Grik5 (glutamate ionotropic receptor kainate type subunit 5) - Rat Genome Database

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Gene: Grik5 (glutamate ionotropic receptor kainate type subunit 5) Rattus norvegicus
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Symbol: Grik5
Name: glutamate ionotropic receptor kainate type subunit 5
RGD ID: 2735
Description: Enables identical protein binding activity; kainate selective glutamate receptor activity; and protein domain specific binding activity. Contributes to glutamate-gated receptor activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of neuron apoptotic process; and protein retention in ER lumen. Located in dendrite; perikaryon; and terminal bouton. Part of ionotropic glutamate receptor complex. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Colocalizes with plasma membrane. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human GRIK5 (glutamate ionotropic receptor kainate type subunit 5); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; 1-naphthyl isothiocyanate; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GluK5; glutamate receptor ionotropic, kainate 5; glutamate receptor KA-2; glutamate receptor KA2; glutamate receptor, ionotropic kainate 5; glutamate receptor, ionotropic, kainate 5; iGlu5; KA2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,733,736 - 89,795,769 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl189,733,741 - 89,794,962 (-)EnsemblGRCr8
mRatBN7.2180,605,878 - 80,667,896 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,605,892 - 80,667,125 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx185,998,459 - 86,059,573 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,549,318 - 94,610,432 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,754,221 - 87,815,339 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,885,516 - 81,946,731 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,885,521 - 81,946,714 (-)Ensemblrn6Rnor6.0
Rnor_5.0183,137,805 - 83,207,039 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,313,801 - 80,384,390 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,051,832 - 75,112,171 (-)NCBICelera
RGSC_v3.1180,391,911 - 80,462,398 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (EXP,ISO)
cocaine  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
diazinon  (EXP)
endosulfan  (EXP)
enzacamene  (EXP)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
folic acid  (ISO)
graphite  (EXP)
haloperidol  (EXP,ISO)
kainic acid  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
niclosamide  (ISO)
O-methyleugenol  (ISO)
orphenadrine  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pyrethrins  (EXP)
pyrimidifen  (ISO)
sarin  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning of a putative glutamate receptor: a low affinity kainate-binding subunit. Bettler B, etal., Neuron 1992 Feb;8(2):257-65.
2. Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density. Feligioni M, etal., J Neurochem. 2006 Oct;99(2):549-60. Epub 2006 Aug 11.
3. Contributions of different kainate receptor subunits to the properties of recombinant homomeric and heteromeric receptors. Fisher MT and Fisher JL, Neuroscience. 2014 Oct 10;278:70-80. doi: 10.1016/j.neuroscience.2014.08.009. Epub 2014 Aug 17.
4. SAP90 binds and clusters kainate receptors causing incomplete desensitization. Garcia EP, etal., Neuron. 1998 Oct;21(4):727-39.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Functional cooperation between KA2 and GluR6 subunits is involved in the ischemic brain injury. Jiang HX, etal., J Neurosci Res. 2007 Oct;85(13):2960-70.
8. Ionotropic glutamate receptor expression in preganglionic neurons of the rat inferior salivatory nucleus. Kim M, etal., Auton Neurosci. 2008 Feb 29;138(1-2):83-90. Epub 2007 Dec 21.
9. [Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and Serotonin Receptor (HTR2A) Genes Are Associated with Chronic Obstructive Pulmonary Disease]. Korytina GF, etal., Mol Biol (Mosk). 2017 Jul-Aug;51(4):603-614. doi: 10.7868/S0026898417040127.
10. High-affinity kainate and domoate receptors in rat brain. Lomeli H, etal., FEBS Lett 1992 Jul 28;307(2):139-43.
11. Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn. Lu CR, etal., J Comp Neurol. 2005 May 30;486(2):169-78.
12. Presynaptic low- and high-affinity kainate receptors in nociceptive spinal afferents. Lucifora S, etal., Pain. 2006 Jan;120(1-2):97-105. Epub 2005 Dec 15.
13. Altered hippocampal kainate-receptor mRNA levels in temporal lobe epilepsy patients. Mathern GW, etal., Neurobiol Dis. 1998 Sep;5(3):151-76.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. GluR5 and GluR6 kainate receptor subunits coexist in hippocampal neurons and coassemble to form functional receptors. Paternain AV, etal., J Neurosci. 2000 Jan 1;20(1):196-205.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. Assembly stoichiometry of the GluK2/GluK5 kainate receptor complex. Reiner A, etal., Cell Rep. 2012 Mar 29;1(3):234-40. doi: 10.1016/j.celrep.2012.01.003.
19. Multiple trafficking signals regulate kainate receptor KA2 subunit surface expression. Ren Z, etal., J Neurosci. 2003 Jul 23;23(16):6608-16.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Glutamate receptor subunits GluR5 and KA-2 are coexpressed in rat trigeminal ganglion neurons. Sahara Y, etal., J Neurosci. 1997 Sep 1;17(17):6611-20. doi: 10.1523/JNEUROSCI.17-17-06611.1997.
24. Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism. Sander T, etal., Am J Med Genet 1997 Jul 25;74(4):416-21.
25. Elevated glucose changes the expression of ionotropic glutamate receptor subunits and impairs calcium homeostasis in retinal neural cells. Santiago AR, etal., Invest Ophthalmol Vis Sci. 2006 Sep;47(9):4130-7.
26. Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate. Schiffer HH, etal., Neuron 1997 Nov;19(5):1141-6.
27. Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures. Smolders I, etal., Nat Neurosci 2002 Aug;5(8):796-804.
28. Pursuit auditory tracking of dichotically presented tonal amplitudes. Sussman HM, etal., J Speech Hear Res. 1975 Mar;18(1):74-81.
29. Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Wyneken U, etal., Neuroscience. 2001;102(1):65-74.
Additional References at PubMed
PMID:1310861   PMID:1321949   PMID:1373632   PMID:12477932   PMID:12533602   PMID:12954862   PMID:15796762   PMID:16814779   PMID:17110338   PMID:17174564   PMID:22114280   PMID:22345355  
PMID:23288040   PMID:23975096   PMID:33724189  


Genomics

Comparative Map Data
Grik5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,733,736 - 89,795,769 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl189,733,741 - 89,794,962 (-)EnsemblGRCr8
mRatBN7.2180,605,878 - 80,667,896 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,605,892 - 80,667,125 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx185,998,459 - 86,059,573 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,549,318 - 94,610,432 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,754,221 - 87,815,339 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,885,516 - 81,946,731 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,885,521 - 81,946,714 (-)Ensemblrn6Rnor6.0
Rnor_5.0183,137,805 - 83,207,039 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,313,801 - 80,384,390 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,051,832 - 75,112,171 (-)NCBICelera
RGSC_v3.1180,391,911 - 80,462,398 (-)NCBI
Cytogenetic Map1q21NCBI
GRIK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,998,324 - 42,070,206 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,998,316 - 42,070,240 (-)Ensemblhg38GRCh38
GRCh371942,502,476 - 42,574,358 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,194,313 - 47,261,797 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341947,194,312 - 47,261,797NCBI
Celera1939,302,092 - 39,369,575 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,934,282 - 39,001,175 (-)NCBIHuRef
CHM1_11942,504,085 - 42,571,606 (-)NCBICHM1_1
T2T-CHM13v2.01944,817,686 - 44,889,570 (-)NCBIT2T-CHM13v2.0
Grik5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,709,274 - 24,775,421 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,709,274 - 24,771,771 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38725,009,849 - 25,075,694 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,009,849 - 25,072,346 (-)Ensemblmm10GRCm38
MGSCv37725,794,868 - 25,857,388 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36724,718,636 - 24,781,058 (-)NCBIMGSCv36mm8
Celera719,625,658 - 19,688,340 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.73NCBI
Grik5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555812,928 - 864,874 (+)Ensembl
ChiLan1.0NW_004955555804,907 - 865,395 (+)NCBIChiLan1.0ChiLan1.0
GRIK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22048,103,370 - 48,174,201 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11949,971,984 - 50,042,814 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,886,108 - 38,956,938 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,389,253 - 47,549,018 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,389,804 - 47,544,604 (-)EnsemblpanPan2panpan1.1
GRIK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,270,157 - 112,321,672 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,270,424 - 112,321,672 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1111,702,486 - 111,753,731 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01112,887,140 - 112,941,269 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,889,737 - 112,941,269 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,443,154 - 112,494,596 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,079,617 - 112,130,847 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,005,888 - 113,057,155 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grik5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934916,062,693 - 16,121,657 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706410,938 - 464,714 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936706410,806 - 469,000 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,845,656 - 49,902,080 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1649,840,671 - 49,901,656 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,891,687 - 45,922,679 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRIK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,199,358 - 36,273,355 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl636,199,349 - 36,269,591 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607314,441,791 - 14,521,580 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grik5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907653,895 - 710,791 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624907653,568 - 711,358 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Grik5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12169,634,743 - 169,695,614 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grik5
322 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:230
Count of miRNA genes:141
Interacting mature miRNAs:163
Transcripts:ENSRNOT00000027578
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat

Markers in Region
D1Wox65  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8189,794,123 - 89,794,335 (+)Marker Load Pipeline
Rnor_6.0181,945,931 - 81,946,140NCBIRnor6.0
Rnor_5.0183,206,263 - 83,206,472UniSTSRnor5.0
RGSC_v3.4180,383,607 - 80,383,816UniSTSRGSC3.4
Celera175,111,416 - 75,111,597UniSTS
Cytogenetic Map1q21UniSTS
BF404569  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8189,771,849 - 89,771,948 (+)Marker Load Pipeline
mRatBN7.2180,644,005 - 80,644,105 (+)MAPPERmRatBN7.2
Rnor_6.0181,923,654 - 81,923,753NCBIRnor6.0
Rnor_5.0183,174,789 - 83,174,888UniSTSRnor5.0
RGSC_v3.4180,360,726 - 80,360,825UniSTSRGSC3.4
Celera175,089,199 - 75,089,298UniSTS
RH 3.4 Map1824.1UniSTS
Cytogenetic Map1q21UniSTS
RH139022  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2180,645,930 - 80,646,103 (+)MAPPERmRatBN7.2
Rnor_6.0181,925,579 - 81,925,751NCBIRnor6.0
Rnor_5.0183,186,701 - 83,186,873UniSTSRnor5.0
RGSC_v3.4180,363,192 - 80,363,364UniSTSRGSC3.4
Celera175,091,065 - 75,091,237UniSTS
RH 3.4 Map6791.5UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 73 59 6 337 173 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027578   ⟹   ENSRNOP00000027578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl189,733,741 - 89,794,909 (-)Ensembl
mRatBN7.2 Ensembl180,605,892 - 80,667,072 (-)Ensembl
Rnor_6.0 Ensembl181,885,521 - 81,946,714 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107115   ⟹   ENSRNOP00000091191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl189,733,741 - 89,794,962 (-)Ensembl
mRatBN7.2 Ensembl180,605,892 - 80,667,125 (-)Ensembl
RefSeq Acc Id: NM_031508   ⟹   NP_113696
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,733,736 - 89,794,909 (-)NCBI
mRatBN7.2180,605,887 - 80,667,072 (-)NCBI
Rnor_6.0181,885,516 - 81,946,714 (-)NCBI
Rnor_5.0183,137,805 - 83,207,039 (-)NCBI
RGSC_v3.4180,313,801 - 80,384,390 (-)RGD
Celera175,051,832 - 75,112,171 (-)RGD
Sequence:
RefSeq Acc Id: XM_006228382   ⟹   XP_006228444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,733,736 - 89,795,769 (-)NCBI
mRatBN7.2180,605,878 - 80,667,895 (-)NCBI
Rnor_6.0181,885,516 - 81,946,731 (-)NCBI
Rnor_5.0183,137,805 - 83,207,039 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758889   ⟹   XP_008757111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,733,736 - 89,795,174 (-)NCBI
mRatBN7.2180,605,878 - 80,667,896 (-)NCBI
Rnor_6.0181,885,516 - 81,946,731 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095322   ⟹   XP_038951250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,733,736 - 89,795,769 (-)NCBI
mRatBN7.2180,605,878 - 80,667,896 (-)NCBI
RefSeq Acc Id: XM_039095358   ⟹   XP_038951286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,733,736 - 89,784,211 (-)NCBI
mRatBN7.2180,605,878 - 80,656,361 (-)NCBI
RefSeq Acc Id: NP_113696   ⟸   NM_031508
- Peptide Label: precursor
- UniProtKB: Q62643 (UniProtKB/Swiss-Prot),   Q63273 (UniProtKB/Swiss-Prot),   A6J936 (UniProtKB/TrEMBL),   A0A8I6ABK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228444   ⟸   XM_006228382
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QF05 (UniProtKB/TrEMBL),   A0A8I6ABK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757111   ⟸   XM_008758889
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ABK8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027578   ⟸   ENSRNOT00000027578
RefSeq Acc Id: XP_038951250   ⟸   XM_039095322
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ABK8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951286   ⟸   XM_039095358
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000091191   ⟸   ENSRNOT00000107115
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63273-F1-model_v2 AlphaFold Q63273 1-979 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2735 AgrOrtholog
BioCyc Gene G2FUF-60406 BioCyc
Ensembl Genes ENSRNOG00000020310 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000027578 ENTREZGENE
  ENSRNOT00000107115 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  Glu/Gly-bd UniProtKB/Swiss-Prot
  Iono_rcpt_met UniProtKB/Swiss-Prot
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot
  Iontro_rcpt UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report rno:24407 UniProtKB/Swiss-Prot
NCBI Gene 24407 ENTREZGENE
PANTHER IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot
  Lig_chan UniProtKB/Swiss-Prot
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot
PharmGKB GRIK5 RGD
PhenoGen Grik5 PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020310 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot
  PBPe UniProtKB/Swiss-Prot
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot
  SSF53822 UniProtKB/Swiss-Prot
UniProt A0A8I6ABK8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QF05 ENTREZGENE, UniProtKB/TrEMBL
  A6J936 ENTREZGENE, UniProtKB/TrEMBL
  GRIK5_RAT UniProtKB/Swiss-Prot
  Q62643 ENTREZGENE
  Q63273 ENTREZGENE
UniProt Secondary Q62643 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grik5  glutamate ionotropic receptor kainate type subunit 5  Grik5  glutamate receptor, ionotropic, kainate 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Grik5  Glutamate receptor, ionotropic, kainate 5      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease allelic variants of the gene are associated with susceptibility to juvenile absence epilepsy 625595
gene_drugs antagonists (LY377770 and LY382884 ) prevent and interrupt limbic seizures induced by intra-hippocampal pilocarpine perfusion 625595
gene_function receptor for kainic acid ( a powerful convulsant) 625595
gene_process plays a role in frequency facilitation and induction of long-term potentiation (LTP) in mossy fiber pathways and in excitatory drives of inhibitory CA1 interneurons 625595