Apob (apolipoprotein B) - Rat Genome Database

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Gene: Apob (apolipoprotein B) Rattus norvegicus
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Symbol: Apob
Name: apolipoprotein B
RGD ID: 2129
Description: Predicted to enable several functions, including cholesterol transfer activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to tumor necrosis factor; response to estradiol; and triglyceride catabolic process. Located in extracellular space and vesicle lumen. Part of high-density lipoprotein particle; low-density lipoprotein particle; and very-low-density lipoprotein particle. Biomarker of nephrotic syndrome and steatotic liver disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B); PARTICIPATES IN altered lipoprotein metabolic pathway; forkhead class A signaling pathway; lipoprotein metabolic pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Aa1064; Ac1-060; Apo B-100; ApoB-100; ApoB-48; apolipoprotein B (including Ag(x) antigen); apolipoprotein B PI; apolipoprotein B-100; apolipoprotein B-48
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8636,563,704 - 36,603,300 (+)NCBIGRCr8
mRatBN7.2630,844,386 - 30,883,983 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl630,844,368 - 30,892,497 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx631,136,522 - 31,176,112 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0631,452,442 - 31,492,039 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0630,926,947 - 30,966,539 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0633,176,826 - 33,216,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl633,176,778 - 33,224,997 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0642,956,372 - 42,995,922 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4631,508,060 - 31,548,083 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1631,546,139 - 31,550,758 (+)NCBI
Celera630,299,724 - 30,339,330 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
aortic valve stenosis  (ISO)
arteriosclerosis  (ISO)
autosomal recessive hypercholesterolemia  (ISO)
Behcet's disease  (ISO)
beta thalassemia  (ISO)
bile duct cancer  (ISO)
biliary tract cancer  (ISO)
cardiovascular system disease  (ISO)
celiac disease  (ISO)
cerebral infarction  (ISO)
classic citrullinemia  (ISO)
common bile duct neoplasm  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Coumarin Sensitivity  (ISO)
Death  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy 1B  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dyslipidemias  (ISO)
Endotoxemia  (IEP)
Experimental Diabetes Mellitus  (IEP)
familial combined hyperlipidemia  (ISO)
familial hypercholesterolemia  (ISO)
Familial Hypercholesterolemia due to Ligand-Defective Apolipoprotein B  (ISO)
familial hyperlipidemia  (ISO)
familial hypobetalipoproteinemia 1  (ISO)
familial hypobetalipoproteinemia 2  (ISS)
Familial Hypobetalipoproteinemia, Apolipoprotein B  (ISO)
familial isolated deficiency of vitamin E  (ISO)
gallbladder cancer  (ISO)
Hemorrhage  (ISO)
Hypercholesterolemia  (IEP,ISO)
Hypercholesterolemia, Autosomal Dominant, 3  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (IEP,ISO)
hypobetalipoproteinemia  (ISO)
Isolated Systolic Hypertension  (ISO)
Marfanoid Mental Retardation Syndrome, Autosomal  (ISO)
Metabolic Syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
nephrotic syndrome  (IEP)
obesity  (ISO)
ovarian cancer  (ISO)
peripheral vascular disease  (ISO)
sickle cell anemia  (ISO)
spastic ataxia  (ISO)
steatotic liver disease  (IEP,ISO)
Sudden Cardiac Death  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
warfarin resistance  (ISO)
warfarin sensitivity  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-taxifolin  (ISO)
(-)-ephedrine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
acetamide  (EXP)
acetic anhydride  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
allopurinol  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
atenolol  (ISO)
atorvastatin calcium  (EXP,ISO)
benazepril  (ISO)
bendroflumethiazide  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (EXP,ISO)
bexarotene  (EXP)
bezafibrate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcidiol  (EXP)
calcium silicate  (ISO)
capsaicin  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
cholesterol  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
cortisol  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
D-glucose  (ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diethyl pyrocarbonate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
endosulfan  (EXP)
ethanol  (EXP,ISO)
ethanolamine  (EXP)
fenofibrate  (ISO)
fenthion  (ISO)
ferulic acid  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
fructose  (EXP,ISO)
gadolinium trichloride  (EXP)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gemfibrozil  (EXP,ISO)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
graphite  (EXP)
GW 4064  (ISO)
GW 7647  (ISO)
hexadecanoic acid  (EXP)
hydrogen peroxide  (ISO)
indinavir  (ISO)
indometacin  (ISO)
inulin  (ISO)
irbesartan  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lactacystin  (EXP,ISO)
levonorgestrel  (ISO)
linsidomine  (EXP)
lovastatin  (ISO)
mercury dichloride  (ISO)
Mesaconitine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
morphine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
Nandrolone decanoate  (ISO)
nickel atom  (ISO)
nicotinic acid  (ISO)
nitrofen  (EXP)
Nonylphenol  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
olanzapine  (ISO)
oleic acid  (EXP,ISO)
orotic acid  (EXP)
palmitoyl ethanolamide  (ISO)
paracetamol  (ISO)
perfluorobutyric acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
Primycin  (ISO)
Propiverine  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rosuvastatin calcium  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
senecionine  (ISO)
simvastatin  (EXP,ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulindac  (ISO)
tamoxifen  (EXP)
tauroursodeoxycholic acid  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vitamin E  (ISO)
voriconazole  (EXP)
vorinostat  (ISO)
warfarin  (ISO)
wortmannin  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
artery morphogenesis  (IEA,ISO)
cellular response to lipoprotein particle stimulus  (IEA,ISO)
cellular response to prostaglandin stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP)
cholesterol efflux  (IEA,ISO)
cholesterol homeostasis  (IBA,IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
cholesterol transport  (IBA,ISO)
establishment of localization in cell  (IEA,ISO)
fertilization  (IEA,ISO)
flagellated sperm motility  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
lipid catabolic process  (ISO)
lipid metabolic process  (IEA,ISO)
lipid transport  (IEA)
lipoprotein biosynthetic process  (IEA,ISO)
lipoprotein catabolic process  (IEA,ISO)
lipoprotein metabolic process  (ISO)
lipoprotein transport  (IBA,IEA,ISO)
low-density lipoprotein particle clearance  (IEA,ISO)
low-density lipoprotein particle remodeling  (IEA,ISO)
nervous system development  (IEA,ISO)
positive regulation of cholesterol storage  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of lipid storage  (ISO)
positive regulation of macrophage derived foam cell differentiation  (IEA,ISO)
post-embryonic development  (IEA,ISO)
regulation of cholesterol biosynthetic process  (IEA,ISO)
response to carbohydrate  (IDA)
response to estradiol  (IEP)
response to lipopolysaccharide  (IEP)
response to selenium ion  (IEP)
response to virus  (IEA,ISO)
signal transduction  (IEA)
spermatogenesis  (IEA,ISO)
triglyceride catabolic process  (IEA,IMP,ISO)
triglyceride mobilization  (IBA,IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Abifadel M, etal., Nat Genet. 2003 Jun;34(2):154-6.
2. Apolipoprotein A-I, A-II, B, C-II, and C-III in children with insulin-dependent diabetes mellitus. al Muhtaseb N, etal., Pediatrics. 1992 May;89(5 Pt 1):936-41.
3. Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China. Andreotti G, etal., Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):525-34. Epub 2008 Feb 22.
4. Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population-based study in China. Andreotti G, etal., Int J Cancer. 2008 May 15;122(10):2322-9.
5. Impaired response of VLDL lipid and apoB secretion to endotoxin in the fasted rat liver. Aspichueta P, etal., J Endotoxin Res. 2006;12(3):181-92.
6. Apolipoproteins AI, B, and E polymorphisms in severe aortic valve stenosis. Avakian SD, etal., Clin Genet. 2001 Nov;60(5):381-4.
7. Serum cholesterol and apolipoprotein B levels may reflect disease activity in ovarian cancer patients. Avall-Lundqvist EH and Peterson CO, Acta Oncol. 1996;35(8):1007-10.
8. Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women. Baez S, etal., World J Gastroenterol. 2010 Jan 21;16(3):372-8.
9. Early atherosclerosis and vascular inflammation in mice with diet-induced type 2 diabetes. Bartels ED, etal., Eur J Clin Invest. 2009 Mar;39(3):190-9.
10. Upregulation of apolipoprotein B secretion, but not lipid, by tumor necrosis factor-alpha in rat hepatocyte cultures in the absence of extracellular fatty acids. Bartolome N, etal., Ann N Y Acad Sci. 2007 Jan;1096:55-69.
11. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
12. Assessment of tocopherol metabolism and oxidative stress in familial hypobetalipoproteinemia. Clarke MW, etal., Clin Chem. 2006 Jul;52(7):1339-45. Epub 2006 May 25.
13. SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors. Corella D and Ordovas JM, Annu Rev Nutr. 2005;25:341-90.
14. Apolipoprotein E levels and apolipoprotein E genotypes in incident cardiovascular disease risk in subjects of the Prevention of Renal and Vascular End-stage disease study. Corsetti JP, etal., J Clin Lipidol. 2016 Jul-Aug;10(4):842-850. doi: 10.1016/j.jacl.2016.03.003. Epub 2016 Mar 12.
15. An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis. Crooke RM, etal., J Lipid Res. 2005 May;46(5):872-84. doi: 10.1194/jlr.M400492-JLR200. Epub 2005 Feb 16.
16. Modulation of hypercholesterolemia-induced alterations in apolipoprotein B and HMG-CoA reductase expression by selenium supplementation. Dhingra S and Bansal MP, Chem Biol Interact. 2006 May 15;161(1):49-56. Epub 2006 Apr 3.
17. Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetes. Fredrikson GN, etal., Diabetologia. 2009 Jul;52(7):1426-33. Epub 2009 May 12.
18. Independent mutations at codon 3500 of the apolipoprotein B gene are associated with hyperlipidemia. Gaffney D, etal., Arterioscler Thromb Vasc Biol. 1995 Aug;15(8):1025-9.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. The influence of pharmacogenetics on fatty liver disease in the wistar and kyoto rats: a combined transcriptomic and metabonomic study. Griffin JL, etal., J Proteome Res. 2007 Jan;6(1):54-61.
22. Golgi-associated maturation of very low density lipoproteins involves conformational changes in apolipoprotein B, but is not dependent on apolipoprotein E. Gusarova V, etal., J Biol Chem. 2007 Jul 6;282(27):19453-62. Epub 2007 May 11.
23. Decreased secretion of very-low-density lipoprotein triacylglycerol and apolipoprotein B is associated with decreased intracellular triacylglycerol lipolysis in hepatocytes derived from rats fed orotic acid or n-3 fatty acids. Hebbachi AM, etal., Biochem J. 1997 Aug 1;325 ( Pt 3):711-9.
24. Lack of association between the apolipoprotein B gene 3' hypervariable region alleles and coronary artery disease in Finnish patients with angiographically documented coronary artery disease. Helio T, etal., J Intern Med. 1992 Jan;231(1):49-57.
25. Mechanism of hypertriglyceridemia in Dahl salt-sensitive rats, an animal model of spontaneous nephrotic syndrome. Hirano T, etal., Metabolism. 1994 Feb;43(2):248-56.
26. Effects of apolipoprotein B-100 on the metabolism of a lipid microemulsion model in rats. Hirata RD, etal., Biochim Biophys Acta. 1999 Jan 29;1437(1):53-62.
27. Deletion in the gene for the low-density-lipoprotein receptor in a majority of French Canadians with familial hypercholesterolemia. Hobbs HH, etal., N Engl J Med. 1987 Sep 17;317(12):734-7.
28. Estrogen replacement during hypoalbuminemia may enhance atherosclerotic risk. Joles JA, etal., J Am Soc Nephrol. 1997 Dec;8(12):1870-6.
29. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics Konemori G, etal., Nippon Ronen Igakkai Zasshi. 1990 Jan;27(1):22-7.
30. Genes that affect cholesterol synthesis, cholesterol absorption, and chylomicron assembly: the relationship between the liver and intestine in control and streptozotosin diabetic rats. Lally S, etal., Metabolism. 2007 Mar;56(3):430-8.
31. Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion. Leng SH, etal., Acta Pharmacol Sin. 2004 Apr;25(4):496-502.
32. Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons. Levy E, etal., J Biol Chem. 2002 May 10;277(19):16470-7. Epub 2002 Feb 5.
33. Epigallocatechin gallate increases the formation of cytosolic lipid droplets and decreases the secretion of apoB-100 VLDL. Li L, etal., J Lipid Res. 2006 Jan;47(1):67-77. Epub 2005 Oct 14.
34. Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48. Linden D, etal., J Biol Chem 2002 Jun 21;277(25):23044-53.
35. Plasma lipoprotein composition, apolipoprotein(a) concentration and isoforms in beta-thalassemia. Maioli M, etal., Atherosclerosis. 1997 May;131(1):127-33.
36. Cloning and regulation of rat apolipoprotein B mRNA. Matsumoto A, etal., Biochem Biophys Res Commun 1987 Jan 15;142(1):92-9.
37. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
38. Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance. Mulvihill EE, etal., Diabetes. 2009 Oct;58(10):2198-210. Epub 2009 Jul 10.
39. ApoB-100 carrying lipoprotein, but not apoB-48, is the major subset of proatherogenic remnant-like lipoprotein particles detected in plasma of sudden cardiac death cases. Nakajima K, etal., Atherosclerosis. 2006 Oct 10;.
40. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
41. Estimation of VLDL, IDL, LDL, HDL(2), apoA-I, and apoB from the Friedewald inputs-apoB and IDL, but not LDL, are associated with mortality in type 1 diabetes. Niemi J, etal., Ann Med. 2009 May 1:1-11.
42. Inhibition of phosphatidylcholine synthesis via the phosphatidylethanolamine methylation pathway impairs incorporation of bulk lipids into VLDL in cultured rat hepatocytes. Nishimaki-Mogami T, etal., J Lipid Res. 2002 Jul;43(7):1035-45.
43. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
44. Polymorphisms of the apolipoprotein B 3' variable number of tandem repeats region associated with coronary artery disease in Taiwanese. Pan JP, etal., J Formos Med Assoc. 1998 Apr;97(4):233-8.
45. Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control. Pan M, etal., Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5862-7. doi: 10.1073/pnas.0707460104. Epub 2008 Apr 7.
46. Haplotype analysis of signal peptide (insertion/deletion) and XbaI polymorphisms of the APOB gene in gallbladder cancer. Pandey SN, etal., Liver Int. 2007 Sep;27(7):1008-15.
47. Developmental regulation of apolipoprotein B mRNA editing is an autonomous function of small intestine involving homeobox gene Cdx1. Patterson AP, etal., J Biol Chem 2003 Feb 28;278(9):7600-6.
48. Associations of apolipoprotein B with pulse pressure and glucose in Chinese families with familial combined hyperlipidemia. Pei WD, etal., Int J Cardiol. 2007 Feb 14;115(3):293-6. Epub 2006 Jun 22.
49. Apolipoprotein B is associated with metabolic syndrome in Chinese families with familial combined hyperlipidemia, familial hypertriglyceridemia and familial hypercholesterolemia. Pei WD, etal., Int J Cardiol. 2007 Mar 20;116(2):194-200. Epub 2006 Jul 10.
50. The 2-series prostaglandins suppress VLDL secretion in an inflammatory condition-dependent manner in primary rat hepatocytes. Perez S, etal., Biochim Biophys Acta. 2006 Feb;1761(2):160-71. Epub 2006 Mar 3.
51. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
52. Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteins. Qiu W, etal., J Lipid Res. 2006 Aug;47(8):1749-61. Epub 2006 May 3.
53. GOA pipeline RGD automated data pipeline
54. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
55. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
56. Ragaglitazar improves glycemic control and lipid profile in type 2 diabetic subjects: a 12-week, double-blind, placebo-controlled dose-ranging study with an open pioglitazone arm. Saad MF, etal., Diabetes Care. 2004 Jun;27(6):1324-9.
57. Effect of extended-release niacin on serum lipids and on endothelial function in adults with sickle cell anemia and low high-density lipoprotein cholesterol levels. Scoffone HM, etal., Am J Cardiol. 2013 Nov 1;112(9):1499-504. doi: 10.1016/j.amjcard.2013.06.035. Epub 2013 Sep 13.
58. Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants. Shahid SU, etal., Atherosclerosis. 2017 Mar;258:1-7. doi: 10.1016/j.atherosclerosis.2017.01.024. Epub 2017 Jan 22.
59. Hypoalbuminemia and proteinuria contribute separately to reduced lipoprotein catabolism in the nephrotic syndrome. Shearer GC, etal., Kidney Int. 2001 Jan;59(1):179-89.
60. Mechanisms of disease: genetic causes of familial hypercholesterolemia. Soutar AK and Naoumova RP, Nat Clin Pract Cardiovasc Med. 2007 Apr;4(4):214-25.
61. The production and utility of monoclonal antibodies to rat apolipoprotein B lipoproteins. Sparks JD, etal., Atherosclerosis. 1986 Sep;61(3):205-11.
62. Impaired postprandial metabolism of apolipoprotein B48-containing remnant particles in normolipidemic subjects with brittle type 1 diabetes. Su JW, etal., Diabetes Care. 2009 Feb;32(2):e21.
63. Expression of apolipoprotein B mRNAs encoding higher- and lower-molecular weight isoproteins in rat liver and intestine. Tennyson GE, etal., Proc Natl Acad Sci U S A 1989 Jan;86(2):500-4.
64. Differential dyslipidemia associated with albuminuria in type 2 diabetic patients in Taiwan. Tseng CH Clin Biochem. 2009 Jul;42(10-11):1019-24. Epub 2009 Mar 24.
65. Association of mutations in the apolipoprotein B gene with hypercholesterolemia and the risk of ischemic heart disease. Tybjaerg-Hansen A, etal., N Engl J Med. 1998 May 28;338(22):1577-84.
66. Cardiovascular risk factors among youth with and without type 2 diabetes: differences and possible mechanisms. West NA, etal., Diabetes Care. 2009 Jan;32(1):175-80. Epub 2008 Oct 22.
67. Genetic analysis of a kindred with familial hypobetalipoproteinemia. Evidence for two separate gene defects: one associated with an abnormal apolipoprotein B species, apolipoprotein B-37; and a second associated with low plasma concentrations of apolipoprotein B-100. Young SG, etal., J Clin Invest. 1987 Jun;79(6):1842-51.
Additional References at PubMed
PMID:1917954   PMID:2563166   PMID:3235917   PMID:3417667   PMID:3860811   PMID:4363408   PMID:7126555   PMID:7593600   PMID:7878058   PMID:8245722   PMID:8460149   PMID:8855280  
PMID:8889548   PMID:8921909   PMID:9202070   PMID:9502790   PMID:9685400   PMID:9852051   PMID:10705993   PMID:10713055   PMID:10893242   PMID:11120757   PMID:11577082   PMID:12072432  
PMID:12477932   PMID:12917397   PMID:12960170   PMID:13130124   PMID:14570923   PMID:14970200   PMID:15124019   PMID:15308631   PMID:15520448   PMID:15790761   PMID:15797858   PMID:15863839  
PMID:16230502   PMID:16233946   PMID:16396637   PMID:16455790   PMID:16548883   PMID:16624317   PMID:17244792   PMID:17690102   PMID:18322245   PMID:19114110   PMID:20181985   PMID:20651008  
PMID:22257482   PMID:22326345   PMID:22363685   PMID:22546076   PMID:22580899   PMID:22897442   PMID:23533145   PMID:23911221   PMID:24334870   PMID:26184122   PMID:26616056   PMID:27068509  
PMID:27138255   PMID:27477018   PMID:27495870   PMID:28694219   PMID:31176989  


Genomics

Comparative Map Data
Apob
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8636,563,704 - 36,603,300 (+)NCBIGRCr8
mRatBN7.2630,844,386 - 30,883,983 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl630,844,368 - 30,892,497 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx631,136,522 - 31,176,112 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0631,452,442 - 31,492,039 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0630,926,947 - 30,966,539 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0633,176,826 - 33,216,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl633,176,778 - 33,224,997 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0642,956,372 - 42,995,922 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4631,508,060 - 31,548,083 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1631,546,139 - 31,550,758 (+)NCBI
Celera630,299,724 - 30,339,330 (+)NCBICelera
Cytogenetic Map6q14NCBI
APOB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38221,001,429 - 21,044,073 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl221,001,429 - 21,044,073 (-)EnsemblGRCh38hg38GRCh38
GRCh37221,224,301 - 21,266,945 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36221,077,806 - 21,120,450 (-)NCBINCBI36Build 36hg18NCBI36
Build 34221,135,952 - 21,178,597NCBI
Celera221,063,779 - 21,106,429 (-)NCBICelera
Cytogenetic Map2p24.1NCBI
HuRef220,956,976 - 20,999,627 (-)NCBIHuRef
CHM1_1221,153,564 - 21,196,210 (-)NCBICHM1_1
T2T-CHM13v2.0221,034,648 - 21,077,293 (-)NCBIT2T-CHM13v2.0
Apob
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39128,027,629 - 8,066,839 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl128,027,648 - 8,066,835 (+)EnsemblGRCm39 Ensembl
GRCm38127,977,629 - 8,016,839 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl127,977,648 - 8,016,835 (+)EnsemblGRCm38mm10GRCm38
MGSCv37127,984,483 - 8,023,645 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36128,003,656 - 8,042,849 (+)NCBIMGSCv36mm8
Celera128,374,429 - 8,411,685 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map123.53NCBI
Apob
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554693,436,450 - 3,478,424 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554693,437,422 - 3,478,408 (-)NCBIChiLan1.0ChiLan1.0
APOB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212105,485,757 - 105,528,305 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A105,489,857 - 105,532,277 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A20,986,464 - 21,029,004 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A21,100,349 - 21,142,545 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A21,100,356 - 21,145,129 (-)Ensemblpanpan1.1panPan2
APOB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11715,877,937 - 15,916,032 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1715,878,244 - 15,915,135 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1715,842,555 - 15,879,853 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01716,030,075 - 16,067,405 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1716,030,161 - 16,067,623 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11715,883,776 - 15,920,986 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01715,891,112 - 15,928,422 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01715,923,305 - 15,960,613 (-)NCBIUU_Cfam_GSD_1.0
Apob
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629260,290,128 - 60,327,775 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649310,509,118 - 10,549,144 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649310,509,118 - 10,549,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3117,250,096 - 117,316,200 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13117,250,096 - 117,316,200 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap3q24-qterNCBI
APOB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11486,624,209 - 86,669,175 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1486,624,332 - 86,668,704 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604525,515,337 - 25,558,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apob
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247383,580,033 - 3,620,192 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247383,579,747 - 3,622,508 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apob
162 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:121
Interacting mature miRNAs:131
Transcripts:ENSRNOT00000007371, ENSRNOT00000046811
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat

Markers in Region
RH130075  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2630,883,711 - 30,883,903 (+)MAPPERmRatBN7.2
Rnor_6.0633,216,110 - 33,216,301NCBIRnor6.0
Rnor_5.0642,995,651 - 42,995,842UniSTSRnor5.0
RGSC_v3.4631,547,812 - 31,548,003UniSTSRGSC3.4
Celera630,339,059 - 30,339,250UniSTS
RH 3.4 Map6123.98UniSTS
Cytogenetic Map6q14UniSTS
AI315052  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2630,882,756 - 30,882,962 (+)MAPPERmRatBN7.2
Rnor_6.0633,215,155 - 33,215,360NCBIRnor6.0
Rnor_5.0642,994,696 - 42,994,901UniSTSRnor5.0
RGSC_v3.4631,546,857 - 31,547,062UniSTSRGSC3.4
Celera630,338,104 - 30,338,309UniSTS
Cytogenetic Map6q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 30 75 91 87 59 21 59 6 187 70 55 41 53 28

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA997806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB694353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB771776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB801343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV796295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M23049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U53873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X55969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000007371   ⟹   ENSRNOP00000007371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl630,844,386 - 30,883,980 (+)Ensembl
Rnor_6.0 Ensembl633,176,826 - 33,216,378 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000046811   ⟹   ENSRNOP00000039779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl630,845,076 - 30,892,497 (+)Ensembl
Rnor_6.0 Ensembl633,176,778 - 33,224,997 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105148   ⟹   ENSRNOP00000093102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl630,844,368 - 30,883,980 (+)Ensembl
RefSeq Acc Id: NM_019287   ⟹   NP_062160
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8636,563,704 - 36,603,300 (+)NCBI
mRatBN7.2630,844,386 - 30,883,983 (+)NCBI
Rnor_6.0633,176,826 - 33,216,381 (+)NCBI
Rnor_5.0642,956,372 - 42,995,922 (+)NCBI
RGSC_v3.4631,508,060 - 31,548,083 (+)RGD
Celera630,299,724 - 30,339,330 (+)RGD
Sequence:
RefSeq Acc Id: NP_062160   ⟸   NM_019287
- Peptide Label: precursor
- UniProtKB: F1M6Z1 (UniProtKB/TrEMBL),   A0A8I6AJ20 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039779   ⟸   ENSRNOT00000046811
Ensembl Acc Id: ENSRNOP00000007371   ⟸   ENSRNOT00000007371
Ensembl Acc Id: ENSRNOP00000093102   ⟸   ENSRNOT00000105148
Protein Domains
Apolipoprotein B100 C-terminal   Vitellogenin

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694482
Promoter ID:EPDNEW_R5005
Type:multiple initiation site
Name:Apob_1
Description:apolipoprotein B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0633,176,813 - 33,176,873EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2129 AgrOrtholog
BioCyc Gene G2FUF-38203 BioCyc
Ensembl Genes ENSRNOG00000005542 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007371.7 UniProtKB/TrEMBL
  ENSRNOT00000046811.5 UniProtKB/TrEMBL
  ENSRNOT00000105148.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipovitellin-phosvitin complex, chain A, domain 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7370830 IMAGE-MGC_LOAD
InterPro ApoB100_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Apolipoprotein_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipid_transp_b-sht_shell UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipid_transpt_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipid_transpt_open_b-sht UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipovitellin_superhlx_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vitellinogen_b-sht_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vitellinogen_open_b-sht UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:112785 IMAGE-MGC_LOAD
NCBI Gene 54225 ENTREZGENE
PANTHER APOLIPOPROTEIN B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APOLIPOPROTEIN B-100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ApoB100_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1081 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1943 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vitellogenin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB APOB RGD
PhenoGen Apob PhenoGen
PROSITE VITELLOGENIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005542 RatGTEx
SMART CYCLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1943 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LPD_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48431 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AJ20 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QJJ3_RAT UniProtKB/TrEMBL
  A6HAL1_RAT UniProtKB/TrEMBL
  APOB_RAT UniProtKB/Swiss-Prot
  F1M6Z1 ENTREZGENE, UniProtKB/TrEMBL
  Q4G047_RAT UniProtKB/TrEMBL
  Q62970_RAT UniProtKB/TrEMBL
  Q63051_RAT UniProtKB/TrEMBL
  Q63052_RAT UniProtKB/TrEMBL
  Q7TMA5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-06-09 Apob  apolipoprotein B  Apob  apolipoprotein B (including Ag(x) antigen)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Apob  apolipoprotein B (including Ag(x) antigen)  Apob  apolipoprotein B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Apob  Apolipoprotein B      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver and intestine 634660
gene_process may play a role in cholesterol metabolism 634659
gene_protein apoB products of lower and higher molecular weight (apoBL and apoBH) are detected 634660
gene_regulation increased mRNA levels are detected in liver after feeding with a cholesterol rich diet 634659
gene_transcript transcripts are modified by RNA editing 634660