Tp63 (tumor protein p63) - Rat Genome Database

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Gene: Tp63 (tumor protein p63) Rattus norvegicus
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Symbol: Tp63
Name: tumor protein p63
RGD ID: 620863
Description: Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and protein domain specific binding activity. Involved in aging; positive regulation of cell population proliferation; and spermatogenesis. Located in dendrite; nucleus; and rough endoplasmic reticulum. Part of protein-containing complex. Human ortholog(s) of this gene implicated in several diseases, including ADULT syndrome; EEC syndrome (multiple); ectodermal dysplasia (multiple); orofacial cleft 8; and split hand-foot malformation 4. Orthologous to human TP63 (tumor protein p63); PARTICIPATES IN altered p53 signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 3,4-dichloroaniline; acrylamide.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: keratinocyte transcription factor KET; Ket; p73L; Tp73l; transformation related protein 63; Trp63; tumor protein 63; tumor protein 63 kDa; tumor protein p73-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21174,838,858 - 75,049,764 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1174,838,859 - 75,049,398 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1183,648,386 - 83,858,432 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01176,283,447 - 76,493,481 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01175,342,697 - 75,553,279 (-)NCBIRnor_WKY
Rnor_6.01178,234,853 - 78,456,559 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,234,800 - 78,456,501 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,262,234 - 82,484,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41176,900,622 - 77,200,251 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11176,958,211 - 77,257,840 (-)NCBI
Celera1173,744,494 - 73,953,104 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
ADULT syndrome  (ISO)
amenorrhea  (ISO)
ankyloblepharon-ectodermal defects-cleft lip/palate syndrome  (ISO)
bladder exstrophy  (ISS)
bladder exstrophy-epispadias-cloacal exstrophy complex  (ISO)
breast disease  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cervix uteri carcinoma in situ  (ISO)
cleft lip  (ISO)
Cleft Lip with or without Cleft Palate, Nonsyndromic, 8  (ISO)
cleft palate  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Foot Deformities  (ISO)
Congenital Hand Deformities  (ISO)
Congenital Limb Deformities  (ISO)
Corneal Injuries  (ISO)
Craniofacial Abnormalities  (ISO)
ectodermal dysplasia  (ISO)
ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3  (ISO)
EEC syndrome  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Neoplasms  (ISO)
Female Urogenital Diseases  (ISO)
fissured tongue  (ISO)
gastroesophageal reflux disease  (ISS)
genetic disease  (ISO)
Limb-Mammary Syndrome  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
Multiple Abnormalities  (ISO)
muscular dystrophy  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
orofacial cleft 8  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
primary ovarian insufficiency  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
Rapp-Hodgkin syndrome  (ISO)
schizophrenia  (ISO)
Skin Abnormalities  (ISO)
split hand-foot malformation  (ISO)
split hand-foot malformation 4  (ISO)
squamous cell carcinoma  (ISO)
squamous cell neoplasm  (ISO)
Sweat Gland Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dibromoethane  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-dichloroaniline  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-vinylcyclohexene dioxide  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimonite  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
emodin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylenediaminetetraacetic acid  (ISO)
eugenol  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
Fusarenone X  (ISO)
genistein  (EXP,ISO)
glycidol  (ISO)
graphite  (ISO)
hydroxyurea  (ISO)
isobutanol  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
leptomycin B  (ISO)
lithium chloride  (ISO)
luteolin  (ISO)
melphalan  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
myricetin  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel dichloride  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
PhIP  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
anatomical structure formation involved in morphogenesis  (ISO)
animal organ morphogenesis  (ISO)
apoptotic process  (IEA,ISO)
cell differentiation  (ISO)
cell population proliferation  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular senescence  (ISO)
chromatin remodeling  (ISO)
cloacal septation  (ISO)
cranial skeletal system development  (ISO)
developmental process  (IEA)
ectoderm and mesoderm interaction  (ISO)
embryonic forelimb morphogenesis  (ISO)
embryonic hindlimb morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
epidermal cell differentiation  (ISO)
epidermal cell division  (ISO)
epidermis development  (ISO)
epithelial cell apoptotic process  (ISO)
epithelial cell development  (ISO)
epithelial cell differentiation  (ISO)
establishment of planar polarity  (ISO)
establishment of skin barrier  (ISO,ISS)
female genitalia morphogenesis  (ISO)
hair follicle development  (ISO)
hair follicle morphogenesis  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
keratinocyte development  (ISO)
keratinocyte differentiation  (ISO)
keratinocyte proliferation  (ISO)
morphogenesis of a polarized epithelium  (ISO)
multicellular organism aging  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell apoptotic process  (ISO)
negative regulation of intracellular estrogen receptor signaling pathway  (ISO)
negative regulation of keratinocyte differentiation  (ISO)
negative regulation of mesoderm development  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron apoptotic process  (ISO)
Notch signaling pathway  (ISO)
obsolete cell aging  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
pattern specification process  (ISO)
polarized epithelial cell differentiation  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cell cycle G1/S phase transition  (ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of fibroblast apoptotic process  (ISO)
positive regulation of keratinocyte proliferation  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of somatic stem cell population maintenance  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
post-anal tail morphogenesis  (ISO)
prostate gland development  (ISO)
prostatic bud formation  (ISO)
protein tetramerization  (IEA)
proximal/distal pattern formation  (ISO)
regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of epidermal cell division  (ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA)
skeletal system development  (ISO)
skin epidermis development  (ISO)
skin morphogenesis  (ISO)
smooth muscle tissue development  (ISO)
spermatogenesis  (IEP)
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development  (ISO)
stem cell differentiation  (ISO)
stem cell proliferation  (ISO)
sympathetic nervous system development  (ISO)
transcription by RNA polymerase II  (ISO)
urinary bladder development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A novel c.1037C > G (p.Ala346Gly) mutation in TP63 as cause of the ectrodactyly-ectodermal dysplasia and cleft lip/palate (EEC) syndrome. Alves LU, etal., Genet Mol Biol. 2015 Mar;38(1):37-41. doi: 10.1590/S1415-475738120140125. Epub 2014 Mar 17.
2. Proliferation and apoptotic rates and increased frequency of p63-positive cells in the prostate acinar epithelium of alloxan-induced diabetic rats. Arcolino FO, etal., Int J Exp Pathol. 2010 Apr;91(2):144-54. doi: 10.1111/j.1365-2613.2009.00696.x. Epub 2009 Dec 22.
3. Identification and tissue distribution of novel KET/p63 splice variants. Bamberger C and Schmale H, FEBS Lett 2001 Jul 20;501(2-3):121-6.
4. Analysis of the p63 gene in classical EEC syndrome, related syndromes, and non-syndromic orofacial clefts. Barrow LL, etal., J Med Genet. 2002 Aug;39(8):559-66.
5. Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome. Celli J, etal., Cell. 1999 Oct 15;99(2):143-53.
6. Molecular basis of EEC (ectrodactyly, ectodermal dysplasia, clefting) syndrome: five new mutations in the DNA-binding domain of the TP63 gene and genotype-phenotype correlation. Clements SE, etal., Br J Dermatol. 2010 Jan;162(1):201-7. doi: 10.1111/j.1365-2133.2009.09496.x. Epub 2009 Nov 9.
7. Differential protein expression, DNA binding and interaction with SV40 large tumour antigen implicate the p63-family of proteins in replicative senescence. Djelloul S, etal., Oncogene. 2002 Feb 7;21(7):981-9.
8. Clinical Variability in a Family with an Ectodermal Dysplasia Syndrome and a Nonsense Mutation in the TP63 Gene. Eisenkraft A, etal., Fetal Pediatr Pathol. 2015;34(6):400-6. doi: 10.3109/15513815.2015.1095261. Epub 2015 Oct 16.
9. Interaction of microtubule-associated protein-2 and p63: a new link between microtubules and rough endoplasmic reticulum membranes in neurons. Farah CA, etal., J Biol Chem. 2005 Mar 11;280(10):9439-49. Epub 2004 Dec 28.
10. Mutant p53: one name, many proteins. Freed-Pastor WA and Prives C, Genes Dev. 2012 Jun 15;26(12):1268-86. doi: 10.1101/gad.190678.112.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Expression of the p63 and Notch signaling systems in rat testes during postnatal development: comparison with their expression levels in the epididymis and vas deferens. Hayashi T, etal., J Androl. 2004 Sep-Oct;25(5):692-8.
13. Impaired delta NP63 expression is associated with poor tumor development in transitional cell carcinoma of the bladder. He Y, etal., J Korean Med Sci. 2008 Oct;23(5):825-32.
14. Age-related expressions of p63 and other keratinocyte stem cell markers in rat cornea. Hsueh YJ, etal., J Biomed Sci. 2004 Sep-Oct;11(5):641-51.
15. Periacinar Clefting and p63 Immunostaining in Prostatic Intraepithelial Neoplasia and Prostatic Carcinoma. Kruslin B, etal., Pathol Oncol Res. 2006;12(4):205-9. Epub 2006 Dec 25.
16. DeltaNp63 protein expression in uterine cervical and endometrial cancers. Lin Z, etal., J Cancer Res Clin Oncol. 2006 Dec;132(12):811-6. Epub 2006 Jun 28.
17. DeltaNp63 expression is associated with poor survival in ovarian cancer. Marchini S, etal., Ann Oncol. 2008 Mar;19(3):501-7. Epub 2007 Nov 12.
18. Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63. McGrath JA, etal., Hum Mol Genet. 2001 Feb 1;10(3):221-9.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. The corneal epithelial stem cell. Moore JE, etal., DNA Cell Biol. 2002 May-Jun;21(5-6):443-51.
21. p53 mutations in cancer. Muller PA and Vousden KH, Nat Cell Biol. 2013 Jan;15(1):2-8. doi: 10.1038/ncb2641.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. TP63 mutation and clefting modifier genes in an EEC syndrome family. Ray AK, etal., Clin Genet. 2004 Sep;66(3):217-22.
25. Progression of prostate cancer from a subset of p63-positive basal epithelial cells in FG/Tag transgenic mice. Reiner T, etal., Mol Cancer Res. 2007 Nov;5(11):1171-9. Epub 2007 Nov 2.
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. A novel protein with strong homology to the tumor suppressor p53. Schmale H and Bamberger C, Oncogene 1997 Sep;15(11):1363-7.
29. EEC (Ectrodactyly, Ectodermal dysplasia, Clefting) syndrome: heterozygous mutation in the p63 gene (R279H) and DNA-based prenatal diagnosis. South AP, etal., Br J Dermatol. 2002 Feb;146(2):216-20.
30. E-cadherin and p63 immunoexpression in dysplastic lesions and urothelial carcinomas of the bladder. Stepan A, etal., Rom J Morphol Embryol. 2009;50(3):461-5.
31. Anorectal malformation associated with a mutation in the P63 gene in a family with split hand-foot malformation. Su P, etal., Int J Colorectal Dis. 2013 Dec;28(12):1621-7. doi: 10.1007/s00384-013-1725-6. Epub 2013 Jun 5.
32. Diagnostic and prognostic impact of p63 immunoreactivity in renal malignancies. Tuna B, etal., Anal Quant Cytol Histol. 2009 Apr;31(2):118-22.
33. p63 Gene mutations in eec syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation. van Bokhoven H, etal., Am J Hum Genet. 2001 Sep;69(3):481-92. Epub 2001 Jul 17.
34. An allelic series of Trp63 mutations defines TAp63 as a modifier of EEC syndrome. Vernersson Lindahl E, etal., Am J Med Genet A. 2013 Aug;161A(8):1961-71. doi: 10.1002/ajmg.a.36074. Epub 2013 Jun 14.
35. Integrating expression-related SNPs into genome-wide gene- and pathway-based analyses identified novel lung cancer susceptibility genes. Wang Y, etal., Int J Cancer. 2018 Apr 15;142(8):1602-1610. doi: 10.1002/ijc.31182. Epub 2017 Dec 12.
36. Analysis of large phenotypic variability of EEC and SHFM4 syndromes caused by K193E mutation of the TP63 gene. Wei J, etal., PLoS One. 2012;7(5):e35337. doi: 10.1371/journal.pone.0035337. Epub 2012 May 4.
37. Insertion/deletion polymorphisms in the DeltaNp63 promoter are a risk factor for bladder exstrophy epispadias complex. Wilkins S, etal., PLoS Genet. 2012;8(12):e1003070. doi: 10.1371/journal.pgen.1003070. Epub 2012 Dec 20.
38. TP63 gene mutations in Chinese P63 syndrome patients. Yin W, etal., J Dent Res. 2010 Aug;89(8):813-7. doi: 10.1177/0022034510366804. Epub 2010 Apr 21.
Additional References at PubMed
PMID:9774969   PMID:10227293   PMID:10227294   PMID:10373484   PMID:10657951   PMID:11106548   PMID:11522642   PMID:11532371   PMID:11641404   PMID:12368184   PMID:12446779   PMID:12446784  
PMID:12789272   PMID:14729569   PMID:15189821   PMID:15361520   PMID:15371309   PMID:15585950   PMID:15982302   PMID:16080917   PMID:16107615   PMID:16337913   PMID:16343436   PMID:16363065  
PMID:16410075   PMID:16466397   PMID:16524929   PMID:16601749   PMID:16618808   PMID:17041603   PMID:17079275   PMID:17093266   PMID:17122775   PMID:17383628   PMID:17522155   PMID:17878916  
PMID:18159078   PMID:18256694   PMID:18326838   PMID:19194497   PMID:19451233   PMID:19815500   PMID:20123734   PMID:21127502   PMID:21285247   PMID:21335238   PMID:21464285   PMID:21930775  
PMID:22274697   PMID:22521434   PMID:22575646   PMID:23608756   PMID:23906066   PMID:24075906   PMID:25417702   PMID:25503409   PMID:25655704   PMID:28827783  


Genomics

Comparative Map Data
Tp63
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21174,838,858 - 75,049,764 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1174,838,859 - 75,049,398 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1183,648,386 - 83,858,432 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01176,283,447 - 76,493,481 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01175,342,697 - 75,553,279 (-)NCBIRnor_WKY
Rnor_6.01178,234,853 - 78,456,559 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,234,800 - 78,456,501 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,262,234 - 82,484,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41176,900,622 - 77,200,251 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11176,958,211 - 77,257,840 (-)NCBI
Celera1173,744,494 - 73,953,104 (-)NCBICelera
Cytogenetic Map11q22NCBI
TP63
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383189,596,746 - 189,897,276 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3189,631,389 - 189,897,276 (+)EnsemblGRCh38hg38GRCh38
GRCh373189,314,535 - 189,615,065 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363190,831,910 - 191,097,759 (+)NCBINCBI36Build 36hg18NCBI36
Celera3187,783,803 - 188,042,610 (+)NCBICelera
Cytogenetic Map3q28NCBI
HuRef3186,752,882 - 187,012,887 (+)NCBIHuRef
CHM1_13189,312,090 - 189,577,623 (+)NCBICHM1_1
T2T-CHM13v2.03192,413,470 - 192,713,713 (+)NCBIT2T-CHM13v2.0
Trp63
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391625,502,513 - 25,710,838 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1625,502,513 - 25,710,852 (+)EnsemblGRCm39 Ensembl
GRCm381625,683,763 - 25,892,088 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1625,683,763 - 25,892,102 (+)EnsemblGRCm38mm10GRCm38
MGSCv371625,683,851 - 25,892,174 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361625,717,291 - 25,807,429 (+)NCBIMGSCv36mm8
Celera1626,227,614 - 26,435,704 (+)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1617.37NCBI
Tp63
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542018,176,155 - 18,384,786 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542018,178,639 - 18,384,786 (-)NCBIChiLan1.0ChiLan1.0
TP63
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13195,172,810 - 195,473,085 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3195,199,167 - 195,474,104 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03186,651,879 - 186,918,300 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TP63
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13421,766,861 - 21,985,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3421,766,496 - 21,983,046 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3425,860,495 - 26,078,655 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03421,700,749 - 21,919,495 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3421,700,663 - 21,918,660 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13421,716,204 - 21,934,749 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03421,710,660 - 21,927,985 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03421,951,749 - 22,170,136 (+)NCBIUU_Cfam_GSD_1.0
Tp63
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602114,397,903 - 114,613,831 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936578492,267 - 705,282 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TP63
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13127,116,105 - 127,347,068 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113127,115,990 - 127,347,082 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213136,309,804 - 136,515,766 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TP63
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11583,861,489 - 84,126,675 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604157,444,595 - 57,708,553 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tp63
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473067,286,160 - 67,489,670 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473067,283,444 - 67,489,808 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2362
Count of miRNA genes:338
Interacting mature miRNAs:471
Transcripts:ENSRNOT00000002636, ENSRNOT00000036179, ENSRNOT00000036193, ENSRNOT00000067251, ENSRNOT00000068116
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 2 9 13 8 11 8 12 22 9 8
Below cutoff 2 14 21 14 6 14 43 21 15 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001127339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ277446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ277447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ277448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ277449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ277450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ277451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ277452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ277453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y10258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000002636   ⟹   ENSRNOP00000002636
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1174,838,859 - 74,931,425 (-)Ensembl
Rnor_6.0 Ensembl1178,234,854 - 78,327,282 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000036179   ⟹   ENSRNOP00000032308
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1174,854,156 - 75,049,398 (-)Ensembl
Rnor_6.0 Ensembl1178,250,397 - 78,456,200 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000036193   ⟹   ENSRNOP00000033463
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1178,234,800 - 78,456,501 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000067251   ⟹   ENSRNOP00000059178
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1174,838,859 - 75,049,398 (-)Ensembl
Rnor_6.0 Ensembl1178,234,854 - 78,456,200 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000068116   ⟹   ENSRNOP00000061884
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1174,838,859 - 75,049,398 (-)Ensembl
Rnor_6.0 Ensembl1178,234,854 - 78,341,349 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113030   ⟹   ENSRNOP00000089600
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1174,912,864 - 75,049,398 (-)Ensembl
RefSeq Acc Id: NM_001127339   ⟹   NP_001120811
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,838,858 - 75,049,398 (-)NCBI
Rnor_6.01178,234,853 - 78,456,200 (-)NCBI
Rnor_5.01182,262,234 - 82,484,354 (+)NCBI
RGSC_v3.41176,900,622 - 77,200,251 (-)RGD
Celera1173,744,494 - 73,953,104 (-)RGD
Sequence:
RefSeq Acc Id: NM_001127341   ⟹   NP_001120813
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,854,400 - 75,049,398 (-)NCBI
Rnor_6.01178,250,397 - 78,456,200 (-)NCBI
Rnor_5.01182,262,234 - 82,484,354 (+)NCBI
RGSC_v3.41176,900,622 - 77,200,251 (-)RGD
Celera1173,760,076 - 73,953,104 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001127342   ⟹   NP_001120814
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,838,858 - 74,931,291 (-)NCBI
Rnor_6.01178,234,853 - 78,327,282 (-)NCBI
Rnor_5.01182,262,234 - 82,484,354 (+)NCBI
RGSC_v3.41176,900,622 - 77,200,251 (-)RGD
Celera1173,744,494 - 73,836,976 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001127343   ⟹   NP_001120815
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,838,858 - 74,931,291 (-)NCBI
Rnor_6.01178,234,853 - 78,327,282 (-)NCBI
Rnor_5.01182,262,234 - 82,484,354 (+)NCBI
RGSC_v3.41176,900,622 - 77,200,251 (-)RGD
Celera1173,744,494 - 73,836,976 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001127344   ⟹   NP_001120816
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,854,400 - 74,931,291 (-)NCBI
Rnor_6.01178,250,397 - 78,327,282 (-)NCBI
Rnor_5.01182,262,234 - 82,484,354 (+)NCBI
RGSC_v3.41176,900,622 - 77,200,251 (-)RGD
Celera1173,760,076 - 73,836,976 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019221   ⟹   NP_062094
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,838,858 - 75,049,398 (-)NCBI
Rnor_6.01178,234,853 - 78,456,200 (-)NCBI
Rnor_5.01182,262,234 - 82,484,354 (+)NCBI
RGSC_v3.41176,900,622 - 77,200,251 (-)RGD
Celera1173,744,494 - 73,953,104 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248500   ⟹   XP_006248562
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,852,197 - 75,049,764 (-)NCBI
Rnor_6.01178,245,462 - 78,456,281 (-)NCBI
Rnor_5.01182,262,234 - 82,484,354 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597881   ⟹   XP_017453370
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21174,838,876 - 75,049,764 (-)NCBI
Rnor_6.01178,234,871 - 78,456,281 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062094   ⟸   NM_019221
- Peptide Label: isoform a
- UniProtKB: Q99JE3 (UniProtKB/Swiss-Prot),   Q9JJP6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001120811   ⟸   NM_001127339
- Peptide Label: isoform b
- UniProtKB: Q9JJP6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001120814   ⟸   NM_001127342
- Peptide Label: isoform d
- UniProtKB: Q9JJP6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001120815   ⟸   NM_001127343
- Peptide Label: isoform e
- UniProtKB: Q9JJP6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001120813   ⟸   NM_001127341
- Peptide Label: isoform c
- UniProtKB: Q9JJP6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001120816   ⟸   NM_001127344
- Peptide Label: isoform f
- UniProtKB: Q9JJP6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006248562   ⟸   XM_006248500
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017453370   ⟸   XM_017597881
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000059178   ⟸   ENSRNOT00000067251
RefSeq Acc Id: ENSRNOP00000033463   ⟸   ENSRNOT00000036193
RefSeq Acc Id: ENSRNOP00000032308   ⟸   ENSRNOT00000036179
RefSeq Acc Id: ENSRNOP00000002636   ⟸   ENSRNOT00000002636
RefSeq Acc Id: ENSRNOP00000061884   ⟸   ENSRNOT00000068116
RefSeq Acc Id: ENSRNOP00000089600   ⟸   ENSRNOT00000113030
Protein Domains
SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJP6-F1-model_v2 AlphaFold Q9JJP6 1-680 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 78250507 78250508 G A snv ACI/EurMcwi (MCW), LL/MavRrrcAek (2020), SBH/Ygl (MCW), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), ACI/N (MCW), F344/NRrrc (MCW), ACI/EurMcwi (RGD), F344/NCrl (RGD), LN/MavRrrc (RGD), SBH/Ygl (RGD), SBN/Ygl (RGD), SR/JrHsd (RGD), SS/JrHsdMcwi (RGD), WKY/NCrl (RGD), WKY/NHsd (RGD), ACI/EurMcwi (2019), ACI/N (2020), DA/OlaHsd (2019), F344/DuCrl (2019), F344/NCrl (2019), F344/Stm (2019), LEXF11/Stm (2020), LEXF2B/Stm (2019), LN/MavRrrcAek (2020), PVG/Seac (2019), SR/JrHsd (2020), SS/JrHsdMcwi (2019), WKY/NCrl (2019), WKY/N (2020), CDS, WKY/N (MCW), LH/MavRrrc (RGD), LL/MavRrrc (RGD), SS/Jr (RGD), F344/N (2020), LEXF4/Stm (2020), LH/MavRrrcAek (2020), COP/CrCrl (MCW & UW)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 82468700 82468701 C T snv ACI/EurMcwi (MCW), F344/Jcl (KyushuU), SBH/Ygl (MCW), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), LH/MavRrrc (KNAW), LL/MavRrrc (KNAW), LN/MavRrrc (KNAW), SR/JrHsd (KNAW), SS/Jr (KNAW), SS/JrHsdMcwi (KNAW), ACI/N (KNAW), ACI/EurMcwi (KNAW), DA/BklArbNsi (KNAW), F344/NRrrc (SOLiD) (KNAW), F344/NCrl (KNAW), F344/NHsd (KNAW), SBH/Ygl (KNAW), SBN/Ygl (KNAW), F344/NRrrc (Illumina) (KNAW), WKY/N (KNAW), WKY/NCrl (KNAW), WKY/NHsd (KNAW), LE/OrlBarth (UDEL), Crl:SD (UDEL), F344/DuCrlCrlj (KyushuU), F344/NSlc (KyushuU), F344/Stm (KyushuU), HWY/Slc (KyushuU), LEC/Tj (KyushuU), COP/CrCrl (MCW & UW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 76917620 76917621 G A snv ACI/EurMcwi (MCW), F344/NHsd (ICAHN), SS/JrHsdMcwi (MCW), SS/JrHsdMcwi (MDC), ACI/N (KNAW), F344/NRrrc (KNAW), WKY/N (KNAW), COP/CrCrl (MCW & UW), ACI/EurMcwi (ICL), F344/NCrl (ICL), LH/MavRrrc (ICL), LL/MavRrrc (ICL), LN/MavRrrc (ICL), SBH/Ygl (ICL), SBN/Ygl (ICL), SR/JrHsd (ICL), SS/Jr (ICL), SS/JrHsdMcwi (ICL), WKY/NCrl (ICL), WKY/NHsd (ICL), HCR/1Mco (UMich), LCR/1Mco (UMich), LCR/2Mco (UMich), DA/BklArbNsi (ICAHN), SR/JrHsd (MCW)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 74854510 74854511 G A snv ACI/EurMcwi (2019), WKY/N (2020), DA/OlaHsd (2019), F344/DuCrl (2019), F344/NCrl (2019), F344/N (2020), F344/Stm (2019), LEXF11/Stm (2020), LEXF2B/Stm (2019), LEXF4/Stm (2020), LH/MavRrrcAek (2020), LL/MavRrrcAek (2020), LN/MavRrrcAek (2020), PVG/Seac (2019), SR/JrHsd (2020), SS/JrHsdMcwi (2019), WKY/NCrl (2019), ACI/N (2020)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620863 AgrOrtholog
BioCyc Gene G2FUF-20930 BioCyc
Ensembl Genes ENSRNOG00000001924 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002636 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000032308 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000059178 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000061884 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000089600.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002636 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000036179 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000067251 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000068116 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000113030.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot
  2.60.40.720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.170.10 UniProtKB/Swiss-Prot
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53/RUNT-type_TF_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53_DNA-bd UniProtKB/Swiss-Prot
  p53_tetramer_sf UniProtKB/Swiss-Prot
  p53_tetrameristn UniProtKB/Swiss-Prot
  p53_tumour_suppressor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM UniProtKB/Swiss-Prot
  SAM/pointed_sf UniProtKB/Swiss-Prot
  Tp63 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumor-p63_SAM UniProtKB/Swiss-Prot
KEGG Report rno:246334 UniProtKB/Swiss-Prot
NCBI Gene 246334 ENTREZGENE
PANTHER PTHR11447 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11447:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam P53 UniProtKB/Swiss-Prot
  P53_tetramer UniProtKB/Swiss-Prot
  SAM_2 UniProtKB/Swiss-Prot
PhenoGen Tp63 PhenoGen
PRINTS P53SUPPRESSR UniProtKB/Swiss-Prot
PROSITE P53 UniProtKB/Swiss-Prot
SMART SAM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47719 UniProtKB/Swiss-Prot
  SSF47769 UniProtKB/Swiss-Prot
  SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GHG9_RAT UniProtKB/TrEMBL
  P63_RAT UniProtKB/Swiss-Prot
  Q99JE3 ENTREZGENE
  Q9JJP6 ENTREZGENE
UniProt Secondary Q99JD6 UniProtKB/Swiss-Prot
  Q99JD7 UniProtKB/Swiss-Prot
  Q99JD8 UniProtKB/Swiss-Prot
  Q99JD9 UniProtKB/Swiss-Prot
  Q99JE0 UniProtKB/Swiss-Prot
  Q99JE1 UniProtKB/Swiss-Prot
  Q99JE2 UniProtKB/Swiss-Prot
  Q99JE3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-21 Tp63  tumor protein p63  Tp73l  tumor protein p73-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Tp73l  tumor protein p73-like  Trp63  transformation related protein 63  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Trp63  transformation related protein 63      Symbol and Name updated 629477 APPROVED
2003-03-12 Trp63  transformation related protein 63  Tp63  tumor protein 63 kDa   Data Merged 628472 PROVISIONAL
2002-08-07 Trp63  transformation related protein 63      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Tp63  tumor protein 63 kDa       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript transcript consists of multiple KET isoforms that are colocalized in different rat tissues 634449