E2f8 (E2F transcription factor 8) - Rat Genome Database

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Gene: E2f8 (E2F transcription factor 8) Rattus norvegicus
Analyze
Symbol: E2f8
Name: E2F transcription factor 8
RGD ID: 1308091
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in several processes, including hepatocyte differentiation; regulation of nucleobase-containing compound metabolic process; and trophoblast giant cell differentiation. Predicted to act upstream of or within fibroblast proliferation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human E2F8 (E2F transcription factor 8); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E2F-8; LOC308607; RGD1308091; similar to hypothetical protein FLJ23311; transcription factor E2F8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81107,701,985 - 107,720,538 (-)NCBIGRCr8
mRatBN7.2198,565,717 - 98,584,265 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl198,565,717 - 98,584,098 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1103,919,427 - 103,937,428 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01112,391,351 - 112,409,352 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01105,713,994 - 105,732,016 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01104,185,436 - 104,203,683 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1104,187,100 - 104,202,591 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01105,245,743 - 105,261,113 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4198,640,381 - 98,694,764 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1198,718,495 - 98,763,993 (-)NCBI
Celera192,773,529 - 92,791,422 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
clofibrate  (ISO)
cobalt atom  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumestrol  (ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dimethylselenide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
escitalopram  (EXP)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glycine betaine  (ISO)
harmine  (ISO)
heptachlor  (EXP)
hydroxyl  (ISO)
hydroxyurea  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isotretinoin  (ISO)
kojic acid  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
monocrotaline  (ISO)
N(4)-hydroxycytidine  (ISO)
N-Nitrosopyrrolidine  (ISO)
niclosamide  (ISO)
nobiletin  (EXP,ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
quinolin-8-ol  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
styrene  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15722552   PMID:16179649   PMID:22516201   PMID:22903062   PMID:23064264   PMID:23064266  


Genomics

Comparative Map Data
E2f8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81107,701,985 - 107,720,538 (-)NCBIGRCr8
mRatBN7.2198,565,717 - 98,584,265 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl198,565,717 - 98,584,098 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1103,919,427 - 103,937,428 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01112,391,351 - 112,409,352 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01105,713,994 - 105,732,016 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01104,185,436 - 104,203,683 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1104,187,100 - 104,202,591 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01105,245,743 - 105,261,113 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4198,640,381 - 98,694,764 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1198,718,495 - 98,763,993 (-)NCBI
Celera192,773,529 - 92,791,422 (-)NCBICelera
Cytogenetic Map1q22NCBI
E2F8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381119,224,063 - 19,241,655 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1119,224,063 - 19,241,620 (-)EnsemblGRCh38hg38GRCh38
GRCh371119,245,610 - 19,263,202 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361119,202,186 - 19,219,083 (-)NCBINCBI36Build 36hg18NCBI36
Celera1119,378,036 - 19,394,995 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,929,541 - 18,947,128 (-)NCBIHuRef
CHM1_11119,244,897 - 19,262,487 (-)NCBICHM1_1
T2T-CHM13v2.01119,344,150 - 19,361,742 (-)NCBIT2T-CHM13v2.0
E2f8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39748,516,177 - 48,531,821 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl748,516,177 - 48,531,344 (-)EnsemblGRCm39 Ensembl
GRCm38748,866,429 - 48,882,073 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl748,866,429 - 48,881,596 (-)EnsemblGRCm38mm10GRCm38
MGSCv37756,121,799 - 56,136,411 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36748,734,481 - 48,749,617 (-)NCBIMGSCv36mm8
Celera744,310,478 - 44,325,086 (-)NCBICelera
Cytogenetic Map7B4NCBI
cM Map731.11NCBI
E2f8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955476197,630 - 213,441 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955476197,699 - 215,227 (-)NCBIChiLan1.0ChiLan1.0
E2F8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2921,529,385 - 21,546,998 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11121,489,669 - 21,507,289 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01119,250,045 - 19,267,629 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11119,162,837 - 19,180,280 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1119,162,837 - 19,179,744 (-)Ensemblpanpan1.1panPan2
E2F8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12141,340,410 - 41,358,261 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2141,340,969 - 41,357,206 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2140,818,978 - 40,836,517 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02142,463,746 - 42,481,520 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2142,463,758 - 42,479,509 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12141,466,050 - 41,483,600 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02141,643,476 - 41,661,038 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02142,020,665 - 42,038,222 (-)NCBIUU_Cfam_GSD_1.0
E2f8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494743,587,159 - 43,603,726 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936654322,863 - 338,699 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936654322,863 - 339,365 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
E2F8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl240,178,177 - 40,194,935 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1240,178,182 - 40,194,932 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,156,985 - 43,173,717 (+)NCBISscrofa10.2Sscrofa10.2susScr3
E2F8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1145,751,937 - 45,772,698 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl145,756,301 - 45,772,632 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038143,089,850 - 143,107,152 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
E2f8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476610,652,745 - 10,669,909 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476610,652,749 - 10,670,886 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in E2f8
70 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:290
Count of miRNA genes:179
Interacting mature miRNAs:204
Transcripts:ENSRNOT00000035512
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat

Markers in Region
RH136884  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2198,566,832 - 98,567,020 (+)MAPPERmRatBN7.2
Rnor_6.01104,186,552 - 104,186,739NCBIRnor6.0
Rnor_5.01105,245,806 - 105,245,993UniSTSRnor5.0
RGSC_v3.4198,640,444 - 98,640,631UniSTSRGSC3.4
Celera192,774,645 - 92,774,832UniSTS
RH 3.4 Map1921.0UniSTS
Cytogenetic Map1q22UniSTS
STS-N22942  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2198,574,536 - 98,575,037 (+)MAPPERmRatBN7.2
Rnor_6.01104,194,256 - 104,194,756NCBIRnor6.0
Rnor_5.01105,253,510 - 105,254,010UniSTSRnor5.0
RGSC_v3.4198,648,148 - 98,648,648UniSTSRGSC3.4
Celera192,782,357 - 92,782,857UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 49 106 91 90 59 25 59 6 216 97 86 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000035512   ⟹   ENSRNOP00000036763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl198,565,717 - 98,584,098 (-)Ensembl
Rnor_6.0 Ensembl1104,187,100 - 104,202,591 (-)Ensembl
RefSeq Acc Id: NM_001100580   ⟹   NP_001094050
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81107,701,985 - 107,720,009 (-)NCBI
mRatBN7.2198,565,717 - 98,583,741 (-)NCBI
RefSeq Acc Id: XM_039112420   ⟹   XP_038968348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81107,703,038 - 107,720,538 (-)NCBI
mRatBN7.2198,566,770 - 98,584,265 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001094050 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968348 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99080 (Get FASTA)   NCBI Sequence Viewer  
  EDM07230 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036763
  ENSRNOP00000036763.7
GenBank Protein F1LMN3 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000036763   ⟸   ENSRNOT00000035512
RefSeq Acc Id: NP_001094050   ⟸   NM_001100580
- UniProtKB: Q4FZV5 (UniProtKB/Swiss-Prot),   F1LMN3 (UniProtKB/Swiss-Prot),   A0A0A0MY11 (UniProtKB/TrEMBL),   A6JBF4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968348   ⟸   XM_039112420
- Peptide Label: isoform X1
- UniProtKB: Q4FZV5 (UniProtKB/Swiss-Prot),   F1LMN3 (UniProtKB/Swiss-Prot),   A0A0A0MY11 (UniProtKB/TrEMBL),   A6JBF4 (UniProtKB/TrEMBL)
Protein Domains
E2F/DP family winged-helix DNA-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LMN3-F1-model_v2 AlphaFold F1LMN3 1-860 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308091 AgrOrtholog
BioCyc Gene G2FUF-59571 BioCyc
Ensembl Genes ENSRNOG00000022537 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035512 ENTREZGENE
  ENSRNOT00000035512.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7443681 IMAGE-MGC_LOAD
InterPro E2F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  E2F_WHTH_DNA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:116118 IMAGE-MGC_LOAD
NCBI Gene 308607 ENTREZGENE
PANTHER PTHR12081 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR E2F8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam E2F_TDP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen E2f8 PhenoGen
RatGTEx ENSRNOG00000022537 RatGTEx
SMART E2F_TDP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MY11 ENTREZGENE, UniProtKB/TrEMBL
  A6JBF4 ENTREZGENE, UniProtKB/TrEMBL
  E2F8_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4FZV5 ENTREZGENE
UniProt Secondary Q4FZV5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 E2f8  E2F transcription factor 8  RGD1308091  similar to hypothetical protein FLJ23311  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1308091  similar to hypothetical protein FLJ23311  RGD1308091_predicted  similar to hypothetical protein FLJ23311 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1308091_predicted  similar to hypothetical protein FLJ23311 (predicted)  LOC308607_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC308607_predicted  similar to hypothetical protein FLJ23311 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL