RGD Reference Report - Developmental changes in the folate-dependent enzymes of de novo purine biosynthesis in rat brain. - Rat Genome Database

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Developmental changes in the folate-dependent enzymes of de novo purine biosynthesis in rat brain.

Authors: Dominguez, J  Ordonez, LA 
Citation: Dominguez J and Ordonez LA, J Neurochem. 1982 Mar;38(3):625-30.
RGD ID: 2301991
Pubmed: PMID:7057182   (View Abstract at PubMed)

The activities of the two folate-dependent enzymes in the de novo purine biosynthetic pathway (e.g., glycinamide ribonucleotide transformylase and aminoimidazolecarboxamide ribonucleotide transformylase), have been evaluated as a function of age in crude extracts from rat brain, liver, kidney, and spleen. The activities of the enzymes in brain are similar to those found in liver and kidney. In all tissues the activity of both enzymes was higher during early development, more than nine times above adult levels. In the CNS the enzymatic activities are apparently related to the periods of increased nucleic acid synthesis, with different activities being found in different regions during development. Our findings lend strong support to the suggestion that folic acid-dependent metabolism plays an important role during early development of the brain.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
brainstem development  IEP 2301991; 2301991 RGD 
cerebellum development  IEP 2301991; 2301991 RGD 
cerebral cortex development  IEP 2301991; 2301991 RGD 
tetrahydrofolate biosynthetic process  IDA 2301991 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Atic  (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase)
Gart  (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase)


Additional Information