Zdhhc8 (zinc finger DHHC-type palmitoyltransferase 8) - Rat Genome Database

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Gene: Zdhhc8 (zinc finger DHHC-type palmitoyltransferase 8) Rattus norvegicus
Analyze
Symbol: Zdhhc8
Name: zinc finger DHHC-type palmitoyltransferase 8
RGD ID: 1308875
Description: Predicted to enable palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and positive regulation of cholesterol efflux. Predicted to act upstream of or within locomotory behavior. Located in synapse. Orthologous to human ZDHHC8 (zinc finger DHHC-type palmitoyltransferase 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC303796; palmitoyltransferase ZDHHC8; probable palmitoyltransferase ZDHHC8; zinc finger, DHHC domain containing 8; zinc finger, DHHC-type containing 8; zinc finger, DHHC-type containing 8-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,755,110 - 82,769,280 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,755,143 - 82,767,734 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,483,528 - 91,496,137 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01184,144,756 - 84,157,365 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01183,198,271 - 83,210,880 (+)NCBIRnor_WKY
Rnor_6.01186,903,122 - 86,917,261 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,903,122 - 86,915,715 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,997,052 - 90,011,199 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,748,939 - 84,762,305 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,789,663 - 84,801,365 (+)NCBI
Celera1181,532,206 - 81,544,662 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking. Thomas GM, etal., Neuron. 2012 Feb 9;73(3):482-96. doi: 10.1016/j.neuron.2011.11.021.
Additional References at PubMed
PMID:15184899   PMID:16647879   PMID:18775783   PMID:23034182   PMID:24912190  


Genomics

Comparative Map Data
Zdhhc8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,755,110 - 82,769,280 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,755,143 - 82,767,734 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,483,528 - 91,496,137 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01184,144,756 - 84,157,365 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01183,198,271 - 83,210,880 (+)NCBIRnor_WKY
Rnor_6.01186,903,122 - 86,917,261 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,903,122 - 86,915,715 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,997,052 - 90,011,199 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,748,939 - 84,762,305 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,789,663 - 84,801,365 (+)NCBI
Celera1181,532,206 - 81,544,662 (+)NCBICelera
Cytogenetic Map11q23NCBI
ZDHHC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,131,804 - 20,148,007 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2220,129,456 - 20,148,007 (+)EnsemblGRCh38hg38GRCh38
GRCh372220,119,327 - 20,135,530 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,499,365 - 18,513,974 (+)NCBINCBI36Build 36hg18NCBI36
Build 342218,493,918 - 18,508,512NCBI
Celera223,971,414 - 3,987,580 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef223,740,057 - 3,756,143 (+)NCBIHuRef
CHM1_12220,119,055 - 20,135,221 (+)NCBICHM1_1
T2T-CHM13v2.02220,510,837 - 20,527,042 (+)NCBIT2T-CHM13v2.0
Zdhhc8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,038,612 - 18,056,471 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,038,617 - 18,053,000 (-)EnsemblGRCm39 Ensembl
GRCm381618,220,748 - 18,235,153 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,220,753 - 18,235,136 (-)EnsemblGRCm38mm10GRCm38
MGSCv371618,220,846 - 18,235,229 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361618,134,316 - 18,148,699 (-)NCBIMGSCv36mm8
Celera1618,793,499 - 18,807,882 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.29NCBI
Zdhhc8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,965,963 - 17,980,854 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,965,186 - 17,980,854 (-)NCBIChiLan1.0ChiLan1.0
ZDHHC8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12222,287,404 - 22,294,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2218,571,565 - 18,581,117 (+)NCBIpanpan1.1panPan2
PanPan1.1 Ensembl2218,571,565 - 18,581,117 (+)Ensemblpanpan1.1panPan2
ZDHHC8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,192,867 - 29,208,105 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,193,682 - 29,208,105 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,153,540 - 29,167,095 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,596,983 - 30,612,849 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,596,996 - 30,612,216 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,646,506 - 28,660,061 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,271,871 - 28,285,426 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,356,852 - 29,370,420 (-)NCBIUU_Cfam_GSD_1.0
Zdhhc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118138,705,995 - 138,722,077 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366194,032,659 - 4,048,155 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366194,032,665 - 4,048,079 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZDHHC8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,503,114 - 51,516,885 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,503,074 - 51,517,577 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21455,140,126 - 55,154,612 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZDHHC8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,591,311 - 5,607,448 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl195,589,090 - 5,607,387 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660851,326,410 - 1,342,682 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zdhhc8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624747739,594 - 754,989 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624747740,352 - 755,891 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zdhhc8
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:89
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000048063
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
2302043Pia27Pristane induced arthritis QTL 2718.60.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)118256654583440803Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 31 4 4 2 4 66 20 28 3
Low 3 12 48 32 17 32 8 11 8 15 13 8 8
Below cutoff 5 5 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000048063   ⟹   ENSRNOP00000040329
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,755,143 - 82,767,734 (+)Ensembl
Rnor_6.0 Ensembl1186,903,122 - 86,915,715 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101480   ⟹   ENSRNOP00000087768
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,755,143 - 82,767,734 (+)Ensembl
RefSeq Acc Id: NM_001039021   ⟹   NP_001034110
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,755,143 - 82,767,752 (+)NCBI
Rnor_6.01186,903,122 - 86,915,733 (+)NCBI
Rnor_5.01189,997,052 - 90,011,199 (+)NCBI
RGSC_v3.41184,748,939 - 84,762,305 (+)RGD
Celera1181,532,206 - 81,544,662 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248610   ⟹   XP_006248672
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,755,114 - 82,769,280 (+)NCBI
Rnor_6.01186,903,140 - 86,917,261 (+)NCBI
Rnor_5.01189,997,052 - 90,011,199 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088268   ⟹   XP_038944196
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,755,110 - 82,769,280 (+)NCBI
RefSeq Acc Id: XM_039088269   ⟹   XP_038944197
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,761,923 - 82,769,280 (+)NCBI
RefSeq Acc Id: XM_039088270   ⟹   XP_038944198
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,761,438 - 82,769,280 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001034110   ⟸   NM_001039021
- UniProtKB: Q2THW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248672   ⟸   XM_006248610
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000040329   ⟸   ENSRNOT00000048063
RefSeq Acc Id: XP_038944196   ⟸   XM_039088268
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038944198   ⟸   XM_039088270
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038944197   ⟸   XM_039088269
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000087768   ⟸   ENSRNOT00000101480
Protein Domains
DHHC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2THW6-F1-model_v2 AlphaFold Q2THW6 1-762 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698309
Promoter ID:EPDNEW_R8833
Type:initiation region
Name:Zdhhc8_1
Description:zinc finger, DHHC-type containing 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01186,903,124 - 86,903,184EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308875 AgrOrtholog
BioCyc Gene G2FUF-20644 BioCyc
Ensembl Genes ENSRNOG00000021891 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000040329 ENTREZGENE
  ENSRNOP00000040329.2 UniProtKB/TrEMBL
  ENSRNOP00000087768.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048063 ENTREZGENE
  ENSRNOT00000048063.4 UniProtKB/TrEMBL
  ENSRNOT00000101480.1 UniProtKB/TrEMBL
InterPro ZDHHC8 UniProtKB/TrEMBL
  Znf_DHHC UniProtKB/TrEMBL
KEGG Report rno:303796 UniProtKB/TrEMBL
NCBI Gene 303796 ENTREZGENE
PANTHER PTHR12349:SF1 UniProtKB/TrEMBL
Pfam zf-DHHC UniProtKB/TrEMBL
PhenoGen Zdhhc8 PhenoGen
UniProt A0A8I6A4S3_RAT UniProtKB/TrEMBL
  Q2THW6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Zdhhc8  zinc finger DHHC-type palmitoyltransferase 8  Zdhhc8  zinc finger, DHHC-type containing 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Zdhhc8  zinc finger, DHHC-type containing 8  LOC100364821  zinc finger, DHHC-type containing 8-like  Data Merged 1643240 APPROVED
2010-05-05 LOC100364821  zinc finger, DHHC-type containing 8-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-11-17 Zdhhc8  zinc finger, DHHC-type containing 8  Zdhhc8  zinc finger, DHHC domain containing 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 Zdhhc8  zinc finger, DHHC domain containing 8  Zdhhc8_predicted  zinc finger, DHHC domain containing 8 (predicted)  Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Zdhhc8_predicted  zinc finger, DHHC domain containing 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED