Tra2b (transformer 2 beta homolog)

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Gene: Tra2b (transformer 2 beta homolog) Chinchilla lanigera

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Symbol:

Tra2b

Name:

transformer 2 beta homolog

RGD ID:

8980792

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); mRNA binding (ortholog); pre-mRNA binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); cerebral cortex regionalization (ortholog); embryonic brain development (ortholog); ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); macular degeneration (ortholog); FOUND IN nuclear inner membrane (ortholog); nucleoplasm (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

transformer 2 beta homolog (Drosophila); transformer-2 protein homolog beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	21,707,618 - 21,728,186 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	21,707,618 - 21,728,186 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

genetic disease (ISO)

macular degeneration (ISO)

progressive supranuclear palsy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to glucose stimulus (ISO)

cerebral cortex regionalization (ISO)

embryonic brain development (ISO)

mRNA splicing, via spliceosome (ISO)

positive regulation of mRNA splicing, via spliceosome (ISO)

regulation of alternative mRNA splicing, via spliceosome (ISO)

regulation of RNA splicing (ISO)

response to reactive oxygen species (ISO)

Cellular Component

nuclear inner membrane (ISO)

nucleoplasm (ISO)

nucleus (ISO)

perinuclear region of cytoplasm (ISO)

protein-containing complex (ISO)

spliceosomal complex (ISO)

Molecular Function

identical protein binding (ISO)

mRNA binding (ISO)

pre-mRNA binding (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

RNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Tra2b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	21,707,618 - 21,728,186 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	21,707,618 - 21,728,186 (+)	NCBI	ChiLan1.0	ChiLan1.0

TRA2B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	185,914,558 - 185,938,014 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	185,914,558 - 185,938,103 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	185,632,346 - 185,655,802 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	187,117,226 - 187,138,450 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	187,117,238 - 187,138,458	NCBI
Celera	3	184,070,271 - 184,093,839 (-)	NCBI		Celera
Cytogenetic Map	3	q27.2	NCBI
HuRef	3	183,042,973 - 183,066,541 (-)	NCBI		HuRef
CHM1_1	3	185,595,300 - 185,618,882 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	188,730,348 - 188,753,803 (-)	NCBI		T2T-CHM13v2.0

Tra2b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	22,063,302 - 22,084,755 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	22,063,299 - 22,084,755 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	22,244,552 - 22,266,005 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	22,244,549 - 22,266,005 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	22,245,814 - 22,266,002 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	22,160,997 - 22,181,185 (-)	NCBI		MGSCv36	mm8
Celera	16	22,813,196 - 22,833,384 (-)	NCBI		Celera
Cytogenetic Map	16	B1	NCBI
cM Map	16	13.18	NCBI

Tra2b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	92,293,403 - 92,311,651 (+)	NCBI		GRCr8
mRatBN7.2	11	78,788,880 - 78,807,252 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	78,788,884 - 78,807,249 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	87,524,054 - 87,542,239 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	80,177,721 - 80,195,907 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	79,238,399 - 79,256,583 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	82,373,828 - 82,392,208 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	82,373,870 - 82,392,083 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	85,462,002 - 85,480,379 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	81,026,729 - 81,044,936 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	81,084,317 - 81,102,525 (+)	NCBI
Celera	11	77,651,350 - 77,669,556 (+)	NCBI		Celera
Cytogenetic Map	11	q23	NCBI

TRA2B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	183,783,455 - 183,804,812 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	183,788,174 - 183,809,531 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	182,942,623 - 182,963,938 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	191,414,777 - 191,436,103 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	191,414,777 - 191,436,103 (-)	Ensembl	panpan1.1		panPan2

TRA2B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	18,637,725 - 18,656,869 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	18,638,325 - 18,657,862 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	22,723,459 - 22,742,316 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	18,547,719 - 18,566,554 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	18,547,709 - 18,567,712 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	18,574,528 - 18,593,359 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	18,579,233 - 18,598,088 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	18,808,612 - 18,827,472 (-)	NCBI		UU_Cfam_GSD_1.0

Tra2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	117,857,971 - 117,878,625 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936578	3,949,820 - 3,970,462 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936578	3,949,820 - 3,970,462 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRA2B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	123,754,864 - 123,780,920 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	123,760,008 - 123,780,919 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TRA2B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	3,493,287 - 3,514,421 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	3,493,541 - 3,513,994 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	12,245,896 - 12,267,049 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tra2b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	70,801,207 - 70,822,178 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	70,801,227 - 70,822,188 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005383286	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01021159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01002404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000022971 ⟹ ENSCLAP00000022762

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955420	21,707,618 - 21,728,186 (+)	Ensembl

Ensembl Acc Id:

ENSCLAT00000022972 ⟹ ENSCLAP00000022763

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955420	21,714,049 - 21,728,186 (+)	Ensembl

RefSeq Acc Id:

XM_005383286 ⟹ XP_005383343

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955420	21,707,618 - 21,728,186 (+)	NCBI

Sequence:

show sequence

GAGTTAGAGTCCTTGCGGAGGAGGTGCGGAGCGCTTCGGCTCTGAGCGACTGACCAAGCCGGGT
TCCGCGAGGCTGCGGCGAAGCCTCTATAGAGAAGGCGCGAGAGCTTGGCAGCTTCGATTGGAGC
CCAGCGAGCGGCGACGTCAAACCAGGAGTCATGAGCGACAGCGGCGAGCAGAACTACGGCGAGC
GGGAATCCCGTTCTGCTTCCAGAAGTGGAAGTGCTCACGGATCGGGGAAATCTGCAAGACATAC
CCCTGCAAGGTCTCGCTCCAAGGAAGATTCCAGGCGTTCCAGATCAAAGTCCAGGTCCAGATCT
GAATCTAGGTCTAGATCCAGAAGGAGTTCTCGAAGGCATTATACAAGGTCACGATCTCGATCTC
GTTCTCATAGACGTTCCCGTAGCAGGTCTTACAGTCGAGATTATCGCAGACGCCACAGCCACAG
CCATTCTCCCATGTCTACTCGAAGGCGTCATGTTGGAAATCGGGCAAATCCTGACCCAAACTGT
TGTCTTGGAGTGTTTGGGTTGAGCTTGTACACCACAGAAAGAGATTTAAGAGAAGTGTTCTCTA
AGTATGGCCCAATTGCTGATGTGTCTATTGTATATGACCAGCAGTCTAGGCGTTCAAGAGGATT
TGCCTTTGTGTATTTTGAAAATGTAGATGATGCCAAGGAAGCTAAAGAACGTGCCAATGGAATG
GAACTTGATGGGCGTAGGATAAGAGTTGATTTCTCTATCACAAAAAGACCACATACCCCAACAC
CAGGAATTTACATGGGGAGACCTACCTATGGCAGTTCACGCCGTCGGGATTACTATGACAGAGG
ATATGATCGCGGCTATGATGATCGGGACTACTACAGCAGATCATACAGAGGAGGTGGTGGAGGA
GGAGGTGGCTGGAGAGCTGCTCAAGACAGGGATCAGATTTATAGAAGGCGGTCACCTTCTCCTT
ATTACAGTCGTGGAGGATACAGATCACGCTCCAGATCTCGGTCCTACTCACCTCGTCGCTATTA
AAGCATGAAGATAAAGACTTTCTGAAACCTGCCATAGAGCTGGGATATTGTTTGTGGACAATAT
TTTTATTGTCTGTTTAAAAAGTGAACAGTGCCTAGTGAAGTTAGGTGACTTTTACACCTTTTAT
GATGACTACTTTTGGTGGAGTTGAAATGCTGTTTTCATTCTGCATTTGTGTAGTTCGGTGCTTT
GTTCAAAGTTAAGTGTTTTCAGAAAAGTATGTTTTGCATGTATTTTTTTACAGTCTTAAATTTT
GACTGCTGAGAAGTTTCTATTGTACAAAAAACTTCATTTAAAAGGTTTTTCTACTGAATCCAGG
GTAATCTGAAGATTGAAGCCTGTGTGTAAAAAGCTACCAAATGGCAAAAAGCAACAATAAACAG
TTTGATTTTTATTTTTCTTTCTAACATTGATACTTAGCAGAACTATTCAGATTTTAAGTTATCA
GTAAGTTCAAAGGCAAAAATACCCACTTTCCTCCAGTCCACGAAACATACCATATTTAATATAC
CTACAACTAAGTGTTAAAAAAATATGCTCTGTAACTCTGTACTGCTAGTATTAGAACTAAGTTT
TTCAATACAGCAAATGCTTAATGCTTATATAAATGTGGATTTGTCAGCCTTTCTGTAATCTGTA
TTATGTTTAGCAGGGAATAAGAAAAGTTACACATTGTGTATGCCTTAAGGCTATTTCTTAAAGC
TGTTAAAAGGGAATAATGGTATTTCAGCTAGTTCTCGGCAAATGACAATACATTCCACCACAAA
TGTACTCTTGATCTTCTAGCTTTTAGACCATTTGAAAAACTGGGTGCTTCAAAGTACAGGATAA
GAGAAGGGAACACTATACCTGTGTCATGGATGACCTGAAGACTGCCTGTTCATTTTTTAAATAT
TATTTTCAGGTCCTTTGCTAATCAAAGGAGGCCCAATTTCACTCAAATGTTTTGAGAACTGTGT
TCAATAAATGAAAACGAAGAGAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005383343	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000022762
	ENSCLAP00000022762.1
	ENSCLAP00000022763.1

RefSeq Acc Id:

XP_005383343 ⟸ XM_005383286

- UniProtKB:

A0A8C2W187 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSDSGEQNYGERESRSASRSGSAHGSGKSARHTPARSRSKEDSRRSRSKSRSRSESRSRSRRSS
RRHYTRSRSRSRSHRRSRSRSYSRDYRRRHSHSHSPMSTRRRHVGNRANPDPNCCLGVFGLSLY
TTERDLREVFSKYGPIADVSIVYDQQSRRSRGFAFVYFENVDDAKEAKERANGMELDGRRIRVD
FSITKRPHTPTPGIYMGRPTYGSSRRRDYYDRGYDRGYDDRDYYSRSYRGGGGGGGGWRAAQDR
DQIYRRRSPSPYYSRGGYRSRSRSRSYSPRRY

hide sequence

Ensembl Acc Id:

ENSCLAP00000022762 ⟸ ENSCLAT00000022971

Ensembl Acc Id:

ENSCLAP00000022763 ⟸ ENSCLAT00000022972

Protein Domains

RRM

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000015607	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000022971	ENTREZGENE
	ENSCLAT00000022971.1	UniProtKB/TrEMBL
	ENSCLAT00000022972.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.330	UniProtKB/TrEMBL
InterPro	Nucleotide-bd_a/b_plait_sf	UniProtKB/TrEMBL
	RBD_domain_sf	UniProtKB/TrEMBL
	RBM	UniProtKB/TrEMBL
	RRM_dom	UniProtKB/TrEMBL
NCBI Gene	Tra2b	ENTREZGENE
PANTHER	TRANSFORMER-2 PROTEIN HOMOLOG BETA	UniProtKB/TrEMBL
	TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED	UniProtKB/TrEMBL
Pfam	RRM_1	UniProtKB/TrEMBL
PROSITE	RRM	UniProtKB/TrEMBL
SMART	RRM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54928	UniProtKB/TrEMBL
UniProt	A0A8C2W187	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2W3Q6_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-04-11	Tra2b	transformer 2 beta homolog		transformer 2 beta homolog (Drosophila)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD