Klk1c9 (kallikrein 1-related peptidase C9) - Rat Genome Database

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Gene: Klk1c9 (kallikrein 1-related peptidase C9) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Klk1c9
Name: kallikrein 1-related peptidase C9
RGD ID: 727805
Description: Predicted to enable serine-type endopeptidase activity. Involved in positive regulation of vasoconstriction. Predicted to be active in secretory granule. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to several human genes including KLK1 (kallikrein 1); INTERACTS WITH aristolochic acid; cyclosporin A; diuron.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kallikrein a2; kallikrein, submaxillary gland S3; KLK-S3; Klk9; Klks3; Klna2; LOC292868; rGK-9; rK9; S3 kallikrein; SEV; submandibular enzymatic vasoconstrictor; submandibular glandular kallikrein-9; submaxillary gland S3 kallikrein; tissue kallikrein
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2194,597,359 - 94,601,245 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,597,359 - 94,601,245 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,982,736 - 99,986,626 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01108,455,371 - 108,459,259 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01101,746,010 - 101,749,912 (+)NCBIRnor_WKY
Rnor_6.01100,086,520 - 100,090,406 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,059,967 - 100,203,329 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,151,631 - 101,155,517 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,579,471 - 94,583,357 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1194,657,581 - 94,661,468 (+)NCBI
Celera188,864,237 - 88,868,123 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide sequences of four distinct types including tonin. Ashley PL and MacDonald RJ, Biochemistry 1985 Aug 13;24(17):4512-20.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat. Iwai N, etal., Hypertension 2005 May;45(5):947-53. Epub 2005 Apr 4.
4. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9. A novel serine protease with vasoconstrictor activity coded by the kallikrein gene S3. Yamaguchi T, etal., J Biol Chem 1991 Mar 15;266(8):5011-7.
Additional References at PubMed
PMID:1315752   PMID:1536657   PMID:15203212   PMID:15489334   PMID:17366701  


Genomics

Variants

.
Variants in Klk1c9
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:79
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000025723
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat

Markers in Region
D1Mit20  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01100,372,157 - 100,372,331NCBIRnor5.0
Rnor_5.01101,154,236 - 101,154,356NCBIRnor5.0
Rnor_5.01100,934,189 - 100,934,363NCBIRnor5.0
Rnor_5.01100,934,188 - 100,934,363NCBIRnor5.0
Rnor_5.01100,372,156 - 100,372,331NCBIRnor5.0
Rnor_5.01101,154,235 - 101,154,356NCBIRnor5.0
RGSC_v3.4194,582,077 - 94,582,196UniSTSRGSC3.4
RGSC_v3.4194,582,076 - 94,582,196RGDRGSC3.4
RGSC_v3.4194,356,875 - 94,357,049RGDRGSC3.4
RGSC_v3.4194,356,876 - 94,357,049UniSTSRGSC3.4
RGSC_v3.1194,660,187 - 94,660,307RGD
Celera188,866,843 - 88,866,962UniSTS
Celera188,646,815 - 88,646,988UniSTS
RH 3.4 Map1905.2RGD
RH 3.4 Map1905.2UniSTS
Cytogenetic Map1q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 3 27 5
Low 1 6 6 8 6 5 6 4 15 5
Below cutoff 15 17 5 8 5 3 5 16 4 16 9 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025723   ⟹   ENSRNOP00000025723
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl194,597,359 - 94,601,245 (+)Ensembl
Rnor_6.0 Ensembl1100,086,520 - 100,090,406 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000025831   ⟹   ENSRNOP00000025831
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1100,199,057 - 100,203,260 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000071416   ⟹   ENSRNOP00000066004
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1100,131,562 - 100,135,556 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081095   ⟹   ENSRNOP00000070080
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1100,059,967 - 100,135,673 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091964   ⟹   ENSRNOP00000073798
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1100,131,449 - 100,203,329 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103423   ⟹   ENSRNOP00000096240
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl194,598,861 - 94,601,245 (+)Ensembl
RefSeq Acc Id: NM_175759   ⟹   NP_786935
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2194,597,359 - 94,601,245 (+)NCBI
Rnor_6.01100,086,520 - 100,090,406 (+)NCBI
Rnor_5.01101,151,631 - 101,155,517 (+)NCBI
RGSC_v3.4194,579,471 - 94,583,357 (+)RGD
Celera188,864,237 - 88,868,123 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_786935 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41467 (Get FASTA)   NCBI Sequence Viewer  
  AAH61771 (Get FASTA)   NCBI Sequence Viewer  
  EDM07521 (Get FASTA)   NCBI Sequence Viewer  
  P07647 (Get FASTA)   NCBI Sequence Viewer  
  SFW93258 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_786935   ⟸   NM_175759
- Peptide Label: precursor
- UniProtKB: P07647 (UniProtKB/Swiss-Prot),   A0A1R3UCK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066004   ⟸   ENSRNOT00000071416
RefSeq Acc Id: ENSRNOP00000070080   ⟸   ENSRNOT00000081095
RefSeq Acc Id: ENSRNOP00000025723   ⟸   ENSRNOT00000025723
RefSeq Acc Id: ENSRNOP00000025831   ⟸   ENSRNOT00000025831
RefSeq Acc Id: ENSRNOP00000073798   ⟸   ENSRNOT00000091964
RefSeq Acc Id: ENSRNOP00000096240   ⟸   ENSRNOT00000103423
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07647-F1-model_v2 AlphaFold P07647 1-259 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689993
Promoter ID:EPDNEW_R517
Type:multiple initiation site
Name:Klk1b3_2
Description:kallikrein 1-related peptidase B3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R518  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01100,086,514 - 100,086,574EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727805 AgrOrtholog
BioCyc Gene G2FUF-59801 BioCyc
Ensembl Genes ENSRNOG00000032857 Ensembl
  ENSRNOG00000067884 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025723 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000096240.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025723 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000103423.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621994 IMAGE-MGC_LOAD
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:292868 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72263 IMAGE-MGC_LOAD
NCBI Gene 292868 ENTREZGENE
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klk1c9 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1R3UCK3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASZ7_RAT UniProtKB/TrEMBL
  KLK9_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-06-29 Klk1c9  kallikrein 1-related peptidase C9  Klks3  kallikrein, submaxillary gland S3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Klks3  kallikrein, submaxillary gland S3  LOC292868  submaxillary gland S3 kallikrein  Symbol and Name updated 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the submaxillary gland and prostate 1302426
gene_homology protein is 84% homologous to rat submaxillary tonin 633345
gene_protein 29 kDa protein appears to consist of an approximately 19.9 kDa heavy chain and 10.7 kDa light chain, possibly as a result of post-translational peptide cleavage; the pI of the disulfide bonded heterodimer is 7.36 1302426