Vcp (valosin-containing protein) - Rat Genome Database

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Gene: Vcp (valosin-containing protein) Rattus norvegicus
Symbol: Vcp
Name: valosin-containing protein
RGD ID: 621595
Description: Enables ATP hydrolysis activity; adenyl ribonucleotide binding activity; and identical protein binding activity. Involved in several processes, including ERAD pathway; endoplasmic reticulum to Golgi vesicle-mediated transport; and positive regulation of ubiquitin-dependent protein catabolic process. Located in cytosol. Part of VCP-NPL4-UFD1 AAA ATPase complex and VCP-NSFL1C complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; frontotemporal dementia and/or amyotrophic lateral sclerosis-6; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
Previously known as: 15S Mg(2+)-ATPase p97 subunit; TER ATPase; transitional endoplasmic reticulum ATPase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Vcpem1Ionsz  
Genetic Models: SD-Vcpem1Ionsz
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2557,210,167 - 57,229,571 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,210,168 - 57,229,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,183,339 - 59,202,747 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0561,002,153 - 61,021,561 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0560,987,322 - 61,006,704 (-)NCBIRnor_WKY
Rnor_6.0558,426,548 - 58,445,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,426,549 - 58,445,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0562,951,999 - 62,971,402 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,472,100 - 59,491,508 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1559,472,279 - 59,491,687 (-)NCBI
Celera555,799,589 - 55,818,873 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP)
7,12-dimethyltetraphene  (EXP)
aflatoxin B1  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (EXP)
ceruletide  (EXP)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chromium trinitrate  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fenthion  (ISO)
fenvalerate  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hyaluronic acid  (EXP)
hydrazine  (EXP)
hydrogen peroxide  (EXP)
isoflavones  (EXP)
ivermectin  (ISO)
L-serine  (ISO)
lactacystin  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
lycopene  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
naphthalene  (ISO)
nefazodone  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
piroxicam  (ISO)
potassium chromate  (ISO)
prostaglandin A1  (ISO)
quartz  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thimerosal  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
aggresome assembly  (ISO)
ATP metabolic process  (ISO)
autophagosome maturation  (IBA,ISO,ISS)
autophagy  (ISO,ISS)
cellular response to arsenite ion  (ISO,ISS)
cellular response to heat  (ISO,ISS)
DNA damage response  (ISO,ISS)
DNA repair  (ISS)
double-strand break repair  (ISO,ISS)
endoplasmic reticulum stress-induced pre-emptive quality control  (ISO,ISS)
endoplasmic reticulum to Golgi vesicle-mediated transport  (IMP)
endosome to lysosome transport via multivesicular body sorting pathway  (ISO,ISS)
ER-associated misfolded protein catabolic process  (IBA,ISO)
ERAD pathway  (ISO,ISS)
flavin adenine dinucleotide catabolic process  (ISO)
interstrand cross-link repair  (ISS)
macroautophagy  (ISO,ISS)
mitotic spindle disassembly  (IBA)
NADH metabolic process  (ISO)
negative regulation of protein localization to chromatin  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of Lys63-specific deubiquitinase activity  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of oxidative phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein K63-linked deubiquitination  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (IMP)
proteasomal protein catabolic process  (ISO,ISS)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO,ISS)
protein ubiquitination  (ISO,ISS)
protein-DNA covalent cross-linking repair  (ISO,ISS)
regulation of aerobic respiration  (ISO)
regulation of protein localization to chromatin  (ISO,ISS)
regulation of synapse organization  (IDA,IMP)
retrograde protein transport, ER to cytosol  (EXP,IBA,ISO)
stress granule disassembly  (ISO,ISS)
translesion synthesis  (ISO,ISS)
ubiquitin-dependent ERAD pathway  (EXP,IBA,ISO,ISS)
ubiquitin-dependent protein catabolic process  (ISO)
viral genome replication  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors. Alzayady KJ, etal., J Biol Chem. 2005 Oct 14;280(41):34530-7. Epub 2005 Aug 15.
2. Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy. Bebeacua C, etal., Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1098-103. doi: 10.1073/pnas.1114341109. Epub 2012 Jan 9.
3. Conformational changes in the AAA ATPase p97-p47 adaptor complex. Beuron F, etal., EMBO J. 2006 May 3;25(9):1967-76. Epub 2006 Apr 6.
4. Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase. Briggs LC, etal., J Biol Chem. 2008 May 16;283(20):13745-52. doi: 10.1074/jbc.M709632200. Epub 2008 Mar 10.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Isolation of a point-mutated p47 lacking binding affinity to p97ATPase. Kaneko Y, etal., FEBS Lett. 2010 Sep 24;584(18):3873-7. doi: 10.1016/j.febslet.2010.07.061. Epub 2010 Aug 6.
8. Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells. Kobayashi T, etal., J Biol Chem 2002 Dec 6;277(49):47358-65.
9. p47 is a cofactor for p97-mediated membrane fusion. Kondo H, etal., Nature 1997 Jul 3;388(6637):75-8.
10. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. Meyer HH, etal., EMBO J 2000 May 15;19(10):2181-92.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Double-strand break repair: 53BP1 comes into focus. Panier S and Boulton SJ, Nat Rev Mol Cell Biol. 2014 Jan;15(1):7-18. doi: 10.1038/nrm3719. Epub 2013 Dec 11.
15. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Panier S and Durocher D, Nat Rev Mol Cell Biol. 2013 Oct;14(10):661-72. doi: 10.1038/nrm3659. Epub 2013 Sep 4.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic beta-cells. Tiwari A, etal., J Cell Sci. 2013 May 1;126(Pt 9):1962-8. doi: 10.1242/jcs.117374. Epub 2013 Feb 26.
22. Valosin-containing protein and neurofibromin interact to regulate dendritic spine density. Wang HF, etal., J Clin Invest. 2011 Dec;121(12):4820-37. doi: 10.1172/JCI45677. Epub 2011 Nov 21.
23. Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. Watts GD, etal., Nat Genet. 2004 Apr;36(4):377-81. Epub 2004 Mar 21.
24. Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. Ye Y, etal., J Cell Biol. 2003 Jul 7;162(1):71-84.
25. Isolation and characterization of the principal ATPase associated with transitional endoplasmic reticulum of rat liver. Zhang L, etal., J Cell Biol 1994 Dec;127(6 Pt 2):1871-83.
Additional References at PubMed
PMID:8413590   PMID:9452483   PMID:9506515   PMID:10364224   PMID:10715114   PMID:10855792   PMID:10930451   PMID:11483959   PMID:12146947   PMID:12411482   PMID:12473691   PMID:12810701  
PMID:14561754   PMID:15215856   PMID:15362974   PMID:15489334   PMID:15740751   PMID:16140914   PMID:16186510   PMID:16275660   PMID:16635246   PMID:16810319   PMID:16854843   PMID:17000876  
PMID:17141156   PMID:17550236   PMID:17584300   PMID:17634366   PMID:17785525   PMID:17872946   PMID:18462676   PMID:18775313   PMID:19056867   PMID:19182904   PMID:19335618   PMID:19666135  
PMID:20104022   PMID:20410307   PMID:20458337   PMID:20512113   PMID:21107009   PMID:21186355   PMID:21630459   PMID:21636303   PMID:21733848   PMID:21822278   PMID:21983102   PMID:22051847  
PMID:22102169   PMID:22120668   PMID:22206666   PMID:22379090   PMID:22590560   PMID:22607976   PMID:22681889   PMID:22871113   PMID:22970133   PMID:23042605   PMID:23297223   PMID:23349634  
PMID:23376485   PMID:23498975   PMID:23533145   PMID:23737493   PMID:23747190   PMID:24055316   PMID:24089527   PMID:24534009   PMID:25002582   PMID:25088257   PMID:25125609   PMID:25660456  
PMID:25878907   PMID:26265139   PMID:26316108   PMID:26565908   PMID:26692333   PMID:26712278   PMID:26754107   PMID:26822609   PMID:26842564   PMID:26849035   PMID:27000202   PMID:27753622  
PMID:28689657   PMID:28799247   PMID:29804830  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2557,210,167 - 57,229,571 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,210,168 - 57,229,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,183,339 - 59,202,747 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0561,002,153 - 61,021,561 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0560,987,322 - 61,006,704 (-)NCBIRnor_WKY
Rnor_6.0558,426,548 - 58,445,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,426,549 - 58,445,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0562,951,999 - 62,971,402 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,472,100 - 59,491,508 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1559,472,279 - 59,491,687 (-)NCBI
Celera555,799,589 - 55,818,873 (-)NCBICelera
Cytogenetic Map5q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38935,056,064 - 35,072,625 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl935,053,928 - 35,072,668 (-)EnsemblGRCh38hg38GRCh38
GRCh37935,056,061 - 35,072,622 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,046,560 - 35,062,564 (-)NCBINCBI36Build 36hg18NCBI36
Build 34935,046,560 - 35,062,564NCBI
Celera934,988,041 - 35,004,706 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,011,651 - 35,028,327 (-)NCBIHuRef
CHM1_1935,055,907 - 35,072,605 (-)NCBICHM1_1
T2T-CHM13v2.0935,075,243 - 35,091,804 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39442,979,964 - 43,000,507 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl442,979,963 - 43,000,507 (-)EnsemblGRCm39 Ensembl
GRCm38442,979,964 - 43,000,507 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl442,979,963 - 43,000,507 (-)EnsemblGRCm38mm10GRCm38
MGSCv37442,992,836 - 43,013,379 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,001,064 - 43,021,534 (-)NCBIMGSCv36mm8
Celera443,010,123 - 43,030,659 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map422.95NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554721,107,164 - 1,124,076 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554721,111,649 - 1,124,076 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1989,522,985 - 89,539,187 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0934,907,147 - 34,923,227 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1935,712,937 - 35,729,588 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl935,712,937 - 35,729,588 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11151,636,986 - 51,651,749 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1151,637,411 - 51,651,714 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,205,792 - 50,220,556 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01152,702,444 - 52,717,215 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1152,702,830 - 52,724,878 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,246,536 - 51,261,297 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,231,677 - 51,246,443 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01151,933,494 - 51,948,301 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947166,538,385 - 166,554,770 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365243,085,500 - 3,102,466 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365243,085,959 - 3,102,461 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1235,851,206 - 235,869,634 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11235,854,532 - 235,869,712 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21263,379,929 - 263,394,992 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11245,545,139 - 45,560,702 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1245,545,507 - 45,563,380 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603842,661,397 - 42,677,470 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624915253,240 - 270,501 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624915253,240 - 270,440 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Vcp
68 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:306
Count of miRNA genes:196
Interacting mature miRNAs:222
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat

Genetic Models
This gene Vcp is modified in the following models/strains


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000046102   ⟹   ENSRNOP00000040121
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl557,210,168 - 57,229,571 (-)Ensembl
Rnor_6.0 Ensembl558,426,549 - 58,445,953 (-)Ensembl
RefSeq Acc Id: NM_053864   ⟹   NP_446316
Rat AssemblyChrPosition (strand)Source
mRatBN7.2557,210,167 - 57,229,571 (-)NCBI
Rnor_6.0558,426,548 - 58,445,953 (-)NCBI
Rnor_5.0562,951,999 - 62,971,402 (-)NCBI
RGSC_v3.4559,472,100 - 59,491,508 (-)RGD
Celera555,799,589 - 55,818,873 (-)RGD
Protein Sequences
Protein RefSeqs NP_446316 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52154 (Get FASTA)   NCBI Sequence Viewer  
  AAH60518 (Get FASTA)   NCBI Sequence Viewer  
  EDL98716 (Get FASTA)   NCBI Sequence Viewer  
  EDL98717 (Get FASTA)   NCBI Sequence Viewer  
  P46462 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446316   ⟸   NM_053864
- UniProtKB: P46462 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000040121   ⟸   ENSRNOT00000046102

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P46462-F1-model_v2 AlphaFold P46462 1-806 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693667
Promoter ID:EPDNEW_R4192
Type:initiation region
Description:valosin-containing protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0558,445,989 - 58,446,049EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621595 AgrOrtholog
BIND 130679
BioCyc Gene G2FUF-41527 BioCyc
Ensembl Genes ENSRNOG00000034242 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000040121 ENTREZGENE
  ENSRNOP00000040121.2 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046102 ENTREZGENE
  ENSRNOT00000046102.3 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot
  3.10.330.10 UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  AAA_ATPase_CDC48 UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  Asp_de-COase-like_dom_sf UniProtKB/Swiss-Prot
  ATPase_AAA_core UniProtKB/Swiss-Prot
  ATPase_AAA_CS UniProtKB/Swiss-Prot
  Cdc48_dom2 UniProtKB/Swiss-Prot
  CDC48_domain_2-like_sf UniProtKB/Swiss-Prot
  CDC4_N-term_subdom UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Vps4_C UniProtKB/Swiss-Prot
KEGG Report rno:116643 UniProtKB/Swiss-Prot
Pfam AAA UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  CDC48_2 UniProtKB/Swiss-Prot
  CDC48_N UniProtKB/Swiss-Prot
  Vps4_C UniProtKB/Swiss-Prot
PhenoGen Vcp PhenoGen
PROSITE AAA UniProtKB/Swiss-Prot
SMART AAA UniProtKB/Swiss-Prot
  CDC48_2 UniProtKB/Swiss-Prot
  CDC48_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50692 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  SSF54585 UniProtKB/Swiss-Prot
TIGRFAMs CDC48 UniProtKB/Swiss-Prot
UniProt P46462 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Vcp  valosin-containing protein      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Vcp  valosin-containing protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains two conserved ATPase domains (D1 and D2) 727438
gene_process may be important for degrading membrane-associated ubiquitinated proteins in the endoplasmic reticulum 727438