Arhgap35 (Rho GTPase activating protein 35) - Rat Genome Database
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Gene: Arhgap35 (Rho GTPase activating protein 35) Rattus norvegicus
Analyze
Symbol: Arhgap35
Name: Rho GTPase activating protein 35
RGD ID: 1308738
Description: Exhibits GTPase activating protein binding activity and GTPase activator activity. Involved in positive regulation of GTPase activity. Localizes to cytosol. Orthologous to human ARHGAP35 (Rho GTPase activating protein 35); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; platelet-derived growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: GAP-associated protein p190; glucocorticoid receptor DNA binding factor 1; glucocorticoid receptor DNA-binding factor 1; Grlf1; LOC306400; p190RhoGAP; rho GTPase-activating protein 35
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Grlf1-ps1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2177,202,436 - 77,319,298 (-)NCBI
Rnor_6.0 Ensembl178,456,409 - 78,573,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0178,456,409 - 78,573,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0179,703,650 - 79,820,568 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,757,031 - 76,824,155 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11628,093,164 - 28,259,729 (+)NCBI
Celera171,687,713 - 71,804,603 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cytoskeleton  (IEA,ISO)
ciliary basal body  (IEA,ISO,ISS)
cytoplasm  (IEA,ISO)
cytosol  (IDA)
nucleus  (IEA)
plasma membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1581965   PMID:1894621   PMID:7503985   PMID:11044403   PMID:11283609   PMID:15084284   PMID:15280098   PMID:16188938   PMID:16971514   PMID:17562701   PMID:18267090   PMID:18502760  
PMID:19540230   PMID:19632305   PMID:19673492   PMID:20439493   PMID:21945077   PMID:22357865   PMID:23595732   PMID:26859289   PMID:27212270   PMID:27646271   PMID:30174148  


Genomics

Comparative Map Data
Arhgap35
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2177,202,436 - 77,319,298 (-)NCBI
Rnor_6.0 Ensembl178,456,409 - 78,573,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0178,456,409 - 78,573,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0179,703,650 - 79,820,568 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,757,031 - 76,824,155 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11628,093,164 - 28,259,729 (+)NCBI
Celera171,687,713 - 71,804,603 (-)NCBICelera
Cytogenetic Map1q21NCBI
ARHGAP35
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1946,860,997 - 47,005,077 (+)EnsemblGRCh38hg38GRCh38
GRCh381946,860,997 - 47,005,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371947,364,254 - 47,508,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361952,113,773 - 52,200,174 (+)NCBINCBI36hg18NCBI36
Celera1944,226,291 - 44,312,689 (+)NCBI
Cytogenetic Map19q13.32NCBI
HuRef1943,846,727 - 43,932,756 (+)NCBIHuRef
CHM1_11947,423,799 - 47,510,216 (+)NCBICHM1_1
Arhgap35
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,228,398 - 16,349,313 (-)NCBIGRCm39mm39
GRCm39 Ensembl716,227,644 - 16,348,918 (-)Ensembl
GRCm38716,494,473 - 16,614,993 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,493,719 - 16,614,993 (-)EnsemblGRCm38mm10GRCm38
MGSCv37717,079,822 - 17,200,342 (-)NCBIGRCm37mm9NCBIm37
MGSCv36715,653,561 - 15,773,515 (-)NCBImm8
Celera713,691,036 - 13,812,194 (-)NCBICelera
Cytogenetic Map7A2NCBI
Arhgap35
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574915,325 - 984,744 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955574915,604 - 984,744 (+)NCBIChiLan1.0ChiLan1.0
ARHGAP35
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11952,435,379 - 52,521,104 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,435,379 - 52,521,104 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01943,850,692 - 43,994,487 (+)NCBIMhudiblu_PPA_v0panPan3
ARHGAP35
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1108,952,562 - 109,034,337 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11108,952,836 - 109,034,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Arhgap35
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936664714,036 - 788,584 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP35
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,711,901 - 52,841,288 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,711,463 - 52,841,295 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2648,200,461 - 48,215,323 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP35
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,264,466 - 40,353,157 (+)NCBI
ChlSab1.1 Ensembl640,205,892 - 40,353,280 (+)Ensembl
Arhgap35
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248326,650,383 - 6,773,828 (-)NCBI

Position Markers
BF405601  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01627,233,388 - 27,233,580NCBIRnor6.0
Rnor_5.01627,104,254 - 27,104,446UniSTSRnor5.0
RGSC_v3.41628,259,238 - 28,259,430UniSTSRGSC3.4
Celera1625,424,195 - 25,424,387UniSTS
RH 3.4 Map16310.9UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map1q21UniSTS
RH139289  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0178,469,056 - 78,469,177NCBIRnor6.0
Rnor_5.0179,716,297 - 79,716,418UniSTSRnor5.0
RGSC_v3.4176,769,659 - 76,769,780UniSTSRGSC3.4
Celera171,700,199 - 71,700,320UniSTS
RH 3.4 Map1789.5UniSTS
Cytogenetic Map1q21UniSTS
WI-9140  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01627,233,054 - 27,233,163NCBIRnor6.0
Rnor_5.01627,103,920 - 27,104,029UniSTSRnor5.0
RGSC_v3.41628,258,904 - 28,259,013UniSTSRGSC3.4
Celera1625,423,861 - 25,423,970UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map1q21UniSTS
RH132160  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0178,456,627 - 78,456,808NCBIRnor6.0
Rnor_5.0179,703,868 - 79,704,049UniSTSRnor5.0
RGSC_v3.4176,754,454 - 76,754,635UniSTSRGSC3.4
Celera171,687,931 - 71,688,112UniSTS
RH 3.4 Map1769.8UniSTS
Cytogenetic Map1q21UniSTS
RH134350  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0178,457,069 - 78,457,249NCBIRnor6.0
Rnor_6.01627,236,186 - 27,236,366NCBIRnor6.0
Rnor_5.01627,107,052 - 27,107,232UniSTSRnor5.0
Rnor_5.0179,704,310 - 79,704,490UniSTSRnor5.0
RGSC_v3.41628,262,036 - 28,262,216UniSTSRGSC3.4
RGSC_v3.4176,754,896 - 76,755,076UniSTSRGSC3.4
Celera1625,426,994 - 25,427,174UniSTS
Celera171,688,373 - 71,688,553UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map16p13UniSTS
BE110269  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01627,234,536 - 27,234,709NCBIRnor6.0
Rnor_6.0178,458,757 - 78,458,930NCBIRnor6.0
Rnor_5.01627,105,402 - 27,105,575UniSTSRnor5.0
Rnor_5.0179,705,998 - 79,706,171UniSTSRnor5.0
RGSC_v3.41628,260,386 - 28,260,559UniSTSRGSC3.4
RGSC_v3.4176,756,584 - 76,756,757UniSTSRGSC3.4
Celera171,690,061 - 71,690,234UniSTS
Celera1625,425,343 - 25,425,516UniSTS
RH 3.4 Map16297.41UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map1q21UniSTS
RH135367  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0178,544,961 - 78,545,162NCBIRnor6.0
Rnor_5.0179,792,202 - 79,792,403UniSTSRnor5.0
RGSC_v3.4176,847,422 - 76,847,623UniSTSRGSC3.4
Celera171,776,347 - 71,776,548UniSTS
RH 3.4 Map1790.7UniSTS
Cytogenetic Map1q21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)125439386904217Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15655769122614963Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1565577285706974Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11131448983657083Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11131448983657083Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11131448983657083Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11131448983657083Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123406428108057505Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)12429779978748000Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)125951907130917265Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13148945479689689Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13444911279449112Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13444911279449112Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13537750894364229Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13585416780854167Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13585416780854167Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13585416780854167Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13603316579689689Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13603316579689689Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14190724986907249Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143579208126240667Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143579208126240667Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143579208126240667Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143579208126240667Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143579208126240667Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14611346179689689Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)149147799156446783Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14954732883657083Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14957857794578577Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15052271494225616Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15385134883657083Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15385134883657083Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157761301104391981Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)158209327103209327Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)158354072161711996Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)164588516125875986Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)166113339122614963Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)16722768394201552Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:82
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000021223
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 3 3 74 35 41 11 3
Low 1 5 8 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021223   ⟹   ENSRNOP00000021223
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl178,459,543 - 78,521,999 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090519   ⟹   ENSRNOP00000075649
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl178,456,409 - 78,573,374 (-)Ensembl
RefSeq Acc Id: NM_001271132   ⟹   NP_001258061
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2177,202,436 - 77,319,298 (-)NCBI
Rnor_6.0178,456,409 - 78,573,374 (-)NCBI
Rnor_5.0179,703,650 - 79,820,568 (-)NCBI
Celera171,687,713 - 71,804,603 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006228412   ⟹   XP_006228474
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2177,202,452 - 77,274,128 (-)NCBI
Rnor_6.0178,456,637 - 78,528,912 (-)NCBI
Rnor_5.0179,703,650 - 79,820,568 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008758919   ⟹   XP_008757141
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2177,202,452 - 77,292,695 (-)NCBI
Rnor_6.0178,456,637 - 78,546,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039110038   ⟹   XP_038965966
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2177,202,506 - 77,318,980 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001258061 (Get FASTA)   NCBI Sequence Viewer  
  XP_006228474 (Get FASTA)   NCBI Sequence Viewer  
  XP_008757141 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965966 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein P81128 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001258061   ⟸   NM_001271132
- UniProtKB: P81128 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006228474   ⟸   XM_006228412
- Peptide Label: isoform X1
- UniProtKB: P81128 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008757141   ⟸   XM_008758919
- Peptide Label: isoform X1
- UniProtKB: P81128 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021223   ⟸   ENSRNOT00000021223
RefSeq Acc Id: ENSRNOP00000075649   ⟸   ENSRNOT00000090519
RefSeq Acc Id: XP_038965966   ⟸   XM_039110038
- Peptide Label: isoform X1
Protein Domains
FF   pG1 pseudoGTPase   pG2 pseudoGTPase   Rho-GAP

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689733
Promoter ID:EPDNEW_R258
Type:multiple initiation site
Name:Arhgap35_1
Description:Rho GTPase activating protein 35
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R259  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,572,988 - 78,573,048EPDNEW
RGD ID:13689734
Promoter ID:EPDNEW_R259
Type:multiple initiation site
Name:Arhgap35_2
Description:Rho GTPase activating protein 35
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R258  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,573,386 - 78,573,446EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308738 AgrOrtholog
Ensembl Genes ENSRNOG00000015852 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021223 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000075649 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021223 UniProtKB/TrEMBL
  ENSRNOT00000090519 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FF_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FF_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  pG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP-FF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_pG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:306400 UniProtKB/Swiss-Prot
NCBI Gene 306400 ENTREZGENE
Pfam PF01846 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP-FF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arhgap35 PhenoGen
PROSITE PG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS51676 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00441 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81698 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D4AD82_RAT UniProtKB/TrEMBL
  P81128 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A0G2KB46 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Arhgap35  Rho GTPase activating protein 35  Grlf1  glucocorticoid receptor DNA binding factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-17 Grlf1  glucocorticoid receptor DNA binding factor 1   LOC686520  similar to Glucocorticoid receptor DNA-binding factor 1 (GAP-associated protein p190)  Data Merged 1643240 APPROVED
2008-04-30 Grlf1  glucocorticoid receptor DNA binding factor 1   Grlf1_predicted  glucocorticoid receptor DNA binding factor 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC686520  similar to Glucocorticoid receptor DNA-binding factor 1 (GAP-associated protein p190)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Grlf1_predicted  glucocorticoid receptor DNA binding factor 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED