RGD Reference Report - Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China. - Rat Genome Database

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Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China.

Authors: Andreotti, G  Chen, J  Gao, YT  Rashid, A  Chen, BE  Rosenberg, P  Sakoda, LC  Deng, J  Shen, MC  Wang, BS  Han, TQ  Zhang, BH  Yeager, M  Welch, R  Chanock, S  Fraumeni JF, JR  Hsing, AW 
Citation: Andreotti G, etal., Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):525-34. Epub 2008 Feb 22.
RGD ID: 2317550
Pubmed: PMID:18296645   (View Abstract at PubMed)
PMCID: PMC2897750   (View Article at PubMed Central)
DOI: DOI:10.1158/1055-9965.EPI-07-2704   (Journal Full-text)

Biliary tract cancers, encompassing the gallbladder, extrahepatic bile duct, and ampulla of Vater, are uncommon yet highly fatal malignancies. Gallstones, the primary risk factor for biliary cancers, are linked with hyperlipidemia. We examined the associations of 12 single nucleotide polymorphisms of five genes in the lipid metabolism pathway with the risks of biliary cancers and stones in a population-based case-control study in Shanghai, China. We included 235 gallbladder, 125 extrahepatic bile duct, and 46 ampulla of Vater cancer cases, 880 biliary stone cases, and 779 population controls. Subjects completed an in-person interview and gave blood. Genotyping was conducted by TaqMan assay using DNA from buffy coats. The effects of APOE IVS1+69 (rs440446) and APOB IVS6+360C>T (rs520354) markers were limited to men. Men carrying the G allele of APOE IVS1+69 had a 1.7-fold risk of stones [95% confidence interval (95% CI), 1.2-2.4], a 1.8-fold risk of gallbladder cancer (95% CI, 1.0-3.3), a 3.7-fold risk of bile duct cancer (95% CI, 2.0-7.0), and a 4-fold risk of ampullary cancer (95% CI, 1.4-12.4). Male carriers of the T allele of APOB IVS6+360C>T had a 2-fold risk of bile duct cancer (95% CI, 1.2-3.4). The APOB T-T haplotype (APOB IVS6+360C>T, EX4+56C>T) was associated with a 1.6-fold risk of bile duct cancer (95% CI, 1.1-2.3). Male and female carriers of the T allele of LDLR IVS9-30C>T (rs1003723) had a 1.5-fold risk of bile duct cancer. Our findings suggest that gene variants in the lipid metabolism pathway contribute to the risk of biliary tract stones and cancers, particularly of the bile duct.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
APOBHumanbile duct cancer susceptibilityIAGP DNA:polymorphisms:intron more ...RGD 
APOEHumanbile duct cancer susceptibilityIAGP DNA:SNP:intron:rs440446 (human)RGD 
ApobRatbile duct cancer susceptibilityISOAPOB (Homo sapiens)DNA:polymorphisms:intron more ...RGD 
ApobMousebile duct cancer susceptibilityISOAPOB (Homo sapiens)DNA:polymorphisms:intron more ...RGD 
ApoeRatbile duct cancer susceptibilityISOAPOE (Homo sapiens)DNA:SNP:intron:rs440446 (human)RGD 
ApoeMousebile duct cancer susceptibilityISOAPOE (Homo sapiens)DNA:SNP:intron:rs440446 (human)RGD 
APOEHumancholelithiasis susceptibilityIAGP DNA:SNP:intron:rs440446 (human)RGD 
ApoeRatcholelithiasis susceptibilityISOAPOE (Homo sapiens)DNA:SNP:intron:rs440446 (human)RGD 
ApoeMousecholelithiasis susceptibilityISOAPOE (Homo sapiens)DNA:SNP:intron:rs440446 (human)RGD 
APOEHumangallbladder cancer susceptibilityIAGP DNA:SNP:intron:rs440446 (human)RGD 
ApoeRatgallbladder cancer susceptibilityISOAPOE (Homo sapiens)DNA:SNP:intron:rs440446 (human)RGD 
ApoeMousegallbladder cancer susceptibilityISOAPOE (Homo sapiens)DNA:SNP:intron:rs440446 (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Apob  (apolipoprotein B)
Apoe  (apolipoprotein E)

Genes (Mus musculus)
Apob  (apolipoprotein B)
Apoe  (apolipoprotein E)

Genes (Homo sapiens)
APOB  (apolipoprotein B)
APOE  (apolipoprotein E)


Additional Information