Kcne1 (potassium voltage-gated channel subfamily E regulatory subunit 1) - Rat Genome Database

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Gene: Kcne1 (potassium voltage-gated channel subfamily E regulatory subunit 1) Ictidomys tridecemlineatus
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Symbol: Kcne1
Name: potassium voltage-gated channel subfamily E regulatory subunit 1
RGD ID: 12599073
Description: ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); protein-containing complex binding (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN cellular response to acidic pH (ortholog); cellular response to light stimulus (ortholog); epithelial cell maturation (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); arrhythmogenic right ventricular cardiomyopathy (ortholog); atrial fibrillation (ortholog); FOUND IN apical plasma membrane (ortholog); voltage-gated potassium channel complex (ortholog); Z disc (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: potassium voltage-gated channel subfamily E member 1; potassium voltage-gated channel, Isk-related family, member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497129,459,975 - 29,505,317 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365008,007,291 - 8,007,680 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365007,998,464 - 8,007,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle cell action potential involved in contraction  (IEA)
cellular response to acidic pH  (ISO)
cellular response to cAMP  (IEA)
cellular response to light stimulus  (ISO)
epithelial cell maturation  (IEA,ISO)
heart contraction  (IEA,ISO)
male gonad development  (ISO)
membrane repolarization  (IEA)
membrane repolarization during action potential  (IEA)
membrane repolarization during cardiac muscle cell action potential  (IEA)
membrane repolarization during ventricular cardiac muscle cell action potential  (IEA)
negative regulation of delayed rectifier potassium channel activity  (ISO)
negative regulation of protein targeting to membrane  (ISO)
negative regulation of voltage-gated potassium channel activity  (ISO)
positive regulation of potassium ion transmembrane transport  (IEA,ISO)
positive regulation of voltage-gated calcium channel activity  (ISO)
positive regulation of voltage-gated potassium channel activity  (ISO)
potassium ion export across plasma membrane  (IEA)
potassium ion transmembrane transport  (IEA)
potassium ion transport  (IEA)
regulation of delayed rectifier potassium channel activity  (ISO)
regulation of heart rate by cardiac conduction  (IEA,ISO)
regulation of potassium ion transmembrane transport  (IEA)
regulation of potassium ion transport  (IEA)
regulation of ventricular cardiac muscle cell membrane repolarization  (IEA)
secretory granule organization  (IEA)
ventricular cardiac muscle cell action potential  (IEA)
vestibular nucleus development  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Kcne1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497129,459,975 - 29,505,317 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365008,007,291 - 8,007,680 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365007,998,464 - 8,007,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382134,446,688 - 34,512,210 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2134,446,688 - 34,512,214 (-)EnsemblGRCh38hg38GRCh38
GRCh372135,818,986 - 35,884,508 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362134,740,858 - 34,806,443 (-)NCBINCBI36Build 36hg18NCBI36
Build 342134,740,858 - 34,806,443NCBI
Celera2121,018,555 - 21,083,181 (-)NCBICelera
Cytogenetic Map21q22.12ENTREZGENE
HuRef2121,297,857 - 21,363,444 (-)NCBIHuRef
CHM1_12135,381,239 - 35,446,817 (-)NCBICHM1_1
T2T-CHM13v2.02132,829,243 - 32,898,958 (-)NCBIT2T-CHM13v2.0
Kcne1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391692,142,889 - 92,156,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1692,142,870 - 92,156,356 (-)EnsemblGRCm39 Ensembl
GRCm381692,346,001 - 92,359,468 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1692,345,982 - 92,359,468 (-)EnsemblGRCm38mm10GRCm38
MGSCv371692,346,246 - 92,359,713 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361692,234,860 - 92,248,327 (-)NCBIMGSCv36mm8
Celera1693,429,327 - 93,442,798 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1653.57NCBI
Kcne1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81145,066,875 - 45,080,024 (-)NCBIGRCr8
mRatBN7.21131,580,951 - 31,594,116 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1131,580,742 - 31,593,901 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,275,474 - 40,285,587 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,946,932 - 32,957,045 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01132,105,499 - 32,115,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01132,498,260 - 32,511,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1132,498,261 - 32,508,420 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01136,101,918 - 36,117,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,344,529 - 32,355,189 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11132,400,771 - 32,411,432 (-)NCBI
Celera1131,234,627 - 31,244,787 (-)NCBICelera
RH 3.4 Map11214.7RGD
Cytogenetic Map11q11NCBI
Kcne1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540733,807,581 - 33,814,356 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540733,807,581 - 33,814,356 (-)NCBIChiLan1.0ChiLan1.0
KCNE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22230,566,300 - 30,634,574 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12125,424,445 - 25,492,209 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02120,818,395 - 20,884,053 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12134,187,482 - 34,252,573 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2134,190,043 - 34,190,441 (-)Ensemblpanpan1.1panPan2
KCNE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13129,858,428 - 29,868,315 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3128,958,149 - 28,967,760 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03129,159,562 - 29,169,178 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13129,025,740 - 29,034,430 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03129,040,518 - 29,050,143 (-)NCBIUNSW_CanFamBas_1.0
KCNE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13198,051,282 - 198,059,296 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113198,051,281 - 198,059,444 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213207,879,823 - 207,887,895 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1278,500,755 - 78,557,275 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl278,503,317 - 78,503,757 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660546,317,391 - 6,329,488 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcne1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474522,624,765 - 22,631,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474522,624,414 - 22,631,625 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000025910   ⟹   ENSSTOP00000014972
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365008,007,291 - 8,007,680 (+)Ensembl
RefSeq Acc Id: XM_005323506   ⟹   XP_005323563
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440497129,459,975 - 29,469,394 (-)NCBI
SpeTri2.0NW_0049365007,998,464 - 8,007,848 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040287014   ⟹   XP_040142948
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440497129,459,975 - 29,505,317 (-)NCBI
RefSeq Acc Id: XM_040287015   ⟹   XP_040142949
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440497129,459,975 - 29,469,900 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005323563 (Get FASTA)   NCBI Sequence Viewer  
  XP_040142948 (Get FASTA)   NCBI Sequence Viewer  
  XP_040142949 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000014972.1
GenBank Protein KAG3283941 (Get FASTA)   NCBI Sequence Viewer  
  KAG3283942 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005323563   ⟸   XM_005323506
- UniProtKB: I3MS77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040142948   ⟸   XM_040287014
- UniProtKB: I3MS77 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040142949   ⟸   XM_040287015
- UniProtKB: I3MS77 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000014972   ⟸   ENSSTOT00000025910


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000020255 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000025910.1 UniProtKB/TrEMBL
InterPro K_chnl_KCNE UniProtKB/TrEMBL
  K_chnl_volt-dep_bsu_KCNE1 UniProtKB/TrEMBL
NCBI Gene Kcne1 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1-RELATED UniProtKB/TrEMBL
  PTHR15282 UniProtKB/TrEMBL
Pfam ISK_Channel UniProtKB/TrEMBL
PRINTS KCNE1CHANNEL UniProtKB/TrEMBL
  KCNECHANNEL UniProtKB/TrEMBL
UniProt I3MS77 ENTREZGENE, UniProtKB/TrEMBL