(+)-catechin multiple interactions EXP 6480464 Catechin inhibits the reaction [APOE gene mutant form results in increased expression of EDN1 protein] CTD PMID:20093625 (+)-schisandrin B multiple interactions ISO RGD:2138 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of APOE mRNA] CTD PMID:31150632 (25R)-cholest-5-ene-3beta,26-diol increases expression ISO RGD:2138 6480464 27-hydroxycholesterol results in increased expression of APOE mRNA, 27-hydroxycholesterol results in increased expression of APOE protein CTD PMID:28167099 (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of APOE mRNA CTD PMID:17997037 1,1-dichloroethene increases expression EXP 6480464 vinylidene chloride results in increased expression of APOE mRNA CTD PMID:26682919 11-dehydro-thromboxane B2 multiple interactions ISO RGD:736378 6480464 APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2] more ... CTD PMID:20530721 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of APOE mRNA CTD PMID:17555576 17alpha-ethynylestradiol decreases expression ISO RGD:2138 6480464 Ethinyl Estradiol results in decreased expression of APOE mRNA CTD PMID:17351261 , PMID:17557909 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of APOE mRNA CTD PMID:14976129 more ... 17alpha-ethynylestradiol increases expression ISO RGD:2138 6480464 Ethinyl Estradiol results in increased expression of APOE mRNA CTD PMID:16174780 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of APOE mRNA CTD PMID:17942748 17beta-estradiol multiple interactions EXP 6480464 ESR1 protein promotes the reaction [Estradiol results in decreased expression of APOE mRNA] CTD PMID:25210133 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of APOE mRNA CTD PMID:19484750 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of APOE mRNA CTD PMID:25210133 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO RGD:736378 6480464 APOE gene polymorphism affects the reaction [Dihydrotestosterone affects the phosphorylation of MAPK10 protein], APOE gene polymorphism affects the reaction [Dihydrotestosterone affects the phosphorylation of MAPK9 protein] CTD PMID:17395708 17beta-hydroxy-5alpha-androstan-3-one affects response to substance ISO RGD:736378 6480464 APOE gene polymorphism affects the susceptibility to Dihydrotestosterone CTD PMID:17395708 2,2',5,5'-tetrachlorobiphenyl affects expression ISO RGD:736378 6480464 2 more ... CTD PMID:21703328 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of APOE mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:2138 6480464 Tetrachlorodibenzodioxin results in decreased expression of APOE mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:2138 6480464 Tetrachlorodibenzodioxin affects the expression of APOE mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of APOE mRNA CTD PMID:21570461 , PMID:24680724 2,3,7,8-tetrachlorodibenzodioxine affects response to substance EXP 6480464 APOE protein affects the susceptibility to Tetrachlorodibenzodioxin CTD PMID:12213967 , PMID:21441140 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:736378 6480464 Tetrachlorodibenzodioxin results in increased expression of APOE mRNA CTD PMID:20106945 , PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of APOE mRNA CTD PMID:21041162 2,3,7,8-Tetrachlorodibenzofuran decreases expression ISO RGD:2138 6480464 2 more ... CTD PMID:32109520 2-amino-2-deoxy-D-galactopyranose decreases expression ISO RGD:2138 6480464 Galactosamine results in decreased expression of APOE protein CTD PMID:6631239 2-amino-2-deoxy-D-glucopyranose multiple interactions EXP 6480464 [Streptozocin co-treated with APOE mutant form] results in increased abundance of Glucosamine, INS1 inhibits the reaction [[Streptozocin co-treated with APOE mutant form] results in increased abundance of Glucosamine] CTD PMID:16380481 2-arachidonoylglycerol multiple interactions EXP 6480464 [[APOE protein affects the susceptibility to [Cholesterol, Dietary co-treated with Dietary Fats]] which affects the susceptibility to JZL 184] which affects the abundance of glyceryl 2-arachidonate CTD PMID:29813086 2-butoxyethanol decreases expression EXP 6480464 n-butoxyethanol results in decreased expression of APOE mRNA CTD PMID:19812364 2-methyl-6-(phenylethynyl)pyridine multiple interactions ISO RGD:736378 6480464 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Sodium Glutamate results in increased expression of APOE mRNA] CTD PMID:31981724 26-hydroxycholesterol increases expression ISO RGD:2138 6480464 27-hydroxycholesterol results in increased expression of APOE mRNA, 27-hydroxycholesterol results in increased expression of APOE protein CTD PMID:28167099 3',5'-cyclic GMP decreases abundance EXP 6480464 APOE gene mutant form results in decreased abundance of Cyclic GMP CTD PMID:11397713 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine decreases response to substance EXP 6480464 APOE protein results in decreased susceptibility to Puromycin Aminonucleoside CTD PMID:12472773 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression ISO RGD:2138 6480464 Puromycin Aminonucleoside results in increased expression of APOE protein CTD PMID:7442475 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine affects expression ISO RGD:2138 6480464 Puromycin Aminonucleoside affects the expression of APOE mRNA CTD PMID:8413767 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO RGD:2138 6480464 3 more ... CTD PMID:23196670 3,3',5-triiodo-L-thyronine multiple interactions ISO RGD:2138 6480464 Triiodothyronine results in increased expression of [APOE protein co-treated with APOA4 protein] CTD PMID:6816881 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:2138 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of APOE mRNA CTD PMID:30071829 3-chloropropane-1,2-diol increases expression ISO RGD:2138 6480464 alpha-Chlorohydrin analog results in increased expression of APOE protein CTD PMID:26597043 3-Nitrobenzanthrone increases expression ISO RGD:736378 6480464 3-nitrobenzanthrone results in increased expression of APOE mRNA CTD PMID:34036453 3H-1,2-dithiole-3-thione increases expression ISO RGD:2138 6480464 1, 2-dithiol-3-thione results in increased expression of APOE mRNA CTD PMID:19162173 4,4'-sulfonyldiphenol increases expression ISO RGD:736378 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of APOE mRNA CTD PMID:27685785 4-hydroxy-TEMPO multiple interactions ISO RGD:736378 6480464 tempol inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] CTD PMID:20530721 4-hydroxy-TEMPO multiple interactions EXP 6480464 tempol inhibits the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid] CTD PMID:20530721 5-aza-2'-deoxycytidine multiple interactions ISO RGD:2138 6480464 Decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of APOE mRNA] more ... CTD PMID:28315714 , PMID:30185694 6-oxoprostaglandin F1alpha increases abundance EXP 6480464 APOE results in increased abundance of 6-Ketoprostaglandin F1 alpha CTD PMID:14966570 6-oxoprostaglandin F1alpha multiple interactions EXP 6480464 nimesulide inhibits the reaction [APOE results in increased abundance of 6-Ketoprostaglandin F1 alpha] CTD PMID:14966570 7,12-dimethyltetraphene affects expression EXP 6480464 9 more ... CTD PMID:21785161 8-epi-prostaglandin F2alpha multiple interactions EXP 6480464 [APOE gene mutant form affects the susceptibility to Folic Acid] which results in decreased abundance of 8-epi-prostaglandin F2alpha CTD PMID:17118406 acenocoumarol affects response to substance ISO RGD:736378 6480464 APOE gene polymorphism affects the susceptibility to Acenocoumarol CTD PMID:15861030 acetamide decreases expression ISO RGD:2138 6480464 acetamide results in decreased expression of APOE mRNA CTD PMID:31881176 acetylcholine affects response to substance EXP 6480464 APOE protein affects the susceptibility to Acetylcholine CTD PMID:17899169 acetylcholine decreases response to substance EXP 6480464 APOE gene mutant form results in decreased susceptibility to Acetylcholine CTD PMID:11397713 acetylsalicylic acid affects response to substance ISO RGD:736378 6480464 APOE polymorphism affects the susceptibility to Aspirin CTD PMID:15084783 acetylsalicylic acid multiple interactions EXP 6480464 Aspirin inhibits the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid] CTD PMID:20530721 acetylsalicylic acid multiple interactions ISO RGD:736378 6480464 Aspirin inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] CTD PMID:20530721 acrolein affects folding ISO RGD:736378 6480464 Acrolein affects the folding of APOE protein CTD PMID:17580963 acrolein decreases activity ISO RGD:736378 6480464 Acrolein results in decreased activity of APOE protein CTD PMID:17580963 aflatoxin B1 affects expression ISO RGD:736378 6480464 Aflatoxin B1 affects the expression of APOE protein CTD PMID:20106945 aflatoxin B1 decreases expression ISO RGD:736378 6480464 Aflatoxin B1 results in decreased expression of APOE mRNA CTD PMID:27153756 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of APOE mRNA CTD PMID:19770486 aldehydo-D-glucosamine multiple interactions EXP 6480464 [Streptozocin co-treated with APOE mutant form] results in increased abundance of Glucosamine, INS1 inhibits the reaction [[Streptozocin co-treated with APOE mutant form] results in increased abundance of Glucosamine] CTD PMID:16380481 aldehydo-D-glucose affects secretion ISO RGD:736378 6480464 Glucose deficiency affects the secretion of APOE protein CTD PMID:24802182 all-trans-retinoic acid multiple interactions EXP 6480464 AGN 193109 inhibits the reaction [Tretinoin results in increased expression of APOE mRNA] CTD PMID:16505366 all-trans-retinoic acid decreases expression ISO RGD:736378 6480464 Tretinoin results in decreased expression of APOE mRNA CTD PMID:23724009 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of APOE mRNA CTD PMID:16505366 amiodarone decreases expression ISO RGD:2138 6480464 Amiodarone results in decreased expression of APOE mRNA CTD PMID:17991464 ammonium chloride affects expression ISO RGD:2138 6480464 Ammonium Chloride affects the expression of APOE mRNA CTD PMID:16483693 amphibole asbestos increases expression ISO RGD:2138 6480464 Asbestos, Amphibole results in increased expression of APOE mRNA CTD PMID:22352330 arachidonic acid multiple interactions ISO RGD:736378 6480464 APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2] more ... CTD PMID:20530721 arachidonic acid decreases response to substance EXP 6480464 APOE gene mutant form results in decreased susceptibility to Arachidonic Acid CTD PMID:20530721 arachidonic acid multiple interactions EXP 6480464 Aspirin inhibits the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid] more ... CTD PMID:20530721 aristolochic acid increases expression ISO RGD:736378 6480464 aristolochic acid I results in increased expression of APOE mRNA CTD PMID:33212167 Aroclor 1254 increases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of APOE mRNA CTD PMID:25270620 arsane multiple interactions EXP 6480464 [APOE protein affects the susceptibility to Arsenic] which affects the expression of AQP1 mRNA more ... CTD PMID:22719926 arsane increases response to substance ISO RGD:736378 6480464 APOE polymorphism results in increased susceptibility to Arsenic CTD PMID:18022660 arsane increases response to substance EXP 6480464 APOE gene mutant form results in increased susceptibility to Arsenic CTD PMID:22956628 arsane affects response to substance EXP 6480464 APOE protein affects the susceptibility to Arsenic CTD PMID:22719926 arsane increases expression EXP 6480464 Arsenic results in increased expression of APOE mRNA CTD PMID:24019935 arsenic atom increases response to substance ISO RGD:736378 6480464 APOE polymorphism results in increased susceptibility to Arsenic CTD PMID:18022660 arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of APOE mRNA CTD PMID:24019935 arsenic atom increases response to substance EXP 6480464 APOE gene mutant form results in increased susceptibility to Arsenic CTD PMID:22956628 arsenic atom affects response to substance EXP 6480464 APOE protein affects the susceptibility to Arsenic CTD PMID:22719926 arsenic atom multiple interactions EXP 6480464 [APOE protein affects the susceptibility to Arsenic] which affects the expression of AQP1 mRNA more ... CTD PMID:22719926 arsenite(3-) increases response to substance EXP 6480464 APOE gene mutant form results in increased susceptibility to arsenite CTD PMID:30376133 arsenous acid decreases expression ISO RGD:736378 6480464 Arsenic Trioxide results in decreased expression of APOE mRNA CTD PMID:22521957 arsenous acid multiple interactions ISO RGD:736378 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to APOE protein] CTD PMID:26598702 aspartame decreases expression ISO RGD:736378 6480464 Aspartame results in decreased expression of APOE mRNA CTD PMID:31655124 atorvastatin calcium decreases expression ISO RGD:736378 6480464 Atorvastatin results in decreased expression of APOE mRNA, Atorvastatin results in decreased expression of APOE protein CTD PMID:16386711 atorvastatin calcium multiple interactions EXP 6480464 Atorvastatin inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the activity of GPT protein] more ... CTD PMID:32976958 atorvastatin calcium multiple interactions ISO RGD:736378 6480464 [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein CTD PMID:19603250 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of APOE mRNA CTD PMID:19770486 benzo[a]pyrene decreases expression ISO RGD:736378 6480464 Benzo(a)pyrene results in decreased expression of APOE mRNA, Benzo(a)pyrene results in decreased expression of APOE protein CTD PMID:32234424 , PMID:33278487 benzo[a]pyrene decreases methylation ISO RGD:736378 6480464 Benzo(a)pyrene results in decreased methylation of APOE 5' UTR CTD PMID:27901495 benzo[a]pyrene increases methylation ISO RGD:736378 6480464 Benzo(a)pyrene results in increased methylation of APOE promoter CTD PMID:27901495 beta-D-glucosamine multiple interactions EXP 6480464 [Streptozocin co-treated with APOE mutant form] results in increased abundance of Glucosamine, INS1 inhibits the reaction [[Streptozocin co-treated with APOE mutant form] results in increased abundance of Glucosamine] CTD PMID:16380481 bezafibrate multiple interactions ISO RGD:736378 6480464 [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein CTD PMID:19603250 bezafibrate increases expression ISO RGD:736378 6480464 Bezafibrate results in increased expression of APOE protein CTD PMID:8017468 bezafibrate decreases expression ISO RGD:2138 6480464 Bezafibrate results in decreased expression of APOE protein CTD PMID:9006809 bezafibrate multiple interactions ISO RGD:2138 6480464 [Bezafibrate co-treated with Ethanolamine] results in decreased secretion of APOE protein CTD PMID:8944747 bifenthrin increases expression EXP 6480464 bifenthrin results in increased expression of APOE mRNA CTD PMID:26071804 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [APOE gene mutant form results in increased susceptibility to Diethylhexyl Phthalate] which results in decreased expression of ABCG5 protein more ... CTD PMID:25270622 bis(2-ethylhexyl) phthalate increases response to substance EXP 6480464 APOE gene mutant form results in increased susceptibility to Diethylhexyl Phthalate CTD PMID:25270622 bisphenol A affects expression ISO RGD:2138 6480464 bisphenol A affects the expression of APOE mRNA CTD PMID:25181051 , PMID:30903817 bisphenol A affects expression ISO RGD:736378 6480464 bisphenol A affects the expression of APOE mRNA CTD PMID:30903817 bisphenol A decreases expression ISO RGD:2138 6480464 bisphenol A results in decreased expression of APOE mRNA CTD PMID:30816183 bisphenol A multiple interactions ISO RGD:2138 6480464 [bisphenol A co-treated with tributyltin] results in increased expression of APOE mRNA CTD PMID:31129395 bisphenol A affects methylation EXP 6480464 bisphenol A affects the methylation of APOE promoter CTD PMID:27334623 bisphenol A increases expression ISO RGD:736378 6480464 bisphenol A results in increased expression of APOE mRNA CTD PMID:27685785 BQ 123 multiple interactions EXP 6480464 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [[APOE protein affects the susceptibility to Vehicle Emissions] which results in increased expression of EDN1 mRNA] more ... CTD PMID:19150882 Brodifacoum increases expression ISO RGD:2138 6480464 bromfenacoum results in increased expression of APOE protein CTD PMID:28903499 cadmium atom multiple interactions EXP 6480464 [APOE gene mutant form results in increased susceptibility to Cadmium] which results in increased expression of HSPD1 more ... CTD PMID:21799275 , PMID:31626305 cadmium atom decreases expression ISO RGD:2138 6480464 Cadmium results in decreased expression of APOE mRNA, Cadmium results in decreased expression of APOE protein CTD PMID:28315714 cadmium atom multiple interactions ISO RGD:2138 6480464 [[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in decreased expression of APOE mRNA more ... CTD PMID:28315714 , PMID:33188856 cadmium atom affects binding ISO RGD:736378 6480464 APOE protein binds to Cadmium CTD PMID:23896426 cadmium atom increases response to substance EXP 6480464 APOE gene mutant form results in increased susceptibility to Cadmium CTD PMID:21799275 cadmium dichloride decreases expression ISO RGD:2138 6480464 Cadmium Chloride results in decreased expression of APOE mRNA CTD PMID:30185694 cadmium dichloride multiple interactions EXP 6480464 APOE gene polymorphism results in increased susceptibility to [Cadmium Chloride results in increased abundance of Cadmium] CTD PMID:31626305 cadmium dichloride multiple interactions ISO RGD:2138 6480464 [[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in decreased expression of APOE mRNA more ... CTD PMID:30185694 , PMID:33188856 cadmium dichloride increases methylation ISO RGD:2138 6480464 Cadmium Chloride results in increased methylation of APOE promoter CTD PMID:30185694 Calcimycin decreases response to substance EXP 6480464 APOE gene mutant form results in decreased susceptibility to Calcimycin CTD PMID:11397713 calcium atom affects abundance EXP 6480464 APOE protein affects the abundance of Calcium CTD PMID:17899169 calcium atom affects expression ISO RGD:2138 6480464 Calcium affects the expression of APOE mRNA CTD PMID:15913539 calcium(0) affects abundance EXP 6480464 APOE protein affects the abundance of Calcium CTD PMID:17899169 calcium(0) affects expression ISO RGD:2138 6480464 Calcium affects the expression of APOE mRNA CTD PMID:15913539 capsaicin multiple interactions EXP 6480464 APOE affects the reaction [Capsaicin results in decreased expression of LRP1 protein] more ... CTD PMID:21908651 captan decreases expression EXP 6480464 Captan results in decreased expression of APOE mRNA CTD PMID:31558096 carbon nanotube decreases expression EXP 6480464 Nanotubes more ... CTD PMID:25448806 , PMID:25554681 cerium trichloride multiple interactions ISO RGD:736378 6480464 [cerous chloride co-treated with lanthanum chloride] results in increased expression of APOE mRNA CTD PMID:28954213 cerium trichloride affects expression ISO RGD:736378 6480464 cerous chloride affects the expression of APOE mRNA CTD PMID:28954213 cetirizine multiple interactions EXP 6480464 [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CCL23 protein more ... CTD PMID:24852568 , PMID:25020133 cetirizine decreases expression EXP 6480464 Cetirizine results in decreased expression of APOE mRNA CTD PMID:24852568 cetrorelix multiple interactions ISO RGD:736378 6480464 [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of APOE mRNA, [cetrorelix co-treated with testosterone enanthate] results in decreased expression of APOE mRNA CTD PMID:18160741 chlordecone decreases expression EXP 6480464 Chlordecone results in decreased expression of APOE mRNA CTD PMID:33711761 chloropicrin decreases expression ISO RGD:736378 6480464 chloropicrin results in decreased expression of APOE mRNA CTD PMID:26352163 chloroquine affects localization ISO RGD:2138 6480464 Chloroquine affects the localization of APOE protein CTD PMID:8616629 chlorpyrifos multiple interactions ISO RGD:736378 6480464 [APOE gene polymorphism affects the susceptibility to Chlorpyrifos] which affects the expression of AVP mRNA more ... CTD PMID:29729306 more ... chlorpyrifos affects response to substance ISO RGD:736378 6480464 APOE gene polymorphism affects the susceptibility to Chlorpyrifos CTD PMID:31472362 chlorpyrifos multiple interactions EXP 6480464 [APOE protein results in increased susceptibility to Chlorpyrifos] which results in decreased expression of PON1 mRNA more ... CTD PMID:29404631 chlorpyrifos increases response to substance EXP 6480464 APOE protein results in increased susceptibility to Chlorpyrifos CTD PMID:29404631 cholesterol affects response to substance EXP 6480464 APOE protein affects the susceptibility to Cholesterol CTD PMID:16179587 cholesterol affects localization ISO RGD:2138 6480464 Cholesterol affects the localization of APOE protein CTD PMID:21169230 cholesterol multiple interactions ISO RGD:2138 6480464 Cholesterol promotes the reaction [APOE protein binds to CAV1 protein] CTD PMID:21169230 cholesterol affects localization EXP 6480464 Cholesterol affects the localization of APOE protein CTD PMID:21169230 cholesterol increases export EXP 6480464 APOE protein results in increased export of Cholesterol CTD PMID:22022523 cholesterol increases abundance EXP 6480464 APOE gene mutant form results in increased abundance of Cholesterol CTD PMID:24933211 , PMID:25037058 cholesterol multiple interactions EXP 6480464 24-diamino-5-phenylthiazole inhibits the reaction [TO-901317 promotes the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]] more ... CTD PMID:11397713 more ... cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of APOE mRNA CTD PMID:21151649 cisplatin decreases expression ISO RGD:736378 6480464 Cisplatin results in decreased expression of APOE mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:736378 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of APOE mRNA CTD PMID:27392435 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of APOE mRNA CTD PMID:24865317 cisplatin decreases response to substance ISO RGD:736378 6480464 APOE protein results in decreased susceptibility to Cisplatin CTD PMID:20430468 clofibrate increases expression EXP 6480464 Clofibrate results in increased expression of APOE mRNA CTD PMID:25270620 clofibric acid multiple interactions ISO RGD:2138 6480464 [Clofibric Acid co-treated with Ethanolamine] results in decreased secretion of APOE protein CTD PMID:8944747 cobalt atom multiple interactions ISO RGD:736378 6480464 [tungsten carbide co-treated with Cobalt] results in decreased expression of APOE mRNA CTD PMID:18078969 copper atom increases expression ISO RGD:2138 6480464 Copper deficiency results in increased expression of APOE mRNA CTD PMID:19821111 copper atom affects binding ISO RGD:736378 6480464 APOE protein binds to Copper CTD PMID:23896426 copper atom increases uptake EXP 6480464 APOE gene mutant form results in increased uptake of Copper CTD PMID:25749341 copper atom decreases expression ISO RGD:2138 6480464 Copper results in decreased expression of APOE mRNA CTD PMID:22465980 copper(0) increases expression ISO RGD:2138 6480464 Copper deficiency results in increased expression of APOE mRNA CTD PMID:19821111 copper(0) affects binding ISO RGD:736378 6480464 APOE protein binds to Copper CTD PMID:23896426 copper(0) increases uptake EXP 6480464 APOE gene mutant form results in increased uptake of Copper CTD PMID:25749341 copper(0) decreases expression ISO RGD:2138 6480464 Copper results in decreased expression of APOE mRNA CTD PMID:22465980 copper(II) sulfate affects response to substance EXP 6480464 APOE protein mutant form affects the susceptibility to Copper Sulfate CTD PMID:9568736 copper(II) sulfate multiple interactions EXP 6480464 APOE protein inhibits the reaction [Copper Sulfate results in increased expression of HMOX1 protein], APOE protein inhibits the reaction [Copper Sulfate results in increased expression of NQO1 protein] CTD PMID:25749341 copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of APOE mRNA CTD PMID:18579281 copper(II) sulfate increases response to substance EXP 6480464 APOE protein mutant form results in increased susceptibility to Copper Sulfate CTD PMID:9409251 curcumin affects expression EXP 6480464 Curcumin affects the expression of APOE mRNA CTD PMID:27208389 cyclophosphamide decreases expression EXP 6480464 Cyclophosphamide results in decreased expression of APOE mRNA CTD PMID:15331540 cyclophosphamide increases expression EXP 6480464 Cyclophosphamide results in increased expression of APOE mRNA CTD PMID:21041162 cyclosporin A decreases expression ISO RGD:736378 6480464 Cyclosporine results in decreased expression of APOE mRNA CTD PMID:20106945 more ... cypermethrin decreases expression ISO RGD:2138 6480464 cypermethrin results in decreased expression of APOE mRNA CTD PMID:11428908 , PMID:9650644 cypermethrin increases expression EXP 6480464 cypermethrin results in increased expression of APOE mRNA CTD PMID:21142847 D-glucose affects secretion ISO RGD:736378 6480464 Glucose deficiency affects the secretion of APOE protein CTD PMID:24802182 DDE increases response to substance ISO RGD:736378 6480464 APOE gene polymorphism results in increased susceptibility to Dichlorodiphenyl Dichloroethylene CTD PMID:24473795 Deoxycorticosterone acetate multiple interactions ISO RGD:2138 6480464 [Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in increased expression of APOE mRNA CTD PMID:22228705 desogestrel multiple interactions ISO RGD:736378 6480464 [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of APOE mRNA CTD PMID:18160741 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of APOE mRNA CTD PMID:21041162 dexamethasone increases expression ISO RGD:736378 6480464 Dexamethasone results in increased expression of APOE mRNA CTD PMID:25047013 dextran sulfate multiple interactions EXP 6480464 Erianin inhibits the reaction [Dextran Sulfate results in increased expression of APOE protein] CTD PMID:32272095 dextran sulfate increases expression EXP 6480464 Dextran Sulfate results in increased expression of APOE protein CTD PMID:32272095 diarsenic trioxide multiple interactions ISO RGD:736378 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to APOE protein] CTD PMID:26598702 diarsenic trioxide decreases expression ISO RGD:736378 6480464 Arsenic Trioxide results in decreased expression of APOE mRNA CTD PMID:22521957 diazinon affects expression ISO RGD:2138 6480464 Diazinon affects the expression of APOE mRNA CTD PMID:22546817 dibutyl phthalate decreases expression ISO RGD:2138 6480464 Dibutyl Phthalate results in decreased expression of APOE mRNA CTD PMID:33983380 diethylstilbestrol increases expression ISO RGD:736378 6480464 Diethylstilbestrol results in increased expression of APOE mRNA CTD PMID:15766595 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of APOE mRNA CTD PMID:21041162 diethylstilbestrol decreases expression EXP 6480464 Diethylstilbestrol results in decreased expression of APOE mRNA CTD PMID:15171707 dimethylarsinic acid affects response to substance EXP 6480464 APOE protein affects the susceptibility to Cacodylic Acid CTD PMID:28728140 dimethylarsinic acid multiple interactions EXP 6480464 AS3MT protein affects the reaction [APOE protein affects the susceptibility to Cacodylic Acid] CTD PMID:28728140 dimethylarsinous acid affects response to substance EXP 6480464 APOE protein affects the susceptibility to dimethylarsinous acid CTD PMID:28728140 dipyridamole multiple interactions ISO RGD:736378 6480464 [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein CTD PMID:19603250 diuron decreases expression ISO RGD:2138 6480464 Diuron results in decreased expression of APOE mRNA CTD PMID:21551480 , PMID:25152437 dorsomorphin multiple interactions ISO RGD:736378 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOE mRNA CTD PMID:27188386 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of APOE mRNA CTD PMID:15033991 doxorubicin increases expression ISO RGD:2138 6480464 Doxorubicin results in increased expression of APOE protein CTD PMID:8255516 elemental selenium increases expression ISO RGD:736378 6480464 Selenium results in increased expression of APOE mRNA CTD PMID:19244175 elemental selenium affects expression EXP 6480464 Selenium affects the expression of APOE protein CTD PMID:17996733 enalapril multiple interactions ISO RGD:736378 6480464 [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein CTD PMID:19603250 enalapril multiple interactions EXP 6480464 Enalapril inhibits the reaction [APOE gene mutant form results in decreased abundance of Antioxidants], Enalapril inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol] CTD PMID:25037058 endosulfan increases expression ISO RGD:2138 6480464 Endosulfan results in increased expression of APOE mRNA CTD PMID:29391264 entinostat multiple interactions ISO RGD:736378 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOE mRNA CTD PMID:27188386 entinostat increases expression ISO RGD:736378 6480464 entinostat results in increased expression of APOE mRNA CTD PMID:26272509 epoxiconazole increases expression ISO RGD:2138 6480464 epoxiconazole results in increased expression of APOE mRNA CTD PMID:28454766 ethanol increases secretion ISO RGD:2138 6480464 Ethanol results in increased secretion of APOE protein CTD PMID:17478430 ethanol increases expression EXP 6480464 Ethanol results in increased expression of APOE mRNA CTD PMID:30319688 ethanol affects splicing EXP 6480464 Ethanol affects the splicing of APOE mRNA CTD PMID:30319688 ethanolamine multiple interactions ISO RGD:2138 6480464 [3-deazaadenosine co-treated with Ethanolamine] results in decreased secretion of APOE protein more ... CTD PMID:8944747 felodipine multiple interactions EXP 6480464 Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol more ... CTD PMID:18287887 fenvalerate increases expression ISO RGD:2138 6480464 fenvalerate results in increased expression of APOE mRNA CTD PMID:30307764 Fexofenadine hydrochloride multiple interactions EXP 6480464 [fexofenadine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CKM protein more ... CTD PMID:24852568 , PMID:25020133 Fexofenadine hydrochloride decreases expression EXP 6480464 fexofenadine results in decreased expression of APOE mRNA CTD PMID:24852568 flusilazole affects expression EXP 6480464 flusilazole affects the expression of APOE mRNA CTD PMID:22634333 flutamide increases expression ISO RGD:2138 6480464 Flutamide results in increased expression of APOE protein CTD PMID:17311803 fluvastatin multiple interactions ISO RGD:736378 6480464 [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin CTD PMID:19773416 fluvastatin increases expression ISO RGD:736378 6480464 fluvastatin results in increased expression of APOE protein CTD PMID:8017468 folic acid affects response to substance EXP 6480464 APOE gene mutant form affects the susceptibility to Folic Acid CTD PMID:17118406 folic acid decreases expression ISO RGD:736378 6480464 Folic Acid results in decreased expression of APOE mRNA CTD PMID:21867686 folic acid multiple interactions EXP 6480464 [APOE gene mutant form affects the susceptibility to Folic Acid] which results in decreased abundance of 8-epi-prostaglandin F2alpha more ... CTD PMID:17118406 , PMID:28475147 folpet decreases expression EXP 6480464 folpet results in decreased expression of APOE mRNA CTD PMID:31558096 furan decreases expression ISO RGD:2138 6480464 furan results in decreased expression of APOE mRNA CTD PMID:26194646 Ganoderic acid A decreases expression ISO RGD:736378 6480464 ganoderic acid A results in decreased expression of APOE mRNA CTD PMID:29852127 gemfibrozil increases expression ISO RGD:2138 6480464 Gemfibrozil results in increased expression of APOE protein CTD PMID:9006809 genistein decreases expression EXP 6480464 Genistein results in decreased expression of APOE mRNA CTD PMID:21048042 gentamycin increases expression ISO RGD:2138 6480464 Gentamicins results in increased expression of APOE mRNA CTD PMID:33387578 ginkgolide B multiple interactions EXP 6480464 ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the activity of GPT protein] more ... CTD PMID:32976958 glucose affects secretion ISO RGD:736378 6480464 Glucose deficiency affects the secretion of APOE protein CTD PMID:24802182 glutathione multiple interactions EXP 6480464 notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in decreased abundance of Glutathione] CTD PMID:24933211 glutathione decreases abundance EXP 6480464 APOE gene mutant form results in decreased abundance of Glutathione CTD PMID:24933211 GW 3965 increases expression ISO RGD:736378 6480464 GW 3965 results in increased expression of APOE mRNA CTD PMID:17449538 , PMID:27598782 GW 3965 increases expression EXP 6480464 GW 3965 results in increased expression of APOE mRNA CTD PMID:27598782 GW 3965 multiple interactions EXP 6480464 NR1H2 protein affects the reaction [GW 3965 results in increased expression of APOE mRNA], NR1H3 protein affects the reaction [GW 3965 results in increased expression of APOE mRNA] CTD PMID:27598782 GW 3965 multiple interactions ISO RGD:2138 6480464 GW 3965 promotes the reaction [Decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of APOE mRNA]] CTD PMID:30185694 GW 3965 multiple interactions ISO RGD:736378 6480464 GW 3965 results in increased expression of and results in increased secretion of APOE protein CTD PMID:27598782 GW 4064 multiple interactions EXP 6480464 GW 4064 promotes the reaction [NR1H4 protein binds to APOE gene] CTD PMID:20091679 GW 4064 multiple interactions ISO RGD:736378 6480464 [GW 4064 co-treated with Oleic Acid] results in decreased expression of APOE mRNA CTD PMID:30611723 GW 4064 increases expression EXP 6480464 GW 4064 results in increased expression of APOE mRNA CTD PMID:26655953 GW 7647 multiple interactions ISO RGD:736378 6480464 [GW 7647 co-treated with Oleic Acid] results in decreased expression of APOE mRNA CTD PMID:30611723 high-density lipoprotein cholesterol multiple interactions EXP 6480464 [APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased abundance of Cholesterol more ... CTD PMID:17118406 , PMID:32853627 high-density lipoprotein cholesterol affects abundance ISO RGD:736378 6480464 APOE gene polymorphism affects the abundance of Cholesterol, HDL CTD PMID:16030523 high-density lipoprotein cholesterol increases abundance ISO RGD:736378 6480464 APOE gene polymorphism results in increased abundance of Cholesterol, HDL CTD PMID:17289397 hydrazine decreases expression ISO RGD:2138 6480464 hydrazine results in decreased expression of APOE mRNA, hydrazine results in decreased expression of APOE protein CTD PMID:15370871 hydrogen peroxide affects localization ISO RGD:2138 6480464 Hydrogen Peroxide affects the localization of APOE protein CTD PMID:19720132 hydrogen peroxide increases expression ISO RGD:2138 6480464 Hydrogen Peroxide results in increased expression of APOE mRNA CTD PMID:19720132 hydroquinone multiple interactions ISO RGD:2138 6480464 [[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in decreased expression of APOE mRNA more ... CTD PMID:33188856 hydroquinone decreases expression ISO RGD:2138 6480464 hydroquinone results in decreased expression of APOE mRNA CTD PMID:33188856 indometacin multiple interactions EXP 6480464 Indomethacin promotes the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid] CTD PMID:20530721 iron atom increases response to substance ISO RGD:736378 6480464 APOE gene polymorphism results in increased susceptibility to Iron CTD PMID:15993987 iron(0) increases response to substance ISO RGD:736378 6480464 APOE gene polymorphism results in increased susceptibility to Iron CTD PMID:15993987 isotretinoin affects response to substance ISO RGD:736378 6480464 APOE gene polymorphism affects the susceptibility to Isotretinoin CTD PMID:12622636 ivabradine affects response to substance EXP 6480464 APOE affects the susceptibility to ivabradine CTD PMID:21821843 ivermectin decreases expression ISO RGD:736378 6480464 Ivermectin results in decreased expression of APOE protein CTD PMID:32959892 kaempferol multiple interactions EXP 6480464 kaempferol inhibits the reaction [APOE affects the expression of CD44 mRNA] more ... CTD PMID:22005275 kainic acid decreases expression EXP 6480464 Kainic Acid results in decreased expression of APOE mRNA CTD PMID:17997037 ketamine decreases response to substance ISO RGD:736378 6480464 APOE results in decreased susceptibility to Ketamine CTD PMID:9778666 ketamine increases expression ISO RGD:2138 6480464 Ketamine results in increased expression of APOE mRNA CTD PMID:20080153 kuwanone G multiple interactions EXP 6480464 kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IFNG protein] more ... CTD PMID:29355567 L-ascorbic acid increases expression ISO RGD:2138 6480464 Ascorbic Acid results in increased expression of APOE mRNA CTD PMID:15372504 lansoprazole increases expression ISO RGD:736378 6480464 Lansoprazole results in increased expression of APOE mRNA, Lansoprazole results in increased expression of APOE protein CTD PMID:20060385 lansoprazole increases expression EXP 6480464 Lansoprazole results in increased expression of APOE protein CTD PMID:20060385 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of APOE mRNA CTD PMID:21829687 , PMID:29746905 lead diacetate increases methylation ISO RGD:2138 6480464 lead acetate results in increased methylation of APOE gene CTD PMID:29571894 lead(0) affects expression ISO RGD:736378 6480464 Lead affects the expression of APOE protein CTD PMID:20681587 lead(2+) affects expression ISO RGD:736378 6480464 Lead affects the expression of APOE protein CTD PMID:20681587 Licochalcone B increases expression ISO RGD:736378 6480464 licochalcone B results in increased expression of APOE mRNA CTD PMID:33647349 lipopolysaccharide decreases expression EXP 6480464 Lipopolysaccharides results in decreased expression of APOE mRNA CTD PMID:16847310 lovastatin affects expression EXP 6480464 Lovastatin affects the expression of APOE mRNA CTD PMID:27208389 lovastatin multiple interactions EXP 6480464 [Dietary Fats co-treated with Lovastatin] affects the expression of APOE mRNA CTD PMID:29852127 mechlorethamine multiple interactions ISO RGD:2138 6480464 Valproic Acid promotes the reaction [Mechlorethamine results in increased expression of APOE mRNA] CTD PMID:28184907 mechlorethamine increases expression ISO RGD:2138 6480464 Mechlorethamine results in increased expression of APOE mRNA CTD PMID:26273949 , PMID:28184907 menadione affects response to substance EXP 6480464 APOE protein affects the susceptibility to Vitamin K 3 CTD PMID:28728140 mercury atom affects response to substance ISO RGD:736378 6480464 APOE gene polymorphism affects the susceptibility to Mercury, APOE polymorphism affects the susceptibility to Mercury CTD PMID:12897404 , PMID:23603214 mercury(0) affects response to substance ISO RGD:736378 6480464 APOE gene polymorphism affects the susceptibility to Mercury, APOE polymorphism affects the susceptibility to Mercury CTD PMID:12897404 , PMID:23603214 methyl beta-cyclodextrin multiple interactions EXP 6480464 methyl-beta-cyclodextrin inhibits the reaction [Cholesterol affects the localization of APOE protein] CTD PMID:21169230 methylmercury chloride decreases expression ISO RGD:736378 6480464 methylmercuric chloride results in decreased expression of APOE mRNA CTD PMID:23179753 microcystin-LR increases expression EXP 6480464 cyanoginosin LR results in increased expression of APOE protein CTD PMID:26984711 mono(2-ethylhexyl) phthalate increases expression ISO RGD:2138 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of APOE mRNA CTD PMID:22087261 monosodium L-glutamate increases expression EXP 6480464 Sodium Glutamate results in increased expression of APOE mRNA CTD PMID:31981724 monosodium L-glutamate multiple interactions ISO RGD:736378 6480464 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Sodium Glutamate results in increased expression of APOE mRNA] CTD PMID:31981724 monosodium L-glutamate increases expression ISO RGD:736378 6480464 Sodium Glutamate results in increased expression of APOE mRNA, Sodium Glutamate results in increased expression of APOE protein CTD PMID:31981724 monosodium L-glutamate increases expression ISO RGD:2138 6480464 Sodium Glutamate results in increased expression of APOE mRNA CTD PMID:31981724 morphine increases expression ISO RGD:2138 6480464 Morphine results in increased expression of APOE protein CTD PMID:23056601 morphine multiple interactions ISO RGD:2138 6480464 Morphine deficiency affects the reaction [Morphine results in increased expression of APOE protein] CTD PMID:23056601 myricitrin multiple interactions EXP 6480464 myricitrin inhibits the reaction [APOE gene mutant form results in decreased activity of CAT protein] more ... CTD PMID:23639522 N,N-diethyl-m-toluamide multiple interactions ISO RGD:2138 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of APOE mRNA CTD PMID:28659758 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO RGD:736378 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [APOA1 protein results in increased expression of APOE mRNA], N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [APOA1 protein results in increased secretion of APOE protein] CTD PMID:22056562 N-acetyl-L-cysteine multiple interactions ISO RGD:2138 6480464 Acetylcysteine inhibits the reaction [[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in decreased expression of APOE mRNA] more ... CTD PMID:33188856 N-acetyl-L-cysteine increases expression ISO RGD:2138 6480464 Acetylcysteine results in increased expression of APOE mRNA CTD PMID:33188856 N-Acetyl-S-(1,2-dichlorovinyl)-cysteine affects expression ISO RGD:736378 6480464 S-1, 2-dichlorovinyl-N-acetylcysteine affects the expression of APOE mRNA CTD PMID:16844155 N-methyl-4-phenylpyridinium affects expression ISO RGD:736378 6480464 1-Methyl-4-phenylpyridinium affects the expression of APOE mRNA CTD PMID:12710931 N-nitrosodiethylamine multiple interactions ISO RGD:2138 6480464 [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of APOE protein CTD PMID:20935162 N-tosyl-L-phenylalanyl chloromethyl ketone multiple interactions ISO RGD:736378 6480464 Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased expression of APOE mRNA], Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased secretion of APOE protein] CTD PMID:22056562 nickel atom affects binding ISO RGD:736378 6480464 APOE protein binds to Nickel CTD PMID:23896426 nickel atom decreases expression ISO RGD:736378 6480464 Nickel results in decreased expression of APOE mRNA CTD PMID:24768652 , PMID:25583101 nickel sulfate decreases expression ISO RGD:736378 6480464 nickel sulfate results in decreased expression of APOE mRNA CTD PMID:16780908 nickel sulfate increases expression ISO RGD:736378 6480464 nickel sulfate results in increased expression of APOE mRNA CTD PMID:16780908 nicotine increases expression EXP 6480464 Nicotine results in increased expression of APOE mRNA CTD PMID:17997037 nimesulide multiple interactions EXP 6480464 nimesulide inhibits the reaction [APOE results in decreased expression of CCNA2 protein], nimesulide inhibits the reaction [APOE results in increased abundance of 6-Ketoprostaglandin F1 alpha] CTD PMID:14966570 nitric oxide decreases chemical synthesis EXP 6480464 APOE gene mutant form results in decreased chemical synthesis of Nitric Oxide CTD PMID:11397713 nitrofen increases expression ISO RGD:2138 6480464 nitrofen results in increased expression of APOE mRNA CTD PMID:33484710 NONOate(1-) decreases response to substance EXP 6480464 APOE gene mutant form results in decreased susceptibility to 1, 1-diethyl-2-hydroxy-2-nitrosohydrazine CTD PMID:11397713 notoginsenoside R1 multiple interactions EXP 6480464 notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in decreased abundance of Glutathione] more ... CTD PMID:24933211 obeticholic acid decreases expression ISO RGD:736378 6480464 obeticholic acid results in decreased expression of APOE mRNA CTD PMID:27939613 ochratoxin A increases expression ISO RGD:2138 6480464 ochratoxin A results in increased expression of APOE mRNA CTD PMID:23358140 oleic acid multiple interactions ISO RGD:736378 6480464 [GW 4064 co-treated with Oleic Acid] results in decreased expression of APOE mRNA, [GW 7647 co-treated with Oleic Acid] results in decreased expression of APOE mRNA CTD PMID:30611723 oxaliplatin increases expression ISO RGD:2138 6480464 oxaliplatin results in increased expression of APOE mRNA CTD PMID:25729387 oxaliplatin multiple interactions ISO RGD:2138 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of APOE mRNA CTD PMID:25729387 ozone decreases expression EXP 6480464 Ozone results in decreased expression of APOE mRNA CTD PMID:12763052 palbociclib increases expression ISO RGD:736378 6480464 palbociclib results in increased expression of APOE mRNA CTD PMID:28620137 paracetamol decreases expression ISO RGD:2138 6480464 Acetaminophen results in decreased expression of APOE protein CTD PMID:16687475 paracetamol decreases expression ISO RGD:736378 6480464 Acetaminophen results in decreased expression of APOE mRNA CTD PMID:29067470 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of APOE mRNA CTD PMID:23358195 paracetamol affects expression ISO RGD:2138 6480464 Acetaminophen affects the expression of APOE protein CTD PMID:16099942 paricalcitol multiple interactions EXP 6480464 paricalcitol inhibits the reaction [APOE gene mutant form results in decreased abundance of Antioxidants], paricalcitol inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol] CTD PMID:25037058 paricalcitol multiple interactions ISO RGD:736378 6480464 [Phosphorus co-treated with paricalcitol] results in decreased expression of APOE mRNA CTD PMID:17715259 pentanal increases expression ISO RGD:736378 6480464 pentanal results in increased expression of APOE mRNA CTD PMID:26079696 perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of APOE protein CTD PMID:26178269 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:736378 6480464 perfluorooctane sulfonic acid results in decreased expression of APOE mRNA CTD PMID:32253466 perfluorooctanoic acid increases expression ISO RGD:736378 6480464 perfluorooctanoic acid results in increased expression of APOE protein CTD PMID:22609092 perfluorooctanoic acid decreases expression ISO RGD:736378 6480464 perfluorooctanoic acid results in decreased expression of APOE mRNA CTD PMID:32253466 permethrin multiple interactions ISO RGD:2138 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of APOE mRNA CTD PMID:28659758 Phenelzine increases expression EXP 6480464 Phenelzine results in increased expression of APOE mRNA CTD PMID:31249575 phenobarbital affects expression ISO RGD:2138 6480464 Phenobarbital affects the expression of APOE protein CTD PMID:16099942 phenobarbital multiple interactions ISO RGD:2138 6480464 [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of APOE protein CTD PMID:20935162 phenylephrine affects response to substance EXP 6480464 APOE protein affects the susceptibility to Phenylephrine CTD PMID:17899169 phenytoin increases expression EXP 6480464 Phenytoin results in increased expression of APOE mRNA CTD PMID:15136057 phosphorus atom multiple interactions ISO RGD:736378 6480464 [Phosphorus co-treated with paricalcitol] results in decreased expression of APOE mRNA CTD PMID:17715259 phosphorus(.) multiple interactions ISO RGD:736378 6480464 [Phosphorus co-treated with paricalcitol] results in decreased expression of APOE mRNA CTD PMID:17715259 phytosterols multiple interactions EXP 6480464 APOE gene mutant form affects the reaction [Phytosterols results in increased expression of CYP51 mRNA] more ... CTD PMID:18155511 pirinixic acid affects expression ISO RGD:2138 6480464 pirinixic acid affects the expression of APOE protein CTD PMID:16099942 potassium chloride multiple interactions ISO RGD:2138 6480464 [Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in increased expression of APOE mRNA CTD PMID:22228705 probucol affects response to substance EXP 6480464 APOE protein affects the susceptibility to Probucol CTD PMID:19394937 probucol decreases response to substance EXP 6480464 APOE protein results in decreased susceptibility to Probucol CTD PMID:10998462 probucol multiple interactions EXP 6480464 Probucol promotes the reaction [APOE gene mutant form results in increased expression of C1QC mRNA] more ... CTD PMID:19394937 propanal increases expression ISO RGD:736378 6480464 propionaldehyde results in increased expression of APOE mRNA CTD PMID:26079696 Pyridostigmine bromide multiple interactions ISO RGD:2138 6480464 [Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of APOE mRNA CTD PMID:28659758 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [APOE gene mutant form results in decreased activity of NOS3 protein] more ... CTD PMID:20093625 , PMID:24017971 quercetin increases expression ISO RGD:736378 6480464 Quercetin results in increased expression of APOE mRNA CTD PMID:21632981 quercetin increases expression EXP 6480464 Quercetin results in increased expression of APOE mRNA CTD PMID:16455785 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of APOE mRNA CTD PMID:22610192 resveratrol affects secretion ISO RGD:736378 6480464 resveratrol affects the secretion of APOE protein CTD PMID:24802182 resveratrol decreases expression ISO RGD:2138 6480464 resveratrol results in decreased expression of APOE mRNA CTD PMID:19228061 resveratrol increases expression ISO RGD:736378 6480464 resveratrol results in increased expression of APOE mRNA CTD PMID:19371625 retinyl acetate increases expression EXP 6480464 retinol acetate results in increased expression of APOE mRNA CTD PMID:16772331 rotenone affects response to substance EXP 6480464 APOE protein affects the susceptibility to Rotenone CTD PMID:28728140 sarin increases expression ISO RGD:736378 6480464 Sarin results in increased expression of APOE mRNA, Sarin results in increased expression of APOE protein CTD PMID:19522546 SB 431542 multiple interactions ISO RGD:736378 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOE mRNA CTD PMID:27188386 selenium atom increases expression ISO RGD:736378 6480464 Selenium results in increased expression of APOE mRNA CTD PMID:19244175 selenium atom affects expression EXP 6480464 Selenium affects the expression of APOE protein CTD PMID:17996733 simvastatin decreases expression ISO RGD:2138 6480464 Simvastatin results in decreased expression of APOE mRNA, Simvastatin results in decreased expression of APOE protein CTD PMID:25055962 more ... simvastatin affects response to substance ISO RGD:736378 6480464 APOE polymorphism affects the susceptibility to Simvastatin CTD PMID:11849659 , PMID:12901521 simvastatin multiple interactions ISO RGD:2138 6480464 Polystyrenes analog inhibits the reaction [Simvastatin results in decreased expression of APOE protein] CTD PMID:8461338 simvastatin affects response to substance EXP 6480464 APOE affects the susceptibility to Simvastatin CTD PMID:11947894 simvastatin decreases expression ISO RGD:736378 6480464 Simvastatin results in decreased expression of APOE, Simvastatin results in decreased expression of APOE mRNA CTD PMID:18270459 , PMID:19461118 sodium arsenite increases expression ISO RGD:736378 6480464 sodium arsenite results in increased expression of APOE mRNA CTD PMID:28229933 sodium arsenite decreases expression ISO RGD:736378 6480464 sodium arsenite results in decreased expression of APOE mRNA CTD PMID:29301061 sodium arsenite affects methylation ISO RGD:736378 6480464 sodium arsenite affects the methylation of APOE gene CTD PMID:28589171 sodium arsenite increases response to substance EXP 6480464 APOE gene mutant form results in increased susceptibility to sodium arsenite CTD PMID:14594625 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of APOE mRNA CTD PMID:19822182 sodium arsenite multiple interactions EXP 6480464 [APOE gene mutant form affects the susceptibility to sodium arsenite] which results in increased expression of CCL2 protein more ... CTD PMID:14594625 more ... sodium arsenite affects response to substance EXP 6480464 APOE gene mutant form affects the susceptibility to sodium arsenite, APOE protein affects the susceptibility to sodium arsenite CTD PMID:19682479 , PMID:28728140 sodium dichromate increases expression ISO RGD:2138 6480464 sodium bichromate results in increased expression of APOE mRNA CTD PMID:22561333 sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of APOE protein CTD PMID:28918527 streptozocin increases expression ISO RGD:2138 6480464 Streptozocin results in increased expression of APOE mRNA CTD PMID:16684804 streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with APOE mutant form] results in increased abundance of Glucosamine, INS1 inhibits the reaction [[Streptozocin co-treated with APOE mutant form] results in increased abundance of Glucosamine] CTD PMID:16380481 streptozocin multiple interactions ISO RGD:2138 6480464 vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of APOE mRNA] CTD PMID:16684804 sunitinib decreases expression ISO RGD:736378 6480464 Sunitinib results in decreased expression of APOE mRNA CTD PMID:31533062 superoxide increases chemical synthesis EXP 6480464 APOE gene mutant form results in increased chemical synthesis of Superoxides CTD PMID:12871831 superoxide increases abundance EXP 6480464 APOE gene mutant form results in increased abundance of Superoxides CTD PMID:11397713 superoxide multiple interactions EXP 6480464 imisopasem manganese inhibits the reaction [APOE gene mutant form results in increased chemical synthesis of Superoxides], manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [APOE gene mutant form results in increased abundance of Superoxides] CTD PMID:11397713 , PMID:12871831 T-2 toxin increases expression ISO RGD:2138 6480464 T-2 Toxin results in increased expression of APOE mRNA CTD PMID:26141394 tamoxifen affects response to substance ISO RGD:736378 6480464 APOE gene polymorphism affects the susceptibility to Tamoxifen CTD PMID:19103187 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of APOE mRNA CTD PMID:17555576 taurocholic acid multiple interactions ISO RGD:2138 6480464 [Taurocholic Acid co-treated with Triolein co-treated with Lecithins] results in decreased expression of APOE protein CTD PMID:6631239 tert-butyl hydroperoxide increases expression ISO RGD:736378 6480464 tert-Butylhydroperoxide results in increased expression of APOE mRNA CTD PMID:15336504 tert-butyl hydroperoxide affects localization ISO RGD:2138 6480464 tert-Butylhydroperoxide affects the localization of APOE protein CTD PMID:19720132 tert-butyl hydroperoxide increases expression ISO RGD:2138 6480464 tert-Butylhydroperoxide results in increased expression of APOE mRNA CTD PMID:19720132 testosterone enanthate multiple interactions ISO RGD:736378 6480464 [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of APOE mRNA, [cetrorelix co-treated with testosterone enanthate] results in decreased expression of APOE mRNA CTD PMID:18160741 tetrachloromethane increases expression ISO RGD:2138 6480464 Carbon Tetrachloride results in increased expression of APOE protein CTD PMID:16845489 tetrachloromethane multiple interactions ISO RGD:2138 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of APOE mRNA] CTD PMID:31150632 tetrachloromethane decreases expression ISO RGD:2138 6480464 Carbon Tetrachloride results in decreased expression of APOE mRNA CTD PMID:31150632 theaflavin multiple interactions EXP 6480464 theaflavin inhibits the reaction [APOE gene mutant form results in decreased activity of NOS3 protein] more ... CTD PMID:20093625 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of APOE mRNA CTD PMID:23131501 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of APOE mRNA CTD PMID:23557971 tolcapone affects binding ISO RGD:2138 6480464 tolcapone binds to APOE protein CTD PMID:19783845 topotecan increases expression ISO RGD:2138 6480464 Topotecan results in increased expression of APOE mRNA CTD PMID:25729387 topotecan multiple interactions ISO RGD:2138 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of APOE mRNA CTD PMID:25729387 tributylstannane multiple interactions ISO RGD:2138 6480464 [bisphenol A co-treated with tributyltin] results in increased expression of APOE mRNA CTD PMID:31129395 trichloroethene decreases expression ISO RGD:2138 6480464 Trichloroethylene results in decreased expression of APOE mRNA CTD PMID:33387578 Trihexyphenidyl increases response to substance ISO RGD:736378 6480464 APOE gene polymorphism results in increased susceptibility to Trihexyphenidyl CTD PMID:18239197 trimellitic anhydride decreases expression EXP 6480464 trimellitic anhydride results in decreased expression of APOE mRNA CTD PMID:19042947 triolein multiple interactions ISO RGD:2138 6480464 [Taurocholic Acid co-treated with Triolein co-treated with Lecithins] results in decreased expression of APOE protein CTD PMID:6631239 triphenyl phosphate affects response to substance EXP 6480464 APOE protein affects the susceptibility to triphenyl phosphate CTD PMID:31724879 triptonide affects expression EXP 6480464 triptonide affects the expression of APOE mRNA CTD PMID:33045310 troglitazone increases expression ISO RGD:736378 6480464 troglitazone results in increased expression of APOE mRNA CTD PMID:19140230 Tropicamide increases response to substance ISO RGD:736378 6480464 APOE gene polymorphism results in increased susceptibility to Tropicamide CTD PMID:8724673 , PMID:9137131 Tungsten carbide multiple interactions ISO RGD:736378 6480464 [tungsten carbide co-treated with Cobalt] results in decreased expression of APOE mRNA CTD PMID:18078969 valproic acid increases expression ISO RGD:736378 6480464 Valproic Acid results in increased expression of APOE mRNA CTD PMID:23179753 valproic acid multiple interactions ISO RGD:2138 6480464 Valproic Acid promotes the reaction [Mechlorethamine results in increased expression of APOE mRNA] CTD PMID:28184907 valproic acid decreases expression ISO RGD:736378 6480464 Valproic Acid results in decreased expression of APOE mRNA, Valproic Acid results in decreased expression of APOE protein CTD PMID:29154799 , PMID:29501571 valproic acid affects expression ISO RGD:736378 6480464 Valproic Acid affects the expression of APOE mRNA CTD PMID:25979313 valsartan multiple interactions ISO RGD:736378 6480464 [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein, Valsartan inhibits the reaction [AGT protein results in decreased expression of APOE protein] CTD PMID:17785354 , PMID:19603250 vanadyl sulfate multiple interactions ISO RGD:2138 6480464 vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of APOE mRNA] CTD PMID:16684804 varenicline affects response to substance EXP 6480464 APOE protein affects the susceptibility to Varenicline CTD PMID:28202387 vitamin E multiple interactions EXP 6480464 Vitamin E inhibits the reaction [APOE mutant form results in increased abundance of 8, 12-iso-isoprostane F2alpha-VI] CTD PMID:16303615 vitamin K affects abundance ISO RGD:736378 6480464 APOE protein affects the abundance of Vitamin K CTD PMID:15952022 vitamin K affects uptake ISO RGD:736378 6480464 APOE protein affects the uptake of Vitamin K CTD PMID:16847429 vitexin increases expression EXP 6480464 vitexin results in increased expression of APOE mRNA CTD PMID:29545167 warfarin affects response to substance ISO RGD:736378 6480464 APOE gene mutant form affects the susceptibility to Warfarin more ... CTD PMID:15952022 more ... warfarin increases response to substance EXP 6480464 APOE gene mutant form results in increased susceptibility to Warfarin CTD PMID:23415960 zearalenone decreases expression ISO RGD:736378 6480464 Zearalenone results in decreased expression of APOE mRNA CTD PMID:19371625 zinc atom affects binding ISO RGD:736378 6480464 APOE protein binds to Zinc CTD PMID:23896426 zinc sulfate increases expression EXP 6480464 Zinc Sulfate results in increased expression of APOE mRNA, Zinc Sulfate results in increased expression of APOE protein CTD PMID:1883846 zinc(0) affects binding ISO RGD:736378 6480464 APOE protein binds to Zinc CTD PMID:23896426
