Hunk (hormonally upregulated Neu-associated kinase)

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Gene: Hunk (hormonally upregulated Neu-associated kinase) Rattus norvegicus

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Symbol:

Hunk

Name:

hormonally upregulated Neu-associated kinase

RGD ID:

1565091

Description:

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human HUNK (hormonally up-regulated Neu-associated kinase); INTERACTS WITH 6-propyl-2-thiouracil; alpha-Zearalanol; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

hormonally up-regulated neu tumor-associated kinase; LOC288275; RGD1565091; similar to putative serine/threonine protein kinase MAK-V

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	43,127,244 - 43,244,502 (+)	NCBI		GRCr8
mRatBN7.2	11	29,641,122 - 29,758,392 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	29,640,775 - 29,757,526 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	38,312,176 - 38,425,227 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	30,983,563 - 31,096,621 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	30,173,550 - 30,286,847 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	30,550,141 - 30,663,465 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	30,550,141 - 30,663,465 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	34,169,334 - 34,282,445 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	29,511,976 - 29,626,139 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	11	29,310,913 - 29,424,636 (+)	NCBI		Celera
Cytogenetic Map	11	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis type 1 (ISO)

autosomal dominant intellectual developmental disorder 7 (ISO)

Familial Platelet Disorder with Associated Myeloid Malignancy (ISO)

immunodeficiency 28 (ISO)

Parkinson's disease 20 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',5-triiodo-L-thyronine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (EXP)

chlordecone (ISO)

chlorpyrifos (ISO)

chrysene (ISO)

D-glucose (ISO)

dibenz[a,h]anthracene (ISO)

dichloroacetic acid (ISO)

diuron (EXP)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

fonofos (ISO)

fucoxanthin (ISO)

fulvestrant (ISO)

glucose (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

ozone (ISO)

paracetamol (ISO)

parathion (ISO)

PCB138 (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

succimer (ISO)

sunitinib (ISO)

terbufos (ISO)

testosterone (EXP)

tetraphene (ISO)

titanium dioxide (ISO)

trametinib (ISO)

trichloroethene (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular signal transduction (IBA)

protein phosphorylation (IEA,ISO)

Cellular Component

cytoplasm (IBA)

Molecular Function

ATP binding (IEA)

protein binding (ISO)

protein kinase activity (ISO)

protein serine/threonine kinase activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10662544	PMID:22745772

Genomics

Comparative Map Data

Hunk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	43,127,244 - 43,244,502 (+)	NCBI		GRCr8
mRatBN7.2	11	29,641,122 - 29,758,392 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	29,640,775 - 29,757,526 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	38,312,176 - 38,425,227 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	30,983,563 - 31,096,621 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	30,173,550 - 30,286,847 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	30,550,141 - 30,663,465 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	30,550,141 - 30,663,465 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	34,169,334 - 34,282,445 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	29,511,976 - 29,626,139 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	11	29,310,913 - 29,424,636 (+)	NCBI		Celera
Cytogenetic Map	11	q11	NCBI

HUNK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	31,873,020 - 32,004,064 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	31,873,020 - 32,044,633 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	21	33,245,333 - 33,376,377 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	32,167,499 - 32,298,248 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	21	32,167,498 - 32,298,248	NCBI
Celera	21	18,427,991 - 18,558,682 (+)	NCBI		Celera
Cytogenetic Map	21	q22.11	NCBI
HuRef	21	18,704,976 - 18,784,354 (+)	NCBI		HuRef
CHM1_1	21	32,807,370 - 32,938,097 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	30,241,343 - 30,372,246 (+)	NCBI		T2T-CHM13v2.0

Hunk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	90,182,550 - 90,296,443 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	90,182,901 - 90,296,441 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	90,385,284 - 90,499,555 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	90,386,013 - 90,499,553 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	90,386,642 - 90,499,798 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	90,275,256 - 90,388,412 (+)	NCBI		MGSCv36	mm8
Celera	16	90,572,276 - 90,674,679 (+)	NCBI		Celera
Celera	16	91,579,196 - 91,585,226 (+)	NCBI		Celera
Cytogenetic Map	16	C3.3	NCBI
cM Map	16	51.71	NCBI

Hunk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	31,439,124 - 31,552,732 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	31,439,045 - 31,555,542 (+)	NCBI	ChiLan1.0	ChiLan1.0

HUNK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	27,992,574 - 28,119,953 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	22,852,246 - 22,979,604 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	18,242,130 - 18,369,502 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	31,622,432 - 31,748,336 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	31,622,861 - 31,745,517 (+)	Ensembl	panpan1.1		panPan2

HUNK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	26,723,823 - 26,830,420 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	26,748,351 - 26,828,778 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	26,717,636 - 26,822,776 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	26,844,526 - 26,949,540 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	26,844,526 - 26,949,506 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	26,788,981 - 26,894,316 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	26,800,527 - 26,905,728 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	27,308,133 - 27,413,413 (+)	NCBI		UU_Cfam_GSD_1.0

Hunk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	27,312,599 - 27,412,275 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	10,055,515 - 10,155,208 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	10,055,548 - 10,155,224 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HUNK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	195,528,739 - 195,663,902 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	195,528,526 - 195,666,685 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	206,027,443 - 206,035,468 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HUNK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	60,134,093 - 60,256,533 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	60,131,146 - 60,256,424 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	2,673,965 - 2,801,096 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hunk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	20,212,095 - 20,323,330 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624745	20,212,006 - 20,323,213 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Hunk
913 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	108
Count of miRNA genes:	84
Interacting mature miRNAs:	92
Transcripts:	ENSRNOT00000002866
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	1	69446234	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
1598842	Glom10	Glomerulus QTL 10	3.4		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	1	35331169	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
724517	Uae18	Urinary albumin excretion QTL 18	3.7		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	16472047	44285911	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	22959403	67959403	Rat
1300130	Rf20	Renal function QTL 20	4.44		kidney glomerulus integrity trait (VT:0010546)	kidney glomerulus diameter (CMO:0001166)	11	29528418	60324829	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	1041931	66113562	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	23280456	68280456	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	23280456	68280456	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat
1641927	Alcrsp10	Alcohol response QTL 10			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	11	8436674	53436674	Rat

Markers in Region

D11Rat75

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	29,628,942 - 29,629,090 (+)	MAPPER	mRatBN7.2
mRatBN7.2	11	29,628,826 - 29,629,090 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	30,537,317 - 30,537,580	NCBI	Rnor6.0
Rnor_6.0	11	30,537,433 - 30,537,580	NCBI	Rnor6.0
Rnor_5.0	11	34,156,510 - 34,156,773	UniSTS	Rnor5.0
Rnor_5.0	11	34,156,626 - 34,156,773	UniSTS	Rnor5.0
RGSC_v3.4	11	29,638,700 - 29,638,847	UniSTS	RGSC3.4
RGSC_v3.4	11	29,638,700 - 29,638,963	UniSTS	RGSC3.4
RGSC_v3.4	11	29,638,571 - 29,638,940	RGD	RGSC3.4
RGSC_v3.1	11	29,638,700 - 29,638,847	RGD
Celera	11	29,298,232 - 29,298,379	UniSTS
Celera	11	29,298,116 - 29,298,379	UniSTS
RH 3.4 Map	11	164.3	RGD
RH 3.4 Map	11	164.3	UniSTS
RH 2.0 Map	11	489.1	RGD
SHRSP x BN Map	11	8.2299	RGD
Cytogenetic Map	11	q11	UniSTS

D11Got24

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	29,692,698 - 29,692,837 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	30,600,981 - 30,601,119	NCBI	Rnor6.0
Rnor_5.0	11	34,220,174 - 34,220,312	UniSTS	Rnor5.0
RGSC_v3.4	11	29,573,631 - 29,573,770	RGD	RGSC3.4
RGSC_v3.4	11	29,573,632 - 29,573,770	UniSTS	RGSC3.4
RGSC_v3.1	11	29,573,631 - 29,573,770	RGD
Celera	11	29,361,996 - 29,362,134	UniSTS
RH 3.4 Map	11	172.6	UniSTS
RH 3.4 Map	11	172.6	RGD
RH 2.0 Map	11	464.0	RGD
Cytogenetic Map	11	q11	UniSTS

D11Got20

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	29,628,897 - 29,629,061 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	30,537,388 - 30,537,551	NCBI	Rnor6.0
Rnor_5.0	11	34,156,581 - 34,156,744	UniSTS	Rnor5.0
RGSC_v3.4	11	29,638,730 - 29,638,892	RGD	RGSC3.4
RGSC_v3.4	11	29,638,729 - 29,638,892	UniSTS	RGSC3.4
RGSC_v3.1	11	29,638,730 - 29,638,892	RGD
Celera	11	29,298,187 - 29,298,350	UniSTS
RH 3.4 Map	11	163.0	UniSTS
RH 3.4 Map	11	163.0	RGD
RH 2.0 Map	11	483.1	RGD
Cytogenetic Map	11	q11	UniSTS

Hunk

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	29,755,226 - 29,755,476 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	30,663,188 - 30,663,437	NCBI	Rnor6.0
Rnor_5.0	11	34,282,168 - 34,282,417	UniSTS	Rnor5.0
RGSC_v3.4	11	29,512,004 - 29,512,253	UniSTS	RGSC3.4
Celera	11	29,424,359 - 29,424,608	UniSTS
Cytogenetic Map	11	q11	UniSTS

BF400669

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	29,638,222 - 29,638,423 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	30,546,713 - 30,546,913	NCBI	Rnor6.0
Rnor_5.0	11	34,165,906 - 34,166,106	UniSTS	Rnor5.0
RGSC_v3.4	11	29,629,367 - 29,629,567	UniSTS	RGSC3.4
Celera	11	29,307,485 - 29,307,685	UniSTS
RH 3.4 Map	11	164.2	UniSTS
Cytogenetic Map	11	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	10	42	113	86	85	54	23	54	6	202	88	93	44	56	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212830	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000002866 ⟹ ENSRNOP00000002866

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	29,657,184 - 29,757,526 (+)	Ensembl
Rnor_6.0 Ensembl	11	30,550,141 - 30,663,465 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099297 ⟹ ENSRNOP00000083012

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	29,640,775 - 29,757,526 (+)	Ensembl

RefSeq Acc Id:

NM_001191662 ⟹ NP_001178591

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	43,127,244 - 43,244,502 (+)	NCBI
mRatBN7.2	11	29,641,122 - 29,758,392 (+)	NCBI
Rnor_6.0	11	30,550,141 - 30,663,465 (+)	NCBI
Rnor_5.0	11	34,169,334 - 34,282,445 (+)	NCBI
Celera	11	29,310,913 - 29,424,636 (+)	NCBI

Sequence:

show sequence

ATGCCGGCTGCGGCCGGGGACGGGCTCTTGGGGGAGCCGGCGGCGCCGGGGGGCGACGGAGGCG
CGGAGGACACGGCCAGGCCGGCGGCGGCCTGCGAGGGAAGTTTCTTGCCCGCCTGGGTGAGCGG
CGTGTCCCGCGAGCGGCTCCGGGACTTCCAGCATCACAAGCGCGTGGGCAACTACCTCATCGGC
AGCAGGAAGCTGGGAGAAGGCTCCTTCGCCAAGGTGCGCGAGGGGCTGCACGTGCTGACCGGAG
AGAAGGTGGCCATCAAAGTCATCGATAAGAAGAGAGCCAAAAAGGACACCTACGTTACCAAAAA
CCTGCGTCGAGAGGGGCAGATCCAGCAGATGATCCGCCATCCCAACATCACGCAGCTCCTGGAC
ATCTTAGAGACAGAGAACAGCTACTACCTGGTCATGGAGCTGTGTCCCGGCGGCAATCTCATGC
ACAAGATCTATGAAAAGAAGCGGCTAGATGAGGCGGAGGCCCGCAGATACATCCGGCAGCTCAT
CTCTGCCGTGGAACACCTGCACCGTGCCGGGGTGGTGCACAGAGACTTGAAGATAGAGAATTTG
CTCCTAGATGAAGACAATAATATCAAGCTGATTGACTTTGGTTTGAGCAACTGTGCAGGGATCC
TGGGTTACTCTGACCCATTCAGCACACAGTGTGGCAGCCCTGCCTATGCCGCCCCAGAACTGCT
TGCCAGGAAGAAATACGGCCCCAAAATTGATGTCTGGTCAATAGGTGTGAACATGTATGCCATG
TTGACCGGGACCCTGCCTTTCACCGTGGAGCCTTTCAGCCTGAGGGCTCTGTACCAGAAGATGG
TGGACAAAGAAATGAATCCCCTCCCGACCCAGCTCTCCACAGGGGCCATCAACTTTCTGCGCTC
TCTCCTGGAACCAGACCCAGTGAAGAGGCCCAATATCCAGCAAGCGCTGGCAAATCGCTGGCTA
AATGAGAATTACACTGGGAAAGTGCCCTGCAACGTCACCTACCCTAACAGGATTTCTCTGGAAG
ACCTGAGCCCCAGCGTGGTGCTGCACATGACTGAAAAGCTGGGCTACAAGAACAGTGACGTCAT
CAACACGGTGCTCTCCAACCGAGCCTGCCACATCCTGGCCATCTACTTCCTGTTGAACAAGAAA
CTTGAGCGTTATCTGTCAGGGAAATCGGACATCCAAGACAGCATCTGCTACAAGACCCAGCTCT
ACCAGATAGAGAAGTGCAGAGCTACCAAGGAACCCTATGAGGCCTCCCTGGATACCTGGACAAA
GGACTTTGAACTCCATGCTGTGCAGGATAAAAAGCCCAAAGAACAAGATAAAAGAGCTGATTTT
CTTCATCGTCCATTTTCCAAGAAGCTGGACAAGAGCCTGCCTTCTCACAAACAGCCGTCGCCTT
CACTGATCACACAAATCCAGAATACCAAAGCCCTGCTCAAAGACCGGAAGGCCTCCAAGTCAGG
CTTCGGCGACAAAGACTCCTTCGGCTGCCGAAATCTTTTCCGAAAGACCTCTGATTCCAATTGT
GTGGCCTCCTCTTCCATGGAATTCATCCCTGTCCCACCTCCCAGGACACCAAGGATTGTAAAGA
AACAAGAGCCACACCAGCCAGGGCCGGGAAGTGCCAGCATGCTCCCCAAGGAAGAGCCCCTGCT
GCTGGACATGGTTCGCTCCTTTGAGTCAGTGGACCGAGAGGACCACATAGAACTGCTGTCCTCT
TCCCACCATTATAGGATCCTGAGCTCCCCTGTGAGCTTGGCGCGTAGGAATTCTGGTGAGAGGA
CACTCTCCCCAGGGCTGCTGTCCGGAAGCACGTCACCTCTCCAAACGCCTCTGCATTCCACACT
GGTCTCTTTCACTCACGAAGAAAAGAACAGCCCCCCGAAAGAGGAGGGTGTGTGTTCACCACCT
CCGGTCCCCAGCAATGGCCTCATGCAGCCTCTGGGGAGCCCCAACTGTGTGAAAAGCAGGGGAA
GGTTCCCCATGATGGGCATTGGACAGATGCTCAGGAAGCGGCACCAGAGCCTGCAGCCTTCCTC
AGAGAGGTCCCTGGAGGTCAGTATGTCCCCTCTGCAGCCCACAGCCCCCTCCAGCCTCTCCTTC
GACATGGCCGATGGTGTCAAGGGCCAGTGTTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001178591	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM10685	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002866.5
	ENSRNOP00000083012.1

RefSeq Acc Id:

NP_001178591 ⟸ NM_001191662

- UniProtKB:

D4A7Q7 (UniProtKB/TrEMBL), A0A8I5ZV60 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPAAAGDGLLGEPAAPGGDGGAEDTARPAAACEGSFLPAWVSGVSRERLRDFQHHKRVGNYLIG
SRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLD
ILETENSYYLVMELCPGGNLMHKIYEKKRLDEAEARRYIRQLISAVEHLHRAGVVHRDLKIENL
LLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVNMYAM
LTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAINFLRSLLEPDPVKRPNIQQALANRWL
NENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKK
LERYLSGKSDIQDSICYKTQLYQIEKCRATKEPYEASLDTWTKDFELHAVQDKKPKEQDKRADF
LHRPFSKKLDKSLPSHKQPSPSLITQIQNTKALLKDRKASKSGFGDKDSFGCRNLFRKTSDSNC
VASSSMEFIPVPPPRTPRIVKKQEPHQPGPGSASMLPKEEPLLLDMVRSFESVDREDHIELLSS
SHHYRILSSPVSLARRNSGERTLSPGLLSGSTSPLQTPLHSTLVSFTHEEKNSPPKEEGVCSPP
PVPSNGLMQPLGSPNCVKSRGRFPMMGIGQMLRKRHQSLQPSSERSLEVSMSPLQPTAPSSLSF
DMADGVKGQC

hide sequence

Ensembl Acc Id:

ENSRNOP00000002866 ⟸ ENSRNOT00000002866

Ensembl Acc Id:

ENSRNOP00000083012 ⟸ ENSRNOT00000099297

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A7Q7-F1-model_v2	AlphaFold	D4A7Q7	1-714	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565091	AgrOrtholog
BioCyc Gene	G2FUF-21947	BioCyc
Ensembl Genes	ENSRNOG00000002092	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002866.6	UniProtKB/TrEMBL
	ENSRNOT00000099297.1	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Hunk	UniProtKB/TrEMBL
	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_prot_kinase_AS	UniProtKB/TrEMBL
KEGG Report	rno:288275	UniProtKB/TrEMBL
NCBI Gene	288275	ENTREZGENE
PANTHER	HORMONALLY UP-REGULATED NEU TUMOR-ASSOCIATED KINASE	UniProtKB/TrEMBL
	MAP/MICROTUBULE AFFINITY-REGULATING KINASE	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PhenoGen	Hunk	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002092	RatGTEx
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	A0A8I5ZV60	ENTREZGENE, UniProtKB/TrEMBL
	D4A7Q7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Hunk	hormonally upregulated Neu-associated kinase	RGD1565091_predicted	similar to putative serine/threonine protein kinase MAK-V (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1565091_predicted	similar to putative serine/threonine protein kinase MAK-V (predicted)	LOC288275	similar to putative serine/threonine protein kinase MAK-V	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC288275	similar to putative serine/threonine protein kinase MAK-V			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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