Fbl (fibrillarin) - Rat Genome Database

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Gene: Fbl (fibrillarin) Rattus norvegicus
Analyze
Symbol: Fbl
Name: fibrillarin
RGD ID: 1305542
Description: Predicted to enable several functions, including ATPase binding activity; S-adenosylmethionine-dependent methyltransferase activity; and TFIID-class transcription factor complex binding activity. Predicted to be involved in box C/D sno(s)RNA 3'-end processing; ribosome biogenesis; and snoRNA localization. Predicted to act upstream of or within sno(s)RNA metabolic process. Located in Cajal body; chromosome; and dense fibrillar component. Orthologous to human FBL (fibrillarin); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH (+)-schisandrin B; (R,R,R)-alpha-tocopherol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: histone-glutamine methyltransferase; LOC292747; MGC116371; nucleolar protein 1; rRNA 2'-O-methyltransferase fibrillarin; U6 snRNA 2'-O-methyltransferase fibrillarin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,597,407 - 92,606,507 (+)NCBIGRCr8
mRatBN7.2183,469,832 - 83,478,932 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,469,832 - 83,478,932 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx188,880,071 - 88,889,164 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,338,304 - 97,347,397 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,635,930 - 90,645,023 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,103,519 - 85,112,619 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,103,519 - 85,112,619 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,319,815 - 86,328,915 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,271,967 - 83,281,069 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1183,350,077 - 83,359,180 (+)NCBI
Celera177,869,745 - 77,878,845 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,6-dimethoxyphenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5,6-dichlorobenzimidazole riboside  (ISO)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
biochanin A  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (ISO)
Didecyldimethylammonium  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
etoposide  (ISO)
fenpyroximate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
mercury dichloride  (ISO)
methimazole  (EXP)
methylisothiazolinone  (ISO)
miconazole  (ISO)
mitomycin C  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
picoxystrobin  (ISO)
Potassium hexachloropalladate(IV)  (ISO)
pyrimidifen  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Nucleologenesis: use of non-isotopic in situ hybridization and immunocytochemistry to compare the localization of rDNA and nucleolar proteins during mitosis. Jimenez-Garcia LF, etal., Biol Cell. 1989;65(3):239-46.
4. Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine. Lischwe MA, etal., J Biol Chem. 1985 Nov 15;260(26):14304-10.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Neuronal body size correlates with the number of nucleoli and Cajal bodies, and with the organization of the splicing machinery in rat trigeminal ganglion neurons. Pena E, etal., J Comp Neurol. 2001 Feb 5;430(2):250-63.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Immunopurified small nucleolar ribonucleoprotein particles pseudouridylate rRNA independently of their association with phosphorylated Nopp140. Wang C, etal., Mol Cell Biol 2002 Dec;22(24):8457-66.
12. The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA. Watkins NJ and Bohnsack MT, Wiley Interdiscip Rev RNA. 2012 May-Jun;3(3):397-414. doi: 10.1002/wrna.117. Epub 2011 Nov 7.
13. Conserved composition of mammalian box H/ACA and box C/D small nucleolar ribonucleoprotein particles and their interaction with the common factor Nopp140. Yang Y, etal., Mol Biol Cell 2000 Feb;11(2):567-77.
Additional References at PubMed
PMID:7768196   PMID:7772340   PMID:11092755   PMID:11237729   PMID:12477932   PMID:12714744   PMID:14612397   PMID:15485902   PMID:15489334   PMID:15494374   PMID:16129783   PMID:16210410  
PMID:16687569   PMID:16855206   PMID:17158916   PMID:17636026   PMID:18625840   PMID:19056867   PMID:19208757   PMID:20168299   PMID:22658674   PMID:22681889   PMID:22720776   PMID:23203802  
PMID:23500592   PMID:24174535   PMID:24352239   PMID:24625528   PMID:30361391   PMID:30540930  


Genomics

Comparative Map Data
Fbl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,597,407 - 92,606,507 (+)NCBIGRCr8
mRatBN7.2183,469,832 - 83,478,932 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,469,832 - 83,478,932 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx188,880,071 - 88,889,164 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,338,304 - 97,347,397 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,635,930 - 90,645,023 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,103,519 - 85,112,619 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,103,519 - 85,112,619 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,319,815 - 86,328,915 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,271,967 - 83,281,069 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1183,350,077 - 83,359,180 (+)NCBI
Celera177,869,745 - 77,878,845 (+)NCBICelera
Cytogenetic Map1q21NCBI
FBL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,834,458 - 39,846,379 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,834,458 - 39,846,379 (-)EnsemblGRCh38hg38GRCh38
GRCh371940,325,098 - 40,337,019 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,016,938 - 45,028,813 (-)NCBINCBI36Build 36hg18NCBI36
Build 341945,016,937 - 45,028,813NCBI
Celera1937,127,387 - 37,139,349 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,772,106 - 36,784,069 (-)NCBIHuRef
CHM1_11940,326,441 - 40,338,404 (-)NCBICHM1_1
T2T-CHM13v2.01942,639,380 - 42,651,301 (-)NCBIT2T-CHM13v2.0
Fbl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,868,293 - 27,878,701 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,869,135 - 27,878,694 (+)EnsemblGRCm39 Ensembl
GRCm38728,168,893 - 28,179,269 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,169,710 - 28,179,269 (+)EnsemblGRCm38mm10GRCm38
MGSCv37728,954,767 - 28,964,288 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36727,878,508 - 27,888,029 (+)NCBIMGSCv36mm8
Celera722,730,966 - 22,740,488 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.67NCBI
Fbl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555781,176,713 - 1,186,873 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555781,176,713 - 1,186,873 (+)NCBIChiLan1.0ChiLan1.0
FBL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22046,063,417 - 46,075,395 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,934,073 - 47,946,047 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,866,329 - 36,878,293 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,413,978 - 45,425,930 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1945,413,978 - 45,425,930 (-)Ensemblpanpan1.1panPan2
FBL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,632,899 - 113,643,805 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,632,929 - 113,643,748 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,036,931 - 113,047,842 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,233,485 - 114,244,396 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,233,538 - 114,244,391 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,791,323 - 113,802,229 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,424,985 - 113,435,889 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,419,243 - 114,430,150 (+)NCBIUU_Cfam_GSD_1.0
Fbl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,016,916 - 14,027,394 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,444,866 - 2,455,528 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,444,985 - 2,455,423 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,314,783 - 48,326,436 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,314,782 - 48,326,433 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,160,315 - 44,171,969 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,370,558 - 34,382,909 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,370,558 - 34,376,836 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607312,444,667 - 12,457,740 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462492556,421 - 67,082 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462492556,421 - 67,102 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbl
36 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:20
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000026021
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat

Markers in Region
MARC_26184-26185:1030717529:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,476,828 - 83,477,961 (+)MAPPERmRatBN7.2
Rnor_6.0185,110,516 - 85,111,648NCBIRnor6.0
Rnor_5.0186,326,812 - 86,327,944UniSTSRnor5.0
RGSC_v3.4183,278,966 - 83,280,098UniSTSRGSC3.4
Celera177,876,741 - 77,877,873UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026021   ⟹   ENSRNOP00000026021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,469,832 - 83,478,932 (+)Ensembl
Rnor_6.0 Ensembl185,103,519 - 85,112,619 (+)Ensembl
RefSeq Acc Id: NM_001025643   ⟹   NP_001020814
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,597,407 - 92,606,507 (+)NCBI
mRatBN7.2183,469,832 - 83,478,932 (+)NCBI
Rnor_6.0185,103,519 - 85,112,619 (+)NCBI
Rnor_5.0186,319,815 - 86,328,915 (+)NCBI
RGSC_v3.4183,271,967 - 83,281,069 (+)RGD
Celera177,869,745 - 77,878,845 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020814 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99198 (Get FASTA)   NCBI Sequence Viewer  
  EDM07914 (Get FASTA)   NCBI Sequence Viewer  
  EDM07915 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026021
  ENSRNOP00000026021.4
GenBank Protein P22509 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020814   ⟸   NM_001025643
- UniProtKB: Q4KLH8 (UniProtKB/Swiss-Prot),   P22509 (UniProtKB/Swiss-Prot),   A6J9G9 (UniProtKB/TrEMBL),   A6J9H0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026021   ⟸   ENSRNOT00000026021

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22509-F1-model_v2 AlphaFold P22509 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689863
Promoter ID:EPDNEW_R388
Type:initiation region
Name:Fbl_1
Description:fibrillarin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0185,103,540 - 85,103,600EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305542 AgrOrtholog
BioCyc Gene G2FUF-60262 BioCyc
Ensembl Genes ENSRNOG00000019229 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026021 ENTREZGENE
  ENSRNOT00000026021.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7383920 IMAGE-MGC_LOAD
InterPro Fibrillarin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrillarin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:292747 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:116371 IMAGE-MGC_LOAD
NCBI Gene 292747 ENTREZGENE
PANTHER RRNA 2'-O-METHYLTRANSFERASE FIBRILLARIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Fibrillarin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fbl PhenoGen
PRINTS FIBRILLARIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FIBRILLARIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019229 RatGTEx
SMART Fibrillarin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2UK98_RAT UniProtKB/TrEMBL
  A6J9G9 ENTREZGENE, UniProtKB/TrEMBL
  A6J9H0 ENTREZGENE, UniProtKB/TrEMBL
  FBRL_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4KLH8 ENTREZGENE
UniProt Secondary Q4KLH8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Fbl  fibrillarin  Fbl_predicted  fibrillarin (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fbl_predicted  fibrillarin (predicted)      Symbol and Name status set to approved 70820 APPROVED