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Gene: Gart (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase) Rattus norvegicus

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Symbol:

Gart

Name:

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

RGD ID:

1308717

Description:

Enables phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; and phosphoribosylglycinamide formyltransferase activity. Involved in brainstem development; cerebellum development; and cerebral cortex development. Predicted to be active in cytosol. Orthologous to human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC288259; phosphoribosylglycinamide formyltransferase; trifunctional purine biosynthetic protein adenosine-3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	44,351,841 - 44,377,086 (-)	NCBI		GRCr8
mRatBN7.2	11	30,864,896 - 30,891,125 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	30,865,889 - 30,891,125 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	39,559,784 - 39,585,049 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	32,231,220 - 32,256,482 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	31,396,470 - 31,421,682 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	31,780,477 - 31,805,728 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	31,780,487 - 31,805,728 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	35,389,216 - 35,414,461 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	31,594,859 - 31,620,110 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	31,646,660 - 31,659,129 (-)	NCBI
Celera	11	30,533,312 - 30,558,557 (-)	NCBI		Celera
Cytogenetic Map	11	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gart	Rat	Down syndrome		ISO	RGD:1318653	5143983	protein:increased expression:cerebellum (human)	RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gart	Rat	amyotrophic lateral sclerosis type 1		ISO	RGD:1318653	8554872	ClinVar Annotator: match by term: Amyotrophic lateral sclerosis type 1	ClinVar	PMID:17237124\|PMID:23512985\|PMID:28492532
Gart	Rat	autosomal dominant intellectual developmental disorder 7		ISO	RGD:1318653	8554872	ClinVar Annotator: match by term: DYRK1A-related intellectual disability syndrome	ClinVar	PMID:17237124\|PMID:23512985\|PMID:28492532
Gart	Rat	Familial Platelet Disorder with Associated Myeloid Malignancy		ISO	RGD:1318653	8554872	ClinVar Annotator: match by term: Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1	ClinVar	PMID:17237124\|PMID:23512985\|PMID:28492532
Gart	Rat	immunodeficiency 28		ISO	RGD:1318653	8554872	ClinVar Annotator: match by term: Immunodeficiency 28	ClinVar	PMID:17237124\|PMID:23512985\|PMID:28492532
Gart	Rat	intellectual disability		ISO	RGD:1318653	8554872	ClinVar Annotator: match by term: Intellectual disability	ClinVar	PMID:25741868
Gart	Rat	Parkinson's disease 20		ISO	RGD:1318653	8554872	ClinVar Annotator: match by term: Early-onset Parkinson disease 20	ClinVar	PMID:28492532
Gart	Rat	Tracheoesophageal Fistula		ISO	RGD:1318653	8554872	ClinVar Annotator: match by term: Tracheoesophageal fistula	ClinVar	PMID:32641753
Gart	Rat	ZTTK syndrome		ISO	RGD:1318653	8554872	ClinVar Annotator: match by term: ZTTK syndrome	ClinVar	PMID:25741868

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gart	Rat	Animal Disease Models		ISO	RGD:1318653	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:27602772
Gart	Rat	lung adenocarcinoma		ISO	RGD:1318653	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:27602772
Gart	Rat	rheumatoid arthritis		ISO	RGD:1318653	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:23897011

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gart	Rat	1,2-dichloroethane	increases expression	ISO	RGD:1318654	6480464	ethylene dichloride results in increased expression of GART mRNA	CTD	PMID:28960355
Gart	Rat	1,2-dimethylhydrazine	increases expression	ISO	RGD:1318654	6480464	1,2-Dimethylhydrazine results in increased expression of GART mRNA	CTD	PMID:22206623
Gart	Rat	1-chloro-2,4-dinitrobenzene	affects binding	ISO	RGD:1318653	6480464	Dinitrochlorobenzene binds to GART protein	CTD	PMID:32991956
Gart	Rat	17alpha-ethynylestradiol	increases expression	ISO	RGD:1318654	6480464	Ethinyl Estradiol results in increased expression of GART mRNA	CTD	PMID:17942748
Gart	Rat	17alpha-ethynylestradiol	multiple interactions	ISO	RGD:1318654	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GART mRNA	CTD	PMID:17942748
Gart	Rat	17alpha-ethynylestradiol	affects expression	ISO	RGD:1318654	6480464	Ethinyl Estradiol affects the expression of GART mRNA	CTD	PMID:17555576
Gart	Rat	2,3',4,4',5-Pentachlorobiphenyl	increases expression	ISO	RGD:1318654	6480464	2,3',4,4',5-pentachlorobiphenyl results in increased expression of GART mRNA	CTD	PMID:31388691
Gart	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:1318654	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GART mRNA	CTD	PMID:17942748
Gart	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of GART mRNA	CTD	PMID:33387578
Gart	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1318654	6480464	Tetrachlorodibenzodioxin affects the expression of GART mRNA	CTD	PMID:21570461
Gart	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of GART mRNA	CTD	PMID:22298810
Gart	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:1318654	6480464	Tetrachlorodibenzodioxin results in increased expression of GART mRNA	CTD	PMID:17942748
Gart	Rat	2,4,6-tribromophenol	decreases expression	ISO	RGD:1318653	6480464	2,4,6-tribromophenol results in decreased expression of GART mRNA	CTD	PMID:31675489
Gart	Rat	2,4-dinitrotoluene	affects expression	EXP		6480464	2,4-dinitrotoluene affects the expression of GART mRNA	CTD	PMID:21346803
Gart	Rat	2,6-dimethoxyphenol	multiple interactions	ISO	RGD:1318653	6480464	[Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether] results in decreased expression of and affects the more ...	CTD	PMID:38598786
Gart	Rat	2,6-dinitrotoluene	affects expression	EXP		6480464	2,6-dinitrotoluene affects the expression of GART mRNA	CTD	PMID:21346803
Gart	Rat	2-bromohexadecanoic acid	multiple interactions	ISO	RGD:1318653	6480464	2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in more ...	CTD	PMID:38195004
Gart	Rat	2-methylcholine	affects expression	ISO	RGD:1318653	6480464	beta-methylcholine affects the expression of GART mRNA	CTD	PMID:21179406
Gart	Rat	3,3',5,5'-tetrabromobisphenol A	decreases expression	ISO	RGD:1318653	6480464	tetrabromobisphenol A results in decreased expression of GART protein	CTD	PMID:31675489
Gart	Rat	3-isobutyl-1-methyl-7H-xanthine	multiple interactions	ISO	RGD:1318653	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...	CTD	PMID:28628672
Gart	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:1318654	6480464	bisphenol S results in increased expression of GART mRNA	CTD	PMID:39298647
Gart	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:1318653	6480464	bisphenol S results in increased expression of GART protein	CTD	PMID:34186270
Gart	Rat	4-amino-2,6-dinitrotoluene	affects expression	EXP		6480464	4-amino-2,6-dinitrotoluene affects the expression of GART mRNA	CTD	PMID:21346803
Gart	Rat	5-fluorouracil	increases expression	ISO	RGD:1318653	6480464	Fluorouracil results in increased expression of GART mRNA	CTD	PMID:19219653
Gart	Rat	all-trans-retinoic acid	decreases expression	ISO	RGD:1318653	6480464	Tretinoin results in decreased expression of GART mRNA	CTD	PMID:16054129\|PMID:33167477
Gart	Rat	antirheumatic drug	decreases expression	ISO	RGD:1318653	6480464	Antirheumatic Agents results in decreased expression of GART mRNA	CTD	PMID:24449571
Gart	Rat	aristolochic acid A	increases expression	ISO	RGD:1318653	6480464	aristolochic acid I results in increased expression of GART protein	CTD	PMID:33212167
Gart	Rat	arsane	affects methylation	ISO	RGD:1318653	6480464	Arsenic affects the methylation of GART gene	CTD	PMID:25304211
Gart	Rat	arsenic atom	affects methylation	ISO	RGD:1318653	6480464	Arsenic affects the methylation of GART gene	CTD	PMID:25304211
Gart	Rat	arsenite(3-)	affects expression	ISO	RGD:1318653	6480464	arsenite affects the expression of GART mRNA	CTD	PMID:22959463
Gart	Rat	arsenous acid	increases expression	ISO	RGD:1318653	6480464	Arsenic Trioxide results in increased expression of GART mRNA; Arsenic Trioxide results in increased expression more ...	CTD	PMID:22521957\|PMID:25419056
Gart	Rat	arsenous acid	decreases expression	ISO	RGD:1318653	6480464	Arsenic Trioxide results in decreased expression of GART protein	CTD	PMID:19364129
Gart	Rat	arsenous acid	multiple interactions	ISO	RGD:1318653	6480464	Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GART protein]	CTD	PMID:26598702
Gart	Rat	benzatropine	multiple interactions	ISO	RGD:1318653	6480464	[Cuprizone co-treated with Benztropine] results in decreased expression of GART protein	CTD	PMID:34122009
Gart	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1318654	6480464	Benzo(a)pyrene results in increased expression of GART mRNA	CTD	PMID:22228805
Gart	Rat	beta-lapachone	decreases expression	ISO	RGD:1318653	6480464	beta-lapachone results in decreased expression of GART mRNA	CTD	PMID:38218311
Gart	Rat	bisphenol A	decreases expression	ISO	RGD:1318653	6480464	bisphenol A results in decreased expression of GART mRNA; bisphenol A results in decreased expression more ...	CTD	PMID:20678512\|PMID:34186270\|PMID:37567409
Gart	Rat	bisphenol A	increases expression	ISO	RGD:1318654	6480464	bisphenol A results in increased expression of GART mRNA	CTD	PMID:33221593
Gart	Rat	bisphenol A	affects expression	ISO	RGD:1318653	6480464	bisphenol A affects the expression of GART mRNA	CTD	PMID:30903817
Gart	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of GART mRNA	CTD	PMID:30816183\|PMID:32528016
Gart	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of GART mRNA	CTD	PMID:25181051
Gart	Rat	bisphenol AF	increases expression	ISO	RGD:1318653	6480464	bisphenol AF results in increased expression of GART protein	CTD	PMID:34186270
Gart	Rat	Bisphenol B	increases expression	ISO	RGD:1318653	6480464	bisphenol B results in increased expression of GART protein	CTD	PMID:34186270
Gart	Rat	bisphenol F	multiple interactions	ISO	RGD:1318653	6480464	[bisphenol F co-treated with Fulvestrant] results in increased methylation of GART gene; [INS protein co-treated more ...	CTD	PMID:28628672\|PMID:31601247
Gart	Rat	bisphenol F	increases expression	ISO	RGD:1318653	6480464	bisphenol F results in increased expression of GART protein	CTD	PMID:34186270
Gart	Rat	cadmium atom	multiple interactions	ISO	RGD:1318653	6480464	2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in more ...	CTD	PMID:33040242\|PMID:38195004
Gart	Rat	cadmium dichloride	decreases expression	EXP		6480464	Cadmium Chloride results in decreased expression of GART mRNA	CTD	PMID:33453195
Gart	Rat	cadmium dichloride	decreases expression	ISO	RGD:1318653	6480464	Cadmium Chloride results in decreased expression of GART mRNA	CTD	PMID:38382870\|PMID:38568856
Gart	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1318653	6480464	2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in more ...	CTD	PMID:33040242\|PMID:38195004
Gart	Rat	calcitriol	decreases expression	ISO	RGD:1318653	6480464	Calcitriol results in decreased expression of GART mRNA	CTD	PMID:21592394
Gart	Rat	calcitriol	multiple interactions	ISO	RGD:1318653	6480464	[Testosterone co-treated with Calcitriol] results in decreased expression of GART mRNA	CTD	PMID:21592394
Gart	Rat	carbamazepine	affects expression	ISO	RGD:1318653	6480464	Carbamazepine affects the expression of GART mRNA	CTD	PMID:24752500
Gart	Rat	carbon nanotube	increases expression	ISO	RGD:1318654	6480464	Nanotubes, Carbon analog results in increased expression of GART mRNA; Nanotubes, Carbon results in increased more ...	CTD	PMID:25554681
Gart	Rat	chlorophyllin	decreases expression	ISO	RGD:1318653	6480464	chlorophyllin analog results in decreased expression of GART protein	CTD	PMID:22852132
Gart	Rat	chromium(6+)	affects expression	ISO	RGD:1318654	6480464	chromium hexavalent ion affects the expression of GART mRNA	CTD	PMID:28472532
Gart	Rat	clofibric acid	multiple interactions	EXP		6480464	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GART mRNA	CTD	PMID:17602206
Gart	Rat	clozapine	increases expression	ISO	RGD:1318653	6480464	Clozapine results in increased expression of GART protein	CTD	PMID:34122009
Gart	Rat	cobalt dichloride	decreases expression	ISO	RGD:1318653	6480464	cobaltous chloride results in decreased expression of GART mRNA	CTD	PMID:19320972\|PMID:19376846
Gart	Rat	copper atom	multiple interactions	ISO	RGD:1318654	6480464	[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression more ...	CTD	PMID:15467011
Gart	Rat	copper(0)	multiple interactions	ISO	RGD:1318654	6480464	[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression more ...	CTD	PMID:15467011
Gart	Rat	copper(II) sulfate	increases expression	ISO	RGD:1318653	6480464	Copper Sulfate results in increased expression of GART mRNA	CTD	PMID:19549813
Gart	Rat	coumestrol	increases expression	ISO	RGD:1318653	6480464	Coumestrol results in increased expression of GART mRNA	CTD	PMID:19167446
Gart	Rat	Cuprizon	multiple interactions	ISO	RGD:1318653	6480464	[Cuprizone co-treated with Benztropine] results in decreased expression of GART protein	CTD	PMID:34122009
Gart	Rat	cyclosporin A	increases expression	ISO	RGD:1318653	6480464	Cyclosporine results in increased expression of GART mRNA	CTD	PMID:20106945\|PMID:25562108
Gart	Rat	DDE	increases expression	ISO	RGD:1318653	6480464	Dichlorodiphenyl Dichloroethylene results in increased expression of GART mRNA	CTD	PMID:38568856
Gart	Rat	decabromodiphenyl ether	decreases expression	ISO	RGD:1318653	6480464	decabromobiphenyl ether results in decreased expression of GART protein	CTD	PMID:31675489
Gart	Rat	dexamethasone	multiple interactions	ISO	RGD:1318653	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...	CTD	PMID:28628672
Gart	Rat	diarsenic trioxide	multiple interactions	ISO	RGD:1318653	6480464	Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GART protein]	CTD	PMID:26598702
Gart	Rat	diarsenic trioxide	increases expression	ISO	RGD:1318653	6480464	Arsenic Trioxide results in increased expression of GART mRNA; Arsenic Trioxide results in increased expression more ...	CTD	PMID:22521957\|PMID:25419056
Gart	Rat	diarsenic trioxide	decreases expression	ISO	RGD:1318653	6480464	Arsenic Trioxide results in decreased expression of GART protein	CTD	PMID:19364129
Gart	Rat	Dibutyl phosphate	affects expression	ISO	RGD:1318653	6480464	di-n-butylphosphoric acid affects the expression of GART mRNA	CTD	PMID:37042841
Gart	Rat	dibutyl phthalate	decreases expression	ISO	RGD:1318654	6480464	Dibutyl Phthalate results in decreased expression of GART mRNA	CTD	PMID:17361019\|PMID:21266533
Gart	Rat	diclofenac	affects expression	ISO	RGD:1318653	6480464	Diclofenac affects the expression of GART mRNA	CTD	PMID:24752500
Gart	Rat	enzyme inhibitor	multiple interactions	ISO	RGD:1318653	6480464	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ...	CTD	PMID:23301498
Gart	Rat	ethanol	affects splicing	ISO	RGD:1318654	6480464	Ethanol affects the splicing of GART mRNA	CTD	PMID:30319688
Gart	Rat	ethyl methanesulfonate	decreases expression	ISO	RGD:1318653	6480464	Ethyl Methanesulfonate results in decreased expression of GART mRNA	CTD	PMID:23649840
Gart	Rat	folic acid	decreases expression	ISO	RGD:1318654	6480464	Folic Acid results in decreased expression of GART mRNA	CTD	PMID:25629700
Gart	Rat	formaldehyde	decreases expression	ISO	RGD:1318653	6480464	Formaldehyde results in decreased expression of GART mRNA	CTD	PMID:23649840
Gart	Rat	fulvestrant	multiple interactions	ISO	RGD:1318653	6480464	[bisphenol F co-treated with Fulvestrant] results in increased methylation of GART gene	CTD	PMID:31601247
Gart	Rat	furfural	multiple interactions	ISO	RGD:1318653	6480464	[Sodium Chloride co-treated with Furaldehyde] results in decreased expression of GART protein; [Sodium Chloride co-treated more ...	CTD	PMID:38598786
Gart	Rat	gallic acid	decreases expression	ISO	RGD:1318653	6480464	Gallic Acid results in decreased expression of GART mRNA	CTD	PMID:34408198
Gart	Rat	hydrogen peroxide	affects expression	ISO	RGD:1318653	6480464	Hydrogen Peroxide affects the expression of GART mRNA	CTD	PMID:20044591
Gart	Rat	indometacin	multiple interactions	ISO	RGD:1318653	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...	CTD	PMID:28628672
Gart	Rat	ivermectin	decreases expression	ISO	RGD:1318653	6480464	Ivermectin results in decreased expression of GART protein	CTD	PMID:32959892
Gart	Rat	menadione	affects expression	ISO	RGD:1318653	6480464	Vitamin K 3 affects the expression of GART mRNA	CTD	PMID:20044591
Gart	Rat	methotrexate	affects expression	ISO	RGD:1318653	6480464	Methotrexate affects the expression of GART mRNA	CTD	PMID:23897011
Gart	Rat	methotrexate	decreases expression	ISO	RGD:1318653	6480464	Methotrexate results in decreased expression of GART mRNA	CTD	PMID:24449571
Gart	Rat	methyl methanesulfonate	decreases expression	ISO	RGD:1318653	6480464	Methyl Methanesulfonate results in decreased expression of GART mRNA	CTD	PMID:23649840
Gart	Rat	methylmercury chloride	increases expression	ISO	RGD:1318653	6480464	methylmercuric chloride results in increased expression of GART mRNA	CTD	PMID:28001369
Gart	Rat	methylparaben	increases expression	ISO	RGD:1318653	6480464	methylparaben results in increased expression of GART mRNA	CTD	PMID:31745603
Gart	Rat	N-methyl-4-phenylpyridinium	increases expression	ISO	RGD:1318653	6480464	1-Methyl-4-phenylpyridinium results in increased expression of GART mRNA	CTD	PMID:24810058
Gart	Rat	N-nitrosodiethylamine	multiple interactions	EXP		6480464	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GART mRNA	CTD	PMID:17602206
Gart	Rat	nickel atom	decreases expression	ISO	RGD:1318653	6480464	Nickel results in decreased expression of GART mRNA	CTD	PMID:23195993
Gart	Rat	nickel atom	increases expression	ISO	RGD:1318653	6480464	Nickel results in increased expression of GART mRNA	CTD	PMID:24768652\|PMID:25583101
Gart	Rat	nitrates	multiple interactions	ISO	RGD:1318654	6480464	[Particulate Matter results in increased abundance of Nitrates] which results in increased expression of GART more ...	CTD	PMID:35964746
Gart	Rat	oxaliplatin	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of GART mRNA	CTD	PMID:25729387
Gart	Rat	ozone	multiple interactions	ISO	RGD:1318653	6480464	[Air Pollutants results in increased abundance of Ozone] which affects the expression of GART mRNA	CTD	PMID:35430440
Gart	Rat	paracetamol	decreases expression	ISO	RGD:1318653	6480464	Acetaminophen results in decreased expression of GART mRNA	CTD	PMID:21420995
Gart	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of GART mRNA	CTD	PMID:33387578
Gart	Rat	paraquat	increases expression	ISO	RGD:1318654	6480464	Paraquat results in increased expression of GART mRNA	CTD	PMID:21371552
Gart	Rat	paraquat	decreases expression	ISO	RGD:1318654	6480464	Paraquat results in decreased expression of GART mRNA	CTD	PMID:21371552
Gart	Rat	perfluorononanoic acid	increases expression	ISO	RGD:1318653	6480464	perfluoro-n-nonanoic acid results in increased expression of GART mRNA	CTD	PMID:32588087
Gart	Rat	perfluorooctanoic acid	increases expression	ISO	RGD:1318653	6480464	perfluorooctanoic acid results in increased expression of GART protein	CTD	PMID:26879310
Gart	Rat	pyrogallol	increases expression	ISO	RGD:1318654	6480464	Pyrogallol results in increased expression of GART mRNA	CTD	PMID:20362636
Gart	Rat	resveratrol	multiple interactions	ISO	RGD:1318653	6480464	[Plant Extracts co-treated with Resveratrol] results in increased expression of GART mRNA	CTD	PMID:23557933
Gart	Rat	SB 431542	multiple interactions	ISO	RGD:1318653	6480464	[LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of GART more ...	CTD	PMID:37664457
Gart	Rat	sodium arsenite	multiple interactions	ISO	RGD:1318653	6480464	sodium arsenite promotes the reaction [GART protein binds to CAPRIN1 protein]	CTD	PMID:33939924
Gart	Rat	sodium chloride	multiple interactions	ISO	RGD:1318653	6480464	[Sodium Chloride co-treated with Furaldehyde] results in decreased expression of GART protein; [Sodium Chloride co-treated more ...	CTD	PMID:38598786
Gart	Rat	sodium dichromate	increases expression	EXP		6480464	sodium bichromate results in increased expression of GART mRNA	CTD	PMID:25993096
Gart	Rat	sodium fluoride	increases expression	ISO	RGD:1318654	6480464	Sodium Fluoride results in increased expression of GART protein	CTD	PMID:28918527
Gart	Rat	tamoxifen	affects expression	ISO	RGD:1318654	6480464	Tamoxifen affects the expression of GART mRNA	CTD	PMID:17555576
Gart	Rat	testosterone	multiple interactions	ISO	RGD:1318653	6480464	[Testosterone co-treated with Calcitriol] results in decreased expression of GART mRNA	CTD	PMID:21592394
Gart	Rat	testosterone	decreases expression	ISO	RGD:1318653	6480464	Testosterone results in decreased expression of GART mRNA	CTD	PMID:21592394
Gart	Rat	tetrachloromethane	increases expression	EXP		6480464	Carbon Tetrachloride results in increased expression of GART mRNA	CTD	PMID:31150632
Gart	Rat	thioacetamide	increases expression	EXP		6480464	Thioacetamide results in increased expression of GART mRNA	CTD	PMID:23411599\|PMID:34492290
Gart	Rat	thiram	decreases expression	ISO	RGD:1318653	6480464	Thiram results in decreased expression of GART mRNA	CTD	PMID:38568856
Gart	Rat	topotecan	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of GART mRNA	CTD	PMID:25729387
Gart	Rat	trichostatin A	increases expression	ISO	RGD:1318653	6480464	trichostatin A results in increased expression of GART mRNA	CTD	PMID:24935251
Gart	Rat	trimellitic anhydride	increases expression	ISO	RGD:1318654	6480464	trimellitic anhydride results in increased expression of GART mRNA	CTD	PMID:19042947
Gart	Rat	triphenyl phosphate	affects expression	ISO	RGD:1318653	6480464	triphenyl phosphate affects the expression of GART mRNA	CTD	PMID:37042841
Gart	Rat	triptonide	decreases expression	ISO	RGD:1318654	6480464	triptonide results in decreased expression of GART mRNA	CTD	PMID:33045310
Gart	Rat	valproic acid	affects expression	ISO	RGD:1318653	6480464	Valproic Acid affects the expression of GART mRNA	CTD	PMID:25979313
Gart	Rat	valproic acid	decreases expression	ISO	RGD:1318653	6480464	Valproic Acid results in decreased expression of GART mRNA	CTD	PMID:23179753\|PMID:27188386
Gart	Rat	valproic acid	increases expression	ISO	RGD:1318653	6480464	Valproic Acid results in increased expression of GART mRNA	CTD	PMID:23179753\|PMID:26272509\|PMID:29154799
Gart	Rat	vincristine	decreases expression	ISO	RGD:1318653	6480464	Vincristine results in decreased expression of GART mRNA	CTD	PMID:23649840
Gart	Rat	zinc atom	multiple interactions	ISO	RGD:1318653	6480464	[PCI 5002 co-treated with Zinc] results in decreased expression of GART mRNA	CTD	PMID:18593933
Gart	Rat	zinc(0)	multiple interactions	ISO	RGD:1318653	6480464	[PCI 5002 co-treated with Zinc] results in decreased expression of GART mRNA	CTD	PMID:18593933

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gart	Rat	'de novo' AMP biosynthetic process	involved_in	ISO	RGD:1318653	1624291	PMID:2183217	RGD	PMID:2183217
Gart	Rat	'de novo' AMP biosynthetic process	involved_in	IEA	UniProtKB:Q64737\|ensembl:ENSMUSP00000023684	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gart	Rat	'de novo' AMP biosynthetic process	involved_in	IEA	UniProtKB:P22102\|ensembl:ENSP00000371236	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gart	Rat	'de novo' AMP biosynthetic process	involved_in	ISO	RGD:1318654	1624291	PMID:8299947	RGD	PMID:8299947
Gart	Rat	'de novo' IMP biosynthetic process	involved_in	IEA	UniPathway:UPA00074	1600115	GO_REF:0000041	UniProt	GO_REF:0000041
Gart	Rat	'de novo' IMP biosynthetic process	involved_in	IEA	InterPro:IPR004607\|InterPro:IPR004733	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gart	Rat	'de novo' IMP biosynthetic process	involved_in	IEA	UniProtKB:P22102\|ensembl:ENSP00000371236	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gart	Rat	'de novo' IMP biosynthetic process	involved_in	IEA	UniRule:UR000328772	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Gart	Rat	'de novo' IMP biosynthetic process	involved_in	ISO	RGD:1318654	1624291	PMID:8299947	RGD	PMID:8299947
Gart	Rat	'de novo' IMP biosynthetic process	involved_in	IEA	UniProtKB:Q64737\|ensembl:ENSMUSP00000023684	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gart	Rat	'de novo' IMP biosynthetic process	involved_in	ISO	RGD:1318653	1624291	PMID:2183217	RGD	PMID:2183217
Gart	Rat	'de novo' XMP biosynthetic process	involved_in	IEA	UniProtKB:P22102\|ensembl:ENSP00000371236	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gart	Rat	'de novo' XMP biosynthetic process	involved_in	IEA	UniProtKB:Q64737\|ensembl:ENSMUSP00000023684	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gart	Rat	'de novo' XMP biosynthetic process	involved_in	ISO	RGD:1318654	1624291	PMID:8299947	RGD	PMID:8299947
Gart	Rat	'de novo' XMP biosynthetic process	involved_in	ISO	RGD:1318653	1624291	PMID:2183217	RGD	PMID:2183217
Gart	Rat	adenine biosynthetic process	involved_in	IBA	CGD:CAL0000199243\|PANTHER:PTN000055158	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gart	Rat	brainstem development		IEP		2301991		RGD
Gart	Rat	cerebellum development		IEP		2301991		RGD
Gart	Rat	cerebral cortex development		IEP		2301991		RGD
Gart	Rat	GMP biosynthetic process	involved_in	ISO	RGD:1318653	1624291	PMID:2183217	RGD	PMID:2183217
Gart	Rat	GMP biosynthetic process	involved_in	IEA	UniProtKB:Q64737\|ensembl:ENSMUSP00000023684	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gart	Rat	GMP biosynthetic process	involved_in	ISO	RGD:1318654	1624291	PMID:8299947	RGD	PMID:8299947
Gart	Rat	GMP biosynthetic process	involved_in	IEA	UniProtKB:P22102\|ensembl:ENSP00000371236	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gart	Rat	nucleobase-containing small molecule metabolic process	involved_in	IEA	ARBA:ARBA00027681	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Gart	Rat	purine nucleobase biosynthetic process	involved_in	IEA	UniRule:UR000328772	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Gart	Rat	purine nucleobase biosynthetic process	involved_in	IEA	InterPro:IPR000115\|InterPro:IPR020559\|InterPro:IPR020560\|InterPro:IPR020562\|InterPro:IPR037123	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gart	Rat	purine nucleotide biosynthetic process	involved_in	IBA	MGI:95654\|PANTHER:PTN000055158\|PomBase:SPBC405.01\|TAIR:locus:2097203\|UniProtKB:P22102	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gart	Rat	purine nucleotide biosynthetic process	involved_in	IEA	UniProtKB-KW:KW-0658	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gart	Rat	purine-containing compound biosynthetic process	involved_in	IEA	ARBA:ARBA00026861	1600115	GO_REF:0000117	UniProt	GO_REF:0000117

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gart	Rat	cytosol	is_active_in	IEA	UniProtKB:Q64737\|ensembl:ENSMUSP00000023684	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gart	Rat	cytosol	is_active_in	ISO	RGD:1318654	1624291	PMID:8299947	RGD	PMID:8299947
Gart	Rat	cytosol	is_active_in	IBA	MGI:95654\|PANTHER:PTN000055158\|UniProtKB:P08178\|UniProtKB:P22102	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gart	Rat	cytosol	is_active_in	ISO	RGD:1318653	1624291	PMID:2183217	RGD	PMID:2183217
Gart	Rat	cytosol	is_active_in	IEA	UniProtKB:P22102\|ensembl:ENSP00000371236	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gart	Rat	ATP binding	enables	IEA	UniRule:UR000414645	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Gart	Rat	ATP binding	enables	IEA	UniProtKB-KW:KW-0067	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gart	Rat	ATP binding	enables	IEA	InterPro:IPR011761\|InterPro:IPR013815	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gart	Rat	catalytic activity	enables	IEA	UniProtKB-KW:KW-0511	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gart	Rat	catalytic activity	enables	IEA	ARBA:ARBA00027533	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Gart	Rat	ligase activity	enables	IEA	UniProtKB-KW:KW-0436	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gart	Rat	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gart	Rat	metal ion binding	enables	IEA	InterPro:IPR011761	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gart	Rat	nucleotide binding	enables	IEA	UniRule:UR000414645	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Gart	Rat	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gart	Rat	phosphoribosylamine-glycine ligase activity		IDA		5135453		RGD
Gart	Rat	phosphoribosylamine-glycine ligase activity	enables	IEA	UniRule:UR000328772	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Gart	Rat	phosphoribosylamine-glycine ligase activity	enables	IEA	InterPro:IPR000115\|InterPro:IPR020559\|InterPro:IPR020560\|InterPro:IPR020562\|InterPro:IPR037123	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gart	Rat	phosphoribosylamine-glycine ligase activity	enables	IEA	EC:6.3.4.13	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Gart	Rat	phosphoribosylamine-glycine ligase activity	enables	IBA	FB:FBgn0000053\|MGI:95654\|PANTHER:PTN000055158\|PomBase:SPBC405.01\|RGD:1308717	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gart	Rat	phosphoribosylamine-glycine ligase activity	enables	IEA	UniProtKB:Q64737\|ensembl:ENSMUSP00000023684	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gart	Rat	phosphoribosylamine-glycine ligase activity	enables	ISO	RGD:1318654	1624291	PMID:8299947	RGD	PMID:8299947
Gart	Rat	phosphoribosylformylglycinamidine cyclo-ligase activity		IDA		5135453		RGD
Gart	Rat	phosphoribosylformylglycinamidine cyclo-ligase activity	enables	IEA	EC:6.3.3.1	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Gart	Rat	phosphoribosylformylglycinamidine cyclo-ligase activity	enables	IEA	UniProtKB:P22102\|ensembl:ENSP00000371236	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gart	Rat	phosphoribosylformylglycinamidine cyclo-ligase activity	enables	IBA	FB:FBgn0000053\|PANTHER:PTN000055158\|PomBase:SPBC405.01\|RGD:1308717\|TAIR:locus:2097203\|UniProtKB:P08178\|UniProtKB:P22102	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gart	Rat	phosphoribosylformylglycinamidine cyclo-ligase activity	enables	IEA	InterPro:IPR004733	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gart	Rat	phosphoribosylformylglycinamidine cyclo-ligase activity	enables	ISO	RGD:1318653	1624291	PMID:2183217	RGD	PMID:2183217
Gart	Rat	phosphoribosylglycinamide formyltransferase activity		IDA		5135453		RGD
Gart	Rat	phosphoribosylglycinamide formyltransferase activity	enables	IEA	EC:2.1.2.2	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Gart	Rat	phosphoribosylglycinamide formyltransferase activity	enables	IEA	UniProtKB:P22102\|ensembl:ENSP00000371236	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Gart	Rat	phosphoribosylglycinamide formyltransferase activity	enables	IEA	InterPro:IPR004607	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gart	Rat	phosphoribosylglycinamide formyltransferase activity	enables	ISO	RGD:1318653	1624291	PMID:2183217	RGD	PMID:2183217

Molecular Pathway Annotations Click to see Annotation Detail View

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gart	Rat	de novo purine biosynthetic pathway		ISO	RGD:1318653	1547842		RGD
Gart	Rat	folate mediated one-carbon metabolic pathway		ISO	RGD:1318653	1547842		RGD
Gart	Rat	folate mediated one-carbon metabolic pathway		ISO	RGD:1318653	7242561		RGD
Gart	Rat	folate metabolic pathway		ISO	RGD:1318653	1547842		RGD

Imported Annotations - SMPDB

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gart	Rat	adenine phoshoribosyltransferase deficiency pathway		ISO	RGD:1318653	10402751		SMPDB	SMP:00535
Gart	Rat	adenosine monophosphate deaminase deficiency pathway		ISO	RGD:1318653	10402751		SMPDB	SMP:00537
Gart	Rat	adenylosuccinate lyase deficiency pathway		ISO	RGD:1318653	10402751		SMPDB	SMP:00167
Gart	Rat	AICA-ribosuria pathway		ISO	RGD:1318653	10402751		SMPDB	SMP:00168
Gart	Rat	azathioprine pharmacodynamics pathway		ISO	RGD:1318653	10402751		SMPDB	SMP:00427
Gart	Rat	Kelley-Seegmiller syndrome pathway		ISO	RGD:1318653	10402751		SMPDB	SMP:00365
Gart	Rat	Lesch-Nyhan syndrome pathway		ISO	RGD:1318653	10402751		SMPDB	SMP:00364
Gart	Rat	mercaptopurine pharmacodynamics pathway		ISO	RGD:1318653	10402751		SMPDB	SMP:00428
Gart	Rat	molybdenum cofactor deficiency pathway		ISO	RGD:1318653	10402751		SMPDB	SMP:00203
Gart	Rat	purine metabolic pathway		ISO	RGD:1318653	10402751		SMPDB	SMP:00050
Gart	Rat	purine nucleoside phosphorylase deficiency pathway		ISO	RGD:1318653	10402751		SMPDB	SMP:00210
Gart	Rat	tioguanine pharmacodynamics pathway		ISO	RGD:1318653	10402751		SMPDB	SMP:00430
Gart	Rat	xanthinuria type I pathway		ISO	RGD:1318653	10402751		SMPDB	SMP:00512
Gart	Rat	xanthinuria pathway		ISO	RGD:1318653	10402751		SMPDB	SMP:00220
Gart	Rat	xanthinuria type II pathway		ISO	RGD:1318653	10402751		SMPDB	SMP:00513

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gart	Rat	folate mediated one-carbon metabolic pathway		IEA		6907045		KEGG	rno:00670
Gart	Rat	purine metabolic pathway		IEA		6907045		KEGG	rno:00230

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis type 1 (ISO)

Animal Disease Models (ISO)

autosomal dominant intellectual developmental disorder 7 (ISO)

Down syndrome (ISO)

Familial Platelet Disorder with Associated Myeloid Malignancy (ISO)

immunodeficiency 28 (ISO)

intellectual disability (ISO)

lung adenocarcinoma (ISO)

Parkinson's disease 20 (ISO)

rheumatoid arthritis (ISO)

Tracheoesophageal Fistula (ISO)

ZTTK syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,4-dinitrotoluene (EXP)

2,6-dimethoxyphenol (ISO)

2,6-dinitrotoluene (EXP)

2-bromohexadecanoic acid (ISO)

2-methylcholine (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

5-fluorouracil (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzatropine (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chlorophyllin (ISO)

chromium(6+) (ISO)

clofibric acid (EXP)

clozapine (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

DDE (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

diclofenac (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

furfural (ISO)

gallic acid (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

ivermectin (ISO)

menadione (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

methylparaben (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

nitrates (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (ISO)

pyrogallol (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

thiram (ISO)

topotecan (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

vincristine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

'de novo' AMP biosynthetic process (IEA,ISO)

'de novo' IMP biosynthetic process (IEA,ISO)

'de novo' XMP biosynthetic process (IEA,ISO)

adenine biosynthetic process (IBA)

brainstem development (IEP)

cerebellum development (IEP)

cerebral cortex development (IEP)

GMP biosynthetic process (IEA,ISO)

nucleobase-containing small molecule metabolic process (IEA)

purine nucleobase biosynthetic process (IEA)

purine nucleotide biosynthetic process (IBA,IEA)

purine-containing compound biosynthetic process (IEA)

Cellular Component

cytosol (IBA,IEA,ISO)

Molecular Function

ATP binding (IEA)

catalytic activity (IEA)

ligase activity (IEA)

metal ion binding (IEA)

nucleotide binding (IEA)

phosphoribosylamine-glycine ligase activity (IBA,IDA,IEA,ISO)

phosphoribosylformylglycinamidine cyclo-ligase activity (IBA,IDA,IEA,ISO)

phosphoribosylglycinamide formyltransferase activity (IDA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

References

References - curated

#	Reference Title	Reference Citation
1.	The human GARS-AIRS-GART gene encodes two proteins which are differentially expressed during human brain development and temporally overexpressed in cerebellum of individuals with Down syndrome.	Brodsky G, etal., Hum Mol Genet. 1997 Nov;6(12):2043-50.
2.	Characterization of mammalian phosphoribosylglycineamide formyltransferase from transformed cells.	Daubner SC and Benkovic SJ, Cancer Res. 1985 Oct;45(10):4990-7.
3.	Effect of cobalamin inactivation on folate-dependent transformylases involved in purine synthesis in rats.	Deacon R, etal., Biochem J. 1985 Apr 1;227(1):67-71.
4.	Role of folate dependent transformylases in synthesis of purine in bone marrow of man and in bone marrow and liver of rats.	Deacon R, etal., J Clin Pathol. 1985 Dec;38(12):1349-52.
5.	Developmental changes in the folate-dependent enzymes of de novo purine biosynthesis in rat brain.	Dominguez J and Ordonez LA, J Neurochem. 1982 Mar;38(3):625-30.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
8.	Purification of mammalian glycinamide ribonucleotide (GAR) synthetase.	Hards RG, etal., Adv Exp Med Biol. 1986;195 Pt B:315-9.
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation
14.	Trafficking of intracellular folates.	Stover PJ and Field MS, Adv Nutr. 2011 Jul;2(4):325-31. doi: 10.3945/¿an.111.000596. Epub 2011 Jun 28.
15.	Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.	Zhang Y, etal., Biochemistry 2002 Dec 3;41(48):14206-15.

Additional References at PubMed

PMID:12477932	PMID:20458337	PMID:24709117

Genomics

Comparative Map Data

Gart
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	44,351,841 - 44,377,086 (-)	NCBI		GRCr8
mRatBN7.2	11	30,864,896 - 30,891,125 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	30,865,889 - 30,891,125 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	39,559,784 - 39,585,049 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	32,231,220 - 32,256,482 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	31,396,470 - 31,421,682 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	31,780,477 - 31,805,728 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	31,780,487 - 31,805,728 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	35,389,216 - 35,414,461 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	31,594,859 - 31,620,110 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	31,646,660 - 31,659,129 (-)	NCBI
Celera	11	30,533,312 - 30,558,557 (-)	NCBI		Celera
Cytogenetic Map	11	q11	NCBI

GART
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	33,503,931 - 33,542,893 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	33,503,931 - 33,543,491 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	21	34,876,238 - 34,915,198 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	33,798,139 - 33,836,286 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	21	33,818,186 - 33,836,286	NCBI
Celera	21	20,075,872 - 20,114,832 (-)	NCBI		Celera
Cytogenetic Map	21	q22.11	ENTREZGENE
HuRef	21	20,354,547 - 20,393,666 (-)	NCBI		HuRef
CHM1_1	21	34,438,919 - 34,477,881 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	21	31,885,765 - 31,924,746 (-)	NCBI		T2T-CHM13v2.0

Gart
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	91,418,283 - 91,444,505 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	91,418,074 - 91,443,840 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	91,621,395 - 91,646,972 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	91,621,186 - 91,646,952 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	91,621,640 - 91,647,217 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	91,510,268 - 91,535,812 (-)	NCBI		MGSCv36	mm8
Celera	16	92,698,203 - 92,723,705 (-)	NCBI		Celera
Cytogenetic Map	16	C3.3	NCBI
cM Map	16	53.18	NCBI

Gart
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	32,944,164 - 32,973,863 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	32,944,638 - 32,975,142 (-)	NCBI	ChiLan1.0	ChiLan1.0

GART
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	29,622,168 - 29,660,376 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	24,479,281 - 24,520,421 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	19,871,656 - 19,909,893 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	33,244,457 - 33,282,709 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	33,244,457 - 33,282,331 (-)	Ensembl	panpan1.1		panPan2

LOC487740
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	29,032,399 - 29,063,706 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Gart
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	28,685,224 - 28,715,394 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	8,753,463 - 8,786,236 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	8,750,928 - 8,782,303 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GART
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	197,130,904 - 197,161,891 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	197,130,898 - 197,158,797 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	206,941,099 - 206,971,945 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GART
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	58,641,566 - 58,682,014 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	58,643,877 - 58,683,023 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	1,144,831 - 1,183,711 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gart
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	21,734,282 - 21,762,734 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624745	21,735,431 - 21,763,330 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gart
128 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	165
Count of miRNA genes:	118
Interacting mature miRNAs:	130
Transcripts:	ENSRNOT00000032162
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	1	69446234	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
1598842	Glom10	Glomerulus QTL 10	3.4		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	1	35331169	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
10755497	Bp388	Blood pressure QTL 388	2.76		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	19456205	76331918	Rat
724517	Uae18	Urinary albumin excretion QTL 18	3.7		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	16472047	44285911	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	22959403	67959403	Rat
1300130	Rf20	Renal function QTL 20	4.44		kidney glomerulus integrity trait (VT:0010546)	kidney glomerulus diameter (CMO:0001166)	11	29528418	60324829	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	1041931	66113562	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	23280456	68280456	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	23280456	68280456	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat
1641927	Alcrsp10	Alcohol response QTL 10			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	11	8436674	53436674	Rat

Markers in Region

RH140539

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	30,878,931 - 30,879,108 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	31,793,535 - 31,793,711	NCBI	Rnor6.0
Rnor_5.0	11	35,402,268 - 35,402,444	UniSTS	Rnor5.0
RGSC_v3.4	11	31,607,917 - 31,608,093	UniSTS	RGSC3.4
Celera	11	30,546,364 - 30,546,540	UniSTS
RH 3.4 Map	11	176.8	UniSTS
Cytogenetic Map	11	q11	UniSTS

REN85607

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	30,880,554 - 30,880,937 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	31,795,158 - 31,795,540	NCBI	Rnor6.0
Rnor_5.0	11	35,403,891 - 35,404,273	UniSTS	Rnor5.0
RGSC_v3.4	11	31,609,540 - 31,609,922	UniSTS	RGSC3.4
Celera	11	30,547,987 - 30,548,369	UniSTS
Cytogenetic Map	11	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001011899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120736	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC120974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC168661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000032162 ⟹ ENSRNOP00000033253

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	30,865,889 - 30,891,125 (-)	Ensembl
Rnor_6.0 Ensembl	11	31,780,487 - 31,805,728 (-)	Ensembl

RefSeq Acc Id:

NM_001011899 ⟹ NP_001011899

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	44,351,841 - 44,377,086 (-)	NCBI
mRatBN7.2	11	30,865,879 - 30,891,125 (-)	NCBI
Rnor_6.0	11	31,780,477 - 31,805,728 (-)	NCBI
Rnor_5.0	11	35,389,216 - 35,414,461 (-)	NCBI
RGSC_v3.4	11	31,594,859 - 31,620,110 (-)	RGD
Celera	11	30,533,312 - 30,558,557 (-)	RGD

Sequence:

show sequence

ATTCCCGGGGCCAACTTCCGGCGAGTGCGAGTGGCGGGTGCGAATGCGAGCTGCGTGGCCGGGC
TTGCAGGTTTCATTTGGCTTCTGAATTCCTGCTTCGGAGACAACAATGGCAGCCCGAGTTCTTG
TAATCGGTAGTGGAGGAAGGGAACACACCCTGGCCTGGAAACTCGCACAATCCCCTCATGTCAA
ACAAGTGCTGGTTGCCCCAGGAAATGCAGGCACAGCTTCTGCTGGGAAGATCTCCAATGCTGCT
GTCTCCATCAATGATCACACTGCTCTCGCTCGGTTCTGCAAAGATGAAAAGATTGAACTCGTAG
TTGTTGGACCAGAGGCCCCTCTGGCTGCAGGGATTGTTGGGGACCTGACTTCTGCAGGAGTGCG
ATGCTTTGGCCCCACGGCACAAGCAGCTCTACTGGAGTCCAGTAAAAAGTTTGCCAAAGAGTTT
ATGGACCGACATGGCGTCCCAACTGCACAGTGGCGGGCATTCACCAGCCCTGAAGACGCCTGCA
GCTTTATTATGAGCGCGGACTTTCCTGCTTTGGTTGTGAAGGCCAGTGGCCTTGCAGCAGGGAA
GGGGGTGATTGTGGCGAAGAGCAAAGCTGAAGCCTGCGAAGCTGTTCAGGAGATCATGCAAGAA
AAGTCATTTGGAGCAGCCGGTGAAACTGTTGTCGTGGAGGAGCTTCTGGAAGGGGAAGAAGTGT
CTTGCCTGTGCTTCACTGATGGGAAGACAGTGGCCCCAATGCCCCCAGCACAAGACCATAAGCG
ATTGCTGGATGGAGATCGGGGACCCAACACTGGAGGAATGGGAGCCTACTGCCCTGCACCTCAG
GTTCCTAAGGATTTGTTAGTAAAAATTAAAAACACAATTCTTCAGAGAACAGTAGATGGCATGC
AGCAGGAGGGGGTGCCGTACACAGGAATTCTTTATGCTGGTATAATGCTGACCAAAGATGGCCC
AAAAGTTTTGGAGTTTAATTGCCGTTTTGGTGATCCAGAATGCCAGGTCATCCTCCCACTTCTT
AAAAGTGACCTTTATGAAGTGATTCAGTCCACCTTTGATGGCCTGCTGAGCGAGTCTCCGCCTG
TTTGGCTAGAAAACCACAGTGCCGTAACTGTTGTCATGGCGAGTGGAGGGTATCCTGGAGCCTA
CACCAAGGGTGTGGAGATTACAGGGTTTCCTGAGGCCCAAGCTTTAGGACTGCAGGTCTTTCAT
GCAGGCACTGCTCTTAAAGATGCCAAAGTGGTGACCAGCGGGGGCAGAGTCCTCACAGTGACAG
CTGTCCGGGAAAATCTCATGTCAGCCCTTGATGAGGCCAGGAAGGGACTCGCTGCTCTAAAGTT
TGAGGGAGCAGTTTACCGAAAGGACATTGGCTTCCGTGCTGTGGCCTTCCTCCAGCGGCCCAGG
GGCCTGACCTACAAGGACTCTGGAGTAGACATTGCAGCTGGAAATATGCTGGTTAAGAAAATTC
AGCCTTTAGCCAAAGCTACCTCCAGACCAGGCTGCAGTGTTGACCTTGGGGGCTTTGCTGGTCT
TTTTGATTTGAAAGCAGCTGGTTTCAAAGATCCTCTTCTGGCCTCTGGAACAGACGGTGTTGGA
ACTAAACTAAAGATTGCCCAGCTGTGCAATAAGCATGACTCCATCGGTCAGGATCTGGTTGCGA
TGTGCGTGAACGACATCCTCGCACAAGGAGCAGAGCCCCTCTTCTTCCTTGACTACTTTTCCTG
TGGAAAACTTGACCTTAGTACAACTGAGGCTGTGGTTGCTGGAATTGCTGCAGCTTGCCGACAG
GCTGGGTGTGCTCTCCTAGGTGGGGAGACAGCAGAGATGCCCGACATGTACCCCCCTGGAGAGT
ATGATCTTGCCGGATTTGCTGTTGGTGCTATGGAGAGACACCAGAAGCTCCCTCAGCTAGAAAG
GATCGCCGAAGGAGATGCCGTTATTGGAGTGGCTTCATCTGGTCTTCACAGCAATGGCTTTAGC
CTTGTGAGGAAAATTGTGGAGAGGTCTTCACTCCAGTACTCCTCTCCAGCACCGGGTGGTTGTG
GAGATCAGACTTTAGGGGACTTACTTCTAACTCCAACCAGGATCTACAGCCATTCACTGCTGCC
TATCATACGTTCAGGACGTGTCAAAGCTTTTGCTCATATTACTGGAGGTGGATTGCTGGAAAAC
ATCCCCAGAGTCCTCCCTCGGAAGCTTGGAGTAGATTTAGATGCCTATACCTGGAGGGTCCCCA
AGGTCTTCTCATGGCTACAGCAAGAAGGACAGCTCTCTGAAGAAGAAATGGCCAGGACATTCAA
CTGTGGGGTTGGAGCTGCCCTGGTGGTATCAAAGGACCAAACAGAGCAGATTCTCCATGACATT
CGGCAGCACCAGGAAGACGCCTGGGTGATAGGCAGTGTCGTTGAGTGTCCCGAAGATTCCCCTC
GTGTCAGAGTTAAGAATCTGATTGAAACCATGCAAACAAAGGGGTCAGTGGTGACAAACGGCTT
CCTGAGAAGTAATTTCCCTAGCCAGCAAAAGAAAGCAAGAGTGGCTGTCCTAATATCTGGAACA
GGGTCGAACCTCCAGGCACTCATAGACAGCACTCGGGATCCAAAAAGCTCCTCACACATCGTTC
TTGTCATCTCCAACAAAGCTGCAGTTGCTGGCTTAGACCGAGCAGAGCGAGCTGGCATTCCCAC
CAGGGTGATTAATCATAAGTTATATAAAAGTCGTGTCGAGTTTGACAACGCAGTTGACCATGTC
CTGGAAGAGTTCTCAGTAGACATAGTCTGTCTCGCAGGATTCATGAGGATCCTCTCTGGCCCGT
TTGTCAGAAAATGGGATGGGAAAATGCTCAACATCCACCCGTCCTTGCTCCCTTCTTTTAAGGG
TTCAAATGCTCACGAGCAGGTTCTGGAGGCTGGAGTCACCATTACTGGGTGCACCGTACACTTT
GTAGCTGAAGACGTAGATGCCGGGCAAATCATCCTACAGGAAGCTGTCCCTGTGCAGAGGGACG
ACACTGTTGCAACACTGTCTGAACGCGTCAAGGCAGCAGAACATAAGATATTTCCTGCAGCCCT
CCAACTAGTGGCCAGTGGGGCTGTGCAGCTGGGAGAAGACGGCAAGATCCACTGGGCCAGAGAG
CAGTAGCCCGTCCTGAGCAGGAGGGCCAGTGCCGAGAGAGAAGCAGGGCTTGCTGGGTGCCTTT
TCTTCTCTTTTTCTTCCCCAGAGCTGAGGACCAAACCCAGAGCCTTGCACTTGCTAGCAAGCAC
TCTACCACTGAGCTAAATCCCCAGCCCTGCTGGGTGCCTTTTCATCGTGGCCATGGCCCAAACT
TATATACCTGCTAGTAAAAAGTCTTTAATCCTTACCAGCCGCCATGTTTTTAATAAATAGGTTC
ATTAAAAACAAAA

hide sequence

RefSeq Acc Id:

XM_017597941 ⟹ XP_017453430

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	44,351,841 - 44,377,000 (-)	NCBI
mRatBN7.2	11	30,864,896 - 30,891,049 (-)	NCBI
Rnor_6.0	11	31,780,477 - 31,805,629 (-)	NCBI

Sequence:

show sequence

TGCGTGGACTGCGTTTACGCTCTGACCTGTGGGTTTAACCTCAGCAACCGGTTCTGCTATTGAA
ACTTGGCGTGGCTGGCGAAAAGGCCACGTGCTTTGCACAGCCTTGACAGAGGTCGGCCAGGTTT
CATTTGGCTTCTGAATTCCTGCTTCGGAGACAACAATGGCAGCCCGAGTTCTTGTAATCGGTAG
TGGAGGAAGGGAACACACCCTGGCCTGGAAACTCGCACAATCCCCTCATGTCAAACAAGTGCTG
GTTGCCCCAGGAAATGCAGGCACAGCTTCTGCTGGGAAGATCTCCAATGCTGCTGTCTCCATCA
ATGATCACACTGCTCTCGCTCGGTTCTGCAAAGATGAAAAGATTGAACTCGTAGTTGTTGGACC
AGAGGCCCCTCTGGCTGCAGGGATTGTTGGGGACCTGACTTCTGCAGGAGTGCGATGCTTTGGC
CCCACGGCACAAGCAGCTCTACTGGAGTCCAGTAAAAAGTTTGCCAAAGAGTTTATGGACCGAC
ATGGCGTCCCAACTGCACAGTGGCGGGCATTCACCAGCCCTGAAGACGCCTGCAGCTTTATTAT
GAGCGCGGACTTTCCTGCTTTGGTTGTGAAGGCCAGTGGCCTTGCAGCAGGGAAGGGGGTGATT
GTGGCGAAGAGCAAAGCTGAAGCCTGCGAAGCTGTTCAGGAGATCATGCAAGAAAAGTCATTTG
GAGCAGCCGGTGAAACTGTTGTCGTGGAGGAGCTTCTGGAAGGGGAAGAAGTGTCTTGCCTGTG
CTTCACTGATGGGAAGACAGTGGCCCCAATGCCCCCAGCACAAGACCATAAGCGATTGCTGGAT
GGAGATCGGGGACCCAACACTGGAGGAATGGGAGCCTACTGCCCTGCACCTCAGGTTCCTAAGG
ATTTGTTAGTAAAAATTAAAAACACAATTCTTCAGAGAACAGTAGATGGCATGCAGCAGGAGGG
GGTGCCGTACACAGGAATTCTTTATGCTGGTATAATGCTGACCAAAGATGGCCCAAAAGTTTTG
GAGTTTAATTGCCGTTTTGGTGATCCAGAATGCCAGGTCATCCTCCCACTTCTTAAAAGTGACC
TTTATGAAGTGATTCAGTCCACCTTTGATGGCCTGCTGAGCGAGTCTCCGCCTGTTTGGCTAGA
AAACCACAGTGCCGTAACTGTTGTCATGGCGAGTGGAGGGTATCCTGGAGCCTACACCAAGGGT
GTGGAGATTACAGGGTTTCCTGAGGCCCAAGCTTTAGGACTGCAGGTCTTTCATGCAGGCACTG
CTCTTAAAGATGCCAAAGTGGTGACCAGCGGGGGCAGAGTCCTCACAGTGACAGCTGTCCGGGA
AAATCTCATGTCAGCCCTTGATGAGGCCAGGAAGGGACTCGCTGCTCTAAAGTTTGAGGGAGCA
GTTTACCGAAAGGACATTGGCTTCCGTGCTGTGGCCTTCCTCCAGCGGCCCAGGGGCCTGACCT
ACAAGGACTCTGGAGTAGACATTGCAGCTGGAAATATGCTGGTTAAGAAAATTCAGCCTTTAGC
CAAAGCTACCTCCAGACCAGGCTGCAGTGTTGACCTTGGGGGCTTTGCTGGTCTTTTTGATTTG
AAAGCAGCTGGTTTCAAAGATCCTCTTCTGGCCTCTGGAACAGACGGTGTTGGAACTAAACTAA
AGATTGCCCAGCTGTGCAATAAGCATGACTCCATCGGTCAGGATCTGGTTGCGATGTGCGTGAA
CGACATCCTCGCACAAGGAGCAGAGCCCCTCTTCTTCCTTGACTACTTTTCCTGTGGAAAACTT
GACCTTAGTACAACTGAGGCTGTGGTTGCTGGAATTGCTGCAGCTTGCCGACAGGCTGGGTGTG
CTCTCCTAGGTGGGGAGACAGCAGAGATGCCCGACATGTACCCCCCTGGAGAGTATGATCTTGC
CGGATTTGCTGTTGGTGCTATGGAGAGACACCAGAAGCTCCCTCAGCTAGAAAGGATCGCCGAA
GGAGATGCCGTTATTGGAGTGGCTTCATCTGGTCTTCACAGCAATGGCTTTAGCCTTGTGAGGA
AAATTGTGGAGAGGTCTTCACTCCAGTACTCCTCTCCAGCACCGGGTGGTTGTGGAGATCAGAC
TTTAGGGGACTTACTTCTAACTCCAACCAGGATCTACAGCCATTCACTGCTGCCTATCATACGT
TCAGGACGTGTCAAAGCTTTTGCTCATATTACTGGAGGTGGATTGCTGGAAAACATCCCCAGAG
TCCTCCCTCGGAAGCTTGGAGTAGATTTAGATGCCTATACCTGGAGGGTCCCCAAGGTCTTCTC
ATGGCTACAGCAAGAAGGACAGCTCTCTGAAGAAGAAATGGCCAGGACATTCAACTGTGGGGTT
GGAGCTGCCCTGGTGGTATCAAAGGACCAAACAGAGCAGATTCTCCATGACATTCGGCAGCACC
AGGAAGACGCCTGGGTGATAGGCAGTGTCGTTGAGTGTCCCGAAGATTCCCCTCGTGTCAGAGT
TAAGAATCTGATTGAAACCATGCAAACAAAGGGGTCAGTGGTGACAAACGGCTTCCTGAGAAGT
AATTTCCCTAGCCAGCAAAAGAAAGCAAGAGTGGCTGTCCTAATATCTGGAACAGGGTCGAACC
TCCAGGCACTCATAGACAGCACTCGGGATCCAAAAAGCTCCTCACACATCGTTCTTGTCATCTC
CAACAAAGCTGCAGTTGCTGGCTTAGACCGAGCAGAGCGAGCTGGCATTCCCACCAGGGTGATT
AATCATAAGTTATATAAAAGTCGTGTCGAGTTTGACAACGCAGTTGACCATGTCCTGGAAGAGT
TCTCAGTAGACATAGTCTGTCTCGCAGGATTCATGAGGATCCTCTCTGGCCCGTTTGTCAGAAA
ATGGGATGGGAAAATGCTCAACATCCACCCGTCCTTGCTCCCTTCTTTTAAGGGTTCAAATGCT
CACGAGCAGGTTCTGGAGGCTGGAGTCACCATTACTGGGTGCACCGTACACTTTGTAGCTGAAG
ACGTAGATGCCGGGCAAATCATCCTACAGGAAGCTGTCCCTGTGCAGAGGGACGACACTGTTGC
AACACTGTCTGAACGCGTCAAGGCAGCAGAACATAAGATATTTCCTGCAGCCCTCCAACTAGTG
GCCAGTGGGGCTGTGCAGCTGGGAGAAGACGGCAAGATCCACTGGGCCAGAGAGCAGTAGCCCG
TCCTGAGCAGGAGGGCCAGTGCCGAGAGAGAAGCAGGGCTTGCTGGGTGCCTTTTCTTCTCTTT
TTCTTCCCCAGAGCTGAGGACCAAACCCAGAGCCTTGCACTTGCTAGCAAGCACTCTACCACTG
AGCTAAATCCCCAGCCCTGCTGGGTGCCTTTTCATCGTGGCCATGGCCCAAACTTATATACCTG
CTAGTAAAAAGTCTTTAATCCTTACCAGCCGCCATGTTTTTAATAAATAGGTTCATTAAAAACA
AAA

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Protein Sequences


Protein RefSeqs	NP_001011899	(Get FASTA)	NCBI Sequence Viewer
	XP_017453430	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87644	(Get FASTA)	NCBI Sequence Viewer
	AAI68661	(Get FASTA)	NCBI Sequence Viewer
	EDM10733	(Get FASTA)	NCBI Sequence Viewer
	EDM10734	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000033253
	ENSRNOP00000033253.4

RefSeq Acc Id:

NP_001011899 ⟸ NM_001011899

- UniProtKB:

G3V918 (UniProtKB/TrEMBL), A6JLG8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAARVLVIGSGGREHTLAWKLAQSPHVKQVLVAPGNAGTASAGKISNAAVSINDHTALARFCKD
EKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAALLESSKKFAKEFMDRHGVPTAQWRAFT
SPEDACSFIMSADFPALVVKASGLAAGKGVIVAKSKAEACEAVQEIMQEKSFGAAGETVVVEEL
LEGEEVSCLCFTDGKTVAPMPPAQDHKRLLDGDRGPNTGGMGAYCPAPQVPKDLLVKIKNTILQ
RTVDGMQQEGVPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQVILPLLKSDLYEVIQSTFDGL
LSESPPVWLENHSAVTVVMASGGYPGAYTKGVEITGFPEAQALGLQVFHAGTALKDAKVVTSGG
RVLTVTAVRENLMSALDEARKGLAALKFEGAVYRKDIGFRAVAFLQRPRGLTYKDSGVDIAAGN
MLVKKIQPLAKATSRPGCSVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNKHDSI
GQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSTTEAVVAGIAAACRQAGCALLGGETAEMPD
MYPPGEYDLAGFAVGAMERHQKLPQLERIAEGDAVIGVASSGLHSNGFSLVRKIVERSSLQYSS
PAPGGCGDQTLGDLLLTPTRIYSHSLLPIIRSGRVKAFAHITGGGLLENIPRVLPRKLGVDLDA
YTWRVPKVFSWLQQEGQLSEEEMARTFNCGVGAALVVSKDQTEQILHDIRQHQEDAWVIGSVVE
CPEDSPRVRVKNLIETMQTKGSVVTNGFLRSNFPSQQKKARVAVLISGTGSNLQALIDSTRDPK
SSSHIVLVISNKAAVAGLDRAERAGIPTRVINHKLYKSRVEFDNAVDHVLEEFSVDIVCLAGFM
RILSGPFVRKWDGKMLNIHPSLLPSFKGSNAHEQVLEAGVTITGCTVHFVAEDVDAGQIILQEA
VPVQRDDTVATLSERVKAAEHKIFPAALQLVASGAVQLGEDGKIHWAREQ

hide sequence

RefSeq Acc Id:	XP_017453430 ⟸ XM_017597941
- Peptide Label:	isoform X1
- UniProtKB:	G3V918 (UniProtKB/TrEMBL), A6JLG8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAARVLVIGSGGREHTLAWKLAQSPHVKQVLVAPGNAGTASAGKISNAAVSINDHTALARFCKD EKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAALLESSKKFAKEFMDRHGVPTAQWRAFT SPEDACSFIMSADFPALVVKASGLAAGKGVIVAKSKAEACEAVQEIMQEKSFGAAGETVVVEEL LEGEEVSCLCFTDGKTVAPMPPAQDHKRLLDGDRGPNTGGMGAYCPAPQVPKDLLVKIKNTILQ RTVDGMQQEGVPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQVILPLLKSDLYEVIQSTFDGL LSESPPVWLENHSAVTVVMASGGYPGAYTKGVEITGFPEAQALGLQVFHAGTALKDAKVVTSGG RVLTVTAVRENLMSALDEARKGLAALKFEGAVYRKDIGFRAVAFLQRPRGLTYKDSGVDIAAGN MLVKKIQPLAKATSRPGCSVDLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNKHDSI GQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSTTEAVVAGIAAACRQAGCALLGGETAEMPD MYPPGEYDLAGFAVGAMERHQKLPQLERIAEGDAVIGVASSGLHSNGFSLVRKIVERSSLQYSS PAPGGCGDQTLGDLLLTPTRIYSHSLLPIIRSGRVKAFAHITGGGLLENIPRVLPRKLGVDLDA YTWRVPKVFSWLQQEGQLSEEEMARTFNCGVGAALVVSKDQTEQILHDIRQHQEDAWVIGSVVE CPEDSPRVRVKNLIETMQTKGSVVTNGFLRSNFPSQQKKARVAVLISGTGSNLQALIDSTRDPK SSSHIVLVISNKAAVAGLDRAERAGIPTRVINHKLYKSRVEFDNAVDHVLEEFSVDIVCLAGFM RILSGPFVRKWDGKMLNIHPSLLPSFKGSNAHEQVLEAGVTITGCTVHFVAEDVDAGQIILQEA VPVQRDDTVATLSERVKAAEHKIFPAALQLVASGAVQLGEDGKIHWAREQ hide sequence

Ensembl Acc Id:

ENSRNOP00000033253 ⟸ ENSRNOT00000032162

Protein Domains

ATP-grasp

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V918-F1-model_v2	AlphaFold	G3V918	1-1010	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698059

Promoter ID:

EPDNEW_R8584

Type:

multiple initiation site

Name:

Gart_1

Description:

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamidesynthetase, phosphoribosylaminoimidazole synthetase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	31,805,716 - 31,805,776	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308717	AgrOrtholog
BioCyc Gene	G2FUF-21877	BioCyc
Ensembl Genes	ENSRNOG00000028292	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000032162	ENTREZGENE
	ENSRNOT00000032162.5	UniProtKB/TrEMBL
Gene3D-CATH	3.30.1330.10	UniProtKB/TrEMBL
	3.30.1490.20	UniProtKB/TrEMBL
	3.40.50.20	UniProtKB/TrEMBL
	3.90.600.10	UniProtKB/TrEMBL
	3.90.650.10	UniProtKB/TrEMBL
	ATP-grasp fold, B domain	UniProtKB/TrEMBL
	Formyl transferase, N-terminal domain	UniProtKB/TrEMBL
InterPro	AIR_synth_C_dom	UniProtKB/TrEMBL
	ATP-grasp	UniProtKB/TrEMBL
	ATP_grasp_subdomain_1	UniProtKB/TrEMBL
	Formyl_transf_N	UniProtKB/TrEMBL
	Formyl_transf_N_sf	UniProtKB/TrEMBL
	GART_AS	UniProtKB/TrEMBL
	PreATP-grasp-like	UniProtKB/TrEMBL
	PRibGlycinamid_synth_ATP-grasp	UniProtKB/TrEMBL
	PRibGlycinamide_synth	UniProtKB/TrEMBL
	PRibGlycinamide_synth_C-dom	UniProtKB/TrEMBL
	PRibGlycinamide_synth_C_sf	UniProtKB/TrEMBL
	PRibGlycinamide_synth_CS	UniProtKB/TrEMBL
	PRibGlycinamide_synth_N	UniProtKB/TrEMBL
	PurM-like_C_sf	UniProtKB/TrEMBL
	PurM-like_N_sf	UniProtKB/TrEMBL
	PurM_cligase	UniProtKB/TrEMBL
	PurM_N-like	UniProtKB/TrEMBL
	PurN_trans	UniProtKB/TrEMBL
	Rudment_hybrid_motif	UniProtKB/TrEMBL
KEGG Report	rno:288259	UniProtKB/TrEMBL
NCBI Gene	288259	ENTREZGENE
PANTHER	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE	UniProtKB/TrEMBL
	PHOSPHORIBOSYLAMINE--GLYCINE LIGASE, CHLOROPLASTIC	UniProtKB/TrEMBL
	PTHR10520	UniProtKB/TrEMBL
	TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3	UniProtKB/TrEMBL
Pfam	AIRS	UniProtKB/TrEMBL
	AIRS_C	UniProtKB/TrEMBL
	Formyl_trans_N	UniProtKB/TrEMBL
	GARS_A	UniProtKB/TrEMBL
	GARS_C	UniProtKB/TrEMBL
	GARS_N	UniProtKB/TrEMBL
PharmGKB	GART	RGD
PhenoGen	Gart	PhenoGen
PROSITE	ATP_GRASP	UniProtKB/TrEMBL
	GARS	UniProtKB/TrEMBL
	GART	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000028292	RatGTEx
SMART	GARS_A	UniProtKB/TrEMBL
	GARS_C	UniProtKB/TrEMBL
Superfamily-SCOP	AIR_synth_C	UniProtKB/TrEMBL
	formyl_transf	UniProtKB/TrEMBL
	Glutathione synthetase ATP-binding domain-like	UniProtKB/TrEMBL
	PreATP-grasp-like	UniProtKB/TrEMBL
	Rudmnt_hyb_motif	UniProtKB/TrEMBL
	SSF55326	UniProtKB/TrEMBL
UniProt	A6JLG8	ENTREZGENE, UniProtKB/TrEMBL
	A6JLG9_RAT	UniProtKB/TrEMBL
	B5DEG6_RAT	UniProtKB/TrEMBL
	G3V918	ENTREZGENE, UniProtKB/TrEMBL
	Q5PPK3_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-07	Gart	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Gart	phosphoribosylglycinamide formyltransferase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Gart	phosphoribosylglycinamide formyltransferase	Gart_predicted	phosphoribosylglycinamide formyltransferase (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Gart_predicted	phosphoribosylglycinamide formyltransferase (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)