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Gene: Prkdc (protein kinase, DNA-activated, catalytic subunit) Rattus norvegicus
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Symbol: Prkdc
Name: protein kinase, DNA-activated, catalytic subunit
Description: Predicted to have several functions, including DNA-dependent protein kinase activity; double-stranded DNA binding activity; and transcription factor binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of cellular senescence; and negative regulation of response to gamma radiation. Predicted to localize to the nucleus; protein-DNA complex; and transcription factor complex. Used to study severe combined immunodeficiency. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (+)-schisandrin B; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA-dependent protein kinase catalytic subunit; LOC360748; MGC189093
Orthologs:
Allele / Splice: Prkdcem1Kyo   Prkdcem2Kyo   Prkdcem4Kyo  
Genetic Models: TM-Prkdcem4KyoIl2rgem5Kyo F344-Prkdcem2KyoIl2rgem6Kyo F344-Prkdcem1Kyo
Is Marker For: Strains:   F344-Prkdcem1Kyo   F344-Prkdcem2KyoIl2rgem6Kyo   TM-Prkdcem4KyoIl2rgem5Kyo   SD-Prkdcem1Sage  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01189,293,547 - 89,510,948 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,293,696 - 89,510,871 (-)Ensembl
Rnor_5.01192,347,175 - 92,565,022 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,951,420 - 87,169,229 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,992,362 - 87,209,825 (-)NCBI
Celera1183,781,535 - 83,998,574 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Prkdc
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308982
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.