RGD Reference Report - Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice. - Rat Genome Database

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Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice.

Authors: Ishigaki, Y  Oikawa, S  Suzuki, T  Usui, S  Magoori, K  Kim, DH  Suzuki, H  Sasaki, J  Sasano, H  Okazaki, M  Toyota, T  Saito, T  Yamamoto, TT 
Citation: Ishigaki Y, etal., J Biol Chem. 2000 Oct 6;275(40):31269-73.
RGD ID: 6903201
Pubmed: PMID:10903326   (View Abstract at PubMed)
DOI: DOI:10.1074/jbc.M005906200   (Journal Full-text)

Lipoprotein glomerulopathy (LPG) is a unique renal disease characterized by thrombus-like substances in markedly dilated glomerular capillaries, dysbetalipoproteinemia, and elevated plasma concentrations of apoE. Recent studies identified several apoE mutations in patients with LPG, including apoE2(R145P) Sendai (apoE-Sendai). Virus-mediated transduction of apoE-Sendai in apoE-deficient hypercholesterolemic mice resulted in insufficient correction of hypercholesterolemia and a marked and temporal induction of plasma triglyceride levels. In vitro binding studies showed that apoE-Sendai has a reduced affinity for the low density lipoprotein receptor, suggesting that dysbetalipoproteinemia in LPG is caused by the apoE mutation. Furthermore, histological examination revealed marked intraglomerular depositions of apoE-containing lipoproteins in mice injected with apoE-Sendai virus. These LPG-like depositions were detected 6 days after virus injection and were sustained for at least 60 days. Our results demonstrated that apoE-Sendai is an etiological cause of LPG.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Lipoprotein Glomerulopathy  IMP 6903201human mutant gene (p.R145P) in mouse knockoutRGD 
Lipoprotein Glomerulopathy  ISOAPOE (Homo sapiens)6903201; 6903201human mutant gene (p.R145P) in mouse knockoutRGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoe  (apolipoprotein E)

Genes (Mus musculus)
Apoe  (apolipoprotein E)

Genes (Homo sapiens)
APOE  (apolipoprotein E)


Additional Information