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Gene: Kcne1 (potassium voltage-gated channel subfamily E regulatory subunit 1) Rattus norvegicus
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Symbol: Kcne1
Name: potassium voltage-gated channel subfamily E regulatory subunit 1
Description: Exhibits several functions, including delayed rectifier potassium channel activity; ion channel binding activity; and protein heterodimerization activity. Predicted to contribute to voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Involved in several processes, including cellular response to acidic pH; negative regulation of protein targeting to membrane; and regulation of cation channel activity. Localizes to the apical plasma membrane; cytoplasm; and voltage-gated potassium channel complex. Colocalizes with the Golgi apparatus. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in Jervell-Lange Nielsen syndrome; atrial fibrillation; long QT syndrome; and long QT syndrome 5. Orthologous to several human genes including KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH all-trans-retinoic acid; ammonium chloride; aristolochic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Isk; m; minimal potassium channel; mink; Potassium (K+) channel protein slowly activating (Isk); potassium (K+) channel protein, slowly activating (Isk); potassium channel, voltage gated subfamily E regulatory beta subunit 1; potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 1; potassium voltage-gated channel Shaw-related subfamily member 1; potassium voltage-gated channel subfamily E member 1; potassium voltage-gated channel, Isk-related family, member 1; potassium voltage-gated channel, Isk-related subfamily, member 1; potassium voltage-gated channel, Shaw-related subfamily, member 1
Orthologs:
Homo sapiens (human) : KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1)  HGNC  Alliance
Mus musculus (house mouse) : Kcne1 (potassium voltage-gated channel, Isk-related subfamily, member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kcne1 (potassium voltage-gated channel subfamily E regulatory subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1)
Canis lupus familiaris (dog) : KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kcne1 (potassium voltage-gated channel subfamily E regulatory subunit 1)
Sus scrofa (pig) : KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01132,498,260 - 32,511,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01136,101,918 - 36,117,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,344,529 - 32,355,189 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11132,400,771 - 32,411,432 (-)NCBI
Celera1131,234,627 - 31,244,787 (-)NCBICelera
Cytogenetic Map11q11NCBI
RH 3.4 Map11214.7RGD
JBrowse: View Region in Genome Browser (JBrowse)
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More on Kcne1
Alliance Gene
NCBI Gene
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JBrowse: rn5 rn6
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RGD Object Information
RGD ID: 2956
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.