Zdhhc8 (zinc finger DHHC-type palmitoyltransferase 8)

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Gene: Zdhhc8 (zinc finger DHHC-type palmitoyltransferase 8) Rattus norvegicus

Analyze

Symbol:

Zdhhc8

Name:

zinc finger DHHC-type palmitoyltransferase 8

RGD ID:

1308875

Description:

Predicted to enable palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and positive regulation of cholesterol efflux. Predicted to act upstream of or within locomotory behavior. Located in synapse. Orthologous to human ZDHHC8 (zinc finger DHHC-type palmitoyltransferase 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC303796; palmitoyltransferase ZDHHC8; probable palmitoyltransferase ZDHHC8; zinc finger, DHHC domain containing 8; zinc finger, DHHC-type containing 8; zinc finger, DHHC-type containing 8-like

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	82,755,110 - 82,769,280 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	82,755,143 - 82,767,734 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	91,483,528 - 91,496,137 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	11	84,144,756 - 84,157,365 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	11	83,198,271 - 83,210,880 (+)	NCBI	Rnor_WKY
Rnor_6.0	11	86,903,122 - 86,917,261 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	86,903,122 - 86,915,715 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	89,997,052 - 90,011,199 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	84,748,939 - 84,762,305 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	84,789,663 - 84,801,365 (+)	NCBI
Celera	11	81,532,206 - 81,544,662 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

autistic disorder (ISO)

chromosome 22q11.2 deletion syndrome, distal (ISO)

chromosome 22q11.2 microduplication syndrome (ISO)

DiGeorge syndrome (ISO)

Dwarfism (ISO)

epilepsy (ISO)

hemorrhagic disease (ISO)

intellectual disability (ISO)

megacolon (ISO)

Neurodevelopmental Disorders (ISO)

primary immunodeficiency disease (ISO)

prostate cancer (ISO)

schizophrenia (IEA,ISO)

velocardiofacial syndrome (ISO)

Venous Thrombosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,4-methylenedioxymethamphetamine (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

butanal (ISO)

caffeine (ISO)

calyculin a (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

cocaine (EXP)

dicrotophos (ISO)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

okadaic acid (ISO)

orphenadrine (EXP)

paracetamol (ISO)

pentanal (ISO)

propanal (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sunitinib (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

locomotory behavior (ISO)

peptidyl-L-cysteine S-palmitoylation (ISO)

positive regulation by host of viral process (IEA)

positive regulation of cholesterol efflux (ISO)

protein palmitoylation (IBA,ISO)

Cellular Component

Golgi apparatus (IBA,ISO)

Golgi membrane (IEA)

mitochondrion (ISO)

synapse (IDA)

Molecular Function

palmitoyltransferase activity (IBA,ISO)

protein binding (ISO)

protein-cysteine S-palmitoyltransferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	The genetic association database.	Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking.	Thomas GM, etal., Neuron. 2012 Feb 9;73(3):482-96. doi: 10.1016/j.neuron.2011.11.021.

Additional References at PubMed

PMID:15184899	PMID:16647879	PMID:18775783	PMID:23034182	PMID:24912190

Genomics

Comparative Map Data

Zdhhc8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	82,755,110 - 82,769,280 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	82,755,143 - 82,767,734 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	91,483,528 - 91,496,137 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	11	84,144,756 - 84,157,365 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	11	83,198,271 - 83,210,880 (+)	NCBI	Rnor_WKY
Rnor_6.0	11	86,903,122 - 86,917,261 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	86,903,122 - 86,915,715 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	89,997,052 - 90,011,199 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	84,748,939 - 84,762,305 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	84,789,663 - 84,801,365 (+)	NCBI
Celera	11	81,532,206 - 81,544,662 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

ZDHHC8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	20,131,804 - 20,148,007 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	22	20,129,456 - 20,148,007 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	20,119,327 - 20,135,530 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	18,499,365 - 18,513,974 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	18,493,918 - 18,508,512	NCBI
Celera	22	3,971,414 - 3,987,580 (+)	NCBI		Celera
Cytogenetic Map	22	q11.21	NCBI
HuRef	22	3,740,057 - 3,756,143 (+)	NCBI		HuRef
CHM1_1	22	20,119,055 - 20,135,221 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	20,510,837 - 20,527,042 (+)	NCBI		T2T-CHM13v2.0

Zdhhc8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	18,038,612 - 18,056,471 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	18,038,617 - 18,053,000 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	18,220,748 - 18,235,153 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	18,220,753 - 18,235,136 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	18,220,846 - 18,235,229 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	18,134,316 - 18,148,699 (-)	NCBI		MGSCv36	mm8
Celera	16	18,793,499 - 18,807,882 (-)	NCBI		Celera
Cytogenetic Map	16	A3	NCBI
cM Map	16	11.29	NCBI

Zdhhc8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	17,965,963 - 17,980,854 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	17,965,186 - 17,980,854 (-)	NCBI	ChiLan1.0	ChiLan1.0

ZDHHC8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	22	22,287,404 - 22,294,891 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	18,571,565 - 18,581,117 (+)	NCBI	panpan1.1		panPan2
PanPan1.1 Ensembl	22	18,571,565 - 18,581,117 (+)	Ensembl	panpan1.1		panPan2

ZDHHC8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	29,192,867 - 29,208,105 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	29,193,682 - 29,208,105 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	29,153,540 - 29,167,095 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	30,596,983 - 30,612,849 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	30,596,996 - 30,612,216 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	28,646,506 - 28,660,061 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	28,271,871 - 28,285,426 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	29,356,852 - 29,370,420 (-)	NCBI		UU_Cfam_GSD_1.0

Zdhhc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	138,705,995 - 138,722,077 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936619	4,032,659 - 4,048,155 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936619	4,032,665 - 4,048,079 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZDHHC8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	51,503,114 - 51,516,885 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	51,503,074 - 51,517,577 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	55,140,126 - 55,154,612 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ZDHHC8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	5,591,311 - 5,607,448 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	5,589,090 - 5,607,387 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666085	1,326,410 - 1,342,682 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Zdhhc8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	739,594 - 754,989 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	740,352 - 755,891 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Zdhhc8
26 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	140
Count of miRNA genes:	89
Interacting mature miRNAs:	115
Transcripts:	ENSRNOT00000048063
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	55136729	82993457	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	66422148	86241447	Rat
1354593	Stl12	Serum triglyceride level QTL 12	3.36		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	11	66422148	86241447	Rat
1354656	Bvd3	Brain ventricular dilatation QTL 3	3.64	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	11	69446070	82846715	Rat
10450831	Scl80	Serum cholesterol level QTL 80	4.7	0.01	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	11	76957131	83051965	Rat
2302043	Pia27	Pristane induced arthritis QTL 27	18.6	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	11	82566545	83440803	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		31	4	4	2	4			66	20	28	3
Low	3	12	48	32	17	32	8	11	8	15	13	8	8
Below cutoff			5	5		5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001039021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088268	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY871204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000048063 ⟹ ENSRNOP00000040329

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	82,755,143 - 82,767,734 (+)	Ensembl
Rnor_6.0 Ensembl	11	86,903,122 - 86,915,715 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101480 ⟹ ENSRNOP00000087768

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	82,755,143 - 82,767,734 (+)	Ensembl

RefSeq Acc Id:

NM_001039021 ⟹ NP_001034110

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	82,755,143 - 82,767,752 (+)	NCBI
Rnor_6.0	11	86,903,122 - 86,915,733 (+)	NCBI
Rnor_5.0	11	89,997,052 - 90,011,199 (+)	NCBI
RGSC_v3.4	11	84,748,939 - 84,762,305 (+)	RGD
Celera	11	81,532,206 - 81,544,662 (+)	NCBI

Sequence:

show sequence

GGGATTTCCTCCACTGCCGCTGCCGCGGATCCTGCGCCGCGTCCAGCCCGTCGCGCCCGACCCC
GGTCTCTGACCCGGCCGGCCCCGCCCGCCCGGCCCGGGGAGGGATGCGGCGGCGCGGCGCCCAG
GATGCCCCGCAGCCCCGGGACGCGCCTCAAACCCGCCAAGTACATCCCGGTGGCCACGGCCGCG
GCGCTGTTGGTTGGCTCCAGCACCCTCTTCTTCGTATTCACGTGCCCGTGGTTGACAAGAGCTG
TCTCTCCAGCTATTCCTGTCTACAATGGCATCCTCTTCCTCTTTGTCCTGGCCAACTTCAGTAT
GGCTACCTTCATGGACCCCGGAGTCTTCCCCCGAGCGGACGAGGACGAGGACAAGGAGGATGAC
TTCCGGGCCCCACTGTACAAGAACGTGGATGTGCGGGGCATCCAGGTCCGCATGAAGTGGTGTG
CAACATGCCACTTCTACCGTCCGCCGCGCTGCTCACACTGCAGCGTCTGCGACAACTGTGTGGA
GGACTTTGACCACCACTGCCCCTGGGTGAACAACTGCATCGGACGCCGTAACTACCGTTACTTC
TTCCTGTTCCTGCTGTCACTCAGCGCACACATGGTGGGGGTGGTGGCCTTCGGCCTGCTCTACG
TGCTCAACCACTCGGAGGGGCTGGGGGCGGCCCACACCACCATCACCATGGCTGTCATGTGTGT
GGCTGGCCTTTTCTTCATTCCTGTCATCGGCCTCACTGGCTTCCACGTGGTACTGGTCACCCGG
GGACGCACCACCAATGAGCAGGTGACTGGGAAGTTCCGCGGGGGTGTGAATCCCTTCACCCGAG
GCTGCTATGGGAACGTGGAGCACGTGTTATGCAGTCCCCTGGCGCCCCGGTATGTGGTGGAAGC
TCCCAGGATGCCACTCTCAGTGAGCCTAAAGCCACCCTTCCTGAGGCCTGAGCTCCTGGAACGA
GCTGTGCCCCTCAAGGTCAAACTCAGCGACAATGGGCTGAAAGCTGGCCGCAGCAAGTCTAAGG
GCAGTCTAGACCAGCTGGATGAGAAACCTCTGGACCTGGGACCTCCACTGCCCCCCAAGATGGA
GGCTGGCACCTTTGGAAGAGATCTGAAGACCCCAAGACCTGGCAGTGCTGAGAGTGCCCTGTCA
GTACAGAGGACCAGCCCCCCAACACCTGCCATGTATAAGTTCCGGCCAGCCTTCTCCACTGCTC
CCAAGACACCCTTTTGTGGACCTAGTGAGCAGGTCCCAGGCCCTGACTCCCTCACTCTGGCCGA
TGACAGCACCCACAGTCTAGACTTTGTATCAGAGCCCAGCCTGGATCTCCCAGACCATGGGCCT
GGTGGTCTGCATCCTACCTACCCTCCCTCCCCACCCCTCAGTGCCACTGATGCCTTCTCAGGTG
CCTTACGCTCCCTGAGTCTCAAGGCTGCCAGTCGGCGGGGTGGGGACCACATGACCTTACAGCC
ACTGCGCTCTGAAGGTGGGCCCCCTACACCCCACCGTGGTCTCTTTGCTCCTCACGCACTGCCC
AACCGAAATGGCAGCCTGTCATACGACAGCCTACTTAACCCTGGCTCACCCAGTGGCCACGCAT
GCCCCACACACCCCTCTGTTGGTATGGCCGGCTACCATTCACCCTACCTGCACCCTGGGCCATC
AGATCCTCCACGGCCCCCACCCCGCAGCTTCAGCCCTGTGCTGGGTCCCCGGCCTAGGGAGCCC
TCTCCTGTGCGCTATGACAACCTGTCTCGGACCATCATGGCCTCTATCCAGGAGCGCAAGGACA
GAGAAGAGCGTGAACGGCTGCTGCGGTCCCAGACTGACTCACTCTTTGGCGACTCTGGTGTCTA
TGACACACCCAGCTCCTACAGCCTGCAACAGGCCAGTGTGTTAACAGAAGGTCCCCGCGGCTCT
GTGCTGCGCTATGGCTCCAGGGATGACCTCGTGGCCGGGCCTGGCTTTGGTGGTGCCCGAAATC
CTGCCCTGCAGACATCATTGTCCTCACTGTCCAGCTCCATGAGTCGGGCACCTCGGACATCCTC
CTCTTCCCTGCAGGCTGACCAGGCCAACAACAATGCCCCAGGACCCCGGCCTGGCAGTGGTTCA
CACAGGTCACCTGCCCGTCAGGGCCTGCCTTCCCCACCAGGCACCCCCCGATCGCCCTCCTACT
CGGGCTCCAAGGCTGTCGCCTTCATCCACACGGACCTTCCGGACCGGCAGCCCTCACTGGCTAT
GCAGAGGGATCACCCTCAGCTGAAGACCCCCCCAAGTAAGCTTAACGGTCAGTCCCCGGGCATG
GCCCGGCTGGGGCCTGCTGCCAGCCCCATGGGGCCCAACGCCAGCCCTGCCCGGCACACGCTGG
TTAAGAAGGTGTCCGGCGTGGGTGGGACTACGTACGAAATCTCGGTGTGAGAACTGACCACTAC
TCATCTGCTGTGATTCCACGGGGACCAGGACCCCCACAGCAGCTCCCCAACCCTATCAAGTTCT
CTGCCCCAGGGAGGAGGCTACCCAAGCCTGCTGTGGACACGTCAACAGGAAAGAAAGCCTTGCC
TCCACAAGCTTGTGCTCCGGCCTCAGCCTGTTCATCTACTTATCTAGTACTCACAGGGCAGACG
GATCCAAGGCTGTGAGCTGTGATGGGGACCTGGACTGCCTGTCATCAGCCAAGCTCAGCCCTGC
ACCCTCTTGCCCTCATCCCCTAAGGCCAGTCCCCAACAGTCCCGTGGGCCTGCCCACTCCTGTC
TGGATGGGTTGCTCAGCCCTGTTCTCCAGCTGCTCCTAATTCATGGCCTTTCACTGACAAAGCT
GGTCGCTTGTTGCTTGGCAAGGCCTATGCTTTGCAGGGGGCGTAACCCTGGCCTGCTCTGGGTT
GGGATGGATGGATGAACAGATGGACAGATAATCCAGCTGTAGCAGGTCCCAGCTCCCTCTGTTC
CTGTCTTGCCTGGCTGGTGGGTTCATGTCCCTATGTCTGTATGCTGTGCTACCGTCCCATGTCT
GATGTTAGTGCTTGGCTGCCACTGCTCTTTCATCAAAGCCTTAACTTCTGCTTTATGCTCTTGT
GGGAGGTGATGGGGGGTGGGGTAGGCCAGAGCAGAAAGGGGGCCAGATGCTGCCCCAGGGACCA
GCGGGGCCTAGAGCCCCCCCCCCTCAGGCCTTCCCTGCCAAGCTGGAGAGTCCTCACCCCAAAG
CATACCGAGTTCCCAGCACTGGCTTGGCCAGCGCAGCTGGAAAGCACATCAGGGAGGGGTCAGT
TCTTCCCCTGGCGTCAGGGACCTGAGTAAGCACATGGCAGCGTCTGCTTGCATTGTGTCTGTTT
TATGTTTTTATATTTACATCTATATATCTATAATTTTATTAAAAAAAAGGAAAAATCA

hide sequence

RefSeq Acc Id:

XM_006248610 ⟹ XP_006248672

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	82,755,114 - 82,769,280 (+)	NCBI
Rnor_6.0	11	86,903,140 - 86,917,261 (+)	NCBI
Rnor_5.0	11	89,997,052 - 90,011,199 (+)	NCBI

Sequence:

show sequence

GCTGCCGCGGATCCTGCGCCGCGTCCAGCCCGTCGCGCCCGACCCCGGTCTCTGACCCGGCCGG
CCCCGCCCGCCCGGCCCGGGGAGGGATGCGGCGGCGCGGCGCCCAGGATGCCCCGCAGCCCCGG
GACGCGCCTCAAACCCGCCAAGTACATCCCGGTGGCCACGGCCGCGGCGCTGTTGGTTGGCTCC
AGCACCCTCTTCTTCGTATTCACGTGCCCGTGGTTGACAAGAGCTGTCTCTCCAGCTATTCCTG
TCTACAATGGCATCCTCTTCCTCTTTGTCCTGGCCAACTTCAGTATGGCTACCTTCATGGACCC
CGGAGTCTTCCCCCGAGCGGACGAGGACGAGGACAAGGAGGATGACTTCCGGGCCCCACTGTAC
AAGAACGTGGATGTGCGGGGCATCCAGGTCCGCATGAAGTGGTGTGCAACATGCCACTTCTACC
GTCCGCCGCGCTGCTCACACTGCAGCGTCTGCGACAACTGTGTGGAGGACTTTGACCACCACTG
CCCCTGGGTGAACAACTGCATCGGACGCCGTAACTACCGTTACTTCTTCCTGTTCCTGCTGTCA
CTCAGCGCACACATGGTGGGGGTGGTGGCCTTCGGCCTGCTCTACGTGCTCAACCACTCGGAGG
GGCTGGGGGCGGCCCACACCACCATCACCATGGCTGTCATGTGTGTGGCTGGCCTTTTCTTCAT
TCCTGTCATCGGCCTCACTGGCTTCCACGTGGTACTGGTCACCCGGGGACGCACCACCAATGAG
CAGGTGACTGGGAAGTTCCGCGGGGGTGTGAATCCCTTCACCCGAGGCTGCTATGGGAACGTGG
AGCACGTGTTATGCAGTCCCCTGGCGCCCCGGTATGTGGTGGAAGCTCCCAGGATGCCACTCTC
AGTGAGCCTAAAGCCACCCTTCCTGAGGCCTGAGCTCCTGGAACGAGCTGTGCCCCTCAAGGTC
AAACTCAGCGACAATGGGCTGAAAGCTGGCCGCAGCAAGTCTAAGGGCAGTCTAGACCAGCTGG
ATGAGAAACCTCTGGACCTGGGACCTCCACTGCCCCCCAAGATGGAGGCTGGCACCTTTGGAAG
AGATCTGAAGACCCCAAGACCTGGCAGTGCTGAGAGTGCCCTGTCAGTACAGAGGACCAGCCCC
CCAACACCTGCCATGTATAAGTTCCGGCCAGCCTTCTCCACTGCTCCCAAGACACCCTTTTGTG
GACCTAGTGAGCAGGTCCCAGGCCCTGACTCCCTCACTCTGGCCGATGACAGCACCCACAGTCT
AGACTTTGTATCAGAGCCCAGCCTGGATCTCCCAGACCATGGGCCTGGTGGTCTGCATCCTACC
TACCCTCCCTCCCCACCCCTCAGTGCCACTGATGCCTTCTCAGGTGCCTTACGCTCCCTGAGTC
TCAAGGCTGCCAGTCGGCGGGGTGGGGACCACATGACCTTACAGCCACTGCGCTCTGAAGGTGG
GCCCCCTACACCCCACCGTGGTCTCTTTGCTCCTCACGCACTGCCCAACCGAAATGGCAGCCTG
TCATACGACAGCCTACTTAACCCTGGCTCACCCAGTGGCCACGCATGCCCCACACACCCCTCTG
TTGGTATGGCCGGCTACCATTCACCCTACCTGCACCCTGGGCCATCAGATCCTCCACGGCCCCC
ACCCCGCAGCTTCAGCCCTGTGCTGGGTCCCCGGCCTAGGGAGCCCTCTCCTGTGCGCTATGAC
AACCTGTCTCGGACCATCATGGCCTCTATCCAGGAGCGCAAGGACAGAGAAGAGCGTGAACGGC
TGCTGCGGTCCCAGACTGACTCACTCTTTGGCGACTCTGGTGTCTATGACACACCCAGCTCCTA
CAGCCTGCAACAGGCCAGTGTGTTAACAGAAGGTCCCCGCGGCTCTGTGCTGCGCTATGGCTCC
AGGGATGACCTCGTGGCCGGGCCTGGCTTTGGTGGTGCCCGAAATCCTGCCCTGCAGACATCAT
TGTCCTCACTGTCCAGCTCCATGAGTCGGGCACCTCGGACATCCTCCTCTTCCCTGCAGGCTGA
CCAGGCCAACAACAATGCCCCAGGACCCCGGCCTGGCAGTGGTTCACACAGGTCACCTGCCCGT
CAGGGCCTGCCTTCCCCACCAGGCACCCCCCGATCGCCCTCCTACTCGGGCTCCAAGGCTGTCG
CCTTCATCCACACGGACCTTCCGGACCGGCAGCCCTCACTGGCTATGCAGAGGGGGCGCATTGG
CAGCTGTAGCCGTGGATGGGGGTGGCGTGGTCCGCCTAGGGGGACTCCTGGCCTACACCTGTGC
CACCTTGGCCATCCTGAGGATCACCCGCCGCTGCGGGCCCCCTGGAGCGTGGCTGCTGGGGCAG
CCCCCCGTGGGACCATCTGTCGGCTACATTCTGCTGCATCCAGCCTTTTCCCCAGCCTCTCAGG
TCCCTAACAGGACACTAGTAGGTGGCTCTAGGGCCATGGACAATCTTCTGGGGACCCAGAAGAC
CAGGCTACTGTAGAACTTTGGAGTCTGGCTGGATGATACATCGGTAGCCTGGGGATCCCTGCCC
CATACCCTGTCAACCAGCCACATCTTGACTGATGAGTCTGTCAGGGCCCAGGACCCTGGCTCCA
GGTGACCTCAGGAAGTCCCCCCACCTGCTGCAGGGGTCCAGTGCCCCAGTGGGGGTGGCCTCAG
AGATACTGGGAACCAGCATGACCTTCACCCCAACCTCCTTACCCCTTCCAAGCACTTTAAGCCA
CTTCCTCTAGGGAGCCCAGGCCTCTGTGGATTGGGCTGGGGTGGGGGTCTCAGGTCACCGCAGG
TTACTGCACTCCTTCACTCCACCCCAGACCCCTGAACAGATGCCTTAATGTCCTGGAGCTGCCA
GCCAGCCTGGTGCACTGAACCTGGTCCACCCTTCTCTGCCTCTTGCCTGCTCTGTCCCCAACGG
GTTGTCTCTCTGCATCCAAGGGTGATACCTCCGGGAATACCCTAGCCTGGGGGCCTGGATGCCT
CCGGGAGGAGTCAGAACAGAACCCGCCCCCCGCCAACTCCTTTTTTTACACAGGAGCCATGTCC
TGGGGCCCACGTCTGGGCGACAGTTCTGTCTCTCCCATCTGGGGCAGATCCACAAACTGTTTTC
TGTTCTACAGGATTTCCCTCCTTCAACTTCCCTAATAAATTTTTTTTTTTTGTGTTCACACCCA

hide sequence

RefSeq Acc Id:

XM_039088268 ⟹ XP_038944196

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	82,755,110 - 82,769,280 (+)	NCBI

RefSeq Acc Id:

XM_039088269 ⟹ XP_038944197

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	82,761,923 - 82,769,280 (+)	NCBI

RefSeq Acc Id:

XM_039088270 ⟹ XP_038944198

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	82,761,438 - 82,769,280 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001034110	(Get FASTA)	NCBI Sequence Viewer
	XP_006248672	(Get FASTA)	NCBI Sequence Viewer
	XP_038944196	(Get FASTA)	NCBI Sequence Viewer
	XP_038944197	(Get FASTA)	NCBI Sequence Viewer
	XP_038944198	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAX68537	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001034110 ⟸ NM_001039021

- UniProtKB:

Q2THW6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPRSPGTRLKPAKYIPVATAAALLVGSSTLFFVFTCPWLTRAVSPAIPVYNGILFLFVLANFSM
ATFMDPGVFPRADEDEDKEDDFRAPLYKNVDVRGIQVRMKWCATCHFYRPPRCSHCSVCDNCVE
DFDHHCPWVNNCIGRRNYRYFFLFLLSLSAHMVGVVAFGLLYVLNHSEGLGAAHTTITMAVMCV
AGLFFIPVIGLTGFHVVLVTRGRTTNEQVTGKFRGGVNPFTRGCYGNVEHVLCSPLAPRYVVEA
PRMPLSVSLKPPFLRPELLERAVPLKVKLSDNGLKAGRSKSKGSLDQLDEKPLDLGPPLPPKME
AGTFGRDLKTPRPGSAESALSVQRTSPPTPAMYKFRPAFSTAPKTPFCGPSEQVPGPDSLTLAD
DSTHSLDFVSEPSLDLPDHGPGGLHPTYPPSPPLSATDAFSGALRSLSLKAASRRGGDHMTLQP
LRSEGGPPTPHRGLFAPHALPNRNGSLSYDSLLNPGSPSGHACPTHPSVGMAGYHSPYLHPGPS
DPPRPPPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQTDSLFGDSGVY
DTPSSYSLQQASVLTEGPRGSVLRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSMSRAPRTSS
SSLQADQANNNAPGPRPGSGSHRSPARQGLPSPPGTPRSPSYSGSKAVAFIHTDLPDRQPSLAM
QRDHPQLKTPPSKLNGQSPGMARLGPAASPMGPNASPARHTLVKKVSGVGGTTYEISV

hide sequence

RefSeq Acc Id:

XP_006248672 ⟸ XM_006248610

- Peptide Label:

isoform X1

- Sequence:

show sequence

MPRSPGTRLKPAKYIPVATAAALLVGSSTLFFVFTCPWLTRAVSPAIPVYNGILFLFVLANFSM
ATFMDPGVFPRADEDEDKEDDFRAPLYKNVDVRGIQVRMKWCATCHFYRPPRCSHCSVCDNCVE
DFDHHCPWVNNCIGRRNYRYFFLFLLSLSAHMVGVVAFGLLYVLNHSEGLGAAHTTITMAVMCV
AGLFFIPVIGLTGFHVVLVTRGRTTNEQVTGKFRGGVNPFTRGCYGNVEHVLCSPLAPRYVVEA
PRMPLSVSLKPPFLRPELLERAVPLKVKLSDNGLKAGRSKSKGSLDQLDEKPLDLGPPLPPKME
AGTFGRDLKTPRPGSAESALSVQRTSPPTPAMYKFRPAFSTAPKTPFCGPSEQVPGPDSLTLAD
DSTHSLDFVSEPSLDLPDHGPGGLHPTYPPSPPLSATDAFSGALRSLSLKAASRRGGDHMTLQP
LRSEGGPPTPHRGLFAPHALPNRNGSLSYDSLLNPGSPSGHACPTHPSVGMAGYHSPYLHPGPS
DPPRPPPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQTDSLFGDSGVY
DTPSSYSLQQASVLTEGPRGSVLRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSMSRAPRTSS
SSLQADQANNNAPGPRPGSGSHRSPARQGLPSPPGTPRSPSYSGSKAVAFIHTDLPDRQPSLAM
QRGRIGSCSRGWGWRGPPRGTPGLHLCHLGHPEDHPPLRAPWSVAAGAAPRGTICRLHSAASSL
FPSLSGP

hide sequence

RefSeq Acc Id:

ENSRNOP00000040329 ⟸ ENSRNOT00000048063

RefSeq Acc Id:	XP_038944196 ⟸ XM_039088268
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038944198 ⟸ XM_039088270
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038944197 ⟸ XM_039088269
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSRNOP00000087768 ⟸ ENSRNOT00000101480

Protein Domains

DHHC

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q2THW6-F1-model_v2	AlphaFold	Q2THW6	1-762	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698309

Promoter ID:

EPDNEW_R8833

Type:

initiation region

Name:

Zdhhc8_1

Description:

zinc finger, DHHC-type containing 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	86,903,124 - 86,903,184	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308875	AgrOrtholog
BioCyc Gene	G2FUF-20644	BioCyc
Ensembl Genes	ENSRNOG00000021891	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000040329	ENTREZGENE
	ENSRNOP00000040329.2	UniProtKB/TrEMBL
	ENSRNOP00000087768.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000048063	ENTREZGENE
	ENSRNOT00000048063.4	UniProtKB/TrEMBL
	ENSRNOT00000101480.1	UniProtKB/TrEMBL
InterPro	ZDHHC8	UniProtKB/TrEMBL
	Znf_DHHC	UniProtKB/TrEMBL
KEGG Report	rno:303796	UniProtKB/TrEMBL
NCBI Gene	303796	ENTREZGENE
PANTHER	PTHR12349:SF1	UniProtKB/TrEMBL
Pfam	zf-DHHC	UniProtKB/TrEMBL
PhenoGen	Zdhhc8	PhenoGen
UniProt	A0A8I6A4S3_RAT	UniProtKB/TrEMBL
	Q2THW6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-11-11	Zdhhc8	zinc finger DHHC-type palmitoyltransferase 8	Zdhhc8	zinc finger, DHHC-type containing 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-05-24	Zdhhc8	zinc finger, DHHC-type containing 8	LOC100364821	zinc finger, DHHC-type containing 8-like	Data Merged	1643240	APPROVED
2010-05-05	LOC100364821	zinc finger, DHHC-type containing 8-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-11-17	Zdhhc8	zinc finger, DHHC-type containing 8	Zdhhc8	zinc finger, DHHC domain containing 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	Zdhhc8	zinc finger, DHHC domain containing 8	Zdhhc8_predicted	zinc finger, DHHC domain containing 8 (predicted)	Symbol and Name status set to approved	1299863	APPROVED
2005-01-12	Zdhhc8_predicted	zinc finger, DHHC domain containing 8 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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