Hipk4 (homeodomain interacting protein kinase 4) - Rat Genome Database

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Gene: Hipk4 (homeodomain interacting protein kinase 4) Rattus norvegicus
Analyze
Symbol: Hipk4
Name: homeodomain interacting protein kinase 4
RGD ID: 1307541
Description: Predicted to enable histone kinase activity; protein serine/threonine kinase activity; and protein tyrosine kinase activity. Predicted to be involved in peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Predicted to act upstream of or within histone modification; protein autophosphorylation; and regulation of signal transduction by p53 class mediator. Predicted to be active in cytoplasm and nucleus. Orthologous to human HIPK4 (homeodomain interacting protein kinase 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: homeodomain-interacting protein kinase 4; LOC308449
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2182,810,708 - 82,821,080 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,810,708 - 82,821,077 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx188,213,590 - 88,223,723 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0196,700,799 - 96,711,024 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0189,969,453 - 89,979,586 (+)NCBIRnor_WKY
Rnor_6.0184,328,114 - 84,338,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,328,114 - 84,338,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0185,544,935 - 85,555,307 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,601,693 - 82,612,048 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1182,679,800 - 82,690,156 (+)NCBI
Celera177,225,371 - 77,233,912 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:18022393  


Genomics

Comparative Map Data
Hipk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2182,810,708 - 82,821,080 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,810,708 - 82,821,077 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx188,213,590 - 88,223,723 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0196,700,799 - 96,711,024 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0189,969,453 - 89,979,586 (+)NCBIRnor_WKY
Rnor_6.0184,328,114 - 84,338,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,328,114 - 84,338,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0185,544,935 - 85,555,307 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,601,693 - 82,612,048 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1182,679,800 - 82,690,156 (+)NCBI
Celera177,225,371 - 77,233,912 (+)NCBICelera
Cytogenetic Map1q21NCBI
HIPK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,379,271 - 40,390,181 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1940,379,271 - 40,390,181 (-)EnsemblGRCh38hg38GRCh38
GRCh371940,885,178 - 40,896,088 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,577,018 - 45,587,934 (-)NCBINCBI36Build 36hg18NCBI36
Build 341945,577,018 - 45,587,934NCBI
Celera1937,684,720 - 37,695,637 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1937,320,650 - 37,331,675 (-)NCBIHuRef
CHM1_11940,884,875 - 40,895,766 (-)NCBICHM1_1
T2T-CHM13v2.01943,199,897 - 43,210,807 (-)NCBIT2T-CHM13v2.0
Hipk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,222,686 - 27,230,605 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,222,692 - 27,230,600 (+)EnsemblGRCm39 Ensembl
GRCm38727,523,261 - 27,531,180 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl727,523,267 - 27,531,175 (+)EnsemblGRCm38mm10GRCm38
MGSCv37728,308,280 - 28,316,194 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36727,235,819 - 27,239,932 (+)NCBIMGSCv36mm8
Celera722,105,713 - 22,113,627 (+)NCBICelera
Cytogenetic Map7A3NCBI
Hipk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955578876,030 - 884,098 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955578876,022 - 884,098 (+)NCBIChiLan1.0ChiLan1.0
HIPK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11945,940,130 - 45,950,032 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01937,427,496 - 37,439,259 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HIPK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,297,079 - 113,304,399 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,297,258 - 113,304,101 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,699,056 - 112,706,341 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01113,895,477 - 113,902,762 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,895,619 - 113,902,464 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,454,740 - 113,462,021 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,087,236 - 113,094,521 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,081,231 - 114,088,517 (+)NCBIUU_Cfam_GSD_1.0
Hipk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,336,589 - 14,342,039 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,764,661 - 2,770,110 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366612,764,661 - 2,770,110 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIPK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,666,728 - 48,674,346 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,666,726 - 48,672,977 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,413,581 - 44,419,494 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HIPK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,834,526 - 34,848,751 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,835,059 - 34,848,138 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607312,930,020 - 12,944,332 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hipk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624925383,124 - 389,900 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624925382,368 - 391,039 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hipk4
49 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:213
Count of miRNA genes:142
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000028266
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat

Markers in Region
D1Got262  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,816,189 - 82,816,347 (+)MAPPERmRatBN7.2
Rnor_6.0184,333,596 - 84,333,753NCBIRnor6.0
Rnor_5.0185,550,417 - 85,550,574UniSTSRnor5.0
RGSC_v3.4182,607,157 - 82,607,315RGDRGSC3.4
RGSC_v3.4182,607,158 - 82,607,315UniSTSRGSC3.4
RGSC_v3.1182,685,269 - 82,685,426RGD
Celera177,229,020 - 77,229,179UniSTS
RH 3.4 Map1840.5UniSTS
RH 3.4 Map1840.5RGD
RH 2.0 Map1516.0RGD
Cytogenetic Map1q21UniSTS
RH134206  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,820,846 - 82,821,062 (+)MAPPERmRatBN7.2
Rnor_6.0184,338,253 - 84,338,468NCBIRnor6.0
Rnor_5.0185,555,074 - 85,555,289UniSTSRnor5.0
RGSC_v3.4182,611,815 - 82,612,030UniSTSRGSC3.4
Celera177,233,679 - 77,233,894UniSTS
RH 3.4 Map1830.3UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 7
Low 3 38 18 8 13 8 8 11 51 35 34 11 8
Below cutoff 5 39 33 6 33 20

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028266   ⟹   ENSRNOP00000028266
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,810,708 - 82,821,077 (+)Ensembl
Rnor_6.0 Ensembl184,328,114 - 84,338,483 (+)Ensembl
RefSeq Acc Id: NM_001024776   ⟹   NP_001019947
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2182,810,708 - 82,821,080 (+)NCBI
Rnor_6.0184,328,114 - 84,338,486 (+)NCBI
Rnor_5.0185,544,935 - 85,555,307 (+)NCBI
RGSC_v3.4182,601,693 - 82,612,048 (+)RGD
Celera177,225,371 - 77,233,912 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001019947 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98070 (Get FASTA)   NCBI Sequence Viewer  
  CAH68682 (Get FASTA)   NCBI Sequence Viewer  
  Q4V793 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001019947   ⟸   NM_001024776
- UniProtKB: Q4V793 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028266   ⟸   ENSRNOT00000028266
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V793-F1-model_v2 AlphaFold Q4V793 1-616 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689854
Promoter ID:EPDNEW_R379
Type:multiple initiation site
Name:Hipk4_1
Description:homeodomain interacting protein kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0184,328,084 - 84,328,144EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307541 AgrOrtholog
BioCyc Gene G2FUF-60305 BioCyc
Ensembl Genes ENSRNOG00000020835 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000028266 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028266 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7455473 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:308449 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116268 IMAGE-MGC_LOAD
NCBI Gene 308449 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Hipk4 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt HIPK4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Hipk4  homeodomain interacting protein kinase 4  Hipk4_predicted  homeodomain interacting protein kinase 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Hipk4_predicted  homeodomain interacting protein kinase 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED