Gene: Prkdc (protein kinase, DNA activated, catalytic polypeptide) Rattus norvegicus
Symbol: Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Description: ENCODES a protein that exhibits DNA-dependent protein kinase activity (ortholog); double-stranded DNA binding (ortholog); enzyme binding (ortholog); INVOLVED IN immunoglobulin production; negative regulation of cellular senescence; negative regulation of immunoglobulin production; PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH decreased body weight; decreased immunoglobulin level; spleen hypoplasia; ASSOCIATED WITH Severe Combined Immunodeficiency; adenoid cystic carcinoma (ortholog); Carcinoma, Squamous Cell (ortholog); FOUND IN DNA-dependent protein kinase-DNA ligase 4 complex (ortholog); nonhomologous end joining complex (ortholog); nucleolus (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; bisphenol A; dibutyl phthalate
Type: protein-coding
RefSeq Status: MODEL
Also known as: DNA-dependent protein kinase catalytic subunit; LOC360748; MGC189093
Allele / Splice: Prkdcem1Kyo   Prkdcem2Kyo   Prkdcem4Kyo  
Genetic Models: TM-Prkdcem4KyoIl2rgem5Kyo F344-Prkdcem2KyoIl2rgem6Kyo F344-Prkdcem1Kyo
Is Marker For: Strains:   F344-Prkdcem1Kyo   F344-Prkdcem2KyoIl2rgem6Kyo   TM-Prkdcem4KyoIl2rgem5Kyo   SD-Prkdcem1Sage  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01189,293,547 - 89,510,948 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01192,347,175 - 92,565,022 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,951,420 - 87,169,229 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,992,362 - 87,209,825 (-)NCBI
Celera1183,781,535 - 83,998,574 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
More on Prkdc
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308982
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2018-04-10
Status: ACTIVE