Tnk2 (tyrosine kinase, non-receptor, 2) - Rat Genome Database
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Gene: Tnk2 (tyrosine kinase, non-receptor, 2) Rattus norvegicus
Analyze
Symbol: Tnk2
Name: tyrosine kinase, non-receptor, 2
RGD ID: 1305957
Description: Exhibits protein tyrosine kinase activity. Predicted to be involved in several processes, including peptidyl-tyrosine autophosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of clathrin-dependent endocytosis. Predicted to localize to several cellular components, including Grb2-EGFR complex; cytoophidium; and cytoplasmic vesicle. Orthologous to human TNK2 (tyrosine kinase non receptor 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; 2-amino-2-deoxy-D-glucopyranose.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ACK-1; activated CDC42 kinase 1; activated p21cdc42Hs kinase; LOC303882; MGC94214; tyrosine kinase non-receptor protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01171,348,726 - 71,388,520 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,348,717 - 71,387,992 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,431,230 - 74,470,437 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,927,509 - 69,966,854 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11169,985,098 - 70,024,443 (-)NCBI
Celera1167,547,447 - 67,587,473 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Additional References at PubMed
PMID:10587647   PMID:10618719   PMID:12477932   PMID:16472662   PMID:17182860   PMID:18262180   PMID:18993068   PMID:19946888   PMID:20086093   PMID:20333297   PMID:20979614   PMID:21169560  
PMID:23562806   PMID:23686771   PMID:25223282   PMID:25416956  


Genomics

Comparative Map Data
Tnk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01171,348,726 - 71,388,520 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,348,717 - 71,387,992 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,431,230 - 74,470,437 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,927,509 - 69,966,854 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11169,985,098 - 70,024,443 (-)NCBI
Celera1167,547,447 - 67,587,473 (-)NCBICelera
Cytogenetic Map11q22NCBI
TNK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3195,863,364 - 195,911,945 (-)EnsemblGRCh38hg38GRCh38
GRCh383195,863,364 - 195,908,551 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373195,590,235 - 195,635,880 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,074,633 - 197,120,277 (-)NCBINCBI36hg18NCBI36
Build 343197,078,545 - 197,124,190NCBI
Celera3194,132,138 - 194,176,550 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3192,870,965 - 192,916,101 (-)NCBIHuRef
CHM1_13195,555,271 - 195,606,419 (-)NCBICHM1_1
Tnk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,462,699 - 32,502,311 (+)NCBIGRCm39mm39
GRCm381632,644,099 - 32,683,493 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,643,874 - 32,683,493 (+)EnsemblGRCm38mm10GRCm38
MGSCv371632,644,729 - 32,683,579 (+)NCBIGRCm37mm9NCBIm37
MGSCv361632,564,608 - 32,603,240 (+)NCBImm8
Celera1633,124,376 - 33,163,447 (+)NCBICelera
Cytogenetic Map16B3NCBI
Tnk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,300,572 - 12,338,058 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542012,302,463 - 12,337,976 (-)NCBIChiLan1.0ChiLan1.0
TNK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13203,219,978 - 203,254,498 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v03193,254,017 - 193,302,863 (-)NCBIMhudiblu_PPA_v0panPan3
TNK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3329,152,851 - 29,179,718 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13329,153,636 - 29,177,568 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tnk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936784636,105 - 685,080 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13134,081,697 - 134,124,826 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113134,082,266 - 134,124,826 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213143,624,416 - 143,666,696 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNK2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11591,187,702 - 91,232,391 (+)NCBI
ChlSab1.1 Ensembl1591,201,008 - 91,232,399 (+)Ensembl
Tnk2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473061,237,653 - 61,272,499 (-)NCBI

Position Markers
AF037260  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01171,348,941 - 71,349,056NCBIRnor6.0
Rnor_5.01174,431,445 - 74,431,560UniSTSRnor5.0
RGSC_v3.41169,927,724 - 69,927,839UniSTSRGSC3.4
Celera1167,547,662 - 67,547,777UniSTS
Cytogenetic Map11q22UniSTS
RH134491  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01171,348,813 - 71,349,001NCBIRnor6.0
Rnor_5.01174,431,317 - 74,431,505UniSTSRnor5.0
RGSC_v3.41169,927,596 - 69,927,784UniSTSRGSC3.4
Celera1167,547,534 - 67,547,722UniSTS
Cytogenetic Map11q22UniSTS
RH 3.4 Map11393.0UniSTS
RH143928  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01171,349,259 - 71,349,413NCBIRnor6.0
Rnor_5.01174,431,763 - 74,431,917UniSTSRnor5.0
RGSC_v3.41169,928,042 - 69,928,196UniSTSRGSC3.4
Celera1167,547,980 - 67,548,134UniSTS
Cytogenetic Map11q22UniSTS
RH 3.4 Map11403.5UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116010984287141948Rat
4889859Pur28Proteinuria QTL 2819.50.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114790104978471527Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)116265336586714475Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115994302390463843Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)113043533986714631Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114309033886714631Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11172720192Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116449467190463843Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116964970890463843Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116934231986312439Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113590063480900634Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116265336586714483Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115785881090463843Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112831466586994795Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113215552082443118Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111947517979734728Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114658320986714631Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:74
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000002411
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 30 22 13 22 3 74 27 34 3
Low 11 27 19 6 19 8 8 8 7 8 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001008336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAHX01069829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01285344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC136847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000002411   ⟹   ENSRNOP00000002411
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1171,348,727 - 71,387,992 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084768   ⟹   ENSRNOP00000070836
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1171,348,717 - 71,368,456 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085568   ⟹   ENSRNOP00000072336
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1171,350,817 - 71,368,440 (-)Ensembl
RefSeq Acc Id: NM_001008336   ⟹   NP_001008337
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,348,726 - 71,387,992 (-)NCBI
Rnor_5.01174,431,230 - 74,470,437 (-)NCBI
RGSC_v3.41169,927,509 - 69,966,854 (-)RGD
Celera1167,547,447 - 67,587,473 (-)RGD
Sequence:
RefSeq Acc Id: XM_017597980   ⟹   XP_017453469
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,348,726 - 71,371,213 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597981   ⟹   XP_017453470
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,350,857 - 71,371,214 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597982   ⟹   XP_017453471
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,348,726 - 71,371,214 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597983   ⟹   XP_017453472
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,348,726 - 71,374,628 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597984   ⟹   XP_017453473
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,348,726 - 71,371,213 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597985   ⟹   XP_017453474
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,350,857 - 71,371,214 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597986   ⟹   XP_017453475
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,348,726 - 71,371,214 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597987   ⟹   XP_017453476
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,350,857 - 71,371,214 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597988   ⟹   XP_017453477
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,348,726 - 71,371,214 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597989   ⟹   XP_017453478
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,348,726 - 71,388,520 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597990   ⟹   XP_017453479
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,350,857 - 71,371,214 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597991   ⟹   XP_017453480
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,348,726 - 71,371,214 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597992   ⟹   XP_017453481
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,348,726 - 71,371,214 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001008337   ⟸   NM_001008336
- UniProtKB: Q5U2X5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017453478   ⟸   XM_017597989
- Peptide Label: isoform X10
- UniProtKB: A0A0G2JYY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453472   ⟸   XM_017597983
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017453481   ⟸   XM_017597992
- Peptide Label: isoform X13
- Sequence:
RefSeq Acc Id: XP_017453475   ⟸   XM_017597986
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_017453477   ⟸   XM_017597988
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_017453480   ⟸   XM_017597991
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_017453471   ⟸   XM_017597982
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017453473   ⟸   XM_017597984
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017453469   ⟸   XM_017597980
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017453479   ⟸   XM_017597990
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_017453476   ⟸   XM_017597987
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_017453474   ⟸   XM_017597985
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017453470   ⟸   XM_017597981
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000070836   ⟸   ENSRNOT00000084768
RefSeq Acc Id: ENSRNOP00000072336   ⟸   ENSRNOT00000085568
RefSeq Acc Id: ENSRNOP00000002411   ⟸   ENSRNOT00000002411
Protein Domains
Protein kinase   SH3   UBA

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
11 71352474 71352475 G A snv BBDP/Wor (RGD), WKY/Gcrc (RGD), SHR/NHsd (RGD), MNS/Gib (RGD)
11 71361858 71361859 C T snv WAG/Rij (RGD)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305957 AgrOrtholog
Ensembl Genes ENSRNOG00000001769 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002411 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000070836 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000072336 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002411 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000084768 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000085568 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 4.10.680.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130376 IMAGE-MGC_LOAD
InterPro Ack1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cdc42-bd-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cdc42_binding_dom-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mig-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:303882 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94214 IMAGE-MGC_LOAD
NCBI Gene 303882 ENTREZGENE
PANTHER PTHR14254:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GTPase_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Inhibitor_Mig-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tnk2 PhenoGen
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JYY3 ENTREZGENE, UniProtKB/TrEMBL
  ACK1_RAT UniProtKB/Swiss-Prot
  F1M7W9_RAT UniProtKB/TrEMBL
  Q5U2X5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Tnk2  tyrosine kinase, non-receptor, 2  LOC682784  similar to tyrosine kinase, non-receptor, 2  Data Merged 1643240 APPROVED
2006-11-20 LOC682784  similar to tyrosine kinase, non-receptor, 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Tnk2  tyrosine kinase, non-receptor, 2  Tnk2_predicted  tyrosine kinase, non-receptor, 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Tnk2_predicted  tyrosine kinase, non-receptor, 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED