RGD Reference Report - Association of the human minK gene 38G allele with atrial fibrillation: evidence of possible genetic control on the pathogenesis of atrial fibrillation. - Rat Genome Database

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Association of the human minK gene 38G allele with atrial fibrillation: evidence of possible genetic control on the pathogenesis of atrial fibrillation.

Authors: Lai, LP  Su, MJ  Yeh, HM  Lin, JL  Chiang, FT  Hwang, JJ  Hsu, KL  Tseng, CD  Lien, WP  Tseng, YZ  Huang, SK 
Citation: Lai LP, etal., Am Heart J. 2002 Sep;144(3):485-90.
RGD ID: 1580498
Pubmed: PMID:12228786   (View Abstract at PubMed)

BACKGROUND: Human minK protein is the beta-subunit of I(Ks) potassium channel and plays an important role in cardiac cellular electrophysiology. We investigated the association between human atrial fibrillation and the polymorphism of minK gene (38G or 38S) with a case-control study. METHODS: We included 108 patients with atrial fibrillation and 108 control subjects. The case patients and control subjects were matched regarding age, sex, presence of valvular heart disease, and presence of left ventricular dysfunction. The genotype of minK was determined with polymerase chain reaction and restriction fragment analysis. RESULTS: The results showed an association between the minK 38G allele and atrial fibrillation. The odds ratios for atrial fibrillation in patients with 1 and 2 minK 38G alleles were 2.16 (95% CI 0.81-5.74) and 3.58 (95% CI 1.38-9.27), respectively, when compared with patients without minK 38G allele. In a logistic regression model, the odds ratio for atrial fibrillation was 1.80 (95% CI 1.20-2.71, P <.0046) for patients with 1 more minK 38G allele. CONCLUSION: We report the association between the minK 38G allele and clinical atrial fibrillation. Our findings suggest possible genetic control on the pathogenesis of atrial fibrillation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
KCNE1Humanatrial fibrillation  IAGP  RGD 
Kcne1Ratatrial fibrillation  ISOKCNE1 (Homo sapiens) RGD 
Kcne1Mouseatrial fibrillation  ISOKCNE1 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kcne1  (potassium voltage-gated channel subfamily E regulatory subunit 1)

Genes (Mus musculus)
Kcne1  (potassium voltage-gated channel, Isk-related subfamily, member 1)

Genes (Homo sapiens)
KCNE1  (potassium voltage-gated channel subfamily E regulatory subunit 1)


Additional Information