Ehd2 (EH-domain containing 2) - Rat Genome Database

Name: Ehd2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Ehd2 (EH-domain containing 2) Rattus norvegicus

Analyze

Symbol:

Ehd2

Name:

EH-domain containing 2

RGD ID:

1560856

Description:

Predicted to enable identical protein binding activity and protein domain specific binding activity. Predicted to be involved in several processes, including plasma membrane tubulation; positive regulation of endocytic recycling; and positive regulation of myoblast fusion. Predicted to act upstream of or within cortical actin cytoskeleton organization. Predicted to be located in several cellular components, including caveola; intercellular bridge; and microtubule cytoskeleton. Predicted to be active in cytoplasmic vesicle; perinuclear region of cytoplasm; and plasma membrane. Orthologous to human EHD2 (EH domain containing 2); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic AMP.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

EH domain-containing protein 2; MGEPS; putative eps protein

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EHD2 (EH domain containing 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ehd2 (EH-domain containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ehd2 (EH domain containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EHD2 (EH domain containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EHD2 (EH domain containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ehd2 (EH domain containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EHD2 (EH domain containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EHD2 (EH domain containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ehd2 (EH domain containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	EHD2 (EH domain containing 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ehd2 (EH-domain containing 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ehd2b (EH-domain containing 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ehd2a (EH-domain containing 2a)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Past1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rme-1	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IRS4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	SLA1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	ehd2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	76,639,568 - 76,658,747 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	76,637,482 - 76,658,783 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	82,015,477 - 82,032,689 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	90,579,536 - 90,596,748 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	83,770,617 - 83,787,829 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	77,847,599 - 77,865,870 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	77,847,600 - 77,865,870 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	79,112,279 - 79,130,529 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	76,292,179 - 76,310,584 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	71,130,719 - 71,149,079 (-)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (EXP)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3',5'-cyclic AMP (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

acetamide (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

bleomycin A2 (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calcium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

cobalt dichloride (ISO)

cocaine (EXP)

copper(II) sulfate (ISO)

coumarin (ISO)

diazinon (ISO)

dibutyl phthalate (EXP)

diethylstilbestrol (EXP)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

entinostat (ISO)

ethanol (ISO)

fenamidone (ISO)

fluoranthene (ISO)

folic acid (ISO)

gentamycin (EXP)

ivermectin (ISO)

lead diacetate (ISO)

lead(0) (ISO)

leflunomide (EXP)

lipopolysaccharide (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (EXP)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

progesterone (ISO)

resveratrol (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

Soman (EXP)

succimer (ISO)

sunitinib (ISO)

temozolomide (ISO)

thioacetamide (EXP)

topotecan (EXP)

tributylstannane (EXP)

trichloroethene (EXP)

Triptolide (EXP)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cilium assembly (IBA)

cortical actin cytoskeleton organization (ISO)

endocytic recycling (IBA,ISO,ISS)

endocytosis (IBA,ISO)

plasma membrane tubulation (ISO,ISS)

positive regulation of endocytic recycling (ISO,ISS)

positive regulation of myoblast fusion (ISO,ISS)

protein localization to plasma membrane (IBA,ISO,ISS)

Cellular Component

caveola (ISO,ISS)

cytoplasm (IBA)

cytosol (ISO,ISS)

early endosome (IBA)

endocytic vesicle (IBA)

intercellular bridge (IEA,ISO)

membrane (ISO,ISS)

microtubule cytoskeleton (IEA,ISO)

perinuclear region of cytoplasm (IBA,ISO)

plasma membrane (IBA,ISO,ISS)

recycling endosome membrane (IBA,ISO,ISS)

Molecular Function

ATP binding (IEA)

calcium ion binding (IEA)

GTP binding (IEA)

hydrolase activity (IEA)

identical protein binding (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

endocytosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:2227441	PMID:11423532	PMID:14676205	PMID:15182197	PMID:15247266	PMID:15489334	PMID:17233914	PMID:17914359	PMID:19056867	PMID:20489164	PMID:21177873	PMID:24013648
PMID:24508342	PMID:24664435	PMID:29133341	PMID:33450132

Genomics

Comparative Map Data

Ehd2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	76,639,568 - 76,658,747 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	76,637,482 - 76,658,783 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	82,015,477 - 82,032,689 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	90,579,536 - 90,596,748 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	83,770,617 - 83,787,829 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	77,847,599 - 77,865,870 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	77,847,600 - 77,865,870 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	79,112,279 - 79,130,529 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	76,292,179 - 76,310,584 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	71,130,719 - 71,149,079 (-)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

EHD2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	47,713,422 - 47,743,134 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	47,713,422 - 47,743,134 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	48,216,679 - 48,246,391 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	52,908,502 - 52,938,203 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	52,908,501 - 52,938,202	NCBI
Celera	19	45,022,299 - 45,052,093 (+)	NCBI		Celera
Cytogenetic Map	19	q13.33	NCBI
HuRef	19	44,643,202 - 44,673,032 (+)	NCBI		HuRef
CHM1_1	19	48,218,935 - 48,248,702 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	50,544,240 - 50,573,946 (+)	NCBI		T2T-CHM13v2.0

Ehd2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	15,680,883 - 15,701,402 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	15,680,883 - 15,701,492 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	15,946,963 - 15,967,535 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	15,946,958 - 15,967,567 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	16,534,336 - 16,552,884 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	15,107,509 - 15,126,057 (-)	NCBI		MGSCv36	mm8
Celera	7	13,147,692 - 13,166,237 (-)	NCBI		Celera
Cytogenetic Map	7	A2	NCBI
cM Map	7	8.65	NCBI

Ehd2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955574	1,490,877 - 1,503,943 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955574	1,490,877 - 1,503,651 (+)	NCBI	ChiLan1.0	ChiLan1.0

EHD2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	19	55,736,790 - 55,766,387 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	44,707,747 - 44,737,370 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	53,361,831 - 53,390,877 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	53,365,510 - 53,389,159 (+)	Ensembl	panpan1.1		panPan2

EHD2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	108,317,471 - 108,336,032 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	108,318,680 - 108,345,885 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	107,799,663 - 107,818,190 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	108,843,517 - 108,862,065 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	108,843,515 - 108,862,033 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	108,511,223 - 108,529,700 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	108,155,771 - 108,174,509 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	109,023,931 - 109,042,491 (-)	NCBI		UU_Cfam_GSD_1.0

Ehd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	19,698,492 - 19,713,548 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936664	1,316,621 - 1,331,678 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EHD2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	53,423,563 - 53,443,224 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	53,423,489 - 53,442,007 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	48,953,673 - 48,972,126 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EHD2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	41,034,263 - 41,054,340 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	41,034,274 - 41,056,401 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	20,787,175 - 20,807,886 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ehd2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624832	6,155,839 - 6,168,628 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624832	6,156,051 - 6,168,638 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ehd2
101 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	163
Count of miRNA genes:	123
Interacting mature miRNAs:	128
Transcripts:	ENSRNOT00000017353
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	509108	86060548	Rat
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	5925874	115540829	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	11481312	82174945	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	11481312	82174945	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	11481312	82174945	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	11481312	82174945	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	22340647	102268831	Rat
1331785	Rf27	Renal function QTL 27	4.643		urine sodium amount (VT:0006274)	urine sodium level (CMO:0000129)	1	28879780	78430678	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	30882023	123479925	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	32737273	90665040	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
1354599	Bw29	Body weight QTL 29	3.46	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	33449848	78449848	Rat
1354643	Foco2	Food consumption QTL 2	7.17	0.0001	eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	1	33449848	78449848	Rat
8552900	Pigfal1	Plasma insulin-like growth factor 1 level QTL 1	7.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	34836858	79836858	Rat
8552948	Pigfal11	Plasma insulin-like growth factor 1 level QTL 11	4.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	34836858	79836858	Rat
9589820	Insglur3	Insulin/glucose ratio QTL 3	10.75	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	1	34836858	79836858	Rat
1331732	Srn4	Serum renin concentration QTL 4	4.467		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	1	35239598	78430678	Rat
1331792	Rf29	Renal function QTL 29	4.589		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	1	35239598	78430678	Rat
2313051	Bss57	Bone structure and strength QTL 57	3.7	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	43284731	118944897	Rat
2313059	Bss55	Bone structure and strength QTL 55	3.2	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
2313072	Bss53	Bone structure and strength QTL 53	4.3	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	43284731	118944897	Rat
2313078	Bss54	Bone structure and strength QTL 54	3.5	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
2313094	Bss58	Bone structure and strength QTL 58	3.7	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	43284731	118944897	Rat
2313098	Bmd70	Bone mineral density QTL 70	3.6	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	43284731	118944897	Rat
2313099	Bss56	Bone structure and strength QTL 56	2.4	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	1	43284731	118944897	Rat
2302059	Pia36	Pristane induced arthritis QTL 36	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	43333002	88333002	Rat
1331778	Rf28	Renal function QTL 28	4.66		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	1	45803140	78430678	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	48963584	144267916	Rat
4889962	Bss94	Bone structure and strength QTL 94	3.8		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	49361465	82174945	Rat
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	49393172	94393172	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	53863041	90532583	Rat
4889919	Bss86	Bone structure and strength QTL 86	4.1		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	1	53895117	82174945	Rat
4889929	Bss87	Bone structure and strength QTL 87	6.7		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	53895117	82174945	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	56732668	98773277	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	56949932	101949932	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	57336763	151090257	Rat
1300121	Hrtrt1	Heart rate QTL 1	3.7		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	65789093	115540829	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	66023617	118608521	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	72197680	90508767	Rat

Markers in Region

AI555194

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	76,640,499 - 76,640,679 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	77,847,621 - 77,847,800	NCBI	Rnor6.0
Rnor_5.0	1	79,112,301 - 79,112,480	UniSTS	Rnor5.0
RGSC_v3.4	1	76,292,201 - 76,292,380	UniSTS	RGSC3.4
Celera	1	71,130,741 - 71,130,920	UniSTS
Cytogenetic Map	1	q21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	18	4	17	4	8	11	1	35	35	11	8
Low			39	37	2	37			73		6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039081636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF081251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097385	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000017353 ⟹ ENSRNOP00000017353

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	76,637,482 - 76,658,783 (-)	Ensembl
Rnor_6.0 Ensembl	1	77,847,600 - 77,865,870 (-)	Ensembl

RefSeq Acc Id:

NM_001024897 ⟹ NP_001020068

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	76,640,478 - 76,658,747 (-)	NCBI
Rnor_6.0	1	77,847,599 - 77,865,870 (-)	NCBI
Rnor_5.0	1	79,112,279 - 79,130,529 (-)	NCBI
RGSC_v3.4	1	76,292,179 - 76,310,584 (-)	RGD
Celera	1	71,130,719 - 71,149,079 (-)	RGD

Sequence:

show sequence

GCTTGCTCTGCGCTCCCCAGATCCCTGGTGAGCTCTGCACCCAGTAGTCTCTTTGGGTGACCCA
GTGGGCATCGAAAGTCACCATGTTCAGCTGGCTGAAGAAGGGTGGGGCTCGGGGCCAGCGATCT
GAGGCCATCCGCACCGTGACCTCGTCTCTCAAGGAGCTGTATCGCACAAAGCTTCTGCCCCTGG
AGGAACACTACCGTTTCGGGTCTTTCCATTCACCAGCCCTCGAAGATGCTGACTTCGATGGTAA
ACCCATGGTGCTGGTGGCTGGCCAGTATAGCACCGGCAAAACCAGCTTCATCCAGTACCTCCTG
GAGCAGGAGGTCCCTGGCTCCCGCGTGGGTCCTGAGCCCACCACCGACTGCTTCGTGGCTGTCA
TGCACGGCGAGACAGAGGGTACCGTGCCTGGAAATGCTCTCGTTGTGGACCCAGAGAAGCCCTT
CCGCAAACTCAACCCTTTTGGAAACACTTTCCTCAACAGGTTTATGTGTGCCCAACTCCCCAAC
CAGGTCCTGGAGAGCATCAGCATCATCGACACGCCCGGCATCCTATCAGGTGCCAAGCAGAGAG
TGAGCCGGGGCTACGACTTCCCAGCTGTCTTGCGCTGGTTTGCTGAGCGCGTGGACCTCATCAT
CTTGCTCTTTGACGCCCACAAGCTGGAGATTTCTGATGAATTCTCAGAGGCCATTGGTGCCTTG
CGTGGCCACGAGGACAAGATCCGCGTGGTACTCAACAAGGCAGACATGGTGGAGACACAGCAGC
TGATGCGCGTCTATGGGGCGCTCATGTGGGCGCTGGGCAAGGTGGTGGGCACGCCTGAAGTCCT
TCGTGTCTACATCGGCTCCTTCTGGTCCCAGCCGCTCCTTGTGCCAGACAACCGGCGTCTCTTC
GAGCTGGAGGAACAGGACCTCTTCCGTGATATCCAAGGCCTACCGCGCCACGCGGCGCTGCGGA
AGCTCAATGACCTAGTGAAGCGGGCGCGGCTGGTGCGGGTGCACGCTTACATCATCAGCTACCT
GAAGAAGGAGATGCCCTCGGTGTTCGGAAAGGAAAACAAAAAGAAGCAGCTGATCTTCAAGCTG
CCTGTCATCTTCGCCAAGATCCAGCTAGAGCACCACATCTCCCCAGGAGACTTCCCTGACTGCC
AGAAGATGCAGGAGCTGCTGATGGCACATGACTTCACCAAGTTCCACTCCCTAAAGCCGAAGCT
GCTGGAGGCGCTGGACGAGATGCTGACCCACGACATTGCCAAGCTTATGCCGCTGCTTCGGCAG
GAGGAGCTGGAGAGTGTCGAGGCTGGCGTGCAGGGTGGTGCGTTTGAGGGCACCCGCATGGGCC
CCTTCGTGGAGCGGGGCCCTGACGAAGCAATAGAAGATGGCGAGGAGGGCTCAGAAGATGATGC
CGAATGGGTGGTGACCAAGGACAAGTCCAAATACGATGAAATCTTCTACAATTTAGCGCCTGCT
GATGGCAAGCTGAGTGGCTCTAAGGCCAAAACCTGGATGGTGGGCACCAAGCTACCCAACTCCG
TGCTGGGGCGAATCTGGAAGCTGAGCGATGTCGACCGAGATGGCATGCTGGATGATGAGGAGTT
CGCCCTGGCCAGCCACCTCATTGAGGCTAAGCTCGAAGGCCATGGGCTACCCACCAACCTACCC
CGCCGCCTGGTGCCACCTTCTAAGCGACGACAGAAGGGCTCTGCTGAGTGAGACAGCAGGGACT
GCTGGCCCACCCTCCCACTTTGCCCTGCGGTGGCTCCCCAGCTCCAGTCAGCTACACGGCTACA
CGCGGATCCCTGCTCTGGCCCACTGACCCTGCCTACCCACCCTGTCTGGCTATAAGGACTTGAG
GGGGAAGCTTCTCTCCTACACCAGACATTCAGTCAAGGCACTTATAGAGGACCAGGTGGGGGAG
TGACAAACCTTCTCTGTCTGTCCTTCACCTTCACATACACAAGGGCTTATCACAGAAACACACA
CATCCATCCAGCCATCATTCATATAAAGACTTTTTTTTCTTTTAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039081636 ⟹ XP_038937564

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	76,639,568 - 76,656,699 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020068	(Get FASTA)	NCBI Sequence Viewer
	XP_038937564	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC31599	(Get FASTA)	NCBI Sequence Viewer
	AAH97385	(Get FASTA)	NCBI Sequence Viewer
	EDM08346	(Get FASTA)	NCBI Sequence Viewer
	Q4V8H8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001020068 ⟸ NM_001024897

- UniProtKB:

Q4V8H8 (UniProtKB/Swiss-Prot), A6J888 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFSWLKKGGARGQRSEAIRTVTSSLKELYRTKLLPLEEHYRFGSFHSPALEDADFDGKPMVLVA
GQYSTGKTSFIQYLLEQEVPGSRVGPEPTTDCFVAVMHGETEGTVPGNALVVDPEKPFRKLNPF
GNTFLNRFMCAQLPNQVLESISIIDTPGILSGAKQRVSRGYDFPAVLRWFAERVDLIILLFDAH
KLEISDEFSEAIGALRGHEDKIRVVLNKADMVETQQLMRVYGALMWALGKVVGTPEVLRVYIGS
FWSQPLLVPDNRRLFELEEQDLFRDIQGLPRHAALRKLNDLVKRARLVRVHAYIISYLKKEMPS
VFGKENKKKQLIFKLPVIFAKIQLEHHISPGDFPDCQKMQELLMAHDFTKFHSLKPKLLEALDE
MLTHDIAKLMPLLRQEELESVEAGVQGGAFEGTRMGPFVERGPDEAIEDGEEGSEDDAEWVVTK
DKSKYDEIFYNLAPADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGMLDDEEFALASHL
IEAKLEGHGLPTNLPRRLVPPSKRRQKGSAE

hide sequence

RefSeq Acc Id:

ENSRNOP00000017353 ⟸ ENSRNOT00000017353

RefSeq Acc Id:	XP_038937564 ⟸ XM_039081636
- Peptide Label:	isoform X1
- UniProtKB:	Q4V8H8 (UniProtKB/Swiss-Prot), A6J888 (UniProtKB/TrEMBL)

Protein Domains

Dynamin-type G EF-hand EH

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4V8H8-F1-model_v2	AlphaFold	Q4V8H8	1-543	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560856	AgrOrtholog
BioCyc Gene	G2FUF-60629	BioCyc
Ensembl Genes	ENSRNOG00000011346	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000017353	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000017353	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.268.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/Swiss-Prot
	EF-hand	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop containing nucleotide triphosphate hydrolases	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7446444	IMAGE-MGC_LOAD
InterPro	DUF5600	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dynamin_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF-hand-dom_pair	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EH_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EHD_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_DYNAMIN_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:361512	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:114425	IMAGE-MGC_LOAD
NCBI Gene	361512	ENTREZGENE
PANTHER	EH DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DUF5600	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dynamin_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF-hand_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EHD_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ehd2	PhenoGen
PROSITE	EF_HAND_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_DYNAMIN_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PS50031	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	SM00027	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	EF-hand	UniProtKB/TrEMBL
	P-loop containing nucleoside triphosphate hydrolases	UniProtKB/TrEMBL
	SSF47473	UniProtKB/Swiss-Prot
	SSF52540	UniProtKB/Swiss-Prot
UniProt	A6J888	ENTREZGENE, UniProtKB/TrEMBL
	EHD2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Ehd2	EH-domain containing 2	MGEPS	putative eps protein	Symbol and Name updated	1299863	APPROVED
2006-02-09	MGEPS	putative eps protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

Send us a Message

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)