Tra2b (transformer 2 beta) - Rat Genome Database

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Gene: Tra2b (transformer 2 beta) Rattus norvegicus
Analyze
Symbol: Tra2b
Name: transformer 2 beta
RGD ID: 619886
Description: Predicted to enable RNA binding activity; identical protein binding activity; and protein domain specific binding activity. Involved in response to reactive oxygen species. Located in perinuclear region of cytoplasm. Orthologous to human TRA2B (transformer 2 beta homolog); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: RA301; serine/arginine-rich splicing factor 10; Sfrs10; splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila); Srsf10; TRA-2 beta; TRA2-beta; transformer 2 beta homolog; transformer 2 beta homolog (Drosophila); transformer-2 protein homolog B; transformer-2 protein homolog beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,293,403 - 92,311,651 (+)NCBIGRCr8
mRatBN7.21178,788,880 - 78,807,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1178,788,884 - 78,807,249 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1187,524,054 - 87,542,239 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,177,721 - 80,195,907 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01179,238,399 - 79,256,583 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01182,373,828 - 82,392,208 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1182,373,870 - 82,392,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01185,462,002 - 85,480,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,026,729 - 81,044,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11181,084,317 - 81,102,525 (+)NCBI
Celera1177,651,350 - 77,669,556 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
casticin  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (EXP)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
ketoconazole  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
identical protein binding  (IEA,ISO)
mRNA binding  (IEA,ISO,ISS)
pre-mRNA binding  (IEA,ISO)
protein binding  (IPI,ISO)
protein domain specific binding  (IEA,ISO)
RNA binding  (IBA,IEA,ISO,NAS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. Heinrich B, etal., J Biol Chem. 2009 May 22;284(21):14303-15. Epub 2009 Mar 12.
3. Expression analysis of an evolutionarily conserved alternative splicing factor, Sfrs10, in age-related macular degeneration. Karunakaran DK, etal., PLoS One. 2013 Sep 30;8(9):e75964. doi: 10.1371/journal.pone.0075964. eCollection 2013.
4. Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia/reoxygenation. Matsuo N, etal., J Biol Chem 1995 Nov 24;270(47):28216-22.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9546399   PMID:9671816   PMID:10749975   PMID:12165565   PMID:12761049   PMID:15009664   PMID:15489334   PMID:16396499   PMID:16791210   PMID:18669920   PMID:19439532   PMID:21630459  
PMID:22194695   PMID:22535253   PMID:22658674   PMID:22681889   PMID:23932931   PMID:23977258   PMID:24586484   PMID:25689357  


Genomics

Comparative Map Data
Tra2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,293,403 - 92,311,651 (+)NCBIGRCr8
mRatBN7.21178,788,880 - 78,807,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1178,788,884 - 78,807,249 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1187,524,054 - 87,542,239 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01180,177,721 - 80,195,907 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01179,238,399 - 79,256,583 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01182,373,828 - 82,392,208 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1182,373,870 - 82,392,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01185,462,002 - 85,480,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,026,729 - 81,044,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11181,084,317 - 81,102,525 (+)NCBI
Celera1177,651,350 - 77,669,556 (+)NCBICelera
Cytogenetic Map11q23NCBI
TRA2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383185,914,558 - 185,938,014 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3185,914,558 - 185,938,103 (-)EnsemblGRCh38hg38GRCh38
GRCh373185,632,346 - 185,655,802 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363187,117,226 - 187,138,450 (-)NCBINCBI36Build 36hg18NCBI36
Build 343187,117,238 - 187,138,458NCBI
Celera3184,070,271 - 184,093,839 (-)NCBICelera
Cytogenetic Map3q27.2NCBI
HuRef3183,042,973 - 183,066,541 (-)NCBIHuRef
CHM1_13185,595,300 - 185,618,882 (-)NCBICHM1_1
T2T-CHM13v2.03188,730,348 - 188,753,803 (-)NCBIT2T-CHM13v2.0
Tra2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391622,063,302 - 22,084,755 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1622,063,299 - 22,084,755 (-)EnsemblGRCm39 Ensembl
GRCm381622,244,552 - 22,266,005 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1622,244,549 - 22,266,005 (-)EnsemblGRCm38mm10GRCm38
MGSCv371622,245,814 - 22,266,002 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361622,160,997 - 22,181,185 (-)NCBIMGSCv36mm8
Celera1622,813,196 - 22,833,384 (-)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1613.18NCBI
Tra2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542021,707,618 - 21,728,186 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542021,707,618 - 21,728,186 (+)NCBIChiLan1.0ChiLan1.0
TRA2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22183,783,455 - 183,804,812 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13183,788,174 - 183,809,531 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03182,942,623 - 182,963,938 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13191,414,777 - 191,436,103 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3191,414,777 - 191,436,103 (-)Ensemblpanpan1.1panPan2
TRA2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13418,637,725 - 18,656,869 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3418,638,325 - 18,657,862 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3422,723,459 - 22,742,316 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03418,547,719 - 18,566,554 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3418,547,709 - 18,567,712 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13418,574,528 - 18,593,359 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03418,579,233 - 18,598,088 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03418,808,612 - 18,827,472 (-)NCBIUU_Cfam_GSD_1.0
Tra2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602117,857,971 - 117,878,625 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365783,949,820 - 3,970,462 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365783,949,820 - 3,970,462 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRA2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13123,754,864 - 123,780,920 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113123,760,008 - 123,780,919 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TRA2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1153,493,287 - 3,514,421 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl153,493,541 - 3,513,994 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606312,245,896 - 12,267,049 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tra2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473070,801,207 - 70,822,178 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473070,801,227 - 70,822,188 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tra2b
56 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:64
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000002429
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
RH126681  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21178,795,166 - 78,795,379 (+)MAPPERmRatBN7.2
Rnor_6.01182,380,117 - 82,380,329NCBIRnor6.0
Rnor_5.01185,468,288 - 85,468,500UniSTSRnor5.0
RGSC_v3.41181,032,976 - 81,033,188UniSTSRGSC3.4
Celera1177,657,596 - 77,657,808UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002429   ⟹   ENSRNOP00000002429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1178,788,886 - 78,807,129 (+)Ensembl
Rnor_6.0 Ensembl1182,373,870 - 82,392,083 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102904   ⟹   ENSRNOP00000095605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1178,788,906 - 78,807,123 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105364   ⟹   ENSRNOP00000076861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1178,788,884 - 78,807,249 (+)Ensembl
RefSeq Acc Id: NM_057119   ⟹   NP_476460
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,293,442 - 92,311,649 (+)NCBI
mRatBN7.21178,788,920 - 78,807,127 (+)NCBI
Rnor_6.01182,373,870 - 82,392,083 (+)NCBI
Rnor_5.01185,462,002 - 85,480,379 (+)NCBI
RGSC_v3.41181,026,729 - 81,044,936 (+)RGD
Celera1177,651,350 - 77,669,556 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248536   ⟹   XP_006248598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,293,403 - 92,311,651 (+)NCBI
mRatBN7.21178,788,881 - 78,807,252 (+)NCBI
Rnor_6.01182,373,828 - 82,392,208 (+)NCBI
Rnor_5.01185,462,002 - 85,480,379 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063270247   ⟹   XP_063126317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,293,636 - 92,311,651 (+)NCBI
RefSeq Acc Id: NP_476460   ⟸   NM_057119
- UniProtKB: P62997 (UniProtKB/Swiss-Prot),   A6JS59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248598   ⟸   XM_006248536
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000002429   ⟸   ENSRNOT00000002429
Ensembl Acc Id: ENSRNOP00000076861   ⟸   ENSRNOT00000105364
Ensembl Acc Id: ENSRNOP00000095605   ⟸   ENSRNOT00000102904
RefSeq Acc Id: XP_063126317   ⟸   XM_063270247
- Peptide Label: isoform X2
- UniProtKB: A0A8I6B318 (UniProtKB/TrEMBL)
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62997-F1-model_v2 AlphaFold P62997 1-288 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698256
Promoter ID:EPDNEW_R8781
Type:initiation region
Name:Tra2b_1
Description:transformer 2 beta homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01182,373,856 - 82,373,916EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619886 AgrOrtholog
BioCyc Gene G2FUF-20797 BioCyc
Ensembl Genes ENSRNOG00000001783 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055005066 UniProtKB/Swiss-Prot
  ENSRNOG00060011434 UniProtKB/Swiss-Prot
  ENSRNOG00065003758 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002429.6 UniProtKB/TrEMBL
  ENSRNOT00000102904.1 UniProtKB/TrEMBL
  ENSRNOT00000105364.1 UniProtKB/TrEMBL
  ENSRNOT00055008111 UniProtKB/Swiss-Prot
  ENSRNOT00060019354 UniProtKB/Swiss-Prot
  ENSRNOT00065005485 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7097246 IMAGE-MGC_LOAD
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117259 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91536 IMAGE-MGC_LOAD
NCBI Gene 117259 ENTREZGENE
PANTHER TRANSFORMER-2 PROTEIN HOMOLOG BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tra2b PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001783 RatGTEx
  ENSRNOG00055005066 RatGTEx
  ENSRNOG00060011434 RatGTEx
  ENSRNOG00065003758 RatGTEx
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5YBY3_RAT UniProtKB/TrEMBL
  A0A8I6B318 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2PZP1_RAT UniProtKB/TrEMBL
  A6JS59 ENTREZGENE, UniProtKB/TrEMBL
  P62997 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O15449 UniProtKB/Swiss-Prot
  Q15815 UniProtKB/Swiss-Prot
  Q64283 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-05-17 Tra2b  transformer 2 beta  Tra2b  transformer 2 beta homolog  Name changed 629549 APPROVED
2017-04-19 Tra2b  transformer 2 beta homolog  Tra2b  transformer 2 beta homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-20 Tra2b  transformer 2 beta homolog (Drosophila)  Srsf10  serine/arginine-rich splicing factor 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 Tra2b  transformer 2 beta homolog (Drosophila)  Sfrs10  splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Sfrs10  splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)    splicing factor, arginine/serine-rich (transformer 2 Drosophila homolog) 10  Name updated 1299863 APPROVED
2002-08-07 Sfrs10  splicing factor, arginine/serine-rich (transformer 2 Drosophila homolog) 10      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression is induced by reactive oxygen species 729705