Arhgap35 (Rho GTPase activating protein 35) - Rat Genome Database

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Gene: Arhgap35 (Rho GTPase activating protein 35) Rattus norvegicus
Analyze
Symbol: Arhgap35
Name: Rho GTPase activating protein 35
RGD ID: 1308738
Description: Enables GTPase activating protein binding activity and GTPase activator activity. Predicted to be involved in several processes, including axon development; establishment or maintenance of actin cytoskeleton polarity; and regulation of plasma membrane bounded cell projection organization. Predicted to act upstream of or within several processes, including negative regulation of Rho protein signal transduction; negative regulation of vascular permeability; and nervous system development. Predicted to be located in actin cytoskeleton; ciliary basal body; and cytoplasm. Predicted to be active in cytosol. Orthologous to human ARHGAP35 (Rho GTPase activating protein 35); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; platelet-derived growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GAP-associated protein p190; glucocorticoid receptor DNA binding factor 1; glucocorticoid receptor DNA-binding factor 1; Grlf1; LOC306400; p190RhoGAP; rho GTPase-activating protein 35
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Grlf1-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,330,566 - 86,447,414 (-)NCBIGRCr8
mRatBN7.2177,202,436 - 77,319,298 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,202,436 - 77,319,298 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,576,527 - 82,693,394 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,140,568 - 91,257,426 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,331,623 - 84,448,478 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,456,409 - 78,573,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,456,409 - 78,573,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0179,703,650 - 79,820,568 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,757,031 - 76,824,155 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11628,093,164 - 28,259,729 (+)NCBI
Celera171,687,713 - 71,804,603 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein. Moran MF, etal., Mol Cell Biol. 1991 Apr;11(4):1804-12.
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. The function of the p190 Rho GTPase-activating protein is controlled by its N-terminal GTP binding domain. Tatsis N, etal., J Biol Chem. 1998 Dec 18;273(51):34631-8.
Additional References at PubMed
PMID:1581965   PMID:1894621   PMID:7503985   PMID:11044403   PMID:11283609   PMID:15084284   PMID:15280098   PMID:16188938   PMID:16971514   PMID:17562701   PMID:18267090   PMID:18502760  
PMID:19540230   PMID:19632305   PMID:19673492   PMID:20439493   PMID:21945077   PMID:22357865   PMID:23595732   PMID:26859289   PMID:27212270   PMID:27646271   PMID:30174148  


Genomics

Comparative Map Data
Arhgap35
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,330,566 - 86,447,414 (-)NCBIGRCr8
mRatBN7.2177,202,436 - 77,319,298 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,202,436 - 77,319,298 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,576,527 - 82,693,394 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,140,568 - 91,257,426 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,331,623 - 84,448,478 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,456,409 - 78,573,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,456,409 - 78,573,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0179,703,650 - 79,820,568 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,757,031 - 76,824,155 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11628,093,164 - 28,259,729 (+)NCBI
Celera171,687,713 - 71,804,603 (-)NCBICelera
Cytogenetic Map1q21NCBI
ARHGAP35
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,860,997 - 47,005,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1946,860,997 - 47,005,077 (+)EnsemblGRCh38hg38GRCh38
GRCh371947,364,254 - 47,508,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361952,113,773 - 52,200,174 (+)NCBINCBI36Build 36hg18NCBI36
Celera1944,226,291 - 44,312,689 (+)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,846,727 - 43,932,756 (+)NCBIHuRef
CHM1_11947,423,799 - 47,510,216 (+)NCBICHM1_1
T2T-CHM13v2.01949,686,835 - 49,830,977 (+)NCBIT2T-CHM13v2.0
Arhgap35
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,228,398 - 16,349,313 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,227,644 - 16,348,918 (-)EnsemblGRCm39 Ensembl
GRCm38716,494,473 - 16,614,993 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,493,719 - 16,614,993 (-)EnsemblGRCm38mm10GRCm38
MGSCv37717,079,822 - 17,200,342 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36715,653,561 - 15,773,515 (-)NCBIMGSCv36mm8
Celera713,691,036 - 13,812,194 (-)NCBICelera
Cytogenetic Map7A2NCBI
cM Map79.15NCBI
Arhgap35
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574915,325 - 984,744 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955574915,604 - 984,744 (+)NCBIChiLan1.0ChiLan1.0
ARHGAP35
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22053,006,784 - 53,151,982 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11954,878,676 - 55,023,271 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01943,850,692 - 43,994,487 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11952,435,379 - 52,521,104 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,435,379 - 52,521,104 (+)Ensemblpanpan1.1panPan2
ARHGAP35
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11108,952,836 - 109,034,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1108,952,562 - 109,034,337 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,432,475 - 108,561,300 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01109,473,916 - 109,607,035 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,476,089 - 109,607,038 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,144,987 - 109,284,705 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01108,789,454 - 108,918,490 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,657,989 - 109,786,942 (-)NCBIUU_Cfam_GSD_1.0
Arhgap35
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934919,095,903 - 19,170,964 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936664713,984 - 789,344 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936664714,036 - 788,584 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP35
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,711,901 - 52,841,288 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,711,463 - 52,841,295 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2648,200,461 - 48,215,323 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP35
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,264,466 - 40,353,157 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl640,205,892 - 40,353,280 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607319,911,593 - 20,059,133 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap35
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,650,383 - 6,719,786 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248326,650,383 - 6,773,828 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgap35
416 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:82
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000021223
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat

Markers in Region
BF405601  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21625,345,625 - 25,345,818 (+)MAPPERmRatBN7.2
Rnor_6.01627,233,388 - 27,233,580NCBIRnor6.0
Rnor_5.01627,104,254 - 27,104,446UniSTSRnor5.0
RGSC_v3.41628,259,238 - 28,259,430UniSTSRGSC3.4
Celera1625,424,195 - 25,424,387UniSTS
RH 3.4 Map16310.9UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map1q21UniSTS
RH139289  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,215,083 - 77,215,205 (+)MAPPERmRatBN7.2
Rnor_6.0178,469,056 - 78,469,177NCBIRnor6.0
Rnor_5.0179,716,297 - 79,716,418UniSTSRnor5.0
RGSC_v3.4176,769,659 - 76,769,780UniSTSRGSC3.4
Celera171,700,199 - 71,700,320UniSTS
RH 3.4 Map1789.5UniSTS
Cytogenetic Map1q21UniSTS
WI-9140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21625,345,291 - 25,345,401 (+)MAPPERmRatBN7.2
mRatBN7.2177,251,899 - 77,251,999 (-)MAPPERmRatBN7.2
Rnor_6.01627,233,054 - 27,233,163NCBIRnor6.0
Rnor_5.01627,103,920 - 27,104,029UniSTSRnor5.0
RGSC_v3.41628,258,904 - 28,259,013UniSTSRGSC3.4
Celera1625,423,861 - 25,423,970UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map1q21UniSTS
RH132160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,202,653 - 77,202,835 (+)MAPPERmRatBN7.2
Rnor_6.0178,456,627 - 78,456,808NCBIRnor6.0
Rnor_5.0179,703,868 - 79,704,049UniSTSRnor5.0
RGSC_v3.4176,754,454 - 76,754,635UniSTSRGSC3.4
Celera171,687,931 - 71,688,112UniSTS
RH 3.4 Map1769.8UniSTS
Cytogenetic Map1q21UniSTS
RH134350  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,203,095 - 77,203,276 (+)MAPPERmRatBN7.2
mRatBN7.21625,348,423 - 25,348,604 (+)MAPPERmRatBN7.2
Rnor_6.01627,236,186 - 27,236,366NCBIRnor6.0
Rnor_6.0178,457,069 - 78,457,249NCBIRnor6.0
Rnor_5.01627,107,052 - 27,107,232UniSTSRnor5.0
Rnor_5.0179,704,310 - 79,704,490UniSTSRnor5.0
RGSC_v3.4176,754,896 - 76,755,076UniSTSRGSC3.4
RGSC_v3.41628,262,036 - 28,262,216UniSTSRGSC3.4
Celera1625,426,994 - 25,427,174UniSTS
Celera171,688,373 - 71,688,553UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map16p13UniSTS
BE110269  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21625,346,773 - 25,346,947 (-)MAPPERmRatBN7.2
mRatBN7.21625,346,773 - 25,346,947 (+)MAPPERmRatBN7.2
mRatBN7.2177,204,783 - 77,204,957 (-)MAPPERmRatBN7.2
mRatBN7.2177,204,783 - 77,204,957 (+)MAPPERmRatBN7.2
Rnor_6.0178,458,757 - 78,458,930NCBIRnor6.0
Rnor_6.01627,234,536 - 27,234,709NCBIRnor6.0
Rnor_5.0179,705,998 - 79,706,171UniSTSRnor5.0
Rnor_5.01627,105,402 - 27,105,575UniSTSRnor5.0
RGSC_v3.4176,756,584 - 76,756,757UniSTSRGSC3.4
RGSC_v3.41628,260,386 - 28,260,559UniSTSRGSC3.4
Celera1625,425,343 - 25,425,516UniSTS
Celera171,690,061 - 71,690,234UniSTS
RH 3.4 Map16297.41UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map1q21UniSTS
RH135367  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,290,998 - 77,291,200 (+)MAPPERmRatBN7.2
Rnor_6.0178,544,961 - 78,545,162NCBIRnor6.0
Rnor_5.0179,792,202 - 79,792,403UniSTSRnor5.0
RGSC_v3.4176,847,422 - 76,847,623UniSTSRGSC3.4
Celera171,776,347 - 71,776,548UniSTS
RH 3.4 Map1790.7UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 3 3 74 35 41 11 3
Low 1 5 8 5
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000021223   ⟹   ENSRNOP00000021223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl178,459,543 - 78,521,999 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090519   ⟹   ENSRNOP00000075649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,202,436 - 77,319,298 (-)Ensembl
Rnor_6.0 Ensembl178,456,409 - 78,573,374 (-)Ensembl
RefSeq Acc Id: NM_001271132   ⟹   NP_001258061
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,330,566 - 86,447,414 (-)NCBI
mRatBN7.2177,202,436 - 77,319,298 (-)NCBI
Rnor_6.0178,456,409 - 78,573,374 (-)NCBI
Rnor_5.0179,703,650 - 79,820,568 (-)NCBI
Celera171,687,713 - 71,804,603 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758919   ⟹   XP_008757141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,331,094 - 86,447,051 (-)NCBI
mRatBN7.2177,202,452 - 77,292,695 (-)NCBI
Rnor_6.0178,456,637 - 78,546,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039110038   ⟹   XP_038965966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,331,094 - 86,447,050 (-)NCBI
mRatBN7.2177,202,506 - 77,318,980 (-)NCBI
RefSeq Acc Id: XM_063288062   ⟹   XP_063144132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,331,094 - 86,447,050 (-)NCBI
RefSeq Acc Id: XM_063288066   ⟹   XP_063144136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,331,094 - 86,447,050 (-)NCBI
RefSeq Acc Id: NP_001258061   ⟸   NM_001271132
- UniProtKB: A0A0G2KB46 (UniProtKB/Swiss-Prot),   P81128 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008757141   ⟸   XM_008758919
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KB46 (UniProtKB/Swiss-Prot),   P81128 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021223   ⟸   ENSRNOT00000021223
RefSeq Acc Id: ENSRNOP00000075649   ⟸   ENSRNOT00000090519
RefSeq Acc Id: XP_038965966   ⟸   XM_039110038
- Peptide Label: isoform X1
- UniProtKB: P81128 (UniProtKB/Swiss-Prot),   A0A0G2KB46 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063144132   ⟸   XM_063288062
- Peptide Label: isoform X1
- UniProtKB: P81128 (UniProtKB/Swiss-Prot),   A0A0G2KB46 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063144136   ⟸   XM_063288066
- Peptide Label: isoform X1
- UniProtKB: P81128 (UniProtKB/Swiss-Prot),   A0A0G2KB46 (UniProtKB/Swiss-Prot)
Protein Domains
FF   pG1 pseudoGTPase   pG2 pseudoGTPase   Rho-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P81128-F1-model_v2 AlphaFold P81128 1-1499 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689733
Promoter ID:EPDNEW_R258
Type:multiple initiation site
Name:Arhgap35_1
Description:Rho GTPase activating protein 35
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R259  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,572,988 - 78,573,048EPDNEW
RGD ID:13689734
Promoter ID:EPDNEW_R259
Type:multiple initiation site
Name:Arhgap35_2
Description:Rho GTPase activating protein 35
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R258  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,573,386 - 78,573,446EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308738 AgrOrtholog
BioCyc Gene G2FUF-60607 BioCyc
Ensembl Genes ENSRNOG00000015852 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055017051 UniProtKB/Swiss-Prot
  ENSRNOG00060021410 UniProtKB/Swiss-Prot
  ENSRNOG00065031476 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000090519 ENTREZGENE
  ENSRNOT00000090519.2 UniProtKB/Swiss-Prot
  ENSRNOT00055028949 UniProtKB/Swiss-Prot
  ENSRNOT00060037074 UniProtKB/Swiss-Prot
  ENSRNOT00065054241 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.440 UniProtKB/Swiss-Prot
  1.10.555.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro FF_domain UniProtKB/Swiss-Prot
  FF_domain_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  pG1 UniProtKB/Swiss-Prot
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot
  RhoGAP-FF1 UniProtKB/Swiss-Prot
  RhoGAP_dom UniProtKB/Swiss-Prot
  RhoGAP_pG1_pG2 UniProtKB/Swiss-Prot
  RhoGAP_pG2 UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
KEGG Report rno:306400 UniProtKB/Swiss-Prot
NCBI Gene 306400 ENTREZGENE
PANTHER RHO GTPASE-ACTIVATING PROTEIN 190 UniProtKB/Swiss-Prot
  RHO GTPASE-ACTIVATING PROTEIN 35 UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
  RhoGAP UniProtKB/Swiss-Prot
  RhoGAP-FF1 UniProtKB/Swiss-Prot
  RhoGAP_pG1_pG2 UniProtKB/Swiss-Prot
PhenoGen Arhgap35 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE PG1 UniProtKB/Swiss-Prot
  PG2 UniProtKB/Swiss-Prot
  PS51676 UniProtKB/Swiss-Prot
  RHOGAP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015852 RatGTEx
  ENSRNOG00055017051 RatGTEx
  ENSRNOG00060021410 RatGTEx
  ENSRNOG00065031476 RatGTEx
SMART RhoGAP UniProtKB/Swiss-Prot
  SM00441 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48350 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  SSF81698 UniProtKB/Swiss-Prot
UniProt A0A0G2KB46 ENTREZGENE
  P81128 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A0G2KB46 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Arhgap35  Rho GTPase activating protein 35  Grlf1  glucocorticoid receptor DNA binding factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-17 Grlf1  glucocorticoid receptor DNA binding factor 1   LOC686520  similar to Glucocorticoid receptor DNA-binding factor 1 (GAP-associated protein p190)  Data merged from RGD:1596377 1643240 APPROVED
2008-04-30 Grlf1  glucocorticoid receptor DNA binding factor 1   Grlf1_predicted  glucocorticoid receptor DNA binding factor 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC686520  similar to Glucocorticoid receptor DNA-binding factor 1 (GAP-associated protein p190)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Grlf1_predicted  glucocorticoid receptor DNA binding factor 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED