Sod1 (superoxide dismutase 1) - Rat Genome Database

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Gene: Sod1 (superoxide dismutase 1) Rattus norvegicus
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Symbol: Sod1
Name: superoxide dismutase 1
RGD ID: 3731
Description: Enables copper ion binding activity; protein phosphatase 2B binding activity; and superoxide dismutase activity. Involved in several processes, including hydrogen peroxide biosynthetic process; removal of superoxide radicals; and response to antipsychotic drug. Located in several cellular components, including dense core granule; neuronal cell body; and peroxisome. Part of protein-containing complex. Used to study hyperthyroidism; hypothyroidism; middle cerebral artery infarction; and sciatic neuropathy. Biomarker of several diseases, including alcohol use disorder; artery disease (multiple); congenital diaphragmatic hernia; metabolic dysfunction-associated steatohepatitis; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1); PARTICIPATES IN hypertension pathway; amyotrophic lateral sclerosis pathway; forkhead class A signaling pathway; INTERACTS WITH (+)-catechin; (+)-taxifolin; (-)-cotinine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CuZnSOD; Superoxide dimutase 1 soluble; superoxide dismutase; Superoxide dismutase 1 soluble; superoxide dismutase 1, soluble; superoxide dismutase [Cu-Zn]
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,942,742 - 42,948,399 (+)NCBIGRCr8
mRatBN7.21129,456,673 - 29,462,249 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1129,456,558 - 29,462,249 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1138,144,681 - 38,150,257 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01130,816,072 - 30,821,648 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01130,005,455 - 30,011,012 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01130,363,282 - 30,368,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1130,363,280 - 30,368,862 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01133,982,764 - 33,988,340 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41129,810,766 - 29,816,342 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11129,810,765 - 29,816,342 (-)NCBI
Celera1129,143,740 - 29,149,316 (+)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
alcohol use disorder  (IEP)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (IEP,ISO)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 1  (ISO,ISS)
amyotrophic lateral sclerosis type 10  (ISO)
Animal Disease Models  (ISO)
Animal Mammary Neoplasms  (IEP)
Aortic Calcification  (IEP)
aortic disease  (ISO)
asphyxia neonatorum  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
autosomal dominant intellectual developmental disorder 7  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
cardiac arrest  (ISO)
cardiomyopathy  (ISO)
cataract  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis  (ISO)
chronic progressive external ophthalmoplegia  (ISO)
congenital diaphragmatic hernia  (IEP)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
cutaneous leishmaniasis  (ISO)
cystitis  (IEP)
depressive disorder  (ISO)
developmental coordination disorder  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (ISO)
Down syndrome  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO,ISS)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Radiation Injuries  (ISO)
Familial Platelet Disorder with Associated Myeloid Malignancy  (ISO)
Fatigue  (ISO)
Fetal Growth Retardation  (ISO)
fragile X-associated tremor/ataxia syndrome  (ISO)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
Gliosis  (ISO)
Hearing Loss  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Hemolysis  (ISO)
hepatocellular carcinoma  (ISO)
hepatorenal syndrome  (ISO)
high grade glioma  (ISO)
hyperglycemia  (ISO)
hypertension  (IEP,ISO)
hyperthyroidism  (IDA,ISO)
Hypotension  (ISO)
Hypothermia  (ISO)
hypothyroidism  (IDA,IEP)
Hypoxia  (IDA)
immunodeficiency 28  (ISO)
Inflammation  (ISO)
iron deficiency anemia  (ISO)
ischemia  (ISO)
Kidney Calculi  (ISO)
liver disease  (ISO)
Liver Reperfusion Injury  (ISO)
low tension glaucoma  (ISO,ISS)
macular degeneration  (ISO)
Marfan syndrome  (ISO)
MELAS syndrome  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatohepatitis  (IEP)
middle cerebral artery infarction  (IDA,IEP)
motor neuron disease  (ISO)
Muscle Weakness  (ISO)
muscular atrophy  (ISO)
myelomeningocele  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IDA,ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrosis  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Neurologic Gait Disorders  (ISO)
newborn respiratory distress syndrome  (ISO)
nutritional deficiency disease  (IEP,ISO)
obesity  (ISO)
ocular hypertension  (IEP)
Ovarian Neoplasms  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
Paralysis  (ISO)
Parkinson's disease  (ISO)
Parkinson's disease 20  (ISO)
Pathological Protein Aggregation  (ISO)
polycystic kidney disease  (IEP)
Presbycusis  (ISO)
prion disease  (ISO)
progressive supranuclear palsy  (ISO)
Protein Deficiency  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (ISO)
renal artery obstruction  (IEP)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
Retinal Neovascularization  (ISO)
retinitis pigmentosa  (ISO)
retinopathy of prematurity  (ISO)
Schistosomiasis Mansoni  (ISO)
sciatic neuropathy  (IDA,ISO)
scrapie  (ISO)
Sepsis  (IEP)
SPASTIC TETRAPLEGIA AND AXIAL HYPOTONIA, PROGRESSIVE  (ISO)
spinal cord disease  (ISO)
Spinal Cord Injuries  (ISO)
steatotic liver disease  (ISO)
Stroke  (ISO)
transient cerebral ischemia  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Ureteral Calculi  (ISO)
urinary bladder cancer  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-catechin  (EXP)
(+)-isoborneol  (ISO)
(+)-schisandrin B  (ISO)
(+)-taxifolin  (EXP)
(-)-cotinine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(E)-cinnamyl alcohol  (ISO)
(E)-thiamethoxam  (EXP)
(R)-adrenaline  (EXP,ISO)
(R)-camphor  (ISO)
(R)-linalyl acetate  (ISO)
(R)-lipoic acid  (EXP)
(R,R)-tramadol  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-amphetamine  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,8-cineole  (ISO)
1-benzylpiperazine  (ISO)
1-bromopropane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2,2-tetramine  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-dihydroxybenzoic acid  (ISO)
2,5-hexanedione  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-pyridylethylamine  (ISO)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydrocoumarin  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-(Methylthio)-1-propene  (EXP)
3-bromopyruvic acid  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-nitropropanoic acid  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (ISO)
4-vinylcyclohexene dioxide  (EXP,ISO)
5-aminolevulinic acid  (EXP)
5-fluorouracil  (EXP,ISO)
5-fluorouridine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7H-xanthine  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
8-Br-cAMP  (ISO)
9,10-phenanthroquinone  (ISO)
9H-xanthine  (EXP)
acetamide  (EXP)
acetylcholine  (EXP)
acetylsalicylic acid  (ISO)
aclacinomycin A  (ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
alginic acid  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
allethrin  (EXP)
alloxan  (EXP,ISO)
allyl methyl disulfide  (ISO)
Allylamine  (EXP)
alpha,alpha-trehalose  (EXP)
alpha-D-galactose  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
aluminium oxide  (EXP)
aluminium trinitrate  (ISO)
aminoacetone  (EXP)
aminoguanidine  (ISO)
amiodarone  (ISO)
amitraz  (EXP)
amitriptyline  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
amphibole asbestos  (ISO)
andrographolide  (EXP)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimonite  (ISO)
antimony(0)  (ISO)
apigenin  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (EXP)
aristolochic acid A  (EXP)
arjunolic acid  (EXP)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
asoxime chloride  (EXP)
astaxanthin  (ISO)
astragaloside IV  (EXP)
atenolol  (EXP,ISO)
atorvastatin calcium  (EXP)
ATP  (EXP,ISO)
atrasentan  (EXP)
atrazine  (EXP,ISO)
azide  (ISO)
Bandrowski's base  (ISO)
barium(0)  (ISO)
bathocuproine disulfonic acid  (ISO)
benazepril  (ISO)
benfotiamine  (ISO)
benidipine  (EXP)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzoyl peroxide  (ISO)
berberine  (EXP,ISO)
Bergenin  (ISO)
beta-carotene  (ISO)
bezafibrate  (ISO)
bifenthrin  (EXP,ISO)
bilirubin IXalpha  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boron atom  (EXP)
bosentan  (ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
bromocriptine  (ISO)
brucine  (EXP)
Brusatol  (ISO)
Bucillamine  (ISO)
buprofezin  (ISO)
bupropion  (EXP)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium oxalate  (EXP)
calcium silicate  (EXP)
calcium(0)  (EXP,ISO)
camphene  (EXP)
camphor  (ISO)
camptothecin  (ISO)
cannabidiol  (EXP,ISO)
capecitabine  (EXP)
captan  (ISO)
captopril  (EXP)
carbon dioxide  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonates  (ISO)
carboplatin  (EXP)
carmustine  (ISO)
carnosic acid  (EXP,ISO)
carnosine  (ISO)
Carnosol  (EXP)
carteolol  (ISO)
carvedilol  (EXP)
casticin  (ISO)
celecoxib  (ISO)
cerium trichloride  (ISO)
ceruletide  (ISO)
chitosan  (EXP)
chlorite  (ISO)
chlorobenzene  (ISO)
chlorohydrocarbon  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium atom  (EXP,ISO)
chromium(6+)  (EXP,ISO)
chrysazin  (ISO)
cilostazol  (EXP)
cinnamyl alcohol  (ISO)
ciprofibrate  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (EXP,ISO)
corn oil  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (EXP)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (EXP,ISO)
cypermethrin  (EXP,ISO)
D-aspartic acid  (ISO)
D-gluconic acid  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
DDD  (EXP)
DDE  (EXP,ISO)
DDT  (EXP)
Decursin  (ISO)
deferiprone  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
dicoumarol  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl phthalate  (EXP,ISO)
diethyldithiocarbamic acid  (EXP,ISO)
diethylstilbestrol  (EXP)
difenoconazole  (EXP)
dihydroartemisinin  (ISO)
dihydrogen  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl fumarate  (EXP)
Dimethyl phthalate  (EXP)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (ISO)
dioleoyl phosphatidic acid  (ISO)
dioleoyl phosphatidylcholine  (ISO)
Diosbulbin B  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diprotium  (ISO)
diprotium oxide  (ISO)
diquat  (EXP,ISO)
disodium cromoglycate  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
docebenone  (EXP)
donepezil hydrochloride  (EXP)
dopamine  (EXP,ISO)
doxepin  (EXP)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
ebselen  (ISO)
edaravone  (EXP)
elemental boron  (EXP)
elemental selenium  (EXP)
ellagic acid  (EXP)
emamectin benzoate  (EXP)
emodin  (ISO)
enalapril  (ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
enniatin  (ISO)
enzyme inhibitor  (EXP,ISO)
eplerenone  (EXP)
erdosteine  (ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
eugenol  (ISO)
fenitrothion  (EXP)
fenvalerate  (EXP)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
ferrostatin-1  (ISO)
finasteride  (EXP)
fipronil  (EXP,ISO)
flumequine  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (EXP)
formic acid  (ISO)
formononetin  (EXP)
FR900359  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
galactose  (EXP,ISO)
galaxolide  (EXP)
Galbanic acid  (ISO)
gallic acid  (EXP)
gallium nitrate  (ISO)
gamma-tocopherol  (ISO)
Gastrodin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (EXP,ISO)
gingerol  (ISO)
Ginkgolide C  (EXP)
ginsenoside Re  (ISO)
ginsenoside Rg1  (EXP)
Ginsenoside Rh4  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
Glutathione ethyl ester  (EXP)
glyburide  (EXP)
glycerol  (ISO)
glycine  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
guanidine  (ISO)
GW 501516  (ISO)
haloperidol  (EXP)
hesperetin  (ISO)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (EXP,ISO)
histamine  (ISO)
homocysteine  (EXP)
hyaluronic acid  (EXP)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogencarbonate  (ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP)
hydroxylamine  (EXP)
hypochlorous acid  (ISO)
icosanoid  (EXP)
Idoxifene  (EXP)
imetit  (EXP)
imidacloprid  (ISO)
imidazopyrazole  (ISO)
indole-3-acetic acid  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isatin  (ISO)
isoeugenol  (ISO)
isoflurane  (EXP)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
kaempferide  (ISO)
kaempferol  (EXP,ISO)
kainic acid  (ISO)
ketoconazole  (EXP)
ketorolac tromethamine  (EXP)
kojic acid  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (EXP,ISO)
lactacystin  (ISO)
lactose  (EXP)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
lenalidomide  (ISO)
levetiracetam  (EXP)
limonene  (EXP)
linalool  (ISO)
linalyl acetate  (ISO)
linsidomine  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (EXP)
lutein  (ISO)
luteolin  (ISO)
luzindole  (ISO)
LY294002  (ISO)
lycopene  (EXP,ISO)
magnesium sulfate  (EXP)
malathion  (EXP,ISO)
malonaldehyde  (EXP)
mancozeb  (ISO)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
manumycin A  (ISO)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
melamine  (ISO)
melatonin  (EXP,ISO)
meloxicam  (ISO)
menadione  (ISO)
mephedrone  (EXP)
mercaptoethanol  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP)
mercury(0)  (EXP,ISO)
metacetamol  (EXP,ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methidathion  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (EXP,ISO)
methylarsonic acid  (EXP,ISO)
methylglyoxal  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin RR  (ISO)
microcystin-LR  (EXP,ISO)
Miltirone  (ISO)
mitomycin C  (ISO)
Mitotane  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (ISO)
morin  (EXP)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylformamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nifuroxazide  (EXP)
nimesulide  (EXP)
nitric oxide  (EXP,ISO)
nitrites  (ISO)
nitrofen  (EXP)
nitrogen dioxide  (EXP,ISO)
nitroprusside  (ISO)
nitroxoline  (ISO)
NMN zwitterion  (ISO)
Nonylphenol  (EXP)
ochratoxin A  (EXP,ISO)
octadecanoic acid  (EXP)
okadaic acid  (ISO)
olanzapine  (EXP,ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (ISO)
oltipraz  (ISO)
omeprazole  (ISO)
oxidopamine  (EXP,ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
parthenolide  (EXP)
patulin  (ISO)
PCB138  (EXP)
pentachlorophenol  (EXP)
pentetrazol  (EXP)
peptidoglycan  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (EXP,ISO)
permethrin  (EXP)
peroxides  (ISO)
peroxynitrous acid  (ISO)
phencyclidine  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenylpropanolamine  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
piperazine  (ISO)
Pipermethystine  (EXP)
pipoxolan  (ISO)
pirinixic acid  (EXP,ISO)
porphyrins  (ISO)
potassium bromate  (EXP,ISO)
potassium chloride  (EXP,ISO)
potassium cyanide  (ISO)
potassium dichromate  (EXP,ISO)
potassium hydroxide  (ISO)
potassium iodide  (EXP)
procyanidin  (ISO)
profenofos  (EXP)
progesterone  (EXP,ISO)
propane-1,2-diol  (ISO)
propofol  (EXP)
pterostilbene  (ISO)
puerarin  (ISO)
purines  (EXP)
Pyridostigmine bromide  (ISO)
pyrimethamine  (ISO)
pyrogallol  (EXP)
pyrrolidine dithiocarbamate  (ISO)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
quetiapine fumarate  (EXP,ISO)
quinolinic acid  (EXP)
raloxifene  (ISO)
reactive oxygen species  (EXP,ISO)
resolvin D1  (ISO)
resveratrol  (EXP,ISO)
risperidone  (EXP)
rofecoxib  (ISO)
rosmarinic acid  (ISO)
rosuvastatin calcium  (EXP)
rotenone  (EXP,ISO)
rutin  (ISO)
ruxolitinib  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
sabinene  (ISO)
Salidroside  (ISO)
Salinomycin  (ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (ISO)
sarin  (EXP)
SB 431542  (ISO)
selenic acid  (ISO)
selenium atom  (EXP)
selenocystine  (ISO)
selenomethionine  (ISO)
serpentine asbestos  (ISO)
Sesamol  (EXP)
sildenafil citrate  (ISO)
silicic acid  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP,ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (EXP,ISO)
sodium fluoride  (EXP)
sodium sulfide (anhydrous)  (ISO)
spathulenol  (ISO)
spironolactone  (EXP)
starch  (ISO)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
sucrose  (EXP,ISO)
sulfasalazine  (ISO)
sulfluramid  (ISO)
sulfonyldimethane  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sulindac  (ISO)
sunitinib  (EXP)
superoxide  (ISO)
syringic acid  (EXP)
T-2 toxin  (EXP,ISO)
tamoxifen  (EXP)
tannic acid  (EXP)
taurocholic acid  (EXP)
telmisartan  (EXP)
terephthalic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (EXP,ISO)
thalidomide  (EXP,ISO)
thallium atom  (EXP)
thallium(I) acetate  (EXP)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiacloprid  (EXP)
thiamethoxam  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
thiostrepton  (ISO)
thiram  (ISO)
thymoquinone  (EXP,ISO)
thyroxine  (EXP)
tin atom  (ISO)
tin(0)  (ISO)
Tiopronin  (ISO)
Tiron  (ISO)
titanium atom  (ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
tramadol  (EXP)
trans-isoeugenol  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimethylenediamine  (ISO)
triolein  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
Ulipristal  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
verapamil  (EXP)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
water  (ISO)
yttrium chloride  (EXP)
zearalenone  (EXP,ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc oxide  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential initiation  (IEA,ISO)
anterograde axonal transport  (IEA,ISO)
apoptotic process  (IEA,ISO)
auditory receptor cell stereocilium organization  (IEA,ISO,ISS)
cellular response to ATP  (IEP)
cellular response to cadmium ion  (IEP)
cellular response to oxidative stress  (IEP)
cellular response to potassium ion  (IEP)
determination of adult lifespan  (IEA,ISO)
ectopic germ cell programmed cell death  (IEA,ISO)
embryo implantation  (IEA,ISO,ISS)
gene expression  (IEA,ISO)
glutathione metabolic process  (IEA,ISO,ISS)
heart contraction  (IEA,ISO,ISS)
hydrogen peroxide biosynthetic process  (IDA,IEA,IMP,ISO,ISS)
intracellular iron ion homeostasis  (IEA,ISO,ISS)
locomotory behavior  (IEA,ISO,ISS)
muscle cell cellular homeostasis  (IEA,ISO,ISS)
myeloid cell homeostasis  (IEA,ISO,ISS)
negative regulation of apoptotic process  (IEA,IMP,ISO)
negative regulation of developmental process  (IEA,ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,ISO,ISS)
negative regulation of reproductive process  (IEA,ISO)
neurofilament cytoskeleton organization  (IEA,ISO,ISS)
neuronal action potential  (IEA,ISO)
ovarian follicle development  (IEA,ISO,ISS)
peripheral nervous system myelin maintenance  (IEA,ISO,ISS)
positive regulation of catalytic activity  (IDA)
positive regulation of cytokine production  (IEA,ISO,ISS)
positive regulation of MAPK cascade  (IEA,ISO,ISS)
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of phagocytosis  (IEA,ISO)
positive regulation of superoxide anion generation  (IEA,ISO)
reactive oxygen species metabolic process  (IEA,ISO,ISS)
regulation of blood pressure  (IEA,ISO,ISS)
regulation of mitochondrial membrane potential  (IEA,ISO,ISS)
regulation of multicellular organism growth  (IEA,ISO,ISS)
relaxation of vascular associated smooth muscle  (IEA,ISO,ISS)
removal of superoxide radicals  (IBA,IDA,IEA,IMP,ISO,ISS,TAS)
response to amphetamine  (IEP)
response to antipsychotic drug  (IEP)
response to axon injury  (IEA,ISO,ISS)
response to carbon monoxide  (IEP)
response to copper ion  (IEP,IMP)
response to ethanol  (IEA,ISO,ISS)
response to heat  (IEA,ISO,ISS)
response to hydrogen peroxide  (IEA,ISO,ISS)
response to nutrient levels  (IDA,IEP)
response to oxidative stress  (IEA,IMP,ISO,TAS)
response to reactive oxygen species  (IEA,ISO)
response to superoxide  (IEA,ISO,ISS)
response to xenobiotic stimulus  (IEA,ISO)
retina homeostasis  (IEA,ISO,ISS)
retrograde axonal transport  (IEA,ISO)
sensory perception of sound  (IEA,ISO,ISS)
spermatogenesis  (IEA,ISO,ISS)
superoxide anion generation  (IEA,ISO)
superoxide metabolic process  (IDA,IEA,ISO,ISS,TAS)
transmission of nerve impulse  (IEA,ISO,ISS)

Cellular Component
axon cytoplasm  (IEA)
cytoplasm  (IEA,ISO,ISS)
cytoplasmic vesicle  (IEA,ISO,ISS)
cytosol  (IBA,IEA,ISO,ISS)
dendrite cytoplasm  (IEA,ISO,ISS)
dense core granule  (IDA)
extracellular region  (IDA)
extracellular space  (IEA,ISO)
lysosome  (IDA)
mitochondrion  (IBA,IEA,ISO,ISS)
neuronal cell body  (IDA,IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
peroxisome  (IBA,IDA,IEA,ISO)
plasma membrane  (IEA,ISO,ISS)
protein-containing complex  (IDA,IEA,ISO,ISS)
secretory granule  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
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2. Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo. Agbas A, etal., Biochem J. 2007 Jul 1;405(1):51-9.
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5. Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics study. Al-Kateb H, etal., Diabetes. 2008 Jan;57(1):218-28. Epub 2007 Oct 3.
6. Role of superoxide radical anion in the mechanism of apoB100 degradation induced by DHA in hepatic cells. Andreo U, etal., FASEB J. 2011 Oct;25(10):3554-60. doi: 10.1096/fj.11-182725. Epub 2011 Jul 14.
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10. Protective effects of atypical antipsychotic drugs on PC12 cells after serum withdrawal. Bai O, etal., J Neurosci Res. 2002 Jul 15;69(2):278-83.
11. 1-methyl-4-phenylpyridinium neurotoxicity is attenuated by adenoviral gene transfer of human Cu/Zn superoxide dismutase. Barkats M, etal., J Neurosci Res. 2006 Feb 1;83(2):233-42.
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13. Retinal ion regulation in a mouse model of diabetic retinopathy: natural history and the effect of Cu/Zn superoxide dismutase overexpression. Berkowitz BA, etal., Invest Ophthalmol Vis Sci. 2009 May;50(5):2351-8. doi: 10.1167/iovs.08-2918. Epub 2008 Dec 13.
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15. Peroxiredoxin 2 overexpression protects cortical neuronal cultures from ischemic and oxidative injury but not glutamate excitotoxicity, whereas Cu/Zn superoxide dismutase 1 overexpression protects only against oxidative injury. Boulos S, etal., J Neurosci Res. 2007 Nov 1;85(14):3089-97.
16. Expression and activity of antioxidants in the brain in progressive supranuclear palsy. Cantuti-Castelvetri I, etal., Brain Res. 2002 Mar 15;930(1-2):170-81.
17. SOD1 deficiency causes salt sensitivity and aggravates hypertension in hydronephrosis. Carlstrom M, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Jul;297(1):R82-92. Epub 2009 Apr 29.
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19. Transcriptional regulation and environmental induction of gene encoding copper- and zinc-containing superoxide dismutase. Chang MS, etal., Methods Enzymol 2002;349:293-305.
20. Inadequate cytoplasmic antioxidant enzymes response contributes to the oxidative stress in human hypertension. Chaves FJ, etal., Am J Hypertens. 2007 Jan;20(1):62-9.
21. SOD1 aggregation in astrocytes following ischemia/reperfusion injury: a role of NO-mediated S-nitrosylation of protein disulfide isomerase (PDI). Chen X, etal., J Neuroinflammation. 2012 Oct 12;9:237. doi: 10.1186/1742-2094-9-237.
22. Altered expression profile of superoxide dismutase isoforms in nasal polyps from nonallergic patients. Cheng YK, etal., Laryngoscope. 2006 Mar;116(3):417-22.
23. Perturbation of copper (Cu) homeostasis and expression of Cu-binding proteins in cadmium-resistant lung fibroblasts. Chou DK, etal., Toxicol Sci. 2007 Sep;99(1):267-76. Epub 2007 Jun 20.
24. Parameters of antioxidative defense in type 2 diabetic patients with cardiovascular complications. Colak E, etal., Ann Med. 2005;37(8):613-20.
25. Regulation of lung oxidative damage by endogenous superoxide dismutase in sepsis. Constantino L, etal., Intensive Care Med Exp. 2014 Dec;2(1):17. doi: 10.1186/2197-425X-2-17. Epub 2014 May 23.
26. Differential structural remodeling of the left-atrial posterior wall in patients affected by mitral regurgitation with or without persistent atrial fibrillation: a morphological and molecular study. Corradi D, etal., J Cardiovasc Electrophysiol. 2012 Mar;23(3):271-9. doi: 10.1111/j.1540-8167.2011.02187.x. Epub 2011 Sep 28.
27. Overexpression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice. Craven PA, etal., Diabetes. 2001 Sep;50(9):2114-25.
28. Expression of antioxidant enzymes in diseases of the human pancreas: another link between chronic pancreatitis and pancreatic cancer. Cullen JJ, etal., Pancreas. 2003 Jan;26(1):23-7.
29. Gene therapy using SOD1 protects striatal neurons from experimental stroke. Davis AS, etal., Neurosci Lett. 2007 Jan 3;411(1):32-6. Epub 2006 Nov 15.
30. Cloning and sequencing of a rat CuZn superoxide dismutase cDNA. Correlation between CuZn superoxide dismutase mRNA level and enzyme activity in rat and mouse tissues. Delabar JM, etal., Eur J Biochem 1987 Jul 1;166(1):181-7.
31. Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease. Ding A, etal., Clin Exp Pharmacol Physiol. 2012 Nov;39(11):917-29. doi: 10.1111/1440-1681.12013.
32. Superoxide dismutase 1 protects retinal cells from oxidative damage. Dong A, etal., J Cell Physiol. 2006 Sep;208(3):516-26.
33. Oxidative stress promotes ocular neovascularization. Dong A, etal., J Cell Physiol. 2009 Jun;219(3):544-52. doi: 10.1002/jcp.21698.
34. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Elchuri S, etal., Oncogene. 2005 Jan 13;24(3):367-80.
35. Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus. Flekac M, etal., BMC Med Genet. 2008 Apr 21;9:30.
36. Increased gene expression of antioxidant enzymes in KKAy diabetic mice but not in STZ diabetic mice. Fujita A, etal., Diabetes Res Clin Pract. 2005 Aug;69(2):113-9.
37. Reduction of renal superoxide dismutase in progressive diabetic nephropathy. Fujita H, etal., J Am Soc Nephrol. 2009 Jun;20(6):1303-13. Epub 2009 May 21.
38. Effects of Tianshu Capsule on Spontaneously Hypertensive Rats as Revealed by 1H-NMR-Based Metabolic Profiling. Gao J, etal., Front Pharmacol. 2019 Sep 11;10:989. doi: 10.3389/fphar.2019.00989. eCollection 2019.
39. SOD1 overexpression in paraventricular nucleus improves post-infarct myocardial remodeling and ventricular function. Gao J, etal., Pflugers Arch. 2012 Feb;463(2):297-307. doi: 10.1007/s00424-011-1036-0. Epub 2011 Oct 18.
40. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
41. Rat liver Cu,Zn-superoxide dismutase. Subcellular location in lysosomes. Geller BL and Winge DR, J Biol Chem. 1982 Aug 10;257(15):8945-52.
42. Genetic polymorphisms of antioxidant enzymes as risk factors for oxidative stress-associated complications in preterm infants. Giusti B, etal., Free Radic Res. 2012 Sep;46(9):1130-9. doi: 10.3109/10715762.2012.692787. Epub 2012 Jun 13.
43. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
44. Role of extracellular superoxide dismutase in hypertension. Gongora MC, etal., Hypertension. 2006 Sep;48(3):473-81. Epub 2006 Jul 24.
45. Rat lung Cu,Zn superoxide dismutase. Isolation and sequence of a full-length cDNA and studies of enzyme induction. Hass MA, etal., J Clin Invest 1989 Apr;83(4):1241-6.
46. Diabetes and alcohol: Double jeopardy with regard to oxidative toxicity and sexual dysfunction in adult male Wistar rats. Himabindu B, etal., Reprod Toxicol. 2015 Jan;51:57-63. doi: 10.1016/j.reprotox.2014.12.010. Epub 2014 Dec 22.
47. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
48. cDNA and deduced amino acid sequence of rat copper-zinc-containing superoxide dismutase. Ho YS and Crapo JD, Nucleic Acids Res 1987 Aug 25;15(16):6746.
49. Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration. Imamura Y, etal., Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11282-7. Epub 2006 Jul 14.
50. Mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications for mitochondrial energy metabolism and apoptosis. Inarrea P, etal., Biochem J. 2007 Jul 1;405(1):173-9.
51. Hitchhiking of Cu/Zn superoxide dismutase to peroxisomes--evidence for a natural piggyback import mechanism in mammals. Islinger M, etal., Traffic. 2009 Nov;10(11):1711-21. doi: 10.1111/j.1600-0854.2009.00966.x. Epub 2009 Jul 21.
52. Expression of antioxidant genes in renal cortex of PTU-induced hypothyroid rats: effect of vitamin E and curcumin. Jena S, etal., Mol Biol Rep. 2012 Feb;39(2):1193-203. doi: 10.1007/s11033-011-0849-4. Epub 2011 May 24.
53. Induction of oxidative stress and inhibition of superoxide dismutase expression in rat cerebral cortex and cerebellum by PTU-induced hypothyroidism and its reversal by curcumin. Jena S, etal., Neurol Sci. 2012 Aug;33(4):869-73. doi: 10.1007/s10072-011-0853-4. Epub 2011 Nov 11.
54. Curcumin differentially regulates the expression of superoxide dismutase in cerebral cortex and cerebellum of L-thyroxine (T(4))-induced hyperthyroid rat brain. Jena S, etal., Neurol Sci. 2013 Apr;34(4):505-10. doi: 10.1007/s10072-012-1084-z. Epub 2012 Apr 5.
55. Prenatal TCDD exposure predisposes for mammary cancer in rats. Jenkins S, etal., Reprod Toxicol. 2007 Apr-May;23(3):391-6. Epub 2006 Nov 10.
56. Polydatin modulates inflammation by decreasing NF-kappaB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain. Ji H, etal., Brain Res Bull. 2012 Jan 4;87(1):50-9. doi: 10.1016/j.brainresbull.2011.09.021. Epub 2011 Oct 6.
57. Inhibition of sonic hedgehog signaling aggravates brain damage associated with the down-regulation of Gli1, Ptch1 and SOD1 expression in acute ischemic stroke. Ji H, etal., Neurosci Lett. 2012 Jan 6;506(1):1-6. doi: 10.1016/j.neulet.2011.11.027. Epub 2011 Nov 25.
58. Sulfur dioxide preconditioning increases antioxidative capacity in rat with myocardial ischemia reperfusion (I/R) injury. Jin Hf, etal., Nitric Oxide. 2013 Aug 1;32:56-61. doi: 10.1016/j.niox.2013.04.008. Epub 2013 Apr 28.
59. Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: relation to blood-brain barrier dysfunction. Kamada H, etal., Stroke. 2007 Mar;38(3):1044-9. Epub 2007 Feb 1.
60. Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients. Kedziora-Kornatowska K, etal., J Pineal Res. 2009 Apr;46(3):333-7.
61. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
62. Cu/Zn superoxide dismutase and age-related hearing loss. Keithley EM, etal., Hear Res. 2005 Nov;209(1-2):76-85. Epub 2005 Aug 1.
63. Coexistence of dominant and recessive familial amyotrophic lateral sclerosis with the D90A Cu,Zn superoxide dismutase mutation within the same country. Khoris J, etal., Eur J Neurol. 2000 Mar;7(2):207-11.
64. Changes of hippocampal Cu/Zn-superoxide dismutase after kainate treatment in the rat. Kim H, etal., Brain Res. 2000 Jan 24;853(2):215-26.
65. Psychoproteomic analysis of rat cortex following acute methamphetamine exposure. Kobeissy FH, etal., J Proteome Res. 2008 May;7(5):1971-83. Epub 2008 May 2.
66. Alterations of serum selenium, zinc, copper, and iron concentrations and some related antioxidant enzyme activities in patients with cutaneous leishmaniasis. Kocyigit A, etal., Biol Trace Elem Res. 1998 Dec;65(3):271-81.
67. SOD1 overexpression and female sex exhibit region-specific neuroprotection after global cerebral ischemia due to cardiac arrest. Kofler J, etal., J Cereb Blood Flow Metab. 2005 Sep;25(9):1130-7.
68. Characterization of hemizygous SOD1/wild-type transgenic mice with the SHIRPA primary screen and tests of sensorimotor function and anxiety. Lalonde R, etal., Brain Res Bull. 2004 Sep 30;64(3):251-8.
69. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Lehmann TG, etal., Liver Transpl. 2006 Apr;12(4):550-9.
70. A possible cooperation of SOD1 and cytochrome c in mitochondria-dependent apoptosis. Li Q, etal., Free Radic Biol Med. 2006 Jan 1;40(1):173-81. Epub 2005 Oct 21.
71. Expression of superoxide dismutase in whole lens prevents cataract formation. Lin D, etal., Mol Vis. 2005 Oct 11;11:853-8.
72. Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. Liu KM, etal., Am J Physiol Renal Physiol. 2015 Aug 15;309(4):F318-31. doi: 10.1152/ajprenal.00607.2014. Epub 2015 Jun 24.
73. Association between polymorphisms in SOD1 and noise-induced hearing loss in Chinese workers. Liu YM, etal., Acta Otolaryngol. 2010 Apr;130(4):477-86. doi: 10.3109/00016480903253587.
74. Familial ALS with extreme phenotypic variability due to the I113T SOD1 mutation. Lopate G, etal., Amyotroph Lateral Scler. 2010;11(1-2):232-6. doi: 10.3109/17482960902898069.
75. Evidence for oxidative stress in the developing cerebellum of the rat after chronic mild carbon monoxide exposure (0.0025% in air). Lopez IA, etal., BMC Neurosci. 2009 May 27;10:53.
76. Oxidative stress and antioxidant enzyme upregulation in SOD1-G93A mouse skeletal muscle. Mahoney DJ, etal., Muscle Nerve. 2006 Jun;33(6):809-16.
77. Comparative analysis of the time-dependent functional and molecular changes in spinal cord degeneration induced by the G93A SOD1 gene mutation and by mechanical compression. Malaspina A, etal., BMC Genomics. 2008 Oct 23;9:500.
78. Blood expression profiles of fragile X premutation carriers identify candidate genes involved in neurodegenerative and infertility phenotypes. Mateu-Huertas E, etal., Neurobiol Dis. 2014 May;65:43-54. doi: 10.1016/j.nbd.2013.12.020. Epub 2014 Jan 10.
79. Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis. Matsunami T, etal., Int J Clin Exp Pathol. 2010 May 22;3(5):472-81.
80. Cu/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129,CD-1 mice. McFadden SL, etal., J Comp Neurol. 1999 Oct 11;413(1):101-12.
81. The Influence of Superoxide Dismutase and Glutathione Peroxidase Deficiencies on Noise-Induced Hearing Loss in Mice. McFadden SL, etal., Noise Health. 2001;3(11):49-64.
82. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
83. Proteomic analysis of rat retina in a steroid-induced ocular hypertension model: potential vulnerability to oxidative stress. Miyara N, etal., Jpn J Ophthalmol. 2008 Mar-Apr;52(2):84-90. Epub 2008 Apr 30.
84. SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid beta protein oligomerization and memory loss in mouse model of Alzheimer disease. Murakami K, etal., J Biol Chem. 2011 Dec 30;286(52):44557-68. doi: 10.1074/jbc.M111.279208. Epub 2011 Nov 9.
85. Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease. Nagai M, etal., J Neurosci. 2001 Dec 1;21(23):9246-54.
86. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
87. Bilirubin is highly effective in preventing in vivo delta-aminolevulinic acid-induced oxidative cell damage. Noriega GO, etal., Biochim Biophys Acta 2003 Jul 14;1638(2):173-8.
88. The effects of 2% rebamipide ophthalmic solution on the tear functions and ocular surface of the superoxide dismutase-1 (sod1) knockout mice. Ohguchi T, etal., Invest Ophthalmol Vis Sci. 2013 Nov 21;54(12):7793-802. doi: 10.1167/iovs.13-13128.
89. Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss. Ohlemiller KK, etal., Audiol Neurootol. 1999 Sep-Oct;4(5):237-46.
90. Enhanced diabetes-induced cataract in copper-zinc superoxide dismutase-null mice. Olofsson EM, etal., Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2913-8. Epub 2009 Mar 25.
91. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
92. Reduction in superoxide dismutase expression in the epithelial mucosa of eosinophilic chronic rhinosinusitis with nasal polyps. Ono N, etal., Int Arch Allergy Immunol. 2013;162(2):173-80. doi: 10.1159/000353122. Epub 2013 Jul 31.
93. Superoxide dismutase in the prostate lobes of aging Brown Norway rats. Pechenino AS and Brown TR, Prostate. 2006 Apr 1;66(5):522-35.
94. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
95. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
96. Genetic polymorphisms of antioxidant enzymes in preterm infants. Poggi C, etal., J Matern Fetal Neonatal Med. 2012 Oct;25 Suppl 4:131-4. doi: 10.3109/14767058.2012.714976.
97. Copper-zinc superoxide dismutase (SOD1) is released by microglial cells and confers neuroprotection against 6-OHDA neurotoxicity. Polazzi E, etal., Neurosignals. 2013;21(1-2):112-28. doi: 10.1159/000337115. Epub 2012 May 9.
98. Isolation and nucleotide sequence of rat Cu/Zn superoxide dismutase cDNA clones. Puga A and Oates EL, Free Radic Res Commun 1987;3(6):337-46.
99. Exploration of molecular factors impairing superoxide dismutase isoforms activity in human senile cataractous lenses. Rajkumar S, etal., Invest Ophthalmol Vis Sci. 2013 Sep 17;54(9):6224-33. doi: 10.1167/iovs.13-11935.
100. Contrasting and cooperative effects of copper and iron deficiencies in male rats fed different concentrations of manganese and different sources of sulfur amino acids in an AIN-93G-based diet. Reeves PG, etal., J Nutr. 2004 Feb;134(2):416-25.
101. GOA pipeline RGD automated data pipeline
102. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
103. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
104. Superoxide dismutase isoforms 1 and 2 in lumbar spinal cord of neonatal rats after sciatic nerve transection and melatonin treatment. Rogerio F, etal., Brain Res Dev Brain Res. 2005 Feb 8;154(2):217-25. Epub 2005 Jan 16.
105. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Rosen DR, etal., Nature 1993 Mar 4;362(6415):59-62.
106. Evidence of calcium- and SNARE-dependent release of CuZn superoxide dismutase from rat pituitary GH3 cells and synaptosomes in response to depolarization. Santillo M, etal., J Neurochem. 2007 Aug;102(3):679-85. Epub 2007 Apr 2.
107. Rapid disease progression correlates with instability of mutant SOD1 in familial ALS. Sato T, etal., Neurology. 2005 Dec 27;65(12):1954-7. Epub 2005 Nov 16.
108. Characterization of superoxide dismutases in cardiac progenitor cells demonstrates a critical role for manganese superoxide dismutase. Seshadri G, etal., Stem Cells Dev. 2012 Nov 20;21(17):3136-46. doi: 10.1089/scd.2012.0191. Epub 2012 Aug 1.
109. Predictive model for earlier diagnosis of suspected age-related macular degeneration patients. Sharma NK, etal., DNA Cell Biol. 2013 Sep;32(9):549-55. doi: 10.1089/dna.2013.2072. Epub 2013 Jul 13.
110. Activity-dependent neuroprotective protein (ADNP)-derived peptide (NAP) ameliorates hypobaric hypoxia induced oxidative stress in rat brain. Sharma NK, etal., Peptides. 2011 Jun;32(6):1217-24. doi: 10.1016/j.peptides.2011.03.016. Epub 2011 Mar 29.
111. Chronic hypoxia aggravates renal injury via suppression of Cu/Zn-SOD: a proteomic analysis. Son D, etal., Am J Physiol Renal Physiol. 2008 Jan;294(1):F62-72. Epub 2007 Oct 24.
112. Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle. Sreekumar R, etal., Am J Physiol Endocrinol Metab 2002 Jul;283(1):E38-43.
113. Oxidative stress in aging in the C57B16/J mouse cochlea. Staecker H, etal., Acta Otolaryngol. 2001 Sep;121(6):666-72.
114. Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Strassburger M, etal., Free Radic Biol Med. 2005 Jun 1;38(11):1458-70.
115. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
116. Genes contributing to prion pathogenesis. Tamgüney G, etal., J Gen Virol. 2008 Jul;89(Pt 7):1777-88. doi: 10.1099/vir.0.2008/001255-0.
117. Overexpression of human copper/zinc superoxide dismutase (SOD1) suppresses ischemia-reperfusion injury and subsequent development of graft coronary artery disease in murine cardiac grafts. Tanaka M, etal., Circulation. 2004 Sep 14;110(11 Suppl 1):II200-6.
118. Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells. Tatton WG, etal., J Pharmacol Exp Ther. 2002 May;301(2):753-64.
119. Serum oxidant/antioxidant status in patients with Behcet's disease. Taysi S, etal., Ann Clin Lab Sci. 2002 Fall;32(4):377-82.
120. SOD1: a candidate gene for keratoconus. Udar N, etal., Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3345-51.
121. Overexpression of SOD in retina: need for increase in H2O2-detoxifying enzyme in same cellular compartment. Usui S, etal., Free Radic Biol Med. 2011 Oct 1;51(7):1347-54. doi: 10.1016/j.freeradbiomed.2011.06.010. Epub 2011 Jul 5.
122. Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa. Usui S, etal., Mol Ther. 2009 May;17(5):778-86. doi: 10.1038/mt.2009.47. Epub 2009 Mar 17.
123. Limiting iron availability confers neuroprotection from chronic mild carbon monoxide exposure in the developing auditory system of the rat. Webber DS, etal., J Neurosci Res. 2005 Jun 1;80(5):620-33.
124. Dietary red palm oil protects the heart against the cytotoxic effects of anthracycline. Wergeland A, etal., Cell Biochem Funct. 2011 Jul;29(5):356-64. doi: 10.1002/cbf.1756. Epub 2011 May 16.
125. Cu,Zn-superoxide dismutase is lower and copper chaperone CCS is higher in erythrocytes of copper-deficient rats and mice. West EC and Prohaska JR, Exp Biol Med (Maywood) 2004 Sep;229(8):756-64.
126. Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats. Wheeler MD, etal., Gastroenterology. 2001 Apr;120(5):1241-50.
127. Comparison of the effect of adenoviral delivery of three superoxide dismutase genes against hepatic ischemia-reperfusion injury. Wheeler MD, etal., Hum Gene Ther. 2001 Dec 10;12(18):2167-77.
128. Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD. Williams JR, etal., Neurobiol Dis. 2016 May;89:1-9. doi: 10.1016/j.nbd.2016.01.020. Epub 2016 Jan 27.
129. SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy. Winer L, etal., JAMA Neurol. 2013 Feb;70(2):201-7. doi: 10.1001/jamaneurol.2013.593.
130. Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase. Xiong Y, etal., J Neurochem. 2005 Nov;95(3):732-44.
131. Genetic redox preconditioning differentially modulates AP-1 and NF kappa B responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis. Yang J, etal., Mol Ther. 2003 Mar;7(3):341-53.
132. The chronological characteristics of SOD1 activity and inflammatory response in the hippocampi of STZ-induced type 1 diabetic rats. Yi SS, etal., Neurochem Res. 2011 Jan;36(1):117-28. doi: 10.1007/s11064-010-0280-6. Epub 2010 Oct 6.
133. Genetic reduction of lipoic acid synthase expression modestly increases atherosclerosis in male, but not in female, apolipoprotein E-deficient mice. Yi X, etal., Atherosclerosis. 2010 Aug;211(2):424-30. doi: 10.1016/j.atherosclerosis.2010.03.009. Epub 2010 Mar 10.
134. Overexpression of SOD1 in transgenic rats attenuates nuclear translocation of endonuclease G and apoptosis after spinal cord injury. Yu F, etal., J Neurotrauma. 2006 May;23(5):595-603.
135. Spatial and temporal correlation of nitric oxide synthase expression with CuZn-superoxide dismutase reduction in motor neurons following axotomy. Yu WH Ann N Y Acad Sci 2002 May;962:111-21.
136. Retinal ganglion cell loss in superoxide dismutase 1 deficiency. Yuki K, etal., Invest Ophthalmol Vis Sci. 2011 Jun 13;52(7):4143-50. doi: 10.1167/iovs.10-6294.
137. Systemic administration of PEP-1-SOD1 fusion protein improves functional recovery by inhibition of neuronal cell death after spinal cord injury. Yune TY, etal., Free Radic Biol Med. 2008 Oct 15;45(8):1190-200. doi: 10.1016/j.freeradbiomed.2008.07.016. Epub 2008 Jul 27.
138. [Effects of noise exposure level on the relationship between SNPs of SOD1 and the susceptibility to noise-induced hearing loss (NIHL)]. Zeng WF, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012 Jul;30(7):504-8.
139. A maternal high-fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats. Zhang X, etal., J Nutr. 2011 Jul;141(7):1254-9. doi: 10.3945/jn.111.139576. Epub 2011 May 11.
140. Genetic polymorphisms of superoxide dismutases, catalase, and glutathione peroxidase in age-related cataract. Zhang Y, etal., Mol Vis. 2011;17:2325-32. Epub 2011 Aug 30.
141. In vivo protein transduction: delivery of PEP-1-SOD1 fusion protein into myocardium efficiently protects against ischemic insult. Zhang YE, etal., Mol Cells. 2009 Feb 28;27(2):159-66. doi: 10.1007/s10059-009-0020-4. Epub 2009 Feb 20.
142. PEP-1-SOD1 protects brain from ischemic insult following asphyxial cardiac arrest in rats. Zhang YE, etal., Resuscitation. 2011 Aug;82(8):1081-6. doi: 10.1016/j.resuscitation.2011.01.034. Epub 2011 Apr 6.
Additional References at PubMed
PMID:291939   PMID:1332049   PMID:1379810   PMID:3790250   PMID:7172448   PMID:7444718   PMID:8224914   PMID:8673102   PMID:8837775   PMID:9453566   PMID:9516486   PMID:9539776  
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PMID:35998476   PMID:38834681  


Genomics

Comparative Map Data
Sod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,942,742 - 42,948,399 (+)NCBIGRCr8
mRatBN7.21129,456,673 - 29,462,249 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1129,456,558 - 29,462,249 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1138,144,681 - 38,150,257 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01130,816,072 - 30,821,648 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01130,005,455 - 30,011,012 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01130,363,282 - 30,368,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1130,363,280 - 30,368,862 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01133,982,764 - 33,988,340 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41129,810,766 - 29,816,342 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11129,810,765 - 29,816,342 (-)NCBI
Celera1129,143,740 - 29,149,316 (+)NCBICelera
Cytogenetic Map11q11NCBI
SOD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382131,659,693 - 31,668,931 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2131,659,666 - 31,668,931 (+)EnsemblGRCh38hg38GRCh38
GRCh372133,032,006 - 33,041,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,953,806 - 31,963,115 (+)NCBINCBI36Build 36hg18NCBI36
Build 342131,953,805 - 31,963,112NCBI
Celera2118,215,252 - 18,224,561 (+)NCBICelera
Cytogenetic Map21q22.11ENTREZGENE
HuRef2118,441,963 - 18,451,272 (+)NCBIHuRef
CHM1_12132,593,921 - 32,603,230 (+)NCBICHM1_1
T2T-CHM13v2.02130,027,677 - 30,036,914 (+)NCBIT2T-CHM13v2.0
Sod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391690,017,650 - 90,023,221 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1690,017,642 - 90,023,217 (+)EnsemblGRCm39 Ensembl
GRCm381690,220,762 - 90,226,333 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1690,220,754 - 90,226,329 (+)EnsemblGRCm38mm10GRCm38
MGSCv371690,220,987 - 90,226,569 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361690,109,601 - 90,115,183 (+)NCBIMGSCv36mm8
Celera1690,416,380 - 90,421,958 (+)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1651.56NCBI
Sod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540731,263,863 - 31,267,727 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540731,261,451 - 31,267,657 (+)NCBIChiLan1.0ChiLan1.0
SOD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22227,780,102 - 27,788,228 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12122,639,842 - 22,647,619 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02118,029,831 - 18,037,526 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12131,411,702 - 31,419,432 (+)NCBIpanpan1.1PanPan1.1panPan2
SOD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13126,540,291 - 26,544,212 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3126,486,274 - 26,662,815 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3126,528,080 - 26,536,169 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03126,654,922 - 26,662,986 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3126,654,409 - 26,782,319 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13126,600,785 - 26,608,887 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03126,612,632 - 26,620,712 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03127,118,829 - 27,126,937 (+)NCBIUU_Cfam_GSD_1.0
Sod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497127,114,944 - 27,122,669 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650010,345,154 - 10,352,867 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650010,345,154 - 10,352,873 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13195,326,649 - 195,337,729 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113195,326,573 - 195,335,273 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213205,620,994 - 205,629,705 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1260,461,219 - 60,472,999 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660713,004,172 - 3,013,463 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474520,032,011 - 20,037,958 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474520,032,003 - 20,037,958 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sod1
9 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:21
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000002885
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002885   ⟹   ENSRNOP00000002885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1129,456,558 - 29,462,249 (+)Ensembl
Rnor_6.0 Ensembl1130,363,280 - 30,368,862 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097395   ⟹   ENSRNOP00000082831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1129,456,968 - 29,462,249 (+)Ensembl
RefSeq Acc Id: NM_017050   ⟹   NP_058746
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,942,823 - 42,948,399 (+)NCBI
mRatBN7.21129,456,673 - 29,462,249 (+)NCBI
Rnor_6.01130,363,282 - 30,368,858 (+)NCBI
Rnor_5.01133,982,764 - 33,988,340 (+)NCBI
RGSC_v3.41129,810,766 - 29,816,342 (-)RGD
Celera1129,143,740 - 29,149,316 (+)RGD
Sequence:
RefSeq Acc Id: XM_063270289   ⟹   XP_063126359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,942,742 - 42,947,253 (+)NCBI
RefSeq Acc Id: NP_058746   ⟸   NM_017050
- UniProtKB: P07632 (UniProtKB/Swiss-Prot),   A6JLB7 (UniProtKB/TrEMBL),   Q6LDS4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002885   ⟸   ENSRNOT00000002885
Ensembl Acc Id: ENSRNOP00000082831   ⟸   ENSRNOT00000097395
RefSeq Acc Id: XP_063126359   ⟸   XM_063270289
- Peptide Label: isoform X1
Protein Domains
Superoxide dismutase copper/zinc binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07632-F1-model_v2 AlphaFold P07632 1-154 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698043
Promoter ID:EPDNEW_R8568
Type:multiple initiation site
Name:Sod1_1
Description:superoxide dismutase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01130,363,282 - 30,363,342EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3731 AgrOrtholog
BioCyc Gene G2FUF-21954 BioCyc
BioCyc Pathway DETOX1-PWY [superoxide radicals degradation] BioCyc
  DETOX1-PWY-1 [reactive oxygen species degradation] BioCyc
BioCyc Pathway Image DETOX1-PWY BioCyc
  DETOX1-PWY-1 BioCyc
Ensembl Genes ENSRNOG00000002115 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000002885 ENTREZGENE
Gene3D-CATH 2.60.40.200 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7304983 IMAGE-MGC_LOAD
InterPro SOD-like_Cu/Zn_dom_sf UniProtKB/Swiss-Prot
  SOD_Cu/Zn_/chaperone UniProtKB/Swiss-Prot
  SOD_Cu/Zn_BS UniProtKB/Swiss-Prot
  SOD_Cu_Zn_dom UniProtKB/Swiss-Prot
KEGG Report rno:24786 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105454 IMAGE-MGC_LOAD
NCBI Gene 24786 ENTREZGENE
PANTHER PTHR10003 UniProtKB/Swiss-Prot
Pfam Sod_Cu UniProtKB/Swiss-Prot
PharmGKB SOD1 RGD
PhenoGen Sod1 PhenoGen
PRINTS CUZNDISMTASE UniProtKB/Swiss-Prot
PROSITE SOD_CU_ZN_1 UniProtKB/Swiss-Prot
  SOD_CU_ZN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002115 RatGTEx
Superfamily-SCOP SSF49329 UniProtKB/Swiss-Prot
UniProt A0A8I6G9Z6_RAT UniProtKB/TrEMBL
  A0A8L2Q0T2_RAT UniProtKB/TrEMBL
  A6JLB7 ENTREZGENE, UniProtKB/TrEMBL
  P07632 ENTREZGENE
  Q6LDS4 ENTREZGENE, UniProtKB/TrEMBL
  SODC_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-24 Sod1  superoxide dismutase 1  Sod1  superoxide dismutase 1, soluble  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Sod1  superoxide dismutase 1, soluble  Sod1  superoxide dismutase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Sod1  superoxide dismutase 1    Superoxide dismutase 1, soluble  Name updated 629478 APPROVED
2001-12-21 Sod1  Superoxide dismutase 1, soluble      Name updated 69729 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to peroxisome 628320
gene_disease mutation of the human homolog is a cause of familial amyotrophic lateral sclerosis (ALS) 737689
gene_expression expression is decreased 1.9 fold in SHR compared with WKY rats 1357414
gene_function dismutates reactive oxygen radical species (ROS) to hydrogen peroxide and molecular oxygen 628320
gene_process prevents accumulation of superoxides in cells 628320
gene_regulation caloric restriction (CR) significantly increased mRNA (>287%) level 628320