St6gal1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: St6gal1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1) Rattus norvegicus
Analyze
Symbol: St6gal1
Name: ST6 beta-galactoside alpha-2,6-sialyltransferase 1
RGD ID: 3676
Description: Enables sialyltransferase activity. Involved in several processes, including negative regulation of macrophage apoptotic process; regulation of substrate adhesion-dependent cell spreading; and response to ethanol. Located in Golgi medial cisterna and Golgi trans cisterna. Used to study high grade glioma. Orthologous to human ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1); PARTICIPATES IN N-linked glycan biosynthetic pathway; O-linked glycan biosynthetic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha 2,6-ST 1; beta galactoside alpha 2,6 sialyltransferase 1; beta-galactoside alpha-2,6-sialyltransferase 1; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; sialyltransferase 1; Sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); Sialyltransferase 1 (beta-galactoside alpha-26-sialytransferase); Siat1; ST6 beta-galactosamide alpha-2,6-sialyltranferase 1; ST6Gal I; ST6GalI
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,031,481 - 91,158,111 (-)NCBIGRCr8
mRatBN7.21177,526,837 - 77,653,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,526,837 - 77,653,310 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1186,277,327 - 86,319,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,916,068 - 78,958,433 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,991,611 - 78,033,954 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01180,927,601 - 80,981,424 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1180,927,601 - 80,981,422 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01179,754,201 - 79,808,024 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,723,269 - 79,765,645 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11179,780,860 - 79,789,781 (-)NCBI
Celera1176,402,694 - 76,445,042 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
L-ethionine  (EXP)
L-methionine  (ISO)
lithocholic acid  (ISO)
manganese(II) chloride  (EXP)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (ISO)
nicotinic acid  (EXP)
nimesulide  (EXP)
O-methyleugenol  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
oxazepam  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
succimer  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The two rat alpha 2,6-sialyltransferase (ST6Gal I) isoforms: evaluation of catalytic activity and intra-Golgi localization. Chen TL, etal., Glycobiology. 2003 Feb;13(2):109-17. Epub 2002 Nov 1.
2. Development of sandwich enzyme-linked immunosorbent assay systems for plasma beta-galactoside alpha2,6-sialyltransferase, a possible hepatic disease biomarker. Futakawa S, etal., Anal Chim Acta. 2009 Jan 5;631(1):116-20. doi: 10.1016/j.aca.2008.10.028. Epub 2008 Oct 22.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Chronic ethanol induced impairment of hepatic glycosylation machinery in rat is independent of dietary carbohydrate. Ghosh P and Lakshman MR, Alcohol Clin Exp Res. 1997 Feb;21(1):76-81.
5. Liver Galbeta1,4GlcNAc alpha2,6-sialyltransferase is down-regulated in human alcoholics: possible cause for the appearance of asialoconjugates. Gong M, etal., Metabolism. 2007 Sep;56(9):1241-7.
6. ST6Gal-I regulates macrophage apoptosis via alpha2-6 sialylation of the TNFR1 death receptor. Liu Z, etal., J Biol Chem. 2011 Nov 11;286(45):39654-62. doi: 10.1074/jbc.M111.276063. Epub 2011 Sep 19.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Increased alpha2,6 sialylation of N-glycans in a transgenic mouse model of hepatocellular carcinoma. Pousset D, etal., Cancer Res. 1997 Oct 1;57(19):4249-56.
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Mammalian glycosyltransferase expression allows sialoglycoprotein production by baculovirus-infected insect cells. Seo NS, etal., Protein Expr Purif 2001 Jul;22(2):234-41.
14. Transcriptional regulation of the liver beta-galactoside alpha 2,6-sialyltransferase by glucocorticoids. Wang XC, etal., J Biol Chem 1990 Oct 15;265(29):17849-53.
15. Primary structure of beta-galactoside alpha 2,6-sialyltransferase. Conversion of membrane-bound enzyme to soluble forms by cleavage of the NH2-terminal signal anchor. Weinstein J, etal., J Biol Chem 1987 Dec 25;262(36):17735-43.
16. Tissue-specific alternative splicing of the beta-galactoside alpha 2,6-sialyltransferase gene. Wen DX, etal., J Biol Chem 1992 Feb 5;267(4):2512-8.
17. Alpha2,6-sialylation of cell-surface N-glycans inhibits glioma formation in vivo. Yamamoto H, etal., Cancer Res. 2001 Sep 15;61(18):6822-9.
Additional References at PubMed
PMID:1983783   PMID:2249992   PMID:2793863   PMID:8889548   PMID:11278697   PMID:12068010   PMID:12473667   PMID:12966079   PMID:15364953   PMID:17897958   PMID:19150807   PMID:20378551  
PMID:21081508   PMID:21098517   PMID:22039275   PMID:23376485   PMID:23999306   PMID:24155237  


Genomics

Comparative Map Data
St6gal1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,031,481 - 91,158,111 (-)NCBIGRCr8
mRatBN7.21177,526,837 - 77,653,474 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,526,837 - 77,653,310 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1186,277,327 - 86,319,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,916,068 - 78,958,433 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,991,611 - 78,033,954 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01180,927,601 - 80,981,424 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1180,927,601 - 80,981,422 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01179,754,201 - 79,808,024 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,723,269 - 79,765,645 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11179,780,860 - 79,789,781 (-)NCBI
Celera1176,402,694 - 76,445,042 (-)NCBICelera
Cytogenetic Map11q23NCBI
ST6GAL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383186,930,526 - 187,078,553 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3186,930,325 - 187,078,553 (+)EnsemblGRCh38hg38GRCh38
GRCh373186,648,315 - 186,796,341 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363188,131,210 - 188,279,035 (+)NCBINCBI36Build 36hg18NCBI36
Celera3185,080,508 - 185,228,493 (+)NCBICelera
Cytogenetic Map3q27.3NCBI
HuRef3184,053,004 - 184,200,845 (+)NCBIHuRef
CHM1_13186,611,743 - 186,760,043 (+)NCBICHM1_1
T2T-CHM13v2.03189,748,335 - 189,896,308 (+)NCBIT2T-CHM13v2.0
St6gal1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391623,043,478 - 23,179,100 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1623,043,490 - 23,179,100 (+)EnsemblGRCm39 Ensembl
GRCm381623,224,729 - 23,360,350 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1623,224,740 - 23,360,350 (+)EnsemblGRCm38mm10GRCm38
MGSCv371623,224,835 - 23,360,421 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361623,140,096 - 23,275,682 (+)NCBIMGSCv36mm8
Celera1623,783,051 - 23,918,950 (+)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1614.03NCBI
St6gal1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542020,709,301 - 20,801,167 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542020,708,890 - 20,801,167 (-)NCBIChiLan1.0ChiLan1.0
ST6GAL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22184,799,471 - 184,948,596 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13184,804,185 - 184,953,313 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03183,955,462 - 184,104,537 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13192,421,036 - 192,569,970 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3192,488,087 - 192,569,970 (+)Ensemblpanpan1.1panPan2
ST6GAL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13419,497,577 - 19,589,125 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3419,497,922 - 19,586,427 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3423,553,294 - 23,675,456 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03419,379,150 - 19,501,792 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3419,380,090 - 19,501,787 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13419,410,367 - 19,531,590 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03419,410,079 - 19,531,772 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03419,643,504 - 19,764,764 (+)NCBIUU_Cfam_GSD_1.0
St6gal1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602116,874,836 - 117,015,302 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365782,966,694 - 3,003,970 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365782,966,690 - 3,107,237 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ST6GAL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13124,791,751 - 124,837,841 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113124,699,622 - 124,837,847 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ST6GAL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11581,205,121 - 81,346,089 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1581,239,631 - 81,349,173 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604154,697,038 - 54,836,111 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
St6gal1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473069,745,865 - 69,845,367 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473069,746,207 - 69,871,020 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in St6gal1
366 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2255
Count of miRNA genes:332
Interacting mature miRNAs:435
Transcripts:ENSRNOT00000002496, ENSRNOT00000002499, ENSRNOT00000044591
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
D11Mgh7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,570,168 - 77,570,330 (+)MAPPERmRatBN7.2
Rnor_6.01180,982,388 - 80,982,549NCBIRnor6.0
Rnor_5.01179,753,076 - 79,753,237UniSTSRnor5.0
RGSC_v3.41179,766,610 - 79,766,772RGDRGSC3.4
RGSC_v3.41179,766,611 - 79,766,772UniSTSRGSC3.4
RGSC_v3.11179,824,199 - 79,824,361RGD
Celera1176,446,008 - 76,446,169UniSTS
RH 3.4 Map11641.7RGD
RH 3.4 Map11641.7UniSTS
Cytogenetic Map11q23UniSTS
D11Got72  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,570,225 - 77,570,369 (+)MAPPERmRatBN7.2
Rnor_6.01180,982,445 - 80,982,588NCBIRnor6.0
Rnor_5.01179,753,037 - 79,753,180UniSTSRnor5.0
RGSC_v3.41179,766,667 - 79,766,811RGDRGSC3.4
RGSC_v3.41179,766,668 - 79,766,811UniSTSRGSC3.4
RGSC_v3.11179,824,256 - 79,824,400RGD
Celera1176,446,065 - 76,446,208UniSTS
RH 3.4 Map11642.0RGD
RH 3.4 Map11642.0UniSTS
Cytogenetic Map11q23UniSTS
RH129723  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,526,913 - 77,527,133 (+)MAPPERmRatBN7.2
Rnor_6.01180,927,678 - 80,927,897NCBIRnor6.0
Rnor_5.01179,807,728 - 79,807,947UniSTSRnor5.0
RGSC_v3.41179,723,346 - 79,723,565UniSTSRGSC3.4
Celera1176,402,771 - 76,402,990UniSTS
RH 3.4 Map11641.7UniSTS
Cytogenetic Map11q23UniSTS
RH127455  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,527,065 - 77,527,258 (+)MAPPERmRatBN7.2
Rnor_6.01180,927,830 - 80,928,022NCBIRnor6.0
Rnor_5.01179,807,603 - 79,807,795UniSTSRnor5.0
RGSC_v3.41179,723,498 - 79,723,690UniSTSRGSC3.4
Celera1176,402,923 - 76,403,115UniSTS
RH 3.4 Map11641.9UniSTS
Cytogenetic Map11q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 51 41 19 41 66 35 35 11
Low 1 17 6 8 11 8 6 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001113344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_147205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BF418553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M18769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M54999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M73985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M73987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000002496   ⟹   ENSRNOP00000002496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,526,842 - 77,653,310 (-)Ensembl
Rnor_6.0 Ensembl1180,927,612 - 80,981,422 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000002499   ⟹   ENSRNOP00000002499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1180,927,601 - 80,981,415 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000044591   ⟹   ENSRNOP00000041089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,527,806 - 77,535,809 (-)Ensembl
Rnor_6.0 Ensembl1180,927,604 - 80,936,524 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099835   ⟹   ENSRNOP00000085188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,526,837 - 77,535,809 (-)Ensembl
RefSeq Acc Id: NM_001113344   ⟹   NP_001106815
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,031,481 - 91,073,838 (-)NCBI
mRatBN7.21177,526,837 - 77,569,203 (-)NCBI
Rnor_6.01180,927,601 - 80,981,422 (-)NCBI
Rnor_5.01179,754,201 - 79,808,024 (+)NCBI
RGSC_v3.41179,723,269 - 79,765,645 (-)RGD
Celera1176,402,694 - 76,445,042 (-)RGD
Sequence:
RefSeq Acc Id: NM_147205   ⟹   NP_671738
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,031,481 - 91,040,404 (-)NCBI
mRatBN7.21177,526,837 - 77,535,760 (-)NCBI
Rnor_6.01180,927,601 - 80,936,524 (-)NCBI
Rnor_5.01179,754,201 - 79,808,024 (+)NCBI
RGSC_v3.41179,723,269 - 79,765,645 (-)RGD
Celera1176,402,694 - 76,411,617 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248501   ⟹   XP_006248563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,031,481 - 91,158,083 (-)NCBI
mRatBN7.21177,526,837 - 77,653,305 (-)NCBI
Rnor_6.01180,927,601 - 80,981,424 (-)NCBI
Rnor_5.01179,754,201 - 79,808,024 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039087993   ⟹   XP_038943921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,031,481 - 91,158,089 (-)NCBI
mRatBN7.21177,526,837 - 77,653,320 (-)NCBI
RefSeq Acc Id: XM_039087994   ⟹   XP_038943922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,031,481 - 91,157,475 (-)NCBI
mRatBN7.21177,526,837 - 77,652,181 (-)NCBI
RefSeq Acc Id: XM_039087995   ⟹   XP_038943923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,031,481 - 91,158,111 (-)NCBI
mRatBN7.21177,526,837 - 77,653,474 (-)NCBI
RefSeq Acc Id: XM_039087996   ⟹   XP_038943924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,031,481 - 91,157,942 (-)NCBI
mRatBN7.21177,526,837 - 77,653,410 (-)NCBI
RefSeq Acc Id: XM_039087997   ⟹   XP_038943925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,031,481 - 91,082,635 (-)NCBI
mRatBN7.21177,526,837 - 77,578,006 (-)NCBI
RefSeq Acc Id: XM_063270295   ⟹   XP_063126365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,031,481 - 91,156,873 (-)NCBI
RefSeq Acc Id: XM_063270296   ⟹   XP_063126366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,031,481 - 91,158,111 (-)NCBI
RefSeq Acc Id: XM_063270297   ⟹   XP_063126367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,031,481 - 91,082,637 (-)NCBI
RefSeq Acc Id: NP_671738   ⟸   NM_147205
- Peptide Label: isoform 2
- UniProtKB: F2Z3S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106815   ⟸   NM_001113344
- Peptide Label: isoform 1
- UniProtKB: D4ABR2 (UniProtKB/Swiss-Prot),   P13721 (UniProtKB/Swiss-Prot),   G3V680 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248563   ⟸   XM_006248501
- Peptide Label: isoform X1
- UniProtKB: P13721 (UniProtKB/Swiss-Prot),   D4ABR2 (UniProtKB/Swiss-Prot),   G3V680 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002499   ⟸   ENSRNOT00000002499
Ensembl Acc Id: ENSRNOP00000002496   ⟸   ENSRNOT00000002496
Ensembl Acc Id: ENSRNOP00000041089   ⟸   ENSRNOT00000044591
RefSeq Acc Id: XP_038943923   ⟸   XM_039087995
- Peptide Label: isoform X1
- UniProtKB: P13721 (UniProtKB/Swiss-Prot),   D4ABR2 (UniProtKB/Swiss-Prot),   G3V680 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943924   ⟸   XM_039087996
- Peptide Label: isoform X1
- UniProtKB: P13721 (UniProtKB/Swiss-Prot),   D4ABR2 (UniProtKB/Swiss-Prot),   G3V680 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943921   ⟸   XM_039087993
- Peptide Label: isoform X1
- UniProtKB: P13721 (UniProtKB/Swiss-Prot),   D4ABR2 (UniProtKB/Swiss-Prot),   G3V680 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943922   ⟸   XM_039087994
- Peptide Label: isoform X1
- UniProtKB: P13721 (UniProtKB/Swiss-Prot),   D4ABR2 (UniProtKB/Swiss-Prot),   G3V680 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943925   ⟸   XM_039087997
- Peptide Label: isoform X1
- UniProtKB: P13721 (UniProtKB/Swiss-Prot),   D4ABR2 (UniProtKB/Swiss-Prot),   G3V680 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000085188   ⟸   ENSRNOT00000099835
RefSeq Acc Id: XP_063126366   ⟸   XM_063270296
- Peptide Label: isoform X1
- UniProtKB: P13721 (UniProtKB/Swiss-Prot),   G3V680 (UniProtKB/Swiss-Prot),   D4ABR2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063126365   ⟸   XM_063270295
- Peptide Label: isoform X1
- UniProtKB: P13721 (UniProtKB/Swiss-Prot),   G3V680 (UniProtKB/Swiss-Prot),   D4ABR2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063126367   ⟸   XM_063270297
- Peptide Label: isoform X1
- UniProtKB: P13721 (UniProtKB/Swiss-Prot),   G3V680 (UniProtKB/Swiss-Prot),   D4ABR2 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13721-F1-model_v2 AlphaFold P13721 1-403 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698248
Promoter ID:EPDNEW_R8768
Type:initiation region
Name:St6gal1_1
Description:ST6 beta-galactoside alpha-2,6-sialyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01180,981,433 - 80,981,493EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3676 AgrOrtholog
BioCyc Gene G2FUF-20865 BioCyc
BioCyc Pathway PWY-7426 [complex N-linked glycan biosynthesis (vertebrates)] BioCyc
  PWY-7836 [ganglio-series glycosphingolipids biosynthesis] BioCyc
  PWY-7839 [lacto-series glycosphingolipids biosynthesis] BioCyc
  PWY-7841 [neolacto-series glycosphingolipids biosynthesis] BioCyc
BioCyc Pathway Image PWY-7426 BioCyc
  PWY-7836 BioCyc
  PWY-7839 BioCyc
  PWY-7841 BioCyc
Ensembl Genes ENSRNOG00000001823 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002496.8 UniProtKB/Swiss-Prot
  ENSRNOT00000044591.7 UniProtKB/TrEMBL
  ENSRNOT00000099835.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.1480.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glyco_trans_29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GT29-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sialyl_trans UniProtKB/Swiss-Prot
KEGG Report rno:25197 UniProtKB/Swiss-Prot
NCBI Gene 25197 ENTREZGENE
PANTHER BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_transf_29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen St6gal1 PhenoGen
PIRSF Sialyl_trans UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001823 RatGTEx
UniProt A0A8I6A0T1_RAT UniProtKB/TrEMBL
  D4ABR2 ENTREZGENE
  F2Z3S3 ENTREZGENE, UniProtKB/TrEMBL
  G3V680 ENTREZGENE
  P13721 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary D4ABR2 UniProtKB/Swiss-Prot
  G3V680 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 St6gal1  ST6 beta-galactoside alpha-2,6-sialyltransferase 1  St6gal1  ST6 beta-galactosamide alpha-2,6-sialyltranferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 St6gal1  ST6 beta-galactosamide alpha-2,6-sialyltranferase 1  St6gal1  beta galactoside alpha 2,6 sialyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 St6gal1  beta galactoside alpha 2,6 sialyltransferase 1  Siat1  sialyltransferase 1  Symbol and Name updated 1299863 APPROVED
2002-06-10 Siat1  Sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA and protein levels are highest in liver 729777