Sod1 (superoxide dismutase 1) - Rat Genome Database

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Gene: Sod1 (superoxide dismutase 1) Rattus norvegicus
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Symbol: Sod1
Name: superoxide dismutase 1
RGD ID: 3731
Description: Enables copper ion binding activity; protein phosphatase 2B binding activity; and superoxide dismutase activity. Involved in several processes, including cellular response to metal ion; hydrogen peroxide biosynthetic process; and removal of superoxide radicals. Located in several cellular components, including dense core granule; mitochondrial intermembrane space; and neuronal cell body. Part of protein-containing complex. Used to study hyperthyroidism; hypothyroidism; middle cerebral artery infarction; and sciatic neuropathy. Biomarker of several diseases, including artery disease (multiple); congenital diaphragmatic hernia; middle cerebral artery infarction; non-alcoholic steatohepatitis; and ocular hypertension. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1); PARTICIPATES IN hypertension pathway; amyotrophic lateral sclerosis pathway; forkhead class A signaling pathway; INTERACTS WITH (+)-taxifolin; (-)-cotinine; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CuZnSOD; Superoxide dimutase 1 soluble; superoxide dismutase; Superoxide dismutase 1 soluble; superoxide dismutase 1, soluble; superoxide dismutase [Cu-Zn]
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21129,456,673 - 29,462,249 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1129,456,558 - 29,462,249 (+)Ensembl
Rnor_6.01130,363,282 - 30,368,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1130,363,280 - 30,368,862 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01133,982,764 - 33,988,340 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41129,810,766 - 29,816,342 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11129,810,765 - 29,816,342 (-)NCBI
Celera1129,143,740 - 29,149,316 (+)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Alcoholic Fatty Liver  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (IEP,ISO)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 1  (ISO)
Animal Disease Models  (ISO)
Animal Mammary Neoplasms  (IEP)
Aortic Calcification  (IEP)
aortic disease  (ISO)
asphyxia neonatorum  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
cardiac arrest  (ISO)
cardiomyopathy  (ISO)
cataract  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
congenital diaphragmatic hernia  (IEP)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
cutaneous leishmaniasis  (ISO)
cystitis  (IEP)
developmental coordination disorder  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (ISO)
Down syndrome  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO,ISS)
Experimental Diabetes Mellitus  (IEP,ISO)
Fatigue  (ISO)
fatty liver disease  (ISO)
Fetal Growth Retardation  (ISO)
fragile X-associated tremor/ataxia syndrome  (ISO)
Gliosis  (ISO)
Hearing Loss  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Hemolysis  (ISO)
hepatocellular carcinoma  (ISO)
hepatorenal syndrome  (ISO)
high grade glioma  (ISO)
hyperglycemia  (ISO)
hypertension  (IEP,ISO)
hyperthyroidism  (IDA,ISO)
Hypotension  (ISO)
Hypothermia  (ISO)
hypothyroidism  (IDA,IEP)
Hypoxia  (IDA)
immunodeficiency 28  (ISO)
Inflammation  (ISO)
inflammatory bowel disease 25  (ISO)
iron deficiency anemia  (ISO)
ischemia  (ISO)
Kidney Calculi  (ISO)
liver disease  (ISO)
Liver Reperfusion Injury  (ISO)
low tension glaucoma  (ISO,ISS)
macular degeneration  (ISO)
Marfan syndrome  (ISO)
MELAS syndrome  (ISO)
mental depression  (ISO)
middle cerebral artery infarction  (IDA,IEP)
motor neuron disease  (ISO)
Muscle Weakness  (ISO)
muscular atrophy  (ISO)
myelomeningocele  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IDA,ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrosis  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Neurologic Gait Disorders  (ISO)
newborn respiratory distress syndrome  (ISO)
non-alcoholic steatohepatitis  (IEP)
nutritional deficiency disease  (IEP,ISO)
obesity  (ISO)
ocular hypertension  (IEP)
Ovarian Neoplasms  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
Paralysis  (ISO)
Parkinson's disease  (ISO)
Parkinson's disease 20  (ISO)
polycystic kidney disease  (IEP)
Presbycusis  (ISO)
prion disease  (ISO)
progressive supranuclear palsy  (ISO)
Protein Aggregation, Pathological  (ISO)
Protein Deficiency  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (ISO)
Radiation Injuries, Experimental  (ISO)
renal artery obstruction  (IEP)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
Retinal Neovascularization  (ISO)
retinitis pigmentosa  (ISO)
retinopathy of prematurity  (ISO)
Schistosomiasis Mansoni  (ISO)
sciatic neuropathy  (IDA,ISO)
scrapie  (ISO)
Sepsis  (IEP)
SPASTIC TETRAPLEGIA AND AXIAL HYPOTONIA, PROGRESSIVE  (ISO)
spinal cord disease  (ISO)
Spinal Cord Injuries  (ISO)
Stroke  (ISO)
transient cerebral ischemia  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Ureteral Calculi  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-taxifolin  (EXP)
(-)-cotinine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-lipoic acid  (EXP)
(R,R)-tramadol  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-amphetamine  (EXP,ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1-bromopropane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2,2-tetramine  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-pyridylethylamine  (ISO)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5'-triiodothyronine  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydrocoumarin  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-bromopyruvic acid  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-nitropropanoic acid  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-fluorouracil  (ISO)
5-fluorouridine  (ISO)
7,12-dimethyltetraphene  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7H-xanthine  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
8-Br-cAMP  (ISO)
9,10-phenanthroquinone  (ISO)
9H-xanthine  (EXP)
acetamide  (EXP)
acetylcholine  (EXP)
aclacinomycin A  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
alginic acid  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alloxan  (EXP,ISO)
Allylamine  (EXP)
alpha,alpha-trehalose  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
aminoacetone  (EXP)
aminoguanidine  (ISO)
amitraz  (EXP)
amitriptyline  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
amphibole asbestos  (ISO)
andrographolide  (EXP)
aniline  (ISO)
antimonite  (ISO)
apigenin  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (EXP)
arjunolic acid  (EXP)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
astaxanthin  (ISO)
astragaloside IV  (EXP)
atenolol  (EXP,ISO)
atorvastatin calcium  (EXP)
ATP  (EXP,ISO)
atrasentan  (EXP)
atrazine  (EXP,ISO)
azide  (ISO)
Bandrowski's base  (ISO)
bathocuproine disulfonic acid  (ISO)
benazepril  (ISO)
benfotiamine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzoyl peroxide  (ISO)
berberine  (ISO)
beta-carotene  (ISO)
bezafibrate  (ISO)
bifenthrin  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
bosentan  (ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
bromocriptine  (ISO)
Brusatol  (ISO)
Bucillamine  (ISO)
bupropion  (EXP)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcium atom  (EXP,ISO)
calcium silicate  (EXP)
calcium(0)  (EXP,ISO)
camphene  (EXP)
camptothecin  (ISO)
cannabidiol  (EXP)
captan  (ISO)
carbon dioxide  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonates  (ISO)
carboplatin  (EXP)
carmustine  (ISO)
carnosic acid  (EXP,ISO)
carnosine  (ISO)
casticin  (ISO)
celecoxib  (ISO)
cerium trichloride  (ISO)
ceruletide  (ISO)
chitosan  (EXP)
chlorite  (ISO)
chlorobenzene  (ISO)
chlorohydrocarbon  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium atom  (EXP,ISO)
chromium(6+)  (EXP,ISO)
chrysazin  (ISO)
cinnamyl alcohol  (ISO)
ciprofibrate  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (EXP,ISO)
cypermethrin  (EXP,ISO)
D-aspartic acid  (ISO)
D-gluconic acid  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
DDD  (EXP)
DDE  (EXP,ISO)
DDT  (EXP)
Decursin  (ISO)
deferiprone  (EXP)
dexamethasone  (EXP,ISO)
diallyl disulfide  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
dicoumarol  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
diethyldithiocarbamic acid  (EXP,ISO)
dihydroartemisinin  (ISO)
dihydrogen  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (ISO)
dioleoyl phosphatidic acid  (ISO)
dioleoyl phosphatidylcholine  (ISO)
Diosbulbin B  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diprotium  (ISO)
diprotium oxide  (ISO)
diquat  (EXP,ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
docebenone  (EXP)
donepezil hydrochloride  (EXP)
dopamine  (EXP,ISO)
doxepin  (EXP)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
ebselen  (ISO)
edaravone  (EXP)
elemental selenium  (EXP)
emodin  (ISO)
enalapril  (ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
enniatin  (ISO)
enzyme inhibitor  (EXP,ISO)
eplerenone  (EXP)
erdosteine  (ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
eugenol  (ISO)
fenitrothion  (EXP)
fenvalerate  (EXP)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
fipronil  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (EXP)
formic acid  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
Galbanic acid  (ISO)
gamma-tocopherol  (ISO)
Gastrodin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (EXP,ISO)
gingerol  (ISO)
ginsenoside Re  (ISO)
Ginsenoside Rh4  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
Glutathione ethyl ester  (EXP)
glycine  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
guanidine  (ISO)
GW 501516  (ISO)
haloperidol  (EXP)
hesperetin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
histamine  (ISO)
homocysteine  (EXP)
hyaluronic acid  (EXP)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogencarbonate  (ISO)
hydroquinone  (ISO)