Lrp3 (LDL receptor related protein 3)

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Gene: Lrp3 (LDL receptor related protein 3) Rattus norvegicus

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Symbol:

Lrp3

Name:

LDL receptor related protein 3

RGD ID:

619729

Description:

Predicted to be involved in negative regulation of fat cell differentiation; positive regulation of osteoblast differentiation; and regulation of gene expression. Predicted to be located in clathrin-coated pit. Predicted to be active in plasma membrane. Orthologous to human LRP3 (LDL receptor related protein 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

105 kDa low-density lipoprotein receptor-related protein; low density lipoprotein receptor-related protein 3; low-density lipoprotein receptor-related protein 3; LRP-3; rLRp105

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	96,980,762 - 96,996,157 (-)	NCBI		GRCr8
mRatBN7.2	1	87,843,815 - 87,859,147 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	87,844,868 - 87,859,110 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	93,251,338 - 93,265,587 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	101,717,313 - 101,731,562 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	95,009,641 - 95,023,886 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	91,447,308 - 91,462,603 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	91,448,361 - 91,462,603 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	92,578,473 - 92,593,301 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	87,711,390 - 87,725,636 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	87,789,500 - 87,803,747 (-)	NCBI
Celera	1	82,195,662 - 82,209,520 (-)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

hereditary spastic paraplegia 75 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (EXP)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

amiodarone (EXP)

amitrole (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (EXP)

butanal (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clofibrate (EXP)

copper(II) sulfate (ISO)

coumarin (EXP)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

gentamycin (EXP)

L-ethionine (EXP)

malathion (ISO)

methapyrilene (EXP)

methimazole (EXP)

nefazodone (EXP)

omeprazole (EXP)

paracetamol (EXP)

paraquat (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (EXP)

sodium arsenate (ISO)

sulfadimethoxine (EXP)

temozolomide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

valdecoxib (EXP)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

endocytosis (IEA)

negative regulation of fat cell differentiation (IEA,ISO)

negative regulation of gene expression (IEA,ISO)

positive regulation of gene expression (IEA,ISO)

positive regulation of osteoblast differentiation (IEA,ISO)

Cellular Component

clathrin-coated pit (IEA)

plasma membrane (IBA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13. 2.	Ishii H, etal., Genomics 1998 Jul 1;51(1):132-5.
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:11086049	PMID:11390366	PMID:28340487

Genomics

Comparative Map Data

Lrp3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	96,980,762 - 96,996,157 (-)	NCBI		GRCr8
mRatBN7.2	1	87,843,815 - 87,859,147 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	87,844,868 - 87,859,110 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	93,251,338 - 93,265,587 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	101,717,313 - 101,731,562 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	95,009,641 - 95,023,886 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	91,447,308 - 91,462,603 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	91,448,361 - 91,462,603 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	92,578,473 - 92,593,301 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	87,711,390 - 87,725,636 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	87,789,500 - 87,803,747 (-)	NCBI
Celera	1	82,195,662 - 82,209,520 (-)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

LRP3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	33,194,330 - 33,208,864 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	33,177,603 - 33,208,864 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	33,685,236 - 33,699,770 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	38,377,330 - 38,390,383 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	38,377,329 - 38,390,383	NCBI
Celera	19	30,379,187 - 30,393,366 (+)	NCBI		Celera
Cytogenetic Map	19	q13.11	NCBI
HuRef	19	30,187,589 - 30,201,641 (+)	NCBI		HuRef
CHM1_1	19	33,686,533 - 33,700,711 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	35,712,967 - 35,727,506 (+)	NCBI		T2T-CHM13v2.0

Lrp3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	34,900,303 - 34,914,770 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	34,899,452 - 34,914,923 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	35,200,878 - 35,217,392 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	35,200,027 - 35,215,498 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	35,985,953 - 36,000,364 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
Celera	7	30,340,818 - 30,355,363 (-)	NCBI		Celera
Cytogenetic Map	7	B2	NCBI
cM Map	7	21.15	NCBI

Lrp3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	2,957,145 - 2,967,678 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	2,957,156 - 2,967,678 (+)	NCBI	ChiLan1.0	ChiLan1.0

LRP3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	39,167,280 - 39,180,183 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	41,166,176 - 41,179,494 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	30,116,649 - 30,129,964 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	38,863,504 - 38,876,299 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	38,863,504 - 38,876,299 (+)	Ensembl	panpan1.1		panPan2

LRP3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	118,924,195 - 118,934,687 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	118,926,861 - 118,929,769 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	118,323,794 - 118,336,411 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	119,521,455 - 119,534,055 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	119,520,574 - 119,534,638 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	119,081,832 - 119,094,528 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	118,708,306 - 118,720,872 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	119,767,299 - 119,779,954 (-)	NCBI		UU_Cfam_GSD_1.0

Lrp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	9,043,401 - 9,054,989 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936570	2,587,284 - 2,601,203 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936570	2,590,893 - 2,602,749 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRP3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	42,988,482 - 43,001,421 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	42,988,446 - 43,001,424 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	38,565,884 - 38,578,833 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRP3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	28,234,466 - 28,248,467 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	28,234,486 - 28,248,497 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	5,870,589 - 5,884,684 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrp3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	9,892,690 - 9,904,261 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624794	9,892,300 - 9,904,320 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Lrp3
65 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	650
Count of miRNA genes:	279
Interacting mature miRNAs:	340
Transcripts:	ENSRNOT00000015384
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313059	Bss55	Bone structure and strength QTL 55	3.2	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	5925874	115540829	Rat
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	49393172	94393172	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	78479925	123479925	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	30882023	123479925	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
2300324	Fetw1	Fetal weight QTL 1	12.1	0.005	fetal growth trait (VT:0004201)	fetal body weight (CMO:0002080)	1	85424647	100358001	Rat
2302059	Pia36	Pristane induced arthritis QTL 36	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	43333002	88333002	Rat
1300121	Hrtrt1	Heart rate QTL 1	3.7		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	65789093	115540829	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	66023617	118608521	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	22340647	102268831	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	72197680	90508767	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	57336763	151090257	Rat
2313072	Bss53	Bone structure and strength QTL 53	4.3	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	43284731	118944897	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
2313078	Bss54	Bone structure and strength QTL 54	3.5	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	77876254	106047988	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	82174743	118944897	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	48963584	144267916	Rat
4889494	Scort2	Serum corticosterone level QTL 2	4.2		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	80592172	125592172	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	56732668	98773277	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	32737273	90665040	Rat
61344	Bp29	Blood pressure QTL 29	7.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	78350581	123350581	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	77494165	122494165	Rat
2313094	Bss58	Bone structure and strength QTL 58	3.7	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	43284731	118944897	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	53863041	90532583	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	56949932	101949932	Rat
2313099	Bss56	Bone structure and strength QTL 56	2.4	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	1	43284731	118944897	Rat
2313098	Bmd70	Bone mineral density QTL 70	3.6	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	43284731	118944897	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)	1	83547917	128547917	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	50343510	99980958	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	77857876	122857876	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	78430536	123430536	Rat
2313051	Bss57	Bone structure and strength QTL 57	3.7	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	43284731	118944897	Rat
61433	Cia2	Collagen induced arthritis QTL 2	5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	78430754	91209302	Rat
724529	Cm16	Cardiac mass QTL 16	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	1	87580395	150700247	Rat

Markers in Region

RH131383

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	87,845,004 - 87,845,223 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	91,448,498 - 91,448,716	NCBI	Rnor6.0
Rnor_5.0	1	92,579,196 - 92,579,414	UniSTS	Rnor5.0
RGSC_v3.4	1	87,711,527 - 87,711,745	UniSTS	RGSC3.4
Celera	1	82,195,799 - 82,196,017	UniSTS
RH 3.4 Map	1	864.7	UniSTS
Cytogenetic Map	1	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001835496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001835497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005493687	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005493688	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB009463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC109741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ286277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227632	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015384 ⟹ ENSRNOP00000015384

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	87,844,868 - 87,859,110 (-)	Ensembl
Rnor_6.0 Ensembl	1	91,448,361 - 91,462,603 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110388 ⟹ ENSRNOP00000084599

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	87,844,868 - 87,850,835 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111284 ⟹ ENSRNOP00000082642

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	87,844,868 - 87,858,337 (-)	Ensembl

RefSeq Acc Id:

NM_053541 ⟹ NP_445993

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	96,981,815 - 96,996,057 (-)	NCBI
mRatBN7.2	1	87,844,868 - 87,859,110 (-)	NCBI
Rnor_6.0	1	91,448,361 - 91,462,603 (-)	NCBI
Rnor_5.0	1	92,578,473 - 92,593,301 (-)	NCBI
RGSC_v3.4	1	87,711,390 - 87,725,636 (-)	RGD
Celera	1	82,195,662 - 82,209,520 (-)	RGD

Sequence:

show sequence

CCGATCGACGCACCCTCGTTGACATCGTGCGGCGCGGCGCGGCGCGGGCGGCCCGGGGACCGAC
GGGCAGGCGCACCGGGGCATGGGCGCGCCGGAGGTCTCGGTGTGCAGGCAGGGCTGGGTGCGCC
GGCCGGGGCTCGGGGACAGCGGCGGGCTCAGGTCTTCCCTGGCGACCGCTGCTGAGCCCCCGCG
GGGCCCGTGACGCCGCGGCCGATGTGGCCCAGCGCGTTGCGGGCCTGCACCGCCGCTGCACAAA
GACGCCGCCGCAGCCGCCGCCCGCACCCCGGCCGCAGCCGCCGCGCCAGCCCTAGCCCCAGGCG
GAGTCCCGGCCGCAGGGCAGCAGGCGTCCGCGCGCGGCCGGCCACGGCATGGAGAAGCGCGCGG
CCGCGGGGCCGGAGGGGGCGCCGGGCGCCAGGGCGCCGCTCGCAGTCGTCTGCCTGGTGAACCT
CTTTCTCACTGGGAGACTCAGCAGTGCAGTTCCTGCCTTAGCTGCCTGCAGTGGGAAGTTGGAA
CAGCACACTGAACGGCGAGGGGTTATCTACAGCCCAGCCTGGCCCCTCAACTACCCTCCAGGCA
CCAACTGCAGCTGGTACATTCAAGGTGACCGTGGTGACATGATCACCATCAGTTTCCGAAACTT
TGATGTAGAGGAGTCTCACCAGTGTTCCCTGGACTGGCTCCTGCTGGGCCCAGCAGCTCCCCCT
CGCCAGGAGGCCTTCCGCCTCTGTGGTTCAGCCATCCCACCAGCCTTCATCTCTGCCCGTGACC
ACGTCTGGATCTTCTTCCACTCAGACGCCTCCAGTTCCGGCCAGGCCCAGGGTTTTCGCCTCTC
CTATATCCGAGGGAAGCTGGGTCAGGCATCCTGCCAGACAGATGAGTTCCGCTGTGACAACGGT
AAATGCTTGCCTGGTCCTTGGCAGTGCAACATGGTGGATGAGTGTGGAGATGGCTCGGATGAGG
GTAACTGTTCGGCACCTGCCTCAGAGCCACCAGGCAGCCTGTGCCCCGGGGGCACCTTCCCGTG
CAGCGGAGCTCGCTCCACACGCTGCCTGCCGGTAGAGCGGCGCTGCGACGGCACCCAGGACTGC
GGTGATGGCTCTGATGAGGCTGGCTGCCCCGACCTAGCATGTGGCCGGCGGCTAGGCAGTTTCT
ACGGTTCCTTCGCCTCCCCAGACCTGTTTGGTGCCGCCCGTGGGCCTTCGGACCTTCACTGCAC
ATGGCTGGTGGACACGCAGGACCCGAGGCGTGTGCTGCTGCAGCTGGAGCTACGACTGGGTTAT
GATGACTATGTCCAGGTGTATGAAGGCCTGGGCGAGCGTGGGGACCGTCTGCTGCAAACGCTTT
CCTACCGCAGCAACCACCGGCCTGTGAGCCTGGAAGCAGCGCAGGGCCGCCTCACTGTGGCCTA
CCATGCTCGCGCCCGCAGTGCTGGTCACGGCTTCAACGCCACATACCAGGTGAAGGGCTACTGC
CTCCCATGGGAGCAGCCGTGTGGGAGCAGCAGCGAGGGAGATGACGGCAGCACAGGGGAACAGG
GCTGCTTCTCAGAGCCACAGCGCTGTGATGGCTGGTGGCATTGTGCGAGCGGCCGGGATGAGCA
GGGCTGTCCAGCATGCCCTCCGGACCAGTATCCCTGTGAGGGTGGTAGCGGCCTGTGCTATGCA
CCTGCCGATCGTTGCAACAACCAGAAAAGCTGCCCCGATGGCGCCGATGAAAAGAACTGCTTTT
CCTGCCAGCCGGGCACCTTCCACTGTGGTACGAACCTGTGCATCTTTGAGACATGGCGCTGTGA
CGGTCAGGAGGACTGCCAAGATGGCAGCGATGAGCACGGCTGCCTGGCTGCCGTGCCCCGCAAG
GTCATCACCGCCGCCCTCATTGGTAGCCTAGTATGCGGACTGCTGCTTGTTATTGCCCTAGGCT
GTGCCTTCAAACTCTACTCCCTGCGCACGCAGGAGTACAGGGCCTTTGAGACCCAAATGACACG
TTTAGAGGCTGAGTTTGTGCGGCGCGAGGCGCCCCCATCCTACGGTCAGCTCATCGCACAGGGC
CTCATACCACCCGTTGAGGATTTTCCTGTCTACAGTGCATCCCAGGCTTCAGTGCTACAGAACC
TTCGCACAGCCATGCGACGACAGATGCGTCGGCATGCCTCCCGCAGGGGGCCATCTCGTCGCAG
ACTGGGCCGCCTCTGGAACAGGCTCTTCCACCGGCCACGGGCACCTCGAGGCCAGATCCCACTG
CTGACTGCCGCCCGTACCTCACAGACCGTGCTGGGTGATGGGCTCCTCCAGGCAGCACCAGGGC
CTGTACCAGACCCCCCAGTGCCCAATACAGACACAGGCAGCCCCAGGGAGGCTGGAGATGGGCC
TCCTAGTGGCTCTGGCCATGCACCAGAAGTGGGGCCTTCAGTGCCGCCCCCGCCCTTGAACCTT
CGAGACCCAGAGTACAGGCCAGAGGACAAGGAGAGAAAGGCCTGTGTGGACCCTCTGGAAGACA
GTCCAGCCCCTGTGGACACACCTCCAGAGCCCTGCTTGGCCCAAGACCCCCACCCCCAGACTCC
CACTGCCAGTGGCATCCAAGATCCCCACTCAGCAGAGCCACTGGGGGTCTGCAGGAGCCCTCCA
CCAACCTGCTCCCCAATATTGGAGGCTAGTGATGATGAGGCCCTGCTGGTCTGCTGACCCATTG
GACACACTGGTGACTGCCACAGCCCCGCTTTGGAACCAGGGAATACACAGTCATTTCTACCCTG
CCTCTGCATTCTTTCTTACAGAGACCCACCTAGCAGCTCCGGTGAAGGGCCTGGGCACTCAGTC
AGTGGGCTACCTGTGCAGTCCTATTGCTCTGAAGGGCATTACTGTCAGGGGCTTCGGGGGTGGA
CCTGGGAAAGAGGGACCGACCACCTTTGAGATCAGCATGAGCATAGCCCCTTGGAGTCTCACAG
CAAATTGCTCCCTGCTACACTAATCTCGGGACTCATTTCCAGAAAAGCAGGAGAGCCAGAACCA
GGCTTTCCGGAATGTTTTCTGTGGCTTCTCAGTTTATCCACCCTGCAGTGGCACCAGCTGCTCA
TCCTCAGACCTGTGCCAGGAGCTGTAGTTGAGGCCTAAAAAGGCCATGAGAGGGGTAGGGTGGA
CCTCATTCATGGTGAGTACTATATTCATCCTTCCCCACAGGGTCCCTAGGAAAGATGGGCTAGT
GGCTTCTGCCCCAGTCTCATGCCTATGGTGGCAGCATAGGCCTGGCTAGGCTGGGTCAGTCCCC
AAGTATCATGGGTAAGGCTAAAAGTATGAGATAGGATGACCACAAGAGAGGCCATTCTATGCCT
TCAAAGGAGACAGAAGCCAAGGTACTGGCTGACAATGGAAATAACCATTCTGTCTTGCCTCAGA
GTCTCAGTTTCCCCACCTGAAGAGAGGGCTGTGCTATCATAAGTAATAGCATTCACTCTGGTGA
TTTATGGGAAGGACAGTAGTTCAGCTGGGGAATTTCTGGGTTCTTCTGGATGGCCAAGTTCAAG
GTGGCGTGGAGGGTTATGGATGGAGCCTCATTGTCTTCTATGGGCCCCATGGAGCCAGCCTCAG
GTTCAACCAGCAAAACCCACTAGGGCTGAAAACCTCCTCCATAGCACCTTCCCAGCTAGCAACC
CATATACCGCGCTGAGGCATGTCTCCATGAACTCCCCTTACACACAGAACAACCAGCCCTGTTT
ATTTACAGACTTTTCTGGAGAAGCTAGCAGGGCATTGCTAAGGCAGGAAGCCCGACCCCAGTGG
CCAGTCCCTTACAATAGGCCTCTAAGGGTCGGGTCTCTTTTTTTGTGCAGAAAAAAAAATTTTT
GAAAACAAAACAGAACACAAACCCCTTCTCAATAAACAACATGTAAACAGA

hide sequence

RefSeq Acc Id:

XM_039092968 ⟹ XP_038948896

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	96,981,814 - 96,996,157 (-)	NCBI
mRatBN7.2	1	87,844,867 - 87,859,147 (-)	NCBI

RefSeq Acc Id:

XR_005493687

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	96,980,762 - 96,996,157 (-)	NCBI
mRatBN7.2	1	87,843,815 - 87,859,147 (-)	NCBI

RefSeq Acc Id:

XR_005493688

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	96,980,762 - 96,996,157 (-)	NCBI
mRatBN7.2	1	87,843,815 - 87,859,147 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_445993	(Get FASTA)	NCBI Sequence Viewer
	XP_038948896	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA32331	(Get FASTA)	NCBI Sequence Viewer
	CAB71482	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015384.2
	ENSRNOP00000082642.1
	ENSRNOP00000084599.1
	ENSRNOP00055006769
	ENSRNOP00060042330
	ENSRNOP00065045308
GenBank Protein	O88204	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_445993 ⟸ NM_053541
- Peptide Label:	precursor
- UniProtKB:	O88204 (UniProtKB/Swiss-Prot), A0A8L2Q7D1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEKRAAAGPEGAPGARAPLAVVCLVNLFLTGRLSSAVPALAACSGKLEQHTERRGVIYSPAWPL NYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQEAFRLCGSAIPPAF ISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQTDEFRCDNGKCLPGPWQCNMVDECG DGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGTQDCGDGSDEAGCPDLACGR RLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDPRRVLLQLELRLGYDDYVQVYEGLGERGDR LLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSEGDDG STGEQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYAPADRCNNQKSCPDGAD EKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVCGLLL VIALGCAFKLYSLRTQEYRAFETQMTRLEAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSASQA SVLQNLRTAMRRQMRRHASRRGPSRRRLGRLWNRLFHRPRAPRGQIPLLTAARTSQTVLGDGLL QAAPGPVPDPPVPNTDTGSPREAGDGPPSGSGHAPEVGPSVPPPPLNLRDPEYRPEDKERKACV DPLEDSPAPVDTPPEPCLAQDPHPQTPTASGIQDPHSAEPLGVCRSPPPTCSPILEASDDEALL VC hide sequence

Ensembl Acc Id:

ENSRNOP00000015384 ⟸ ENSRNOT00000015384

RefSeq Acc Id:	XP_038948896 ⟸ XM_039092968
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2Q7D1 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000084599 ⟸ ENSRNOT00000110388

Ensembl Acc Id:

ENSRNOP00000082642 ⟸ ENSRNOT00000111284

Protein Domains

CUB LDL-receptor class A

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O88204-F1-model_v2	AlphaFold	O88204	1-770	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689967

Promoter ID:

EPDNEW_R490

Type:

multiple initiation site

Name:

Lrp3_1

Description:

LDL receptor related protein 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	91,462,606 - 91,462,666	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619729	AgrOrtholog
BioCyc Gene	G2FUF-59981	BioCyc
Ensembl Genes	ENSRNOG00000011451	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00055005540	UniProtKB/Swiss-Prot
	ENSRNOG00060029321	UniProtKB/Swiss-Prot
	ENSRNOG00065031986	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000015384.3	UniProtKB/TrEMBL
	ENSRNOT00000110388.1	UniProtKB/TrEMBL
	ENSRNOT00000111284.1	UniProtKB/TrEMBL
	ENSRNOT00055008901	UniProtKB/Swiss-Prot
	ENSRNOT00060050888	UniProtKB/Swiss-Prot
	ENSRNOT00065055109	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.120.290	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	CUB_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDL_receptor-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDLR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDLR_class-A_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDrepeatLR_classA_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sperma_CUB_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:89787	UniProtKB/Swiss-Prot
NCBI Gene	89787	ENTREZGENE
PANTHER	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	CUB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ldl_recept_a	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Lrp3	PhenoGen
PRINTS	LDLRECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	CUB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDLRA_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDLRA_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011451	RatGTEx
	ENSRNOG00055005540	RatGTEx
	ENSRNOG00060029321	RatGTEx
	ENSRNOG00065031986	RatGTEx
SMART	CUB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDLa	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF49854	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF57424	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZVA7_RAT	UniProtKB/TrEMBL
	A0A8I6A1N6_RAT	UniProtKB/TrEMBL
	A0A8L2Q7D1	ENTREZGENE, UniProtKB/TrEMBL
	LRP3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-11	Lrp3	LDL receptor related protein 3	Lrp3	low density lipoprotein receptor-related protein 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Lrp3	low density lipoprotein receptor-related protein 3			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Lrp3	low density lipoprotein receptor-related protein 3			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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