Nanos2 (nanos C2HC-type zinc finger 2) - Rat Genome Database

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Gene: Nanos2 (nanos C2HC-type zinc finger 2) Rattus norvegicus
Analyze
Symbol: Nanos2
Name: nanos C2HC-type zinc finger 2
RGD ID: 1562436
Description: Predicted to enable enzyme activator activity and mRNA binding activity. Predicted to be involved in several processes, including germ-line stem cell population maintenance; negative regulation of gene expression; and negative regulation of meiotic nuclear division. Predicted to act upstream of or within spermatogenesis. Predicted to be located in P-body and nucleus. Predicted to be active in perinuclear region of cytoplasm. Orthologous to human NANOS2 (nanos C2HC-type zinc finger 2); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; bisphenol A; thioacetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC365213; nanos homolog 2; nanos homolog 2 (Drosophila); RGD1562436; similar to Nanos2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8187,763,716 - 87,765,176 (+)NCBIGRCr8
mRatBN7.2178,635,668 - 78,637,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,635,668 - 78,637,128 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,024,658 - 84,026,118 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,582,270 - 92,583,730 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0185,779,762 - 85,781,222 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,894,450 - 79,895,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,894,450 - 79,895,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,155,091 - 81,156,551 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,341,105 - 78,342,565 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera173,101,755 - 73,103,215 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
P-body  (IEA,ISO)
perinuclear region of cytoplasm  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12947200   PMID:18281459   PMID:19168545   PMID:19745153   PMID:20133598   PMID:22190708   PMID:22899867   PMID:24183939   PMID:24736845   PMID:30888312  


Genomics

Comparative Map Data
Nanos2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8187,763,716 - 87,765,176 (+)NCBIGRCr8
mRatBN7.2178,635,668 - 78,637,128 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,635,668 - 78,637,128 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,024,658 - 84,026,118 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,582,270 - 92,583,730 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0185,779,762 - 85,781,222 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,894,450 - 79,895,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,894,450 - 79,895,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,155,091 - 81,156,551 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,341,105 - 78,342,565 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera173,101,755 - 73,103,215 (+)NCBICelera
Cytogenetic Map1q21NCBI
NANOS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,913,214 - 45,914,778 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,913,214 - 45,914,778 (-)EnsemblGRCh38hg38GRCh38
GRCh371946,416,472 - 46,418,036 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,108,312 - 51,109,876 (-)NCBINCBI36Build 36hg18NCBI36
Build 341951,108,314 - 51,109,876NCBI
Celera1943,221,499 - 43,223,063 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,844,824 - 42,846,388 (-)NCBIHuRef
CHM1_11946,418,965 - 46,420,529 (-)NCBICHM1_1
T2T-CHM13v2.01948,740,655 - 48,742,219 (-)NCBIT2T-CHM13v2.0
Nanos2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39718,721,449 - 18,722,887 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl718,721,325 - 18,722,887 (+)EnsemblGRCm39 Ensembl
GRCm38718,987,524 - 18,988,962 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl718,987,400 - 18,988,962 (+)EnsemblGRCm38mm10GRCm38
MGSCv37719,572,873 - 19,574,311 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,146,046 - 18,147,484 (+)NCBIMGSCv36mm8
Celera716,399,407 - 16,400,845 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.45NCBI
Nanos2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574333,116 - 333,529 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955574333,007 - 333,529 (-)NCBIChiLan1.0ChiLan1.0
NANOS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22052,077,294 - 52,086,515 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,948,686 - 53,957,908 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,922,655 - 42,924,679 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,458,466 - 51,460,116 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,459,529 - 51,459,945 (-)Ensemblpanpan1.1panPan2
NANOS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,716,634 - 109,717,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,716,699 - 109,717,115 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1109,202,035 - 109,203,102 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01110,251,017 - 110,252,084 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,251,082 - 110,251,498 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,925,501 - 109,926,568 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,560,220 - 109,561,287 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,428,944 - 110,430,011 (+)NCBIUU_Cfam_GSD_1.0
Nanos2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,884,913 - 17,885,868 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367062,232,265 - 2,232,657 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367062,232,265 - 2,232,657 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NANOS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,219,418 - 52,219,834 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,218,889 - 52,219,834 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,481,251 - 47,481,667 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NANOS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1639,359,581 - 39,361,699 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl639,360,640 - 39,361,056 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607319,001,703 - 19,003,343 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nanos2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248327,309,334 - 7,310,645 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nanos2
10 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:96
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000057963
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 6 88 16 17 1 12 1 31 26 80 3 46 16

Sequence


Ensembl Acc Id: ENSRNOT00000057963   ⟹   ENSRNOP00000054772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,635,668 - 78,637,128 (+)Ensembl
Rnor_6.0 Ensembl179,894,450 - 79,895,910 (+)Ensembl
RefSeq Acc Id: NM_001108908   ⟹   NP_001102378
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,763,716 - 87,765,176 (+)NCBI
mRatBN7.2178,635,668 - 78,637,128 (+)NCBI
Rnor_6.0179,894,450 - 79,895,910 (+)NCBI
Rnor_5.0181,155,091 - 81,156,551 (+)NCBI
RGSC_v3.4178,341,105 - 78,342,565 (+)RGD
Celera173,101,755 - 73,103,215 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102378 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM08248 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054772.2
  ENSRNOP00000106029
RefSeq Acc Id: NP_001102378   ⟸   NM_001108908
- UniProtKB: D4A4B3 (UniProtKB/TrEMBL),   A6J8I6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054772   ⟸   ENSRNOT00000057963
Protein Domains
Nanos-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A4B3-F1-model_v2 AlphaFold D4A4B3 1-136 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562436 AgrOrtholog
BioCyc Gene G2FUF-60546 BioCyc
Ensembl Genes ENSRNOG00000038088 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000074804 ENTREZGENE
Ensembl Transcript ENSRNOT00000057963.3 UniProtKB/TrEMBL
  ENSRNOT00000137435 ENTREZGENE
Gene3D-CATH 4.10.60.30 UniProtKB/TrEMBL
InterPro Nanos_sf UniProtKB/TrEMBL
  Znf_Nanos UniProtKB/TrEMBL
  Znf_nanos-typ UniProtKB/TrEMBL
KEGG Report rno:365213 UniProtKB/TrEMBL
NCBI Gene 365213 ENTREZGENE
PANTHER Znf_Nanos UniProtKB/TrEMBL
Pfam zf-nanos UniProtKB/TrEMBL
PhenoGen Nanos2 PhenoGen
PROSITE ZF_NANOS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038088 RatGTEx
UniProt A6J8I6 ENTREZGENE, UniProtKB/TrEMBL
  D4A4B3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-10 Nanos2  nanos C2HC-type zinc finger 2  Nanos2  nanos homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Nanos2  nanos homolog 2 (Drosophila)  RGD1562436_predicted  similar to Nanos2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562436_predicted  similar to Nanos2 (predicted)  LOC365213  similar to Nanos2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC365213  similar to Nanos2      Symbol and Name status set to provisional 70820 PROVISIONAL