GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Apoe | decreases expression | EXP | | 6480464 | CTD | Cadmium results in decreased expression of APOE mRNA; Cadmium results in decreased expression of APOE protein | PMID:28315714 | Apoe | multiple interactions | EXP | | 6480464 | CTD | [[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in decreased expression of APOE mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of APOE mRNA; Acetylcysteine inhibits the reaction [[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in decreased expression of APOE mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of APOE mRNA]; Decitabine inhibits the reaction [Cadmium results in decreased expression of APOE mRNA] | PMID:28315714 PMID:33188856 | Apoe | affects binding | ISO | APOE (Homo sapiens) | 6480464 | CTD | APOE protein binds to Cadmium | PMID:23896426 | Apoe | increases response to substance | ISO | Apoe (Mus musculus) | 6480464 | CTD | APOE gene mutant form results in increased susceptibility to Cadmium | PMID:21799275 | Apoe | multiple interactions | ISO | Apoe (Mus musculus) | 6480464 | CTD | [APOE gene mutant form results in increased susceptibility to Cadmium] which results in increased expression of HSPD1; [APOE gene mutant form results in increased susceptibility to Cadmium] which results in increased expression of VCAM1; APOE gene polymorphism results in increased susceptibility to [Cadmium Chloride results in increased abundance of Cadmium] | PMID:21799275 PMID:31626305 | | ||||||||||||||||||||||
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