Muc4 (mucin 4, cell surface associated) - Rat Genome Database

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Gene: Muc4 (mucin 4, cell surface associated) Rattus norvegicus
Analyze
Symbol: Muc4
Name: mucin 4, cell surface associated
RGD ID: 621331
Description: Enables ErbB-2 class receptor binding activity. Involved in several processes, including estrous cycle; negative regulation of T cell mediated cytotoxicity directed against tumor cell target; and negative regulation of cell adhesion. Located in apical plasma membrane; extracellular space; and microvillus membrane. Part of protein-containing complex. Biomarker of cholangiocarcinoma; corneal neovascularization; mucositis; and otitis media. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human MUC4 (mucin 4, cell surface associated); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ascites sialoglycoprotein; ASGP; ASGP-1; MUC-4; mucin 4; mucin-4; pancreatic adenocarcinoma mucin; pre-sialomucin complex; Psmc; sialomucin ascites sialoglycoprotein-1; sialomucin complex; testis mucin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,513,321 - 81,575,200 (-)NCBIGRCr8
mRatBN7.21168,008,245 - 68,053,242 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.01171,242,973 - 71,285,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,243,334 - 71,284,939 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,327,777 - 74,369,829 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,830,276 - 69,858,366 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11169,887,864 - 69,915,763 (-)NCBI
Celera1167,453,205 - 67,496,554 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance. Andrianifahanana M, etal., Clin Cancer Res. 2001 Dec;7(12):4033-40.
2. Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines. Balague C, etal., Gastroenterology. 1994 Apr;106(4):1054-61.
3. Effect of tunicamycin on sialomucin and natural killer susceptibility of rat mammary tumor ascites cells. Bharathan S, etal., Cancer Res. 1990 Sep 1;50(17):5250-6.
4. An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling. Carraway KL 3rd, etal., J Biol Chem. 1999 Feb 26;274(9):5263-6.
5. ErbB2 and its ligand Muc4 (sialomucin complex) in rat lacrimal gland. Carraway KL, etal., Adv Exp Med Biol. 2002;506(Pt A):289-95.
6. MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins. Chaturvedi P, etal., Mol Cancer Res. 2007 Apr;5(4):309-20. Epub 2007 Apr 3.
7. Alterations of the ocular surface epithelial mucins 1, 2, 4 and the tear functions in patients with atopic keratoconjunctivitis. Dogru M, etal., Clin Exp Allergy. 2006 Dec;36(12):1556-65.
8. Leptin modulates the expression of secreted and membrane-associated mucins in colonic epithelial cells by targeting PKC, PI3K, and MAPK pathways. El Homsi M, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G365-73. Epub 2007 May 10.
9. Intrauterine growth restriction alters postnatal colonic barrier maturation in rats. Fanca-Berthon P, etal., Pediatr Res. 2009 Jul;66(1):47-52. doi: 10.1203/PDR.0b013e3181a2047e.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Analysis of MUC4 mucin expression in lung carcinoma cells and its immunogenicity. Hanaoka J, etal., Cancer. 2001 Oct 15;92(8):2148-57.
13. Changes in the mucosal barrier during acute and chronic Trichuris muris infection. Hasnain SZ, etal., Parasite Immunol. 2011 Jan;33(1):45-55. doi: 10.1111/j.1365-3024.2010.01258.x.
14. Sialomucin complex (rMuc4) expression during development of the rat cornea. Hu Y, etal., Curr Eye Res. 2000 Oct;21(4):820-3.
15. Mechanism of concanavalin A-induced anchorage of the major cell surface glycoproteins to the submembrane cytoskeleton in 13762 ascites mammary adenocarcinoma cells. Jung G, etal., J Cell Biol. 1984 Jan;98(1):179-87.
16. The expression of MUC4 and MUC5AC is related to the biologic malignancy of intraductal papillary mucinous neoplasms of the pancreas. Kanno A, etal., Pancreas. 2006 Nov;33(4):391-6.
17. Synthesis and secretion of Muc4/sialomucin complex: implication of intracellular proteolysis. Komatsu M, etal., Biochem J. 2002 Nov 15;368(Pt 1):41-8.
18. Overexpression of sialomucin complex, a rat homologue of MUC4, inhibits tumor killing by lymphokine-activated killer cells. Komatsu M, etal., Cancer Res. 1999 May 1;59(9):2229-36.
19. Potentiation of metastasis by cell surface sialomucin complex (rat MUC4), a multifunctional anti-adhesive glycoprotein. Komatsu M, etal., Int J Cancer. 2000 Aug 15;87(4):480-6.
20. Reversible disruption of cell-matrix and cell-cell interactions by overexpression of sialomucin complex. Komatsu M, etal., J Biol Chem. 1997 Dec 26;272(52):33245-54.
21. Alteration in goblet cell numbers and mucin gene expression in a mouse model of allergic conjunctivitis. Kunert KS, etal., Invest Ophthalmol Vis Sci. 2001 Oct;42(11):2483-9.
22. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae Li XH, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005 Oct;27(5):624-7.
23. Expression of mucins in mucoid otitis media. Lin J, etal., J Assoc Res Otolaryngol. 2003 Sep;4(3):384-93.
24. Regulation of the membrane mucin Muc4 in corneal epithelial cells by proteosomal degradation and TGF-beta. Lomako J, etal., J Cell Physiol. 2010 Apr;223(1):209-14.
25. MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer. Matull WR, etal., Br J Cancer. 2008 May 20;98(10):1675-81. Epub 2008 May 13.
26. Characterization of the expression and steroid hormone control of sialomucin complex in the rat uterus: implications for uterine receptivity. McNeer RR, etal., J Cell Physiol. 1998 Jul;176(1):110-9.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. MUC4 down-regulation reverses chemoresistance of pancreatic cancer stem/progenitor cells and their progenies. Mimeault M, etal., Cancer Lett. 2010 Mar 18.
29. MUC4 interacts with ErbB2 in human gallbladder carcinoma: potential pathobiological implications. Miyahara N, etal., Eur J Cancer. 2008 May;44(7):1048-56. Epub 2008 Apr 7.
30. Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells. Moniaux N, etal., Br J Cancer. 2007 Aug 6;97(3):345-57. Epub 2007 Jun 26.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. Aberrant expression of MUC3 and MUC4 membrane-associated mucins and sialyl Le(x) antigen in pancreatic intraepithelial neoplasia. Park HU, etal., Pancreas. 2003 Apr;26(3):e48-54.
33. Post-transcriptional regulation of a milk membrane protein, the sialomucin complex (Ascites sialoglycoprotein (ASGP)-1/ASGP-2, rat muc4), by transforming growth factor beta. Price-Schiavi SA, etal., J Biol Chem. 1998 Dec 25;273(52):35228-37.
34. Expression, location, and interactions of ErbB2 and its intramembrane ligand Muc4 (sialomucin complex) in rat mammary gland during pregnancy. Price-Schiavi SA, etal., J Cell Physiol. 2005 Apr;203(1):44-53.
35. GOA pipeline RGD automated data pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Expression and localization of Muc4/sialomucin complex (SMC) in the adult and developing rat intestine: implications for Muc4/SMC function. Rong M, etal., J Cell Physiol. 2005 Jan;202(1):275-84.
39. MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. Saitou M, etal., J Clin Pathol. 2005 Aug;58(8):845-52.
40. Molecular cloning of the transmembrane component of the 13762 mammary adenocarcinoma sialomucin complex. A new member of the epidermal growth factor superfamily. Sheng Z, etal., J Biol Chem 1992 Aug 15;267(23):16341-6.
41. Topography and microfilament core association of a cell surface glycoprotein of ascites tumor cell microvilli. Sheng Z, etal., J Cell Biochem. 1989 Aug;40(4):453-66.
42. MUC4 is a novel prognostic factor of intrahepatic cholangiocarcinoma-mass forming type. Shibahara H, etal., Hepatology. 2004 Jan;39(1):220-9.
43. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Song XJ, etal., Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4223-9.
44. SMAD2 and SMAD7 involvement in the post-translational regulation of Muc4 via the transforming growth factor-beta and interferon-gamma pathways in rat mammary epithelial cells. Soto P, etal., J Biol Chem. 2003 May 30;278(22):20338-44. Epub 2003 Mar 31.
45. Irinotecan-induced mucositis is associated with changes in intestinal mucins. Stringer AM, etal., Cancer Chemother Pharmacol. 2008 Nov 8.
46. MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma. Tamada S, etal., Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4257-64.
47. Vitamin A deficiency alters the expression of mucin genes by the rat ocular surface epithelium. Tei M, etal., Invest Ophthalmol Vis Sci. 2000 Jan;41(1):82-8.
48. Downregulation of mucins in graft bile ducts after liver transplantation in rats. Tian F, etal., Transplantation. 2011 Sep 15;92(5):529-35. doi: 10.1097/TP.0b013e318229f785.
49. Pattern changes of mucin gene expression with pneumococcal otitis media. Tsuboi Y, etal., Int J Pediatr Otorhinolaryngol. 2001 Oct 19;61(1):23-30.
50. MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma. Tsutsumida H, etal., Lung Cancer. 2007 Feb;55(2):195-203. Epub 2006 Nov 28.
51. Humoral immune response to polymorphic epithelial mucin (MUC-1) in patients with benign and malignant breast tumours. von Mensdorff-Pouilly S, etal., Eur J Cancer. 1996 Jul;32A(8):1325-31.
52. Expression of MUC2 and MUC4 proteins and cytokines: early markers of intestinal graft rejection. Wasserberg N, etal., Transplantation. 2003 Apr 27;75(8):1249-55.
53. The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanisms. Workman HC, etal., Cancer Res. 2009 Apr 1;69(7):2845-52. doi: 10.1158/0008-5472.CAN-08-2089. Epub 2009 Mar 17.
54. Molecular cloning and sequencing of the mucin subunit of a heterodimeric, bifunctional cell surface glycoprotein complex of ascites rat mammary adenocarcinoma cells. Wu K, etal., J Biol Chem 1994 Apr 22;269(16):11950-5.
55. Altered expression of goblet cell- and mucin glycosylation-related genes in the intestinal epithelium during infection with the nematode Nippostrongylus brasiliensis in rat. Yamauchi J, etal., APMIS. 2006 Apr;114(4):270-8.
56. Prognostic value of MUC4 for mass-forming intrahepatic cholangiocarcinoma after hepatectomy. Yeh CN, etal., Oncol Rep. 2009 Jan;21(1):49-56.
57. Muc4 expression during blood vessel formation in damaged rat cornea. Zhang J, etal., Curr Eye Res. 2006 Dec;31(12):1011-4.
58. Extracellular regulated kinase (ERK)-dependent regulation of sialomucin complex/rat Muc4 in mammary epithelial cells. Zhu X, etal., Oncogene. 2000 Sep 7;19(38):4354-61.
Additional References at PubMed
PMID:10880365   PMID:12855694   PMID:15389535   PMID:15672420   PMID:16502470   PMID:17058067   PMID:19190083   PMID:19199708   PMID:19388004   PMID:23533145   PMID:24029230  


Genomics

Comparative Map Data
Muc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,513,321 - 81,575,200 (-)NCBIGRCr8
mRatBN7.21168,008,245 - 68,053,242 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.01171,242,973 - 71,285,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,243,334 - 71,284,939 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,327,777 - 74,369,829 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,830,276 - 69,858,366 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11169,887,864 - 69,915,763 (-)NCBI
Celera1167,453,205 - 67,496,554 (-)NCBICelera
Cytogenetic Map11q22NCBI
MUC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383195,746,771 - 195,811,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3195,746,765 - 195,811,973 (-)EnsemblGRCh38hg38GRCh38
GRCh373195,473,642 - 195,538,800 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363196,959,307 - 197,023,545 (-)NCBINCBI36Build 36hg18NCBI36
Build 343196,963,223 - 197,027,458NCBI
Celera3194,080,875 - 194,081,499 (-)NCBICelera
Celera3193,972,388 - 193,997,732 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3192,745,384 - 192,818,773 (-)NCBIHuRef
CHM1_13195,437,353 - 195,503,105 (-)NCBICHM1_1
T2T-CHM13v2.03198,546,126 - 198,620,098 (+)NCBIT2T-CHM13v2.0
Muc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,555,089 - 32,602,786 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,555,015 - 32,602,754 (+)EnsemblGRCm39 Ensembl
GRCm381632,735,886 - 32,782,391 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,735,886 - 32,782,391 (+)EnsemblGRCm38mm10GRCm38
MGSCv371632,735,972 - 32,782,477 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361632,656,022 - 32,701,973 (+)NCBIMGSCv36mm8
MGSCv361632,523,826 - 32,570,033 (+)NCBIMGSCv36mm8
Celera1633,215,985 - 33,261,178 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1623.3NCBI
Muc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542012,228,801 - 12,274,840 (-)NCBIChiLan1.0ChiLan1.0
MUC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22193,640,920 - 193,716,442 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13193,650,060 - 193,721,162 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03193,050,895 - 193,114,931 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MUC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,061,372 - 29,084,938 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,063,096 - 29,111,802 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3329,083,815 - 29,104,441 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03329,293,733 - 29,314,431 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13329,089,904 - 29,114,815 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03329,135,982 - 29,160,346 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03329,756,115 - 29,781,034 (-)NCBIUU_Cfam_GSD_1.0
Muc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602125,345,354 - 125,369,724 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936784515,608 - 539,915 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113134,192,412 - 134,248,435 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213143,786,443 - 143,842,402 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q41NCBI
LOC103242066
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11591,313,060 - 91,345,172 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604165,216,381 - 65,283,540 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Muc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473061,153,753 - 61,176,859 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Muc4
561 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:219
Count of miRNA genes:151
Interacting mature miRNAs:166
Transcripts:ENSRNOT00000002421
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat

Markers in Region
Muc4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,008,633 - 68,009,770 (+)MAPPERmRatBN7.2
Rnor_6.01171,243,362 - 71,244,498NCBIRnor6.0
Rnor_5.01174,328,166 - 74,329,302UniSTSRnor5.0
RGSC_v3.41169,830,665 - 69,831,801UniSTSRGSC3.4
Celera1167,453,594 - 67,454,730UniSTS
Cytogenetic Map11q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 3 31 44 46 47 17 25 17 5 144 70 27 45 57 30

Sequence


Ensembl Acc Id: ENSRNOT00000002421   ⟹   ENSRNOP00000002421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1171,243,334 - 71,284,939 (-)Ensembl
RefSeq Acc Id: NM_001419613   ⟹   NP_001406542
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,513,321 - 81,558,314 (-)NCBI
mRatBN7.21168,008,245 - 68,053,242 (-)NCBI
RefSeq Acc Id: XM_063270513   ⟹   XP_063126583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,513,321 - 81,575,197 (-)NCBI
RefSeq Acc Id: XM_063270514   ⟹   XP_063126584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,533,075 - 81,575,200 (-)NCBI
Ensembl Acc Id: ENSRNOP00000002421   ⟸   ENSRNOT00000002421
RefSeq Acc Id: NP_001406542   ⟸   NM_001419613
- Peptide Label: precursor
RefSeq Acc Id: XP_063126583   ⟸   XM_063270513
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063126584   ⟸   XM_063270514
- Peptide Label: isoform X2
Protein Domains
AMOP   EGF-like   NIDO   VWFD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63661-F1-model_v2 AlphaFold Q63661 1-2344 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621331 AgrOrtholog
BioCyc Gene G2FUF-21113 BioCyc
Ensembl Genes ENSRNOG00000001777 Ensembl
  ENSRNOG00000089703 ENTREZGENE
Ensembl Transcript ENSRNOT00000135954 ENTREZGENE
InterPro AMOP_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Epithelial_Barrier/Signaling UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NIDO_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_type-D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Muc4 ENTREZGENE
PANTHER MUCIN 4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MUCIN-4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NIDO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Muc4 PhenoGen
PROSITE AMOP UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NIDO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001777 RatGTEx
SMART AMOP UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NIDO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IRP3_RAT UniProtKB/TrEMBL
  MUC4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q63655 UniProtKB/Swiss-Prot
  Q63657 UniProtKB/Swiss-Prot
  Q63659 UniProtKB/Swiss-Prot
  Q9JIC4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-08-29 Muc4  mucin 4, cell surface associated  Muc4  mucin 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Muc4  mucin 4      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Muc4  mucin 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a hydrophobic transmembrane domain, a short COOH-terminal cytoplasmic tail, and a large extracellular domain with 24 potential N-glycosylation sites 633414
gene_protein 2172 amino acids 633413
gene_protein sialomucin complex is synthesized as a high M(r) precursor, pre-sialomucin complex (pSMC-1) 633414