Apoe (apolipoprotein E) - Rat Genome Database

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Gene: Apoe (apolipoprotein E) Mus musculus
Analyze
Symbol: Apoe
Name: apolipoprotein E
RGD ID: 733604
MGI Page MGI
Description: Enables several functions, including cholesterol transfer activity; heparan sulfate proteoglycan binding activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Involved in several processes, including lipid homeostasis; plasma lipoprotein particle remodeling; and regulation of defense response. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including cholesterol catabolic process; cholesterol efflux; and lipoprotein metabolic process. Located in extracellular space. Part of low-density lipoprotein particle. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A; AI255918; apo-E
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,430,169 - 19,434,326 (-)NCBIGRCm39mm39
GRCm39 Ensembl719,430,034 - 19,433,113 (-)Ensembl
GRCm38719,696,244 - 19,701,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,696,109 - 19,699,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv37720,281,593 - 20,284,515 (-)NCBIGRCm37mm9NCBIm37
MGSCv36718,854,794 - 18,857,554 (-)NCBImm8
Celera717,102,329 - 17,105,251 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IMP,ISO)
adenocarcinoma  (ISO)
age related macular degeneration 1  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 2  (ISO)
Alzheimer's disease 3  (ISO)
Alzheimer's disease 4  (ISO)
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Apraxia  (ISO)
amyloidosis  (ISO)
amyotrophic lateral sclerosis  (ISO)
angle-closure glaucoma  (ISO)
anxiety disorder  (ISO)
aortic atherosclerosis  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (IMP,ISO)
atopic dermatitis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
beta thalassemia  (ISO)
bile duct cancer  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Broad-Betalipoproteinemia  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
cerebral amyloid angiopathy  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholelithiasis  (ISO)
cholestasis  (ISO)
Chronic Brain Injury  (ISO)
Chronic Cerebral Hypoperfusion  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
Cognitive Dysfunction  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Coumarin Sensitivity  (ISO)
dementia  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IMP,ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
Dyslipidemias  (ISO)
Emphysema  (ISO)
end stage renal disease  (IMP,ISO)
Endotoxemia  (ISO)
exfoliation syndrome  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial combined hyperlipidemia  (ISO)
familial hypercholesterolemia  (ISO)
familial hyperlipidemia  (ISO)
fatty liver disease  (ISO)
fetal alcohol spectrum disorder  (IMP)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
gallbladder cancer  (ISO)
Genetic Translocation  (ISO)
glaucoma  (ISO)
glomerulonephritis  (IMP)
glomerulosclerosis  (ISO)
Habitual Abortions  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (IEP)
herpes simplex  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
Hypercholesterolemia  (IMP,ISO)
hyperhomocysteinemia  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hyperlipoproteinemia type III  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hyperuricemia  (ISO)
hypothyroidism  (ISO)
kidney failure  (ISO)
Klebsiella Infections  (IMP)
Kuhnt-Junius degeneration  (ISO)
Lewy body dementia  (ISO)
Lipoprotein Glomerulopathy  (ISO)
low tension glaucoma  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
macular degeneration  (ISO)
malaria  (ISO)
Mammary Neoplasms, Experimental  (IMP)
membranous glomerulonephritis  (ISO)
Memory Disorders  (IMP,ISO)
Mercury Poisoning  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (IMP)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
Neurobehavioral Manifestations  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (IMP,ISO)
open-angle glaucoma  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
Peripheral Nerve Injuries  (ISO)
Plaque, Atherosclerotic  (ISO)
Pregnancy Complications, Infectious  (ISO)
Presenile and Senile Dementia  (ISO)
primary cutaneous amyloidosis  (ISO)
primary open angle glaucoma  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
retinal disease  (ISO)
schizophrenia  (IEA,ISO)
sciatic neuropathy  (ISO)
sea-blue histiocytosis  (ISO)
sensorineural hearing loss  (ISO)
Sjogren's syndrome  (ISO)
sleep apnea  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
Spontaneous Abortions  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Vascular System Injuries  (IMP,ISO)
Venous Thrombosis  (IMP)
Ventricular Dysfunction, Left  (ISO)
visual epilepsy  (ISO)
warfarin resistance  (ISO)
warfarin sensitivity  (ISO)
Wilson disease  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-schisandrin B  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-nicotine  (EXP)
1,1-dichloroethene  (EXP)
11-dehydro-thromboxane B2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-arachidonoylglycerol  (EXP)
2-butoxyethanol  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-Nitrobenzanthrone  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-oxoprostaglandin F1alpha  (EXP)
7,12-dimethyltetraphene  (EXP)
8-epi-prostaglandin F2alpha  (EXP)
acenocoumarol  (ISO)
acetamide  (ISO)
acetylcholine  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
arachidonic acid  (EXP,ISO)
aristolochic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (EXP)
bezafibrate  (ISO)
bifenthrin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
BQ 123  (EXP)
Brodifacoum  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
capsaicin  (EXP)
captan  (EXP)
carbon nanotube  (EXP)
cerium trichloride  (ISO)
cetirizine  (EXP)
cetrorelix  (ISO)
chlordecone  (EXP)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
cobalt atom  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
curcumin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (ISO)
DDE  (ISO)
Deoxycorticosterone acetate  (ISO)
desogestrel  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (EXP)
dimethylarsinous acid  (EXP)
dipyridamole  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP,ISO)
enalapril  (EXP,ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethanolamine  (ISO)
felodipine  (EXP)
fenvalerate  (ISO)
Fexofenadine hydrochloride  (EXP)
flusilazole  (EXP)
flutamide  (ISO)
fluvastatin  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
furan  (ISO)
Ganoderic acid A  (ISO)
gemfibrozil  (ISO)
genistein  (EXP)
gentamycin  (ISO)
ginkgolide B  (EXP)
glucose  (ISO)
glutathione  (EXP)
GW 3965  (EXP,ISO)
GW 4064  (EXP,ISO)
GW 7647  (ISO)
high-density lipoprotein cholesterol  (EXP,ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isotretinoin  (ISO)
ivabradine  (EXP)
ivermectin  (ISO)
kaempferol  (EXP)
kainic acid  (EXP)
ketamine  (ISO)
kuwanone G  (EXP)
L-ascorbic acid  (ISO)
lansoprazole  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP)
lovastatin  (EXP)
mechlorethamine  (ISO)
menadione  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methyl beta-cyclodextrin  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP,ISO)
morphine  (ISO)
myricitrin  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nimesulide  (EXP)
nitric oxide  (EXP)
nitrofen  (ISO)
NONOate(1-)  (EXP)
notoginsenoside R1  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
Phenelzine  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenytoin  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phytosterols  (EXP)
pirinixic acid  (ISO)
potassium chloride  (ISO)
probucol  (EXP)
propanal  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (EXP,ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
rotenone  (EXP)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (EXP,ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
superoxide  (EXP)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
taurocholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
theaflavin  (EXP)
titanium dioxide  (EXP)
tolcapone  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
Trihexyphenidyl  (ISO)
trimellitic anhydride  (EXP)
triolein  (ISO)
triphenyl phosphate  (EXP)
triptonide  (EXP)
troglitazone  (ISO)
Tropicamide  (ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vanadyl sulfate  (ISO)
varenicline  (EXP)
vitamin E  (EXP)
vitamin K  (ISO)
vitexin  (EXP)
warfarin  (EXP,ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc sulfate  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
AMPA glutamate receptor clustering  (ISO)
amyloid precursor protein metabolic process  (ISO)
artery morphogenesis  (IGI)
axon regeneration  (IGI)
cellular calcium ion homeostasis  (IDA)
cellular response to cholesterol  (ISO)
cellular response to ethanol  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cGMP-mediated signaling  (ISO)
cholesterol catabolic process  (IBA,IMP)
cholesterol efflux  (IDA,IMP,ISO)
cholesterol homeostasis  (IGI,IMP,ISO)
cholesterol metabolic process  (IMP,ISO)
chylomicron remnant clearance  (ISO)
circulatory system development  (IMP)
fatty acid homeostasis  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
gene expression  (IGI)
high-density lipoprotein particle assembly  (ISO)
high-density lipoprotein particle clearance  (ISO)
high-density lipoprotein particle remodeling  (ISO)
intermediate-density lipoprotein particle clearance  (ISO)
lipid homeostasis  (IMP)
lipid metabolic process  (IGI)
lipid transport  (ISO)
lipid transport involved in lipid storage  (IMP)
lipoprotein biosynthetic process  (IGI,ISO)
lipoprotein catabolic process  (IBA,IMP)
lipoprotein metabolic process  (IGI,IMP,ISO)
locomotory exploration behavior  (ISO)
long-chain fatty acid transport  (ISO)
long-term memory  (ISO)
low-density lipoprotein particle remodeling  (IMP)
maintenance of location in cell  (IMP)
negative regulation of amyloid fibril formation  (IMP)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of blood coagulation  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cellular protein metabolic process  (ISO)
negative regulation of cholesterol biosynthetic process  (ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of dendritic spine development  (ISO)
negative regulation of dendritic spine maintenance  (ISO)
negative regulation of endothelial cell migration  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of gene expression  (IMP)
negative regulation of inflammatory response  (IGI)
negative regulation of lipid biosynthetic process  (ISO)
negative regulation of lipid transport across blood-brain barrier  (ISO)
negative regulation of long-term synaptic potentiation  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of neuron apoptotic process  (IBA,ISO)
negative regulation of neuron death  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of phospholipid efflux  (ISO)
negative regulation of platelet activation  (ISO)
negative regulation of postsynaptic membrane organization  (ISO)
negative regulation of protein secretion  (ISO)
negative regulation of smooth muscle cell proliferation  (IGI)
negative regulation of triglyceride metabolic process  (IGI)
neuron projection development  (ISO)
nitric oxide mediated signal transduction  (ISO)
NMDA glutamate receptor clustering  (ISO)
oligodendrocyte differentiation  (ISO)
peripheral nervous system axon regeneration  (ISO)
phospholipid efflux  (ISO)
positive regulation by host of viral process  (ISO)
positive regulation of amyloid-beta clearance  (IMP)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cholesterol efflux  (IMP,ISO)
positive regulation of cholesterol esterification  (IMP,ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of dendritic spine maintenance  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of heparan sulfate binding  (ISO)
positive regulation of heparan sulfate proteoglycan binding  (ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of lipid transport across blood-brain barrier  (ISO)
positive regulation of low-density lipoprotein particle receptor catabolic process  (ISO)
positive regulation of membrane protein ectodomain proteolysis  (ISO)
positive regulation of neurofibrillary tangle assembly  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neuron projection development  (IMP,ISO)
positive regulation of nitric-oxide synthase activity  (IBA,ISO)
positive regulation of phospholipid efflux  (ISO)
positive regulation of presynaptic membrane organization  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
protein import  (ISO)
protein localization  (IMP)
receptor-mediated endocytosis  (ISO)
regulation of amyloid fibril formation  (ISO)
regulation of amyloid precursor protein catabolic process  (ISO)
regulation of amyloid-beta clearance  (IBA,ISO)
regulation of apoptotic process  (IMP)
regulation of behavioral fear response  (ISO)
regulation of Cdc42 protein signal transduction  (ISO)
regulation of cellular response to very-low-density lipoprotein particle stimulus  (ISO)
regulation of cholesterol metabolic process  (ISO)
regulation of gene expression  (IMP)
regulation of innate immune response  (IMP)
regulation of neuron death  (ISO)
regulation of plasma lipoprotein particle levels  (IMP)
regulation of proteasomal protein catabolic process  (ISO)
regulation of protein metabolic process  (ISO)
regulation of protein-containing complex assembly  (ISO)
regulation of synapse organization  (IDA,IMP)
regulation of tau-protein kinase activity  (ISO)
regulation of triglyceride metabolic process  (ISO)
response to caloric restriction  (ISO)
response to D-galactosamine  (ISO)
response to dietary excess  (IMP)
response to ethanol  (ISO)
response to insulin  (ISO)
response to oxidative stress  (IMP)
response to retinoic acid  (ISO)
response to tumor necrosis factor  (ISO)
response to zinc ion  (ISO)
reverse cholesterol transport  (ISO)
triglyceride homeostasis  (IMP)
triglyceride metabolic process  (ISO)
triglyceride-rich lipoprotein particle clearance  (IMP,ISO)
vasodilation  (IMP)
very-low-density lipoprotein particle clearance  (ISO)
very-low-density lipoprotein particle remodeling  (IMP,ISO)
virion assembly  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View