Tnk2 (tyrosine kinase non receptor 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tnk2 (tyrosine kinase non receptor 2) Heterocephalus glaber
Analyze
Symbol: Tnk2
Name: tyrosine kinase non receptor 2
RGD ID: 18905373
Description: ENCODES a protein that exhibits epidermal growth factor receptor binding (ortholog); identical protein binding (ortholog); protein serine/threonine/tyrosine kinase activity (ortholog); INVOLVED IN phosphorylation (ortholog); positive regulation of peptidyl-tyrosine phosphorylation (ortholog); regulation of clathrin-dependent endocytosis (ortholog); ASSOCIATED WITH Autosomal Recessive Infantile Epilepsy (ortholog); chromosome 3q29 microdeletion syndrome (ortholog); developmental and epileptic encephalopathy (ortholog); FOUND IN axon (ortholog); clathrin-coated pit (ortholog); clathrin-coated vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: activated CDC42 kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,236,983 - 61,273,166 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473061,237,653 - 61,272,499 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tnk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,236,983 - 61,273,166 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473061,237,653 - 61,272,499 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TNK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383195,863,364 - 195,908,551 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3195,863,364 - 195,911,945 (-)EnsemblGRCh38hg38GRCh38
GRCh373195,590,235 - 195,635,422 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,074,633 - 197,120,277 (-)NCBINCBI36Build 36hg18NCBI36
Build 343197,078,545 - 197,124,190NCBI
Celera3194,132,138 - 194,176,550 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3192,870,965 - 192,916,101 (-)NCBIHuRef
CHM1_13195,555,272 - 195,606,419 (-)NCBICHM1_1
T2T-CHM13v2.03198,449,491 - 198,494,501 (+)NCBIT2T-CHM13v2.0
Tnk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,462,699 - 32,502,311 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,462,692 - 32,502,311 (+)EnsemblGRCm39 Ensembl
GRCm381632,644,099 - 32,683,493 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,643,874 - 32,683,493 (+)EnsemblGRCm38mm10GRCm38
MGSCv371632,644,729 - 32,683,579 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361632,564,608 - 32,603,240 (+)NCBIMGSCv36mm8
Celera1633,124,376 - 33,163,447 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1623.16NCBI
Tnk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,619,795 - 81,659,074 (-)NCBIGRCr8
mRatBN7.21168,114,725 - 68,154,254 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,114,726 - 68,154,009 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1176,951,794 - 76,991,071 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,615,223 - 69,654,368 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,640,896 - 68,680,174 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,348,726 - 71,388,520 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,348,717 - 71,387,992 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,431,230 - 74,470,437 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,927,509 - 69,966,854 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11169,985,098 - 70,024,443 (-)NCBI
Celera1167,547,447 - 67,587,473 (-)NCBICelera
Cytogenetic Map11q22NCBI
Tnk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,300,572 - 12,338,058 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542012,302,463 - 12,337,976 (-)NCBIChiLan1.0ChiLan1.0
TNK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22193,777,761 - 193,826,414 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13193,782,481 - 193,831,288 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03193,254,017 - 193,302,863 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13203,219,978 - 203,254,498 (-)NCBIpanpan1.1PanPan1.1panPan2
TNK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,153,636 - 29,177,568 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,152,851 - 29,179,718 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3329,178,360 - 29,220,811 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03329,386,486 - 29,428,984 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3329,386,488 - 29,412,066 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13329,171,866 - 29,196,006 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03329,227,984 - 29,270,384 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03329,848,891 - 29,891,309 (-)NCBIUU_Cfam_GSD_1.0
Tnk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602125,200,392 - 125,249,164 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936784636,139 - 685,210 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936784636,105 - 685,080 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13134,101,377 - 134,124,824 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113134,082,266 - 134,124,826 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213143,624,416 - 143,666,696 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11591,187,702 - 91,232,391 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1591,201,008 - 91,232,399 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604165,037,963 - 65,084,349 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013071874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013071878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013071883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013071888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013071898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013071900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013071901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013071902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013071904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013071906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013071911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021254876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021254885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021254890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021254920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021254925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021254926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01002889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000024296   ⟹   ENSHGLP00000024077
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473061,236,983 - 61,273,166 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000024297   ⟹   ENSHGLP00000024078
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473061,239,365 - 61,273,166 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000024298   ⟹   ENSHGLP00000024079
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473061,239,365 - 61,273,166 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000024299   ⟹   ENSHGLP00000024080
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473061,239,365 - 61,253,730 (-)Ensembl
RefSeq Acc Id: XM_013071874   ⟹   XP_012927328
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,237,653 - 61,272,499 (-)NCBI
RefSeq Acc Id: XM_013071878   ⟹   XP_012927332
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,239,365 - 61,272,499 (-)NCBI
RefSeq Acc Id: XM_013071883   ⟹   XP_012927337
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,237,653 - 61,272,499 (-)NCBI
RefSeq Acc Id: XM_013071888   ⟹   XP_012927342
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,237,653 - 61,257,392 (-)NCBI
RefSeq Acc Id: XM_013071898   ⟹   XP_012927352
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,237,653 - 61,272,499 (-)NCBI
RefSeq Acc Id: XM_013071900   ⟹   XP_012927354
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,237,653 - 61,272,499 (-)NCBI
RefSeq Acc Id: XM_013071901   ⟹   XP_012927355
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,239,365 - 61,272,499 (-)NCBI
RefSeq Acc Id: XM_013071902   ⟹   XP_012927356
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,237,653 - 61,257,392 (-)NCBI
RefSeq Acc Id: XM_013071904   ⟹   XP_012927358
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,237,653 - 61,272,499 (-)NCBI
RefSeq Acc Id: XM_013071906   ⟹   XP_012927360
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,237,653 - 61,272,499 (-)NCBI
RefSeq Acc Id: XM_013071911   ⟹   XP_012927365
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,239,365 - 61,257,393 (-)NCBI
RefSeq Acc Id: XM_021254876   ⟹   XP_021110535
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,237,653 - 61,272,499 (-)NCBI
RefSeq Acc Id: XM_021254885   ⟹   XP_021110544
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,237,653 - 61,259,839 (-)NCBI
RefSeq Acc Id: XM_021254890   ⟹   XP_021110549
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,239,365 - 61,272,499 (-)NCBI
RefSeq Acc Id: XM_021254920   ⟹   XP_021110579
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,237,653 - 61,272,499 (-)NCBI
RefSeq Acc Id: XM_021254925   ⟹   XP_021110584
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,237,653 - 61,256,170 (-)NCBI
RefSeq Acc Id: XM_021254926   ⟹   XP_021110585
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473061,239,365 - 61,259,584 (-)NCBI
RefSeq Acc Id: XP_012927358   ⟸   XM_013071904
- Peptide Label: isoform X11
RefSeq Acc Id: XP_012927360   ⟸   XM_013071906
- Peptide Label: isoform X11
RefSeq Acc Id: XP_012927354   ⟸   XM_013071900
- Peptide Label: isoform X8
RefSeq Acc Id: XP_012927352   ⟸   XM_013071898
- Peptide Label: isoform X6
RefSeq Acc Id: XP_012927337   ⟸   XM_013071883
- Peptide Label: isoform X3
RefSeq Acc Id: XP_012927328   ⟸   XM_013071874
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021110579   ⟸   XM_021254920
- Peptide Label: isoform X11
RefSeq Acc Id: XP_021110535   ⟸   XM_021254876
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021110544   ⟸   XM_021254885
- Peptide Label: isoform X5
RefSeq Acc Id: XP_012927356   ⟸   XM_013071902
- Peptide Label: isoform X10
RefSeq Acc Id: XP_012927342   ⟸   XM_013071888
- Peptide Label: isoform X4
RefSeq Acc Id: XP_021110584   ⟸   XM_021254925
- Peptide Label: isoform X11
RefSeq Acc Id: XP_012927355   ⟸   XM_013071901
- Peptide Label: isoform X9
RefSeq Acc Id: XP_021110549   ⟸   XM_021254890
- Peptide Label: isoform X7
RefSeq Acc Id: XP_012927332   ⟸   XM_013071878
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021110585   ⟸   XM_021254926
- Peptide Label: isoform X12
RefSeq Acc Id: XP_012927365   ⟸   XM_013071911
- Peptide Label: isoform X13
Ensembl Acc Id: ENSHGLP00000024077   ⟸   ENSHGLT00000024296
Ensembl Acc Id: ENSHGLP00000024080   ⟸   ENSHGLT00000024299
Ensembl Acc Id: ENSHGLP00000024078   ⟸   ENSHGLT00000024297
Ensembl Acc Id: ENSHGLP00000024079   ⟸   ENSHGLT00000024298


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017162 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000024297 ENTREZGENE
  ENSHGLT00000024298 ENTREZGENE
NCBI Gene Tnk2 ENTREZGENE
UniProt A0AAX6QSF8_HETGA UniProtKB/TrEMBL
  A0AAX6QTW5_HETGA UniProtKB/TrEMBL
  A0AAX6QU80_HETGA UniProtKB/TrEMBL
  A0AAX6QV46_HETGA UniProtKB/TrEMBL
  A0AAX6QW16_HETGA UniProtKB/TrEMBL
  A0AAX6QWB7_HETGA UniProtKB/TrEMBL
  A0AAX6QWC4_HETGA UniProtKB/TrEMBL
  A0AAX6QX78_HETGA UniProtKB/TrEMBL
  A0AAX6QY01_HETGA UniProtKB/TrEMBL
  A0AAX6SMU6_HETGA UniProtKB/TrEMBL
  A0AAX6SP08_HETGA UniProtKB/TrEMBL
  A0AAX6SPR0_HETGA UniProtKB/TrEMBL
  A0AAX6SQC3_HETGA UniProtKB/TrEMBL