMUSP00000133447
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,431,181 - 19,432,192 (-)Ensembl
GRCm38.p6 Ensembl719,697,256 - 19,698,267 (-)Ensembl
Ensembl Acc Id: ENSMUST00000174355   ⟹   ENSMUSP00000134160
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,430,197 - 19,432,933 (-)Ensembl
GRCm38.p6 Ensembl719,696,272 - 19,699,008 (-)Ensembl
Ensembl Acc Id: ENSMUST00000174710   ⟹   ENSMUSP00000134429
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,431,165 - 19,432,975 (-)Ensembl
GRCm38.p6 Ensembl719,697,240 - 19,699,050 (-)Ensembl
Ensembl Acc Id: ENSMUST00000207525
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl719,430,660 - 19,431,556 (-)Ensembl
GRCm38.p6 Ensembl719,696,735 - 19,697,631 (-)Ensembl
RefSeq Acc Id: NM_001305819   ⟹   NP_001292748
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39719,430,169 - 19,432,323 (-)NCBI
GRCm38719,696,244 - 19,698,398 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001305843   ⟹   NP_001292772
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39719,430,169 - 19,433,113 (-)NCBI
GRCm38719,696,244 - 19,699,188 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001305844   ⟹   NP_001292773
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39719,430,169 - 19,432,546 (-)NCBI
GRCm38719,696,244 - 19,698,621 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009696   ⟹   NP_033826
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39719,430,169 - 19,433,113 (-)NCBI
GRCm38719,696,244 - 19,699,188 (-)NCBI
MGSCv37720,281,593 - 20,284,515 (-)RGD
Celera717,102,329 - 17,105,251 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030242015   ⟹   XP_030097875
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39719,430,195 - 19,434,326 (-)NCBI
GRCm38719,696,270 - 19,701,310 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001292748 (Get FASTA)   NCBI Sequence Viewer  
  NP_001292772 (Get FASTA)   NCBI Sequence Viewer  
  NP_001292773 (Get FASTA)   NCBI Sequence Viewer  
  NP_033826 (Get FASTA)   NCBI Sequence Viewer  
  XP_030097875 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37251 (Get FASTA)   NCBI Sequence Viewer  
  AAA37252 (Get FASTA)   NCBI Sequence Viewer  
  AAH28816 (Get FASTA)   NCBI Sequence Viewer  
  AAH83351 (Get FASTA)   NCBI Sequence Viewer  
  BAA00361 (Get FASTA)   NCBI Sequence Viewer  
  BAC36000 (Get FASTA)   NCBI Sequence Viewer  
  BAE22338 (Get FASTA)   NCBI Sequence Viewer  
  BAE28740 (Get FASTA)   NCBI Sequence Viewer  
  BAE28964 (Get FASTA)   NCBI Sequence Viewer  
  BAE29894 (Get FASTA)   NCBI Sequence Viewer  
  BAE34821 (Get FASTA)   NCBI Sequence Viewer  
  BAE35071 (Get FASTA)   NCBI Sequence Viewer  
  BAE35147 (Get FASTA)   NCBI Sequence Viewer  
  CAJ18420 (Get FASTA)   NCBI Sequence Viewer  
  CAJ18564 (Get FASTA)   NCBI Sequence Viewer  
  EDL23176 (Get FASTA)   NCBI Sequence Viewer  
  EDL23177 (Get FASTA)   NCBI Sequence Viewer  
  EDL23178 (Get FASTA)   NCBI Sequence Viewer  
  EDL23179 (Get FASTA)   NCBI Sequence Viewer  
  EDL23180 (Get FASTA)   NCBI Sequence Viewer  
  EDL23181 (Get FASTA)   NCBI Sequence Viewer  
  EDL23182 (Get FASTA)   NCBI Sequence Viewer  
  EDL23183 (Get FASTA)   NCBI Sequence Viewer  
  EDL23184 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000003066.10
  ENSMUSP00000133302
  ENSMUSP00000133302.2
  ENSMUSP00000133371
  ENSMUSP00000133371.2
  ENSMUSP00000134160.2
GenBank Protein P08226 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_033826   ⟸   NM_009696
- Peptide Label: precursor
- UniProtKB: P08226 (UniProtKB/Swiss-Prot),   Q3TXU4 (UniProtKB/TrEMBL),   Q3UBS0 (UniProtKB/TrEMBL),   Q6GTX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001292772   ⟸   NM_001305843
- Peptide Label: precursor
- UniProtKB: P08226 (UniProtKB/Swiss-Prot),   Q3TXU4 (UniProtKB/TrEMBL),   Q3UBS0 (UniProtKB/TrEMBL),   Q6GTX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001292773   ⟸   NM_001305844
- Peptide Label: precursor
- UniProtKB: P08226 (UniProtKB/Swiss-Prot),   Q3TXU4 (UniProtKB/TrEMBL),   Q3UBS0 (UniProtKB/TrEMBL),   Q6GTX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001292748   ⟸   NM_001305819
- Peptide Label: precursor
- UniProtKB: P08226 (UniProtKB/Swiss-Prot),   Q3TXU4 (UniProtKB/TrEMBL),   Q3UBS0 (UniProtKB/TrEMBL),   Q6GTX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030097875   ⟸   XM_030242015
- Peptide Label: isoform X1
- UniProtKB: P08226 (UniProtKB/Swiss-Prot),   Q3TXU4 (UniProtKB/TrEMBL),   Q3UBS0 (UniProtKB/TrEMBL),   Q6GTX3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000134558   ⟸   ENSMUST00000172808
Ensembl Acc Id: ENSMUSP00000133359   ⟸   ENSMUST00000172983
Ensembl Acc Id: ENSMUSP00000134429   ⟸   ENSMUST00000174710
Ensembl Acc Id: ENSMUSP00000134622   ⟸   ENSMUST00000174144
Ensembl Acc Id: ENSMUSP00000133447   ⟸   ENSMUST00000174191
Ensembl Acc Id: ENSMUSP00000134160   ⟸   ENSMUST00000174355
Ensembl Acc Id: ENSMUSP00000003066   ⟸   ENSMUST00000003066
Ensembl Acc Id: ENSMUSP00000133302   ⟸   ENSMUST00000174064
Ensembl Acc Id: ENSMUSP00000133371   ⟸   ENSMUST00000173739

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08226-F1-model_v2 AlphaFold P08226 1-311 view protein structure

Promoters
RGD ID:6892122
Promoter ID:EPDNEW_M9512
Type:initiation region
Name:Apoe_1
Description:Mus musculus apolipoprotein E , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38719,699,052 - 19,699,112EPDNEW
RGD ID:6848847
Promoter ID:MM_TRO:8706
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   BoneMarrow_0Hour,   ES_Cell,   Kidney,   Lung
Transcripts:MTR001252.7.570.4
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36720,282,611 - 20,283,852 (-)MPROMDB
RGD ID:6840619
Promoter ID:MM_KWN:49093
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:NM_009696,   UC009FMX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36720,284,081 - 20,284,762 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88057 AgrOrtholog
Ensembl Genes ENSMUSG00000002985 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000003066.16 UniProtKB/Swiss-Prot
  ENSMUST00000173739 ENTREZGENE
  ENSMUST00000173739.8 UniProtKB/Swiss-Prot
  ENSMUST00000174064 ENTREZGENE
  ENSMUST00000174064.9 UniProtKB/Swiss-Prot
  ENSMUST00000174355.8 UniProtKB/Swiss-Prot
Gene3D-CATH Apolipoprotein UniProtKB/Swiss-Prot
InterPro ApoA_E UniProtKB/Swiss-Prot
  Apolipoprotein_A1/A4/E UniProtKB/Swiss-Prot
KEGG Report mmu:11816 UniProtKB/Swiss-Prot
MGD MGI:88057 ENTREZGENE
NCBI Gene 11816 ENTREZGENE
PANTHER APOLIPOPROTEIN UniProtKB/Swiss-Prot
  APOLIPOPROTEIN E UniProtKB/Swiss-Prot
Pfam Apolipoprotein UniProtKB/Swiss-Prot
PharmGKB APOE RGD
PhenoGen Apoe PhenoGen
Superfamily-SCOP Apolipoprotein A-I UniProtKB/Swiss-Prot
UniProt A0A1B0GX15_MOUSE UniProtKB/TrEMBL
  APOE_MOUSE UniProtKB/Swiss-Prot
  G3UWN5_MOUSE UniProtKB/TrEMBL
  G3UWW2_MOUSE UniProtKB/TrEMBL
  G3UZM8_MOUSE UniProtKB/TrEMBL
  P08226 ENTREZGENE
  Q3TX45_MOUSE UniProtKB/TrEMBL
  Q3TXU4 ENTREZGENE, UniProtKB/TrEMBL
  Q3UBS0 ENTREZGENE, UniProtKB/TrEMBL
  Q3UEE7_MOUSE UniProtKB/TrEMBL
  Q3UF21_MOUSE UniProtKB/TrEMBL
  Q4FK40_MOUSE UniProtKB/TrEMBL
  Q6GTX3 ENTREZGENE, UniProtKB/TrEMBL
  Q8C6E4_MOUSE UniProtKB/TrEMBL