Eid2b (EP300 interacting inhibitor of differentiation 2B) - Rat Genome Database

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Gene: Eid2b (EP300 interacting inhibitor of differentiation 2B) Rattus norvegicus
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Symbol: Eid2b
Name: EP300 interacting inhibitor of differentiation 2B
RGD ID: 9381183
Description: Predicted to enable identical protein binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and negative regulation of myoblast differentiation. Predicted to be located in nucleus. Predicted to be active in nucleoplasm; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cobalt dichloride.
Type: protein-coding (Ensembl: lncRNA)
RefSeq Status: VALIDATED
Previously known as: EP300-interacting inhibitor of differentiation 2B; RGD1560818; RGD9381183
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,673,119 - 92,674,899 (+)NCBIGRCr8
mRatBN7.2183,545,530 - 83,547,338 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,545,563 - 83,546,734 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0185,508,397 - 85,510,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,509,662 - 85,510,114 (-)EnsemblRnor6.0rn6Rnor6.0
Celera177,944,621 - 77,946,356 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Eid2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,673,119 - 92,674,899 (+)NCBIGRCr8
mRatBN7.2183,545,530 - 83,547,338 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,545,563 - 83,546,734 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0185,508,397 - 85,510,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,509,662 - 85,510,114 (-)EnsemblRnor6.0rn6Rnor6.0
Celera177,944,621 - 77,946,356 (+)NCBICelera
Cytogenetic Map1q21NCBI
EID2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,530,987 - 39,532,852 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,530,987 - 39,532,852 (-)EnsemblGRCh38hg38GRCh38
GRCh371940,021,627 - 40,023,492 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,713,470 - 44,715,334 (-)NCBINCBI36Build 36hg18NCBI36
Celera1936,823,341 - 36,825,205 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,467,983 - 36,469,847 (-)NCBIHuRef
CHM1_11940,022,235 - 40,024,098 (-)NCBICHM1_1
T2T-CHM13v2.01942,335,245 - 42,337,110 (-)NCBIT2T-CHM13v2.0
Eid2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,977,152 - 27,978,916 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,977,164 - 27,978,914 (+)EnsemblGRCm39 Ensembl
GRCm38728,277,706 - 28,280,129 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,277,739 - 28,279,489 (+)EnsemblGRCm38mm10GRCm38
MGSCv37729,062,725 - 29,065,148 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36727,986,400 - 27,987,754 (+)NCBIMGSCv36mm8
Celera722,839,330 - 22,841,753 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.67NCBI
Eid2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546848,573 - 50,029 (+)NCBIChiLan1.0ChiLan1.0
EID2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,823,975 - 45,828,655 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,694,559 - 47,699,595 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,629,480 - 36,631,665 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,177,751 - 45,179,081 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1945,178,537 - 45,179,022 (-)Ensemblpanpan1.1panPan2
Eid2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,923,971 - 13,926,929 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,354,497 - 2,354,966 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,352,726 - 2,354,968 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EID2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,131,492 - 34,133,542 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,132,832 - 34,133,317 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607312,154,801 - 12,156,692 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eid2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479412,826,376 - 12,827,772 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eid2b
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:12
Count of miRNA genes:11
Interacting mature miRNAs:12
Transcripts:ENSRNOT00000074665
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001329142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000074665   ⟹   ENSRNOP00000067743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,545,563 - 83,546,734 (-)Ensembl
Rnor_6.0 Ensembl185,509,662 - 85,510,114 (-)Ensembl
RefSeq Acc Id: NM_001329142   ⟹   NP_001316071
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,673,119 - 92,674,899 (+)NCBI
mRatBN7.2183,545,558 - 83,547,338 (+)NCBI
Rnor_6.0185,508,397 - 85,510,131 (-)NCBI
Celera177,944,621 - 77,946,356 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001316071 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001316071   ⟸   NM_001329142
- UniProtKB: M0RDN8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067743   ⟸   ENSRNOT00000074665

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RDN8-F1-model_v2 AlphaFold M0RDN8 1-151 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689883
Promoter ID:EPDNEW_R402
Type:single initiation site
Name:Eid2b_1
Description:EP300 interacting inhibitor of differentiation 2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0185,510,165 - 85,510,225EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSRNOG00000045545 Ensembl
NCBI Gene Eid2b ENTREZGENE
PhenoGen Eid2b PhenoGen
RatGTEx ENSRNOG00000045545 RatGTEx
UniProt M0RDN8 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Eid2b  EP300 interacting inhibitor of differentiation 2B  RGD1560818  similar to hypothetical protein FLJ38944  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560818  similar to hypothetical protein FLJ38944   RGD1560818_predicted  similar to hypothetical protein FLJ38944 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560818_predicted  similar to hypothetical protein FLJ38944 (predicted)  LOC499112  similar to hypothetical protein FLJ38944  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499112  similar to hypothetical protein FLJ38944      Symbol and Name status set to provisional 70820 PROVISIONAL