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Gene: Tp63 (tumor protein p63) Rattus norvegicus
Symbol: Tp63
Name: tumor protein p63
Description: Exhibits DNA-binding transcription factor activity; double-stranded DNA binding activity; and protein domain specific binding activity. Involved in replicative cell aging and spermatogenesis. Localizes to several cellular components, including dendrite; nucleus; and rough endoplasmic reticulum. Human ortholog(s) of this gene implicated in several diseases, including ADULT syndrome; EEC syndrome (multiple); ectodermal dysplasia (multiple); orofacial cleft 8; and split hand-foot malformation 4. Orthologous to human TP63 (tumor protein p63); PARTICIPATES IN altered p53 signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 3,4-dichloroaniline; acrylamide.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: keratinocyte transcription factor KET; Ket; p73L; Tp73l; transformation related protein 63; Trp63; tumor protein 63; tumor protein 63 kDa; tumor protein p73-like
Homo sapiens (human) : TP63 (tumor protein p63)  HGNC  Alliance
Mus musculus (house mouse) : Trp63 (transformation related protein 63)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tp63 (tumor protein p63)
Pan paniscus (bonobo/pygmy chimpanzee) : TP63 (tumor protein p63)
Canis lupus familiaris (dog) : TP63 (tumor protein p63)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tp63 (tumor protein p63)
Sus scrofa (pig) : TP63 (tumor protein p63)
Chlorocebus sabaeus (African green monkey) : TP63 (tumor protein p63)
Heterocephalus glaber (naked mole-rat) : Tp63 (tumor protein p63)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01178,234,853 - 78,456,559 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,234,800 - 78,456,501 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,262,234 - 82,484,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41176,900,622 - 77,200,251 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11176,958,211 - 77,257,840 (-)NCBI
Celera1173,744,494 - 73,953,104 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tp63
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620863
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.