Grin2d (glutamate ionotropic receptor NMDA type subunit 2D) - Rat Genome Database

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Gene: Grin2d (glutamate ionotropic receptor NMDA type subunit 2D) Rattus norvegicus
Analyze
Symbol: Grin2d
Name: glutamate ionotropic receptor NMDA type subunit 2D
RGD ID: 2740
Description: Enables glutamate binding activity and monoatomic ion channel activity. Involved in several processes, including cellular response to L-glutamate; glutamatergic synaptic transmission; and modulation of chemical synaptic transmission. Located in postsynaptic membrane and presynaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and synaptic membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 46. Orthologous to human GRIN2D (glutamate ionotropic receptor NMDA type subunit 2D); PARTICIPATES IN Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GluN2D; glutamate [NMDA] receptor subunit epsilon-4; Glutamate receptor ionotropic N-methyl D-aspartate 2D; glutamate receptor ionotropic, NMDA 2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D; glutamate receptor, ionotropic, NMDA2D; N-methyl D-aspartate receptor subtype 2D; NMDAR2D; NR2D
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,443,317 - 105,483,400 (-)NCBIGRCr8
mRatBN7.2196,306,871 - 96,346,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,308,365 - 96,344,793 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,694,508 - 101,730,941 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,166,494 - 110,202,933 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,456,865 - 103,493,298 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,819,068 - 101,859,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,820,461 - 101,856,881 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,899,446 - 102,935,845 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,308,548 - 96,345,931 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,386,658 - 96,424,042 (-)NCBI
Celera190,560,875 - 90,597,451 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. Abe M, etal., J Neurosci. 2004 Aug 18;24(33):7292-304. doi: 10.1523/JNEUROSCI.1261-04.2004.
2. Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses. Berg LK, etal., Neuroscience. 2013 Jan 29;230:139-50. doi: 10.1016/j.neuroscience.2012.10.061. Epub 2012 Nov 14.
3. Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells. Bresink I, etal., Br J Pharmacol. 1996 Sep;119(2):195-204. doi: 10.1111/j.1476-5381.1996.tb15971.x.
4. Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors. Chen PE, etal., J Physiol. 2004 Jul 1;558(Pt 1):45-58. Epub 2004 Apr 23.
5. Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Cui Z, etal., Neuron. 2004 Mar 4;41(5):781-93. doi: 10.1016/s0896-6273(04)00072-8.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors. Hansen KB, etal., Mol Pharmacol. 2013 Jul;84(1):114-27. doi: 10.1124/mol.113.085803. Epub 2013 Apr 26.
9. Extrasynaptic NR2D-containing NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs. Harney SC, etal., J Neurosci. 2008 Nov 5;28(45):11685-94. doi: 10.1523/JNEUROSCI.3035-08.2008.
10. Reduced spontaneous activity of mice defective in the epsilon 4 subunit of the NMDA receptor channel. Ikeda K, etal., Brain Res Mol Brain Res 1995 Oct;33(1):61-71.
11. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. Ishii T, etal., J Biol Chem 1993 Feb 5;268(4):2836-43.
12. Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. Kurschner C and Yuzaki M, J Neurosci. 1999 Sep 15;19(18):7770-80.
13. CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. Kurschner C, etal., Mol Cell Neurosci. 1998 Jun;11(3):161-72.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Monyer H, etal., Neuron 1994 Mar;12(3):529-40.
16. Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. Nagy J, etal., Neurochem Int 2003 Jan;42(1):35-43.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Permeant ion effects on external Mg2+ block of NR1/2D NMDA receptors. Qian A and Johnson JW, J Neurosci. 2006 Oct 18;26(42):10899-910.
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia. Schmitt A, etal., Eur Arch Psychiatry Clin Neurosci. 2010 Mar;260(2):101-11. Epub 2009 May 12.
23. A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction. Siegler Retchless B, etal., Nat Neurosci. 2012 Jan 15;15(3):406-13, S1-2. doi: 10.1038/nn.3025.
24. Isoform specificity for oestrogen receptor and thyroid hormone receptor genes and their interactions on the NR2D gene promoter. Vasudevan N, etal., J Neuroendocrinol 2002 Oct;14(10):836-42.
25. Control of NMDA receptor function by the NR2 subunit amino-terminal domain. Yuan H, etal., J Neurosci. 2009 Sep 30;29(39):12045-58. doi: 10.1523/JNEUROSCI.1365-09.2009.
Additional References at PubMed
PMID:1385220   PMID:7569905   PMID:9718984   PMID:10771345   PMID:11488959   PMID:12586431   PMID:12832518   PMID:15146049   PMID:15469880   PMID:16141268   PMID:16190898   PMID:17509768  
PMID:17961930   PMID:17962329   PMID:18033813   PMID:18585442   PMID:20171363   PMID:20887777   PMID:21114966   PMID:21397592   PMID:21522138   PMID:23578394   PMID:23627311   PMID:23639431  
PMID:26875626   PMID:26919761   PMID:27616483   PMID:30261285   PMID:31969570   PMID:38277219  


Genomics

Comparative Map Data
Grin2d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,443,317 - 105,483,400 (-)NCBIGRCr8
mRatBN7.2196,306,871 - 96,346,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,308,365 - 96,344,793 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,694,508 - 101,730,941 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,166,494 - 110,202,933 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,456,865 - 103,493,298 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,819,068 - 101,859,146 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,820,461 - 101,856,881 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,899,446 - 102,935,845 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,308,548 - 96,345,931 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,386,658 - 96,424,042 (-)NCBI
Celera190,560,875 - 90,597,451 (-)NCBICelera
Cytogenetic Map1q22NCBI
GRIN2D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,393,668 - 48,444,931 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,393,668 - 48,444,931 (+)EnsemblGRCh38hg38GRCh38
GRCh371948,896,925 - 48,948,188 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,589,944 - 53,640,000 (+)NCBINCBI36Build 36hg18NCBI36
Build 341953,589,943 - 53,639,205NCBI
Celera1945,763,381 - 45,813,433 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,278,762 - 45,328,386 (+)NCBIHuRef
CHM1_11948,900,198 - 48,950,044 (+)NCBICHM1_1
T2T-CHM13v2.01951,387,832 - 51,439,100 (+)NCBIT2T-CHM13v2.0
Grin2d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,481,307 - 45,520,708 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,481,307 - 45,527,802 (-)EnsemblGRCm39 Ensembl
GRCm38745,831,883 - 45,871,194 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,831,883 - 45,878,378 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,087,853 - 53,122,051 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,700,822 - 45,734,609 (-)NCBIMGSCv36mm8
Celera741,296,635 - 41,330,798 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.54NCBI
Grin2d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555592,042,723 - 2,080,706 (-)NCBIChiLan1.0ChiLan1.0
GRIN2D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22054,496,831 - 54,550,701 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,423,033 - 56,477,035 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,392,258 - 45,447,004 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11953,989,734 - 54,038,371 (+)NCBIpanpan1.1PanPan1.1panPan2
GRIN2D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,821,853 - 107,853,411 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,822,716 - 107,849,945 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,344,687 - 107,375,906 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01108,347,785 - 108,379,031 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,347,734 - 108,379,883 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11108,013,073 - 108,045,131 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,660,406 - 107,692,469 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,496,256 - 108,532,686 (-)NCBIUU_Cfam_GSD_1.0
Grin2d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934920,898,056 - 20,928,675 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,515,928 - 2,546,429 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,512,777 - 2,546,865 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN2D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,806,174 - 53,848,789 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,809,590 - 53,849,535 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,570,829 - 49,613,106 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRIN2D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,650,458 - 41,707,024 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl641,656,334 - 41,706,030 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607321,434,159 - 21,490,139 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grin2d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,362,046 - 5,392,973 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,362,046 - 5,392,988 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grin2d
101 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:103
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000028615
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)183547917128547917Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat

Markers in Region
Grin2d  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,327,702 - 96,329,051 (+)MAPPERmRatBN7.2
Rnor_6.01101,839,795 - 101,841,143NCBIRnor6.0
Rnor_5.01102,918,759 - 102,920,107UniSTSRnor5.0
Celera190,580,365 - 90,581,713UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000028615   ⟹   ENSRNOP00000028615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,308,365 - 96,344,793 (-)Ensembl
Rnor_6.0 Ensembl1101,820,461 - 101,856,881 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084869   ⟹   ENSRNOP00000075255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1101,820,818 - 101,853,055 (-)Ensembl
RefSeq Acc Id: NM_022797   ⟹   NP_073634
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,444,813 - 105,481,236 (-)NCBI
mRatBN7.2196,308,365 - 96,344,793 (-)NCBI
Rnor_6.01101,820,461 - 101,856,881 (-)NCBI
Rnor_5.01102,899,446 - 102,935,845 (-)NCBI
RGSC_v3.4196,308,548 - 96,345,931 (-)RGD
Celera190,560,875 - 90,597,451 (-)RGD
Sequence:
RefSeq Acc Id: XM_039095535   ⟹   XP_038951463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,443,317 - 105,483,400 (-)NCBI
mRatBN7.2196,306,871 - 96,346,994 (-)NCBI
RefSeq Acc Id: XM_063280701   ⟹   XP_063136771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,443,317 - 105,483,400 (-)NCBI
RefSeq Acc Id: XM_063280703   ⟹   XP_063136773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,443,317 - 105,476,818 (-)NCBI
RefSeq Acc Id: XM_063280711   ⟹   XP_063136781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,444,445 - 105,483,400 (-)NCBI
RefSeq Acc Id: NP_073634   ⟸   NM_022797
- Peptide Label: precursor
- UniProtKB: Q63729 (UniProtKB/Swiss-Prot),   Q63382 (UniProtKB/Swiss-Prot),   Q63381 (UniProtKB/Swiss-Prot),   Q62645 (UniProtKB/Swiss-Prot),   Q63730 (UniProtKB/Swiss-Prot),   A6JB94 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075255   ⟸   ENSRNOT00000084869
Ensembl Acc Id: ENSRNOP00000028615   ⟸   ENSRNOT00000028615
RefSeq Acc Id: XP_038951463   ⟸   XM_039095535
- Peptide Label: isoform X1
- UniProtKB: A6JB94 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136771   ⟸   XM_063280701
- Peptide Label: isoform X1
- UniProtKB: A6JB94 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136773   ⟸   XM_063280703
- Peptide Label: isoform X2
- UniProtKB: A6JB95 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136781   ⟸   XM_063280711
- Peptide Label: isoform X3
- UniProtKB: A6JB94 (UniProtKB/TrEMBL)
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62645-F1-model_v2 AlphaFold Q62645 1-1323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2740 AgrOrtholog
BioCyc Gene G2FUF-59643 BioCyc
Ensembl Genes ENSRNOG00000021063 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028615 ENTREZGENE
  ENSRNOT00000028615.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.2300 UniProtKB/Swiss-Prot
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  Glu/Gly-bd UniProtKB/Swiss-Prot
  Iono_rcpt_met UniProtKB/Swiss-Prot
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot
  Iontro_rcpt UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report rno:24412 UniProtKB/Swiss-Prot
NCBI Gene 24412 ENTREZGENE
PANTHER IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot
  Lig_chan UniProtKB/Swiss-Prot
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot
PhenoGen Grin2d PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021063 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot
  PBPe UniProtKB/Swiss-Prot
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot
  SSF53822 UniProtKB/Swiss-Prot
UniProt A6JB94 ENTREZGENE, UniProtKB/TrEMBL
  A6JB95 ENTREZGENE, UniProtKB/TrEMBL
  NMDE4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63381 ENTREZGENE
  Q63382 ENTREZGENE
  Q63729 ENTREZGENE
  Q63730 ENTREZGENE
UniProt Secondary Q63381 UniProtKB/Swiss-Prot
  Q63382 UniProtKB/Swiss-Prot
  Q63729 UniProtKB/Swiss-Prot
  Q63730 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grin2d  glutamate ionotropic receptor NMDA type subunit 2D  Grin2d  glutamate receptor, ionotropic, N-methyl D-aspartate 2D  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Grin2d  glutamate receptor, ionotropic, N-methyl D-aspartate 2D    glutamate receptor, ionotropic, NMDA2D   Name updated 1299863 APPROVED
2002-11-06 Grin2d  glutamate receptor, ionotropic, NMDA2D     Glutamate receptor, ionotropic, N-methyl D-aspartate 2D  Name updated 625702 APPROVED
2002-06-10 Grin2d  Glutamate receptor, ionotropic, N-methyl D-aspartate 2D      Symbol and Name status set to approved 70586 APPROVED