Ncr3lg1 (natural killer cell cytotoxicity receptor 3 ligand 1) - Rat Genome Database

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Gene: Ncr3lg1 (natural killer cell cytotoxicity receptor 3 ligand 1) Rattus norvegicus
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Symbol: Ncr3lg1
Name: natural killer cell cytotoxicity receptor 3 ligand 1
RGD ID: 1588614
Description: Predicted to be located in membrane. Orthologous to human NCR3LG1 (natural killer cell cytotoxicity receptor 3 ligand 1); INTERACTS WITH bisphenol A; 17beta-estradiol (ortholog); 2-palmitoylglycerol (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: B7H6; LOC691092; natural cytotoxicity triggering receptor 3 ligand 1; similar to major histocompatibility complex class II integral membrane alpha chain gene
RGD Orthologs
Human
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,701,953 - 105,718,251 (+)NCBIGRCr8
mRatBN7.2196,565,664 - 96,581,825 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,574,455 - 96,580,466 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01102,078,274 - 102,093,495 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01103,162,093 - 103,177,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,589,432 - 96,604,763 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera190,816,645 - 90,832,290 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:30512185  


Genomics

Comparative Map Data
Ncr3lg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,701,953 - 105,718,251 (+)NCBIGRCr8
mRatBN7.2196,565,664 - 96,581,825 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,574,455 - 96,580,466 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01102,078,274 - 102,093,495 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01103,162,093 - 103,177,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,589,432 - 96,604,763 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera190,816,645 - 90,832,290 (+)NCBICelera
Cytogenetic Map1q22NCBI
NCR3LG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,351,800 - 17,381,661 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,351,800 - 17,377,341 (+)EnsemblGRCh38hg38GRCh38
GRCh371117,373,347 - 17,398,888 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,328,796 - 17,355,464 (+)NCBINCBI36Build 36hg18NCBI36
Celera1117,503,148 - 17,528,717 (+)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,057,164 - 17,082,694 (+)NCBIHuRef
CHM1_11117,372,834 - 17,398,672 (+)NCBICHM1_1
T2T-CHM13v2.01117,449,460 - 17,474,942 (+)NCBIT2T-CHM13v2.0
NCR3LG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2919,684,856 - 19,715,295 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11119,645,278 - 19,677,591 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,392,121 - 17,431,977 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,092,587 - 17,117,870 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,092,843 - 17,113,137 (+)Ensemblpanpan1.1panPan2
NCR3LG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12139,929,041 - 39,948,146 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2139,928,667 - 39,947,879 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2139,429,318 - 39,448,363 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02141,034,770 - 41,053,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,034,746 - 41,054,778 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,047,348 - 40,067,504 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,254,813 - 40,274,951 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,593,669 - 40,613,650 (+)NCBIUU_Cfam_GSD_1.0
Ncr3lg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,659,489 - 45,679,480 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365281,693,469 - 1,714,133 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCR3LG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1147,599,091 - 47,619,120 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,599,091 - 47,618,894 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038145,024,987 - 145,050,435 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ncr3lg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247668,990,525 - 9,006,301 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ncr3lg1
71 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000110312   ⟹   ENSRNOP00000080745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,574,455 - 96,580,466 (+)Ensembl
RefSeq Acc Id: XM_017590129   ⟹   XP_017445618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,701,953 - 105,718,251 (+)NCBI
mRatBN7.2196,565,664 - 96,581,825 (+)NCBI
Rnor_6.01102,078,274 - 102,093,495 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039100956   ⟹   XP_038956884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,701,953 - 105,714,688 (+)NCBI
mRatBN7.2196,565,664 - 96,577,186 (+)NCBI
Protein Sequences
Protein RefSeqs XP_017445618 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956884 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AZL41142 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080745
  ENSRNOP00000080745.1
RefSeq Acc Id: XP_017445618   ⟸   XM_017590129
- Peptide Label: isoform X2
- UniProtKB: A0A3S8TKZ2 (UniProtKB/TrEMBL),   A0A8I5ZRI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038956884   ⟸   XM_039100956
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000080745   ⟸   ENSRNOT00000110312
Protein Domains
Ig-like

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588614 AgrOrtholog
BioCyc Gene G2FUF-59635 BioCyc
Ensembl Genes ENSRNOG00000070704 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000110312.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
KEGG Report rno:691092 UniProtKB/TrEMBL
NCBI Gene 691092 ENTREZGENE
PANTHER NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3 LIGAND 1 UniProtKB/TrEMBL
  TAPASIN UniProtKB/TrEMBL
Pfam C1-set UniProtKB/TrEMBL
PhenoGen Ncr3lg1 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000070704 RatGTEx
SMART IGc1 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A3S8TKZ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZRI3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Ncr3lg1  natural killer cell cytotoxicity receptor 3 ligand 1  Ncr3lg1  natural killer cell cytotoxicity receptor 3 ligand 1  Data merged from RGD:149736330 737654 PROVISIONAL
2021-08-09 Ncr3lg1  natural killer cell cytotoxicity receptor 3 ligand 1      Symbol and Name status set to provisional 45752 PROVISIONAL
2013-07-18 Ncr3lg1  natural killer cell cytotoxicity receptor 3 ligand 1  LOC691092  similar to major histocompatibility complex class II integral membrane alpha chain gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC691092  similar to major histocompatibility complex class II integral membrane alpha chain gene      Symbol and Name status set to provisional 70820 PROVISIONAL