KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1) - Rat Genome Database

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Gene: KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1) Sus scrofa
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Symbol: KCNE1
Name: potassium voltage-gated channel subfamily E regulatory subunit 1
RGD ID: 13957793
Description: ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); potassium channel regulator activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to acidic pH (ortholog); cellular response to light stimulus (ortholog); epithelial cell maturation (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); arrhythmogenic right ventricular cardiomyopathy (ortholog); atrial fibrillation (ortholog); FOUND IN apical plasma membrane (ortholog); plasma membrane (ortholog); voltage-gated potassium channel complex (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; IsK; minimal potassium channel; minK; potassium voltage-gated channel subfamily E member 1; potassium voltage-gated channel, Isk-related family, member 1; slow delayed rectifier K+ channel
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13198,051,282 - 198,059,296 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113198,051,281 - 198,059,444 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213207,879,823 - 207,887,895 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle cell action potential involved in contraction  (IEA)
cellular response to acidic pH  (ISO)
cellular response to cAMP  (IEA)
cellular response to light stimulus  (ISO)
epithelial cell maturation  (IEA,ISO)
heart contraction  (IEA,ISO)
male gonad development  (ISO)
membrane repolarization  (IEA)
membrane repolarization during action potential  (IBA,IEA)
membrane repolarization during cardiac muscle cell action potential  (IEA)
membrane repolarization during ventricular cardiac muscle cell action potential  (IEA)
negative regulation of delayed rectifier potassium channel activity  (ISS)
negative regulation of protein targeting to membrane  (ISO)
negative regulation of voltage-gated potassium channel activity  (ISO)
positive regulation of potassium ion transmembrane transport  (IEA,ISO)
positive regulation of voltage-gated calcium channel activity  (ISO)
positive regulation of voltage-gated potassium channel activity  (ISO)
potassium ion export across plasma membrane  (IBA,IEA)
potassium ion transmembrane transport  (IEA)
potassium ion transport  (IEA)
regulation of delayed rectifier potassium channel activity  (ISO)
regulation of heart rate by cardiac conduction  (IBA,IEA,ISO)
regulation of potassium ion transmembrane transport  (IEA)
regulation of potassium ion transport  (IEA)
regulation of ventricular cardiac muscle cell membrane repolarization  (IBA,IEA)
secretory granule organization  (IEA)
ventricular cardiac muscle cell action potential  (IBA,IEA)
vestibular nucleus development  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:20978892   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13198,051,282 - 198,059,296 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113198,051,281 - 198,059,444 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213207,879,823 - 207,887,895 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382134,446,688 - 34,512,210 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2134,446,688 - 34,512,214 (-)EnsemblGRCh38hg38GRCh38
GRCh372135,818,986 - 35,884,508 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362134,740,858 - 34,806,443 (-)NCBINCBI36Build 36hg18NCBI36
Build 342134,740,858 - 34,806,443NCBI
Celera2121,018,555 - 21,083,181 (-)NCBICelera
Cytogenetic Map21q22.12ENTREZGENE
HuRef2121,297,857 - 21,363,444 (-)NCBIHuRef
CHM1_12135,381,239 - 35,446,817 (-)NCBICHM1_1
T2T-CHM13v2.02132,829,243 - 32,898,958 (-)NCBIT2T-CHM13v2.0
Kcne1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391692,142,889 - 92,156,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1692,142,870 - 92,156,356 (-)EnsemblGRCm39 Ensembl
GRCm381692,346,001 - 92,359,468 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1692,345,982 - 92,359,468 (-)EnsemblGRCm38mm10GRCm38
MGSCv371692,346,246 - 92,359,713 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361692,234,860 - 92,248,327 (-)NCBIMGSCv36mm8
Celera1693,429,327 - 93,442,798 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1653.57NCBI
Kcne1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81145,066,875 - 45,080,024 (-)NCBIGRCr8
mRatBN7.21131,580,951 - 31,594,116 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1131,580,742 - 31,593,901 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,275,474 - 40,285,587 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,946,932 - 32,957,045 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01132,105,499 - 32,115,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01132,498,260 - 32,511,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1132,498,261 - 32,508,420 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01136,101,918 - 36,117,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,344,529 - 32,355,189 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11132,400,771 - 32,411,432 (-)NCBI
Celera1131,234,627 - 31,244,787 (-)NCBICelera
RH 3.4 Map11214.7RGD
Cytogenetic Map11q11NCBI
Kcne1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540733,807,581 - 33,814,356 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540733,807,581 - 33,814,356 (-)NCBIChiLan1.0ChiLan1.0
KCNE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22230,566,300 - 30,634,574 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12125,424,445 - 25,492,209 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02120,818,395 - 20,884,053 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12134,187,482 - 34,252,573 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2134,190,043 - 34,190,441 (-)Ensemblpanpan1.1panPan2
KCNE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13129,858,428 - 29,868,315 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3128,958,149 - 28,967,760 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03129,159,562 - 29,169,178 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13129,025,740 - 29,034,430 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03129,040,518 - 29,050,143 (-)NCBIUNSW_CanFamBas_1.0
Kcne1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497129,459,975 - 29,505,317 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365008,007,291 - 8,007,680 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365007,998,464 - 8,007,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1278,500,755 - 78,557,275 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl278,503,317 - 78,503,757 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660546,317,391 - 6,329,488 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcne1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474522,624,765 - 22,631,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474522,624,414 - 22,631,625 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KCNE1
389 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
7 4 5 3 4 9 9 5 3 4

Sequence


Ensembl Acc Id: ENSSSCT00000013181   ⟹   ENSSSCP00000012830
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13198,051,282 - 198,059,296 (-)Ensembl
RefSeq Acc Id: XM_003358939   ⟹   XP_003358987
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113198,051,281 - 198,059,440 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005657155   ⟹   XP_005657212
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113198,051,281 - 198,059,444 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005657212   ⟸   XM_005657155
- UniProtKB: F1SGX7 (UniProtKB/TrEMBL),   A0A4X1TV48 (UniProtKB/TrEMBL),   A0A8D1LKU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003358987   ⟸   XM_003358939
- UniProtKB: F1SGX7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000012830   ⟸   ENSSSCT00000013181


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012049 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015018599 UniProtKB/TrEMBL
  ENSSSCG00025011142 UniProtKB/TrEMBL
  ENSSSCG00030003569 UniProtKB/TrEMBL
  ENSSSCG00035029740 UniProtKB/TrEMBL
  ENSSSCG00040024502 UniProtKB/TrEMBL
  ENSSSCG00045023117 UniProtKB/TrEMBL
  ENSSSCG00050016730 UniProtKB/TrEMBL
  ENSSSCG00055024361 UniProtKB/TrEMBL
  ENSSSCG00060072593 UniProtKB/TrEMBL
  ENSSSCG00065029343 UniProtKB/TrEMBL
  ENSSSCG00070011934 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000013181 ENTREZGENE
  ENSSSCT00000013181.4 UniProtKB/TrEMBL
  ENSSSCT00015024771.1 UniProtKB/TrEMBL
  ENSSSCT00025014679.1 UniProtKB/TrEMBL
  ENSSSCT00030004674.1 UniProtKB/TrEMBL
  ENSSSCT00035039408.1 UniProtKB/TrEMBL
  ENSSSCT00040032795.1 UniProtKB/TrEMBL
  ENSSSCT00045039482.1 UniProtKB/TrEMBL
  ENSSSCT00050022829.1 UniProtKB/TrEMBL
  ENSSSCT00055047993.1 UniProtKB/TrEMBL
  ENSSSCT00060099295.1 UniProtKB/TrEMBL
  ENSSSCT00065039595.1 UniProtKB/TrEMBL
  ENSSSCT00070023264.1 UniProtKB/TrEMBL
InterPro K_chnl_KCNE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_bsu_KCNE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100621502 UniProtKB/TrEMBL
NCBI Gene KCNE1 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1 UniProtKB/Swiss-Prot
  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1-RELATED UniProtKB/TrEMBL
  PTHR15282 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ISK_Channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS KCNE1CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNECHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1TV48 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1LKU9 ENTREZGENE, UniProtKB/TrEMBL
  F1SGX7 ENTREZGENE
  KCNE1_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1SGX7 UniProtKB/TrEMBL