Abcc5 (ATP binding cassette subfamily C member 5) - Rat Genome Database

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Gene: Abcc5 (ATP binding cassette subfamily C member 5) Rattus norvegicus
Analyze
Symbol: Abcc5
Name: ATP binding cassette subfamily C member 5
RGD ID: 70913
Description: Predicted to have several functions, including anion transmembrane transporter activity; efflux transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in response to insulin and response to lipopolysaccharide. Localizes to basolateral plasma membrane and perinuclear region of cytoplasm. Orthologous to human ABCC5 (ATP binding cassette subfamily C member 5); PARTICIPATES IN multidrug resistance-associated protein mediated transport pathway; azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Abcc5a; ATP-binding cassette sub-family C (CFTR/MRP) member 5; ATP-binding cassette sub-family C (CFTR/MRP) member 5a; ATP-binding cassette sub-family C member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5a; ATP-binding cassette, subfamily C (CFTR/MRP), member 5; MGC156604; Mrp5; multidrug resistance-associated protein 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21180,473,809 - 80,567,257 (+)NCBI
Rnor_6.0 Ensembl1184,396,033 - 84,490,211 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01184,395,982 - 84,490,215 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01187,460,314 - 87,554,521 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,714,334 - 82,809,354 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11182,771,922 - 82,866,943 (+)NCBI
Celera1179,313,876 - 79,407,221 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2',7'-bis-(2-carboxyethyl)carboxyfluorescein  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5(6)-carboxy-2',7'-dichlorofluorescein  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-fluorouridine  (ISO)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
allyl alcohol  (ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
butylated hydroxyanisole  (ISO)
captan  (ISO)
casticin  (ISO)
celecoxib  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumestrol  (ISO)
crotonaldehyde  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
daidzein  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
dUMP  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethoxyquin  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
genistein  (ISO)
glutathione  (ISO)
hesperetin  (ISO)
hexadecanoic acid  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lithocholic acid  (ISO)
LY294002  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
microcystin-LR  (ISO)
MK 571  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
oltipraz  (ISO)
oxaliplatin  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
pemetrexed  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
picene  (ISO)
potassium chromate  (ISO)
probenecid  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
sodium dichromate  (ISO)
soybean oil  (EXP)
streptozocin  (ISO)
sunitinib  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
tioguanine  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
xanthohumol  (ISO)
zearalenone  (EXP)
zidovudine  (ISO)
zoledronic acid  (ISO)

References

Additional References at PubMed
PMID:10840050   PMID:12477932   PMID:14715514   PMID:15297306   PMID:16614078   PMID:22015764   PMID:26244301  


Genomics

Comparative Map Data
Abcc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21180,473,809 - 80,567,257 (+)NCBI
Rnor_6.0 Ensembl1184,396,033 - 84,490,211 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01184,395,982 - 84,490,215 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01187,460,314 - 87,554,521 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,714,334 - 82,809,354 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11182,771,922 - 82,866,943 (+)NCBI
Celera1179,313,876 - 79,407,221 (+)NCBICelera
Cytogenetic Map11q23NCBI
ABCC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3183,919,934 - 184,017,939 (-)EnsemblGRCh38hg38GRCh38
GRCh383183,919,934 - 184,018,010 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373183,637,722 - 183,735,672 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,120,416 - 185,218,421 (-)NCBINCBI36hg18NCBI36
Build 343185,120,427 - 185,218,377NCBI
Celera3182,081,049 - 182,178,505 (-)NCBI
Cytogenetic Map3q27.1NCBI
HuRef3181,047,368 - 181,143,321 (-)NCBIHuRef
CHM1_13183,602,021 - 183,699,879 (-)NCBICHM1_1
Abcc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,150,053 - 20,245,178 (-)NCBIGRCm39mm39
GRCm39 Ensembl1620,150,053 - 20,245,144 (-)Ensembl
GRCm381620,331,303 - 20,426,428 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,331,303 - 20,426,394 (-)EnsemblGRCm38mm10GRCm38
MGSCv371620,331,376 - 20,426,467 (-)NCBIGRCm37mm9NCBIm37
MGSCv361620,244,846 - 20,339,937 (-)NCBImm8
Celera1620,894,801 - 20,990,015 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.41NCBI
Abcc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,447,920 - 23,522,732 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,447,920 - 23,522,732 (+)NCBIChiLan1.0ChiLan1.0
ABCC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13189,122,590 - 189,219,492 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,122,590 - 189,219,492 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03180,956,139 - 181,054,112 (-)NCBIMhudiblu_PPA_v0panPan3
ABCC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13416,856,624 - 16,947,844 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3416,856,633 - 16,946,422 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3420,943,958 - 21,030,248 (-)NCBI
ROS_Cfam_1.03416,763,912 - 16,854,022 (-)NCBI
UMICH_Zoey_3.13416,802,194 - 16,888,327 (-)NCBI
UNSW_CanFamBas_1.03416,797,769 - 16,884,117 (-)NCBI
UU_Cfam_GSD_1.03417,027,936 - 17,114,432 (-)NCBI
Abcc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,746,167 - 119,824,457 (+)NCBI
SpeTri2.0NW_0049365785,838,044 - 5,916,287 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13121,868,614 - 122,060,360 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113121,868,614 - 121,957,901 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,309,020 - 131,358,973 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,409,921 - 5,505,334 (+)NCBI
ChlSab1.1 Ensembl155,409,861 - 5,505,315 (+)Ensembl
Abcc5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473072,529,299 - 72,621,108 (+)NCBI

Position Markers
RH143810  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01184,428,176 - 84,428,440NCBIRnor6.0
Rnor_5.01187,493,015 - 87,493,279UniSTSRnor5.0
RGSC_v3.41182,746,829 - 82,747,093UniSTSRGSC3.4
Celera1179,346,070 - 79,346,334UniSTS
RH 3.4 Map11657.9UniSTS
Cytogenetic Map11q23UniSTS
AI555746  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01184,489,927 - 84,490,129NCBIRnor6.0
Rnor_5.01187,554,233 - 87,554,435UniSTSRnor5.0
RGSC_v3.41182,809,070 - 82,809,272UniSTSRGSC3.4
Celera1179,406,937 - 79,407,139UniSTS
RH 3.4 Map11658.0UniSTS
Cytogenetic Map11q23UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112831466586994795Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)113043533986714631Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114309033886714631Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114658320986714631Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115785881090463843Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115994302390463843Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116010984287141948Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)116265336586714475Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116265336586714483Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116449467190463843Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116934231986312439Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116964970890463843Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117272002986994795Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)118035840887200449Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1191
Count of miRNA genes:345
Interacting mature miRNAs:466
Transcripts:ENSRNOT00000002316, ENSRNOT00000048306
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 33 34 18 19 18 6 9 74 30 35 11 6
Low 10 23 23 23 2 2 5 6 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB020209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000002316   ⟹   ENSRNOP00000002316
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1184,396,033 - 84,490,211 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000048306   ⟹   ENSRNOP00000039986
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1184,399,417 - 84,428,650 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091595   ⟹   ENSRNOP00000073913
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1184,399,417 - 84,488,920 (+)Ensembl
RefSeq Acc Id: NM_053924   ⟹   NP_446376
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,473,872 - 80,567,253 (+)NCBI
Rnor_6.01184,396,033 - 84,490,211 (+)NCBI
Rnor_5.01187,460,314 - 87,554,521 (+)NCBI
RGSC_v3.41182,714,334 - 82,809,354 (+)RGD
Celera1179,313,876 - 79,407,221 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248593   ⟹   XP_006248655
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01184,395,982 - 84,490,215 (+)NCBI
Rnor_5.01187,460,314 - 87,554,521 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597845   ⟹   XP_017453334
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01184,412,717 - 84,490,215 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597846   ⟹   XP_017453335
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01184,412,717 - 84,490,215 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597847   ⟹   XP_017453336
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,490,611 - 80,567,257 (+)NCBI
Rnor_6.01184,434,976 - 84,490,215 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597848   ⟹   XP_017453337
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01184,435,328 - 84,490,215 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597849   ⟹   XP_017453338
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,513,176 - 80,567,257 (+)NCBI
Rnor_6.01184,435,424 - 84,490,215 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039087904   ⟹   XP_038943832
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,474,037 - 80,567,257 (+)NCBI
RefSeq Acc Id: XM_039087905   ⟹   XP_038943833
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,473,811 - 80,516,101 (+)NCBI
RefSeq Acc Id: XM_039087906   ⟹   XP_038943834
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,473,811 - 80,513,197 (+)NCBI
RefSeq Acc Id: XM_039087907   ⟹   XP_038943835
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,473,809 - 80,507,941 (+)NCBI
RefSeq Acc Id: XM_039087908   ⟹   XP_038943836
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,473,811 - 80,508,815 (+)NCBI
RefSeq Acc Id: XM_039087909   ⟹   XP_038943837
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21180,473,811 - 80,507,434 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_446376   ⟸   NM_053924
- UniProtKB: Q9QYM0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006248655   ⟸   XM_006248593
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017453335   ⟸   XM_017597846
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017453334   ⟸   XM_017597845
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017453336   ⟸   XM_017597847
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017453337   ⟸   XM_017597848
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017453338   ⟸   XM_017597849
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000039986   ⟸   ENSRNOT00000048306
RefSeq Acc Id: ENSRNOP00000002316   ⟸   ENSRNOT00000002316
RefSeq Acc Id: ENSRNOP00000073913   ⟸   ENSRNOT00000091595
RefSeq Acc Id: XP_038943835   ⟸   XM_039087907
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038943833   ⟸   XM_039087905
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038943834   ⟸   XM_039087906
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038943836   ⟸   XM_039087908
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038943837   ⟸   XM_039087909
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038943832   ⟸   XM_039087904
- Peptide Label: isoform X1
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698284
Promoter ID:EPDNEW_R8808
Type:initiation region
Name:Abcc5_1
Description:ATP binding cassette subfamily C member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01184,396,076 - 84,396,136EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 87496153 87496154 T G snv SR/JrHsd (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70913 AgrOrtholog
Ensembl Genes ENSRNOG00000029178 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002316 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000039986 UniProtKB/TrEMBL
  ENSRNOP00000073913 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002316 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000048306 UniProtKB/TrEMBL
  ENSRNOT00000091595 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABCC5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116721 UniProtKB/Swiss-Prot
NCBI Gene 116721 ENTREZGENE
PANTHER PTHR24223:SF196 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ABCC5 RGD
PhenoGen Abcc5 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K6R4_RAT UniProtKB/TrEMBL
  A1A5M8_RAT UniProtKB/TrEMBL
  F7EV50_RAT UniProtKB/TrEMBL
  G3V676_RAT UniProtKB/TrEMBL
  MRP5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Abcc5  ATP binding cassette subfamily C member 5  Abcc5  ATP-binding cassette, subfamily C (CFTR/MRP), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcc5  ATP-binding cassette, subfamily C (CFTR/MRP), member 5  Abcc5  ATP-binding cassette, sub-family C (CFTR/MRP), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-04-22 Abcc5  ATP-binding cassette, sub-family C (CFTR/MRP), member 5  Abcc5a  ATP-binding cassette, sub-family C (CFTR/MRP), member 5a  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-07-09 Abcc5a  ATP-binding cassette, sub-family C (CFTR/MRP), member 5a      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference