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Gene: TNK2 (tyrosine kinase non receptor 2) Homo sapiens
Symbol: TNK2
Name: tyrosine kinase non receptor 2
RGD ID: 1346409
Description: Exhibits several functions, including epidermal growth factor receptor binding activity; protein kinase activity; and ubiquitin protein ligase binding activity. Involved in phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of clathrin-dependent endocytosis. Localizes to several cellular components, including Grb2-EGFR complex; clathrin-coated pit; and cytoophidium.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACK; ACK-1; ACK1; activated CDC42 kinase 1; activated Cdc42-associated kinase 1; activated p21cdc42Hs kinase; FLJ44758; FLJ45547; p21cdc42Hs; tyrosine kinase non-receptor protein 2; tyrosine kinase, non-receptor, 2
Mus musculus (house mouse) : Tnk2 (tyrosine kinase, non-receptor, 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tnk2 (tyrosine kinase, non-receptor, 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnk2 (tyrosine kinase non receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TNK2 (tyrosine kinase non receptor 2)
Canis lupus familiaris (dog) : TNK2 (tyrosine kinase non receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnk2 (tyrosine kinase non receptor 2)
Sus scrofa (pig) : TNK2 (tyrosine kinase non receptor 2)
Chlorocebus sabaeus (African green monkey) : TNK2 (tyrosine kinase non receptor 2)
Heterocephalus glaber (naked mole-rat) : Tnk2 (tyrosine kinase non receptor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl3195,863,364 - 195,911,945 (-)EnsemblGRCh38hg38GRCh38
GRCh383195,863,364 - 195,908,551 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373195,590,235 - 195,635,880 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,074,633 - 197,120,277 (-)NCBINCBI36hg18NCBI36
Build 343197,078,545 - 197,124,190NCBI
Celera3194,132,138 - 194,176,550 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3192,870,965 - 192,916,101 (-)NCBIHuRef
CHM1_13195,555,271 - 195,606,419 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TNK2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346409
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.