|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
# | Reference Title | Reference Citation |
1. | Regulation of neuronal type genes in congestive heart failure rats. | Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27. |
2. | Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1. | Balasubramaniam R, etal., J Physiol. 2003 Oct 15;552(Pt 2):535-46. |
3. | Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome. | Duggal P, etal., Circulation. 1998 Jan 20;97(2):142-6. |
4. | Cloning and expression of the delayed-rectifier IsK channel from neonatal rat heart and diethylstilbestrol-primed rat uterus. | Folander K, etal., Proc Natl Acad Sci U S A 1990 Apr;87(8):2975-9. |
5. | Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system. | Furukawa T, etal., J Mol Biol. 2001 Nov 2;313(4):775-84. |
6. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
7. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
8. | Characterization of gene organization and generation of heterogeneous mRNA species of rat ISK protein. | Iwai M, etal., J Biochem (Tokyo) 1990 Aug;108(2):200-6. |
9. | A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. | Kaab S, etal., Circ Cardiovasc Genet. 2012 Feb 1;5(1):91-9. doi: 10.1161/CIRCGENETICS.111.960930. Epub 2011 Nov 18. |
10. | KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels. | Kanda VA, etal., Biophys J. 2011 Sep 21;101(6):1354-63. doi: 10.1016/j.bpj.2011.08.015. Epub 2011 Sep 20. |
11. | KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel a-subunit composition. | Kanda VA, etal., Biophys J. 2011 Sep 21;101(6):1364-75. doi: 10.1016/j.bpj.2011.08.014. Epub 2011 Sep 20. |
12. | High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. | Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
13. | Association of the human minK gene 38G allele with atrial fibrillation: evidence of possible genetic control on the pathogenesis of atrial fibrillation. | Lai LP, etal., Am Heart J. 2002 Sep;144(3):485-90. |
14. | Inhibitory effect of somatostatin on secretin-induced augmentation of the slowly activating K+ current (IKs) in the rat pancreatic acinar cell. | Lee E, etal., Pflugers Arch 2002 Jan;443(3):405-10. |
15. | MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. | Lewis A, etal., J Biol Chem. 2004 Feb 27;279(9):7884-92. Epub 2003 Dec 16. |
16. | Millimeter wave promotes the synthesis of extracellular matrix and the proliferation of chondrocyte by regulating the voltage-gated K+ channel. | Li X, etal., J Bone Miner Metab. 2014 Jul;32(4):367-77. doi: 10.1007/s00774-013-0513-2. Epub 2013 Nov 8. |
17. | Regulation of the Kv2.1 potassium channel by MinK and MiRP1. | McCrossan ZA, etal., J Membr Biol. 2009 Mar;228(1):1-14. doi: 10.1007/s00232-009-9154-8. Epub 2009 Feb 14. |
18. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
19. | Stoichiometry of the KCNQ1 - KCNE1 ion channel complex. | Nakajo K, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18862-7. doi: 10.1073/pnas.1010354107. Epub 2010 Oct 20. |
20. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
21. | D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome. | Nishio Y, etal., J Am Coll Cardiol. 2009 Aug 25;54(9):812-9. doi: 10.1016/j.jacc.2009.06.005. |
22. | Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. | Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87. |
23. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
24. | SMPDB Annotation Import Pipeline | Pipeline to import SMPDB annotations from SMPDB into RGD |
25. | GOA pipeline | RGD automated data pipeline |
26. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
27. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
28. | Immunohistochemical study of a rat membrane protein which induces a selective potassium permeation: its localization in the apical membrane portion of epithelial cells. | Sugimoto T, etal., J Membr Biol. 1990 Jan;113(1):39-47. |
29. | Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing. | Tester DJ, etal., Heart Rhythm. 2005 May;2(5):507-17. |
30. | KCNQ1/KCNE1 channels during germ-cell differentiation in the rat: expression associated with testis pathologies. | Tsevi I, etal., J Cell Physiol. 2005 Feb;202(2):400-10.2: id: 27199802 Error occurred: Document retrieval error: document does notexist |
31. | min K channels form by assembly of at least 14 subunits. | Tzounopoulos T, etal., Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9593-7. |
32. | Upregulation of KCNE1 induces QT interval prolongation in patients with chronic heart failure. | Watanabe E, etal., Circ J. 2007 Apr;71(4):471-8. |
33. | Changes in activation gating of IsK potassium currents brought about by mutations in the transmembrane sequence. | Wilson GG, etal., FEBS Lett. 1994 Oct 24;353(3):251-4. |
34. | Dynamic changes in HCN2, HCN4, KCNE1, and KCNE2 expression in ventricular cells from acute myocardial infarction rat hearts. | Xia S, etal., Biochem Biophys Res Commun. 2010 May 7;395(3):330-5. doi: 10.1016/j.bbrc.2010.04.003. Epub 2010 Apr 8. |
35. | External pH regulates the slowly activating potassium current IsK expressed in Xenopus oocytes. | Yamane T, etal., FEBS Lett. 1993 Mar 22;319(3):229-32. |
36. | Skipping of Exon 1 in the KCNQ1 gene causes Jervell and Lange-Nielsen syndrome. | Zehelein J, etal., J Biol Chem. 2006 Nov 17;281(46):35397-403. Epub 2006 Sep 19. |
PMID:1553557 | PMID:2344412 | PMID:3194754 | PMID:7605639 | PMID:8900282 | PMID:8900283 | PMID:9354802 | PMID:10400998 | PMID:11220365 | PMID:11223304 | PMID:11299204 | PMID:12522251 |
PMID:16780588 | PMID:17289006 | PMID:17698596 | PMID:19646991 | PMID:21669976 | PMID:23504710 | PMID:24269949 | PMID:28064310 | PMID:28611207 | PMID:34907346 |
Kcne1 (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
KCNE1 (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kcne1 (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kcne1 (Chinchilla lanigera - long-tailed chinchilla) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
KCNE1 (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
KCNE1 (Canis lupus familiaris - dog) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kcne1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
KCNE1 (Sus scrofa - pig) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
KCNE1 (Chlorocebus sabaeus - green monkey) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kcne1 (Heterocephalus glaber - naked mole-rat) |
|
.
Variants in Kcne1
75 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
RH94732 |
|
alimentary part of gastrointestinal system
|
appendage
|
circulatory system
|
ectoderm
|
endocrine system
|
endoderm
|
exocrine system
|
hemolymphoid system
|
hepatobiliary system
|
integumental system
|
mesenchyme
|
mesoderm
|
musculoskeletal system
|
nervous system
|
renal system
|
reproductive system
|
respiratory system
|
sensory system
|
visual system
|
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 4 | 61 | 29 | 29 | 27 | 23 | 12 | 23 | 4 | 178 | 77 | 3 | 27 | 75 | 83 | 4 | 2 | 2 |
RefSeq Transcripts | NM_012973 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006248034 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006248035 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008768566 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017597886 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017597887 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC117904 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
CH473989 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
D10709 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000011 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
M22412 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
M36461 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Ensembl Acc Id: | ENSRNOT00000002717 ⟹ ENSRNOP00000002717 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
|
Ensembl Acc Id: | ENSRNOT00000096553 ⟹ ENSRNOP00000086617 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
Ensembl Acc Id: | ENSRNOT00000098014 ⟹ ENSRNOP00000087251 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
Ensembl Acc Id: | ENSRNOT00000114695 ⟹ ENSRNOP00000092414 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
Ensembl Acc Id: | ENSRNOT00000139012 ⟹ ENSRNOP00000111040 | ||||||||
Type: | CODING | ||||||||
Position: |
|
Ensembl Acc Id: | ENSRNOT00000146457 ⟹ ENSRNOP00000106444 | ||||||||
Type: | CODING | ||||||||
Position: |
|
Ensembl Acc Id: | ENSRNOT00000161047 ⟹ ENSRNOP00000099550 | ||||||||
Type: | CODING | ||||||||
Position: |
|
Ensembl Acc Id: | ENSRNOT00000166186 ⟹ ENSRNOP00000100022 | ||||||||
Type: | CODING | ||||||||
Position: |
|
Ensembl Acc Id: | ENSRNOT00000168964 ⟹ ENSRNOP00000108944 | ||||||||
Type: | CODING | ||||||||
Position: |
|
Ensembl Acc Id: | ENSRNOT00000173471 ⟹ ENSRNOP00000103960 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | NM_012973 ⟹ NP_037105 | ||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
|
||||||||||||||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_006248034 ⟹ XP_006248096 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
|
||||||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_006248035 ⟹ XP_006248097 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
|
||||||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_017597886 ⟹ XP_017453375 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
|
||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_017597887 ⟹ XP_017453376 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
|
||||||||||||||||
Sequence: |
Protein RefSeqs | NP_037105 | (Get FASTA) | NCBI Sequence Viewer |
XP_006248096 | (Get FASTA) | NCBI Sequence Viewer | |
XP_006248097 | (Get FASTA) | NCBI Sequence Viewer | |
XP_017453375 | (Get FASTA) | NCBI Sequence Viewer | |
XP_017453376 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAA41098 | (Get FASTA) | NCBI Sequence Viewer |
AAA41822 | (Get FASTA) | NCBI Sequence Viewer | |
BAA01552 | (Get FASTA) | NCBI Sequence Viewer | |
BAA01553 | (Get FASTA) | NCBI Sequence Viewer | |
EDM10760 | (Get FASTA) | NCBI Sequence Viewer | |
EDM10761 | (Get FASTA) | NCBI Sequence Viewer | |
EDM10762 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000002717.1 | ||
ENSRNOP00000086617.1 | |||
ENSRNOP00000087251.1 | |||
ENSRNOP00000092414.1 | |||
ENSRNOP00000106444 | |||
ENSRNOP00000108944 | |||
ENSRNOP00000111040 | |||
GenBank Protein | P15383 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_037105 ⟸ NM_012973 |
- UniProtKB: | P15383 (UniProtKB/Swiss-Prot), A6JLJ7 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006248097 ⟸ XM_006248035 |
- Peptide Label: | isoform X1 |
- UniProtKB: | P15383 (UniProtKB/Swiss-Prot), A6JLJ7 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006248096 ⟸ XM_006248034 |
- Peptide Label: | isoform X1 |
- UniProtKB: | P15383 (UniProtKB/Swiss-Prot), A6JLJ7 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_017453375 ⟸ XM_017597886 |
- Peptide Label: | isoform X1 |
- UniProtKB: | P15383 (UniProtKB/Swiss-Prot), A6JLJ7 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_017453376 ⟸ XM_017597887 |
- Peptide Label: | isoform X1 |
- UniProtKB: | P15383 (UniProtKB/Swiss-Prot), A6JLJ7 (UniProtKB/TrEMBL) |
- Sequence: |
Ensembl Acc Id: | ENSRNOP00000002717 ⟸ ENSRNOT00000002717 |
Ensembl Acc Id: | ENSRNOP00000086617 ⟸ ENSRNOT00000096553 |
Ensembl Acc Id: | ENSRNOP00000087251 ⟸ ENSRNOT00000098014 |
Ensembl Acc Id: | ENSRNOP00000092414 ⟸ ENSRNOT00000114695 |
Ensembl Acc Id: | ENSRNOP00000103960 ⟸ ENSRNOT00000173471 |
Ensembl Acc Id: | ENSRNOP00000100022 ⟸ ENSRNOT00000166186 |
Ensembl Acc Id: | ENSRNOP00000111040 ⟸ ENSRNOT00000139012 |
Ensembl Acc Id: | ENSRNOP00000099550 ⟸ ENSRNOT00000161047 |
Ensembl Acc Id: | ENSRNOP00000106444 ⟸ ENSRNOT00000146457 |
Ensembl Acc Id: | ENSRNOP00000108944 ⟸ ENSRNOT00000168964 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P15383-F1-model_v2 | AlphaFold | P15383 | 1-130 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:2956 | AgrOrtholog |
BioCyc Gene | G2FUF-21838 | BioCyc |
Ensembl Genes | ENSRNOG00000001984 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot |
Ensembl Transcript | ENSRNOT00000002717.3 | UniProtKB/Swiss-Prot |
ENSRNOT00000096553.1 | UniProtKB/Swiss-Prot | |
ENSRNOT00000098014.1 | UniProtKB/Swiss-Prot | |
ENSRNOT00000114695.1 | UniProtKB/Swiss-Prot | |
ENSRNOT00000139012 | ENTREZGENE | |
ENSRNOT00000146457 | ENTREZGENE | |
ENSRNOT00000168964 | ENTREZGENE | |
InterPro | K_chnl_KCNE | UniProtKB/Swiss-Prot |
K_chnl_volt-dep_bsu_KCNE1 | UniProtKB/Swiss-Prot | |
KEGG Report | rno:25471 | UniProtKB/Swiss-Prot |
NCBI Gene | 25471 | ENTREZGENE |
PANTHER | POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1 | UniProtKB/Swiss-Prot |
PTHR15282 | UniProtKB/Swiss-Prot | |
Pfam | ISK_Channel | UniProtKB/Swiss-Prot |
PharmGKB | KCNE1 | RGD |
PhenoGen | Kcne1 | PhenoGen |
PRINTS | KCNE1CHANNEL | UniProtKB/Swiss-Prot |
KCNECHANNEL | UniProtKB/Swiss-Prot | |
RatGTEx | ENSRNOG00000001984 | RatGTEx |
UniProt | A6JLJ7 | ENTREZGENE, UniProtKB/TrEMBL |
KCNE1_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
---|---|---|---|---|---|---|---|
2016-02-11 | Kcne1 | potassium voltage-gated channel subfamily E regulatory subunit 1 | Kcne1 | potassium channel, voltage gated subfamily E regulatory beta subunit 1 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2016-01-27 | Kcne1 | potassium channel, voltage gated subfamily E regulatory beta subunit 1 | Kcne1 | potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 1 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2015-01-26 | Kcne1 | potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 1 | Kcne1 | potassium voltage-gated channel, Isk-related family, member 1 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2002-01-14 | Kcne1 | Potassium voltage-gated channel, Isk-related subfamily, member 1 | Correction to spelling of name | 68913 | APPROVED | ||
2001-10-23 | Kcne1 | Potassium voltage-gated channel, Shaw-related subfamily, member 1 | Name updated to reflect Human and Mouse nomenclature | 68913 | APPROVED |
Note Type | Note | Reference |
---|---|---|
gene_expression | expressed in the fundus and antrum of the stomach, brain, adrenal gland, thymus, retina, and skeletal muscle | 625508 |
gene_expression | expressed in antrum and but not in fundus of the stomach | 625508 |
gene_process | responsible for the potassium current deactivation by depolarization | 625508 |
gene_process | curents generated by channel may counteract in the increase of muscle tone resulting in the regulation of the rhythms in stomach smooth muscle contraction | 625508 |
gene_product | 471 bp | 625508 |