Ufd1 (ubiquitin recognition factor in ER associated degradation 1) - Rat Genome Database

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Gene: Ufd1 (ubiquitin recognition factor in ER associated degradation 1) Rattus norvegicus
Analyze
Symbol: Ufd1
Name: ubiquitin recognition factor in ER associated degradation 1
RGD ID: 619822
Description: Enables ATPase binding activity and signaling receptor binding activity. Involved in retrograde protein transport, ER to cytosol. Part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. Human ortholog(s) of this gene implicated in DiGeorge syndrome and schizophrenia. Orthologous to human UFD1 (ubiquitin recognition factor in ER associated degradation 1); PARTICIPATES IN schizophrenia pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: UB fusion protein 1; ubiquitin fusion degradation 1 like; ubiquitin fusion degradation 1 like (yeast); ubiquitin fusion degradation 1-like; ubiquitin fusion degradation protein 1 homolog; ubiquitin recognition factor in ER-associated degradation protein 1; Ufd1l
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,665,971 - 95,689,423 (-)NCBIGRCr8
mRatBN7.21182,161,618 - 82,185,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,161,619 - 82,185,087 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,890,505 - 90,916,772 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,551,725 - 83,577,992 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,604,993 - 82,631,260 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,304,836 - 86,328,478 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,304,815 - 86,328,469 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,406,802 - 89,430,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1180,942,108 - 80,965,579 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calyculin a  (ISO)
carbon nanotube  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
ivermectin  (ISO)
kojic acid  (ISO)
L-ethionine  (EXP)
leflunomide  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylazoxymethanol  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin RR  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
omeprazole  (EXP)
paracetamol  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
triphenyl phosphate  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (IEA)
nucleus  (IEA)
UFD1-NPL4 complex  (IDA,IEA,ISO)
VCP-NPL4-UFD1 AAA ATPase complex  (EXP,IBA,IDA,IEA,IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors. Alzayady KJ, etal., J Biol Chem. 2005 Oct 14;280(41):34530-7. Epub 2005 Aug 15.
2. Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy. Bebeacua C, etal., Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1098-103. doi: 10.1073/pnas.1114341109. Epub 2012 Jan 9.
3. Absence of mutations in human ubiquitin fusion-degradation protein gene in tetralogy of Fallot. Chung MY, etal., J Mol Med. 2001 Jun;79(5-6):338-42.
4. Association study of a promoter polymorphism of UFD1L gene with schizophrenia. De Luca A, etal., Am J Med Genet 2001 Aug 8;105(6):529-33.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. Meyer HH, etal., EMBO J 2000 May 15;19(10):2181-92.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects. Yamagishi H, etal., Science. 1999 Feb 19;283(5405):1158-61.
14. Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. Ye Y, etal., J Cell Biol. 2003 Jul 7;162(1):71-84.
Additional References at PubMed
PMID:11574150   PMID:16525503   PMID:17000876   PMID:18775783   PMID:19182904   PMID:21630459   PMID:24089527   PMID:25660456   PMID:26471729  


Genomics

Comparative Map Data
Ufd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,665,971 - 95,689,423 (-)NCBIGRCr8
mRatBN7.21182,161,618 - 82,185,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,161,619 - 82,185,087 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,890,505 - 90,916,772 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,551,725 - 83,577,992 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,604,993 - 82,631,260 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,304,836 - 86,328,478 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,304,815 - 86,328,469 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,406,802 - 89,430,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1180,942,108 - 80,965,579 (-)NCBICelera
Cytogenetic Map11q23NCBI
UFD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,449,911 - 19,479,193 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,449,911 - 19,479,202 (-)EnsemblGRCh38hg38GRCh38
GRCh372219,437,434 - 19,466,716 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,817,701 - 17,846,726 (-)NCBINCBI36Build 36hg18NCBI36
Build 342217,812,394 - 17,841,280NCBI
Celera223,289,721 - 3,318,998 (-)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef223,058,276 - 3,087,551 (-)NCBIHuRef
CHM1_12219,437,034 - 19,466,309 (-)NCBICHM1_1
T2T-CHM13v2.02219,826,739 - 19,856,026 (-)NCBIT2T-CHM13v2.0
Ufd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,630,486 - 18,654,011 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,630,529 - 18,654,011 (+)EnsemblGRCm39 Ensembl
GRCm381618,811,736 - 18,835,261 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,811,779 - 18,835,261 (+)EnsemblGRCm38mm10GRCm38
MGSCv371618,812,387 - 18,835,354 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361618,725,889 - 18,748,818 (+)NCBIMGSCv36mm8
Celera1619,386,351 - 19,409,318 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.65NCBI
Ufd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544218,548,545 - 18,569,366 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544218,548,545 - 18,568,989 (+)NCBIChiLan1.0ChiLan1.0
UFD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22329,074,863 - 29,104,101 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12231,622,567 - 31,651,807 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0222,209,590 - 2,238,449 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12217,885,073 - 17,913,506 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2217,885,073 - 17,913,506 (-)Ensemblpanpan1.1panPan2
UFD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,739,062 - 29,763,315 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,739,153 - 29,763,313 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,694,170 - 29,719,526 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02631,140,571 - 31,165,953 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2631,140,615 - 31,165,955 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12629,187,885 - 29,213,241 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,813,584 - 28,838,650 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,900,203 - 29,925,588 (+)NCBIUU_Cfam_GSD_1.0
Ufd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118139,333,947 - 139,358,936 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366193,395,687 - 3,419,472 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366193,395,130 - 3,419,704 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UFD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,113,713 - 51,133,072 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,113,858 - 51,132,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,680,894 - 54,689,406 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UFD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,275,834 - 6,305,940 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl196,275,844 - 6,308,035 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666085627,687 - 657,884 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ufd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624747110,090 - 132,097 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624747110,090 - 132,145 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ufd1
174 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:312
Count of miRNA genes:205
Interacting mature miRNAs:242
Transcripts:ENSRNOT00000071493
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
D11Rat89  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,169,001 - 82,169,223 (+)MAPPERmRatBN7.2
Rnor_6.01186,312,220 - 86,312,439NCBIRnor6.0
Rnor_5.01189,414,186 - 89,414,405UniSTSRnor5.0
Celera1180,949,492 - 80,949,711UniSTS
SHRSP x BN Map1138.2699UniSTS
SHRSP x BN Map1138.2699RGD
FHH x ACI Map1157.2499RGD
Cytogenetic Map11p12UniSTS
RH134555  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,161,917 - 82,162,102 (+)MAPPERmRatBN7.2
Rnor_6.01186,305,136 - 86,305,320NCBIRnor6.0
Rnor_5.01189,407,102 - 89,407,286UniSTSRnor5.0
Celera1180,942,408 - 80,942,592UniSTS
RH 3.4 Map11697.2UniSTS
Cytogenetic Map11p12UniSTS
D18S1297  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,167,480 - 82,168,493 (+)MAPPERmRatBN7.2
Rnor_6.01186,310,699 - 86,311,711NCBIRnor6.0
Rnor_5.01189,412,665 - 89,413,677UniSTSRnor5.0
Celera1180,947,971 - 80,948,983UniSTS
Cytogenetic Map11p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000071493   ⟹   ENSRNOP00000067081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,161,619 - 82,185,073 (-)Ensembl
Rnor_6.0 Ensembl1186,304,815 - 86,328,469 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095316   ⟹   ENSRNOP00000077930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,161,621 - 82,185,040 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100452   ⟹   ENSRNOP00000084640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,161,623 - 82,185,063 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118403   ⟹   ENSRNOP00000086445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,162,344 - 82,185,087 (-)Ensembl
RefSeq Acc Id: NM_053418   ⟹   NP_445870
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,665,971 - 95,689,423 (-)NCBI
mRatBN7.21182,161,618 - 82,185,072 (-)NCBI
Rnor_6.01186,304,836 - 86,328,440 (-)NCBI
Rnor_5.01189,406,802 - 89,430,903 (-)NCBI
Celera1180,942,108 - 80,965,579 (-)RGD
Sequence:
RefSeq Acc Id: XM_008768904   ⟹   XP_008767126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,665,971 - 95,687,335 (-)NCBI
mRatBN7.21182,161,618 - 82,185,107 (-)NCBI
Rnor_6.01186,304,836 - 86,328,478 (-)NCBI
Sequence:
RefSeq Acc Id: NP_445870   ⟸   NM_053418
- UniProtKB: Q9ES53 (UniProtKB/Swiss-Prot),   A0A8I6A8U7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767126   ⟸   XM_008768904
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A8U7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067081   ⟸   ENSRNOT00000071493
Ensembl Acc Id: ENSRNOP00000084640   ⟸   ENSRNOT00000100452
Ensembl Acc Id: ENSRNOP00000086445   ⟸   ENSRNOT00000118403
Ensembl Acc Id: ENSRNOP00000077930   ⟸   ENSRNOT00000095316

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ES53-F1-model_v2 AlphaFold Q9ES53 1-307 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698297
Promoter ID:EPDNEW_R8820
Type:multiple initiation site
Name:Ufd1_1
Description:ubiquitin recognition factor in ER associated degradation 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01186,328,434 - 86,328,494EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619822 AgrOrtholog
BIND 130678
  130682
  130684
  130685
BioCyc Gene G2FUF-20673 BioCyc
Ensembl Genes ENSRNOG00000047394 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055003879 UniProtKB/Swiss-Prot
  ENSRNOG00060012444 UniProtKB/Swiss-Prot
  ENSRNOG00065007746 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071493.3 UniProtKB/TrEMBL
  ENSRNOT00000095316.1 UniProtKB/TrEMBL
  ENSRNOT00000100452.1 UniProtKB/Swiss-Prot
  ENSRNOT00000118403.1 UniProtKB/TrEMBL
  ENSRNOT00055006149 UniProtKB/Swiss-Prot
  ENSRNOT00060021219 UniProtKB/Swiss-Prot
  ENSRNOT00065012190 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.40.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.330.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9101868 IMAGE-MGC_LOAD
InterPro Ufd1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ufd1-like_Nn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84478 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187268 IMAGE-MGC_LOAD
NCBI Gene 84478 ENTREZGENE
PANTHER PTHR12555 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam UFD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ufd1 PhenoGen
RatGTEx ENSRNOG00000047394 RatGTEx
  ENSRNOG00055003879 RatGTEx
  ENSRNOG00060012444 RatGTEx
  ENSRNOG00065007746 RatGTEx
UniProt A0A8I5YCK4_RAT UniProtKB/TrEMBL
  A0A8I6A8U7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UP03_RAT UniProtKB/TrEMBL
  Q9ES53 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-07 Ufd1  ubiquitin recognition factor in ER associated degradation 1  Ufd1l  ubiquitin fusion degradation 1 like (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Ufd1l  ubiquitin fusion degradation 1 like (yeast)  Ufd1l  ubiquitin fusion degradation 1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ufd1l  ubiquitin fusion degradation 1-like      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ufd1l  ubiquitin fusion degradation 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction Ufd1/Npl4 and p47 form mutually exclusive complexes with cytosolic p97 633500