APOB (apolipoprotein B) - Rat Genome Database

Name: APOB
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: APOB (apolipoprotein B) Homo sapiens

Analyze

Symbol:

APOB

Name:

apolipoprotein B

RGD ID:

735787

HGNC Page

HGNC

Description:

Exhibits several functions, including anion binding activity; cholesterol transfer activity; and lipase binding activity. Involved in several processes, including cholesterol homeostasis; low-density lipoprotein particle clearance; and low-density lipoprotein particle remodeling. Localizes to several cellular components, including endoplasmic reticulum exit site; low-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Biomarker of several diseases, including cerebral infarction; common bile duct neoplasm; diabetes mellitus (multiple); familial combined hyperlipidemia; and obesity.

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

apo B-100; apoB-100; apoB-48; apolipoprotein B (including Ag(x) antigen); apolipoprotein B-100; apolipoprotein B48; FCHL2; FLDB; LDLCQ4; mutant Apo B 100

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Apob (apolipoprotein B)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Apob (apolipoprotein B)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Apob (apolipoprotein B)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	APOB (apolipoprotein B)	NCBI	Ortholog
Canis lupus familiaris (dog):	APOB (apolipoprotein B)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Apob (apolipoprotein B)	NCBI	Ortholog
Sus scrofa (pig):	APOB (apolipoprotein B)	HGNC	Ensembl, NCBI, OrthoDB, Panther
Chlorocebus sabaeus (African green monkey):	APOB (apolipoprotein B)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Apob (apolipoprotein B)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Apob (apolipoprotein B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Apob (apolipoprotein B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Danio rerio (zebrafish):	apobb.1 (apolipoprotein Bb, tandem duplicate 1)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB\|TreeFam\|ZFIN)
Danio rerio (zebrafish):	apoba (apolipoprotein Ba)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam\|ZFIN)
Danio rerio (zebrafish):	apobb.2 (apolipoprotein Bb, tandem duplicate 2)	Alliance	DIOPT (ZFIN)
Drosophila melanogaster (fruit fly):	Apoltp	Alliance	DIOPT (PhylomeDB\|Roundup)
Drosophila melanogaster (fruit fly):	apolpp	Alliance	DIOPT (PhylomeDB\|Roundup)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	21,001,429 - 21,044,073 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	21,001,429 - 21,044,073 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	21,224,301 - 21,266,945 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	21,077,806 - 21,120,450 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	21,135,952 - 21,178,597	NCBI
Celera	2	21,063,779 - 21,106,429 (-)	NCBI
Cytogenetic Map	2	p24.1	NCBI
HuRef	2	20,956,976 - 20,999,627 (-)	NCBI		HuRef
CHM1_1	2	21,153,564 - 21,196,210 (-)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar