Muc4 (mucin 4, cell surface associated) - Rat Genome Database

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Gene: Muc4 (mucin 4, cell surface associated) Rattus norvegicus
Analyze
Symbol: Muc4
Name: mucin 4, cell surface associated
RGD ID: 621331
Description: Enables ErbB-2 class receptor binding activity. Involved in several processes, including estrous cycle; negative regulation of T cell mediated cytotoxicity directed against tumor cell target; and negative regulation of cell adhesion. Located in several cellular components, including apical plasma membrane; extracellular space; and microvillus membrane. Part of protein-containing complex. Colocalizes with endoplasmic reticulum. Biomarker of cholangiocarcinoma; corneal neovascularization; mucositis; and otitis media. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human MUC4 (mucin 4, cell surface associated); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ascites sialoglycoprotein; ASGP; ASGP-1; MUC-4; mucin 4; mucin-4; pancreatic adenocarcinoma mucin; pre-sialomucin complex; Psmc; sialomucin ascites sialoglycoprotein-1; sialomucin complex; testis mucin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21168,008,245 - 68,053,229 (-)NCBImRatBN7.2
Rnor_6.01171,242,973 - 71,285,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,243,334 - 71,284,939 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,327,777 - 74,369,829 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,830,276 - 69,858,366 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11169,887,864 - 69,915,763 (-)NCBI
Celera1167,453,205 - 67,496,554 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
1. Andrianifahanana M, etal., Clin Cancer Res. 2001 Dec;7(12):4033-40.
2. Balague C, etal., Gastroenterology. 1994 Apr;106(4):1054-61.
3. Bharathan S, etal., Cancer Res. 1990 Sep 1;50(17):5250-6.
4. Carraway KL 3rd, etal., J Biol Chem. 1999 Feb 26;274(9):5263-6.
5. Carraway KL, etal., Adv Exp Med Biol. 2002;506(Pt A):289-95.
6. Chaturvedi P, etal., Mol Cancer Res. 2007 Apr;5(4):309-20. Epub 2007 Apr 3.
7. Dogru M, etal., Clin Exp Allergy. 2006 Dec;36(12):1556-65.
8. El Homsi M, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G365-73. Epub 2007 May 10.
9. Fanca-Berthon P, etal., Pediatr Res. 2009 Jul;66(1):47-52. doi: 10.1203/PDR.0b013e3181a2047e.
10. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. GOA data from the GO Consortium
12. Hanaoka J, etal., Cancer. 2001 Oct 15;92(8):2148-57.
13. Hasnain SZ, etal., Parasite Immunol. 2011 Jan;33(1):45-55. doi: 10.1111/j.1365-3024.2010.01258.x.
14. Hu Y, etal., Curr Eye Res. 2000 Oct;21(4):820-3.
15. Jung G, etal., J Cell Biol. 1984 Jan;98(1):179-87.
16. Kanno A, etal., Pancreas. 2006 Nov;33(4):391-6.
17. Komatsu M, etal., Biochem J. 2002 Nov 15;368(Pt 1):41-8.
18. Komatsu M, etal., Cancer Res. 1999 May 1;59(9):2229-36.
19. Komatsu M, etal., Int J Cancer. 2000 Aug 15;87(4):480-6.
20. Komatsu M, etal., J Biol Chem. 1997 Dec 26;272(52):33245-54.
21. Kunert KS, etal., Invest Ophthalmol Vis Sci. 2001 Oct;42(11):2483-9.
22. Li XH, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005 Oct;27(5):624-7.
23. Lin J, etal., J Assoc Res Otolaryngol. 2003 Sep;4(3):384-93.
24. Lomako J, etal., J Cell Physiol. 2010 Apr;223(1):209-14.
25. Matull WR, etal., Br J Cancer. 2008 May 20;98(10):1675-81. Epub 2008 May 13.
26. McNeer RR, etal., J Cell Physiol. 1998 Jul;176(1):110-9.
27. MGD data from the GO Consortium
28. Mimeault M, etal., Cancer Lett. 2010 Mar 18.
29. Miyahara N, etal., Eur J Cancer. 2008 May;44(7):1048-56. Epub 2008 Apr 7.
30. Moniaux N, etal., Br J Cancer. 2007 Aug 6;97(3):345-57. Epub 2007 Jun 26.
31. NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. Park HU, etal., Pancreas. 2003 Apr;26(3):e48-54.
33. Price-Schiavi SA, etal., J Biol Chem. 1998 Dec 25;273(52):35228-37.
34. Price-Schiavi SA, etal., J Cell Physiol. 2005 Apr;203(1):44-53.
35. RGD automated data pipeline
36. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. RGD automated import pipeline for gene-chemical interactions
38. Rong M, etal., J Cell Physiol. 2005 Jan;202(1):275-84.
39. Saitou M, etal., J Clin Pathol. 2005 Aug;58(8):845-52.
40. Sheng Z, etal., J Biol Chem 1992 Aug 15;267(23):16341-6.
41. Sheng Z, etal., J Cell Biochem. 1989 Aug;40(4):453-66.
42. Shibahara H, etal., Hepatology. 2004 Jan;39(1):220-9.
43. Song XJ, etal., Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4223-9.
44. Soto P, etal., J Biol Chem. 2003 May 30;278(22):20338-44. Epub 2003 Mar 31.
45. Stringer AM, etal., Cancer Chemother Pharmacol. 2008 Nov 8.
46. Tamada S, etal., Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4257-64.
47. Tei M, etal., Invest Ophthalmol Vis Sci. 2000 Jan;41(1):82-8.
48. Tian F, etal., Transplantation. 2011 Sep 15;92(5):529-35. doi: 10.1097/TP.0b013e318229f785.
49. Tsuboi Y, etal., Int J Pediatr Otorhinolaryngol. 2001 Oct 19;61(1):23-30.
50. Tsutsumida H, etal., Lung Cancer. 2007 Feb;55(2):195-203. Epub 2006 Nov 28.
51. von Mensdorff-Pouilly S, etal., Eur J Cancer. 1996 Jul;32A(8):1325-31.
52. Wasserberg N, etal., Transplantation. 2003 Apr 27;75(8):1249-55.
53. Workman HC, etal., Cancer Res. 2009 Apr 1;69(7):2845-52. doi: 10.1158/0008-5472.CAN-08-2089. Epub 2009 Mar 17.
54. Wu K, etal., J Biol Chem 1994 Apr 22;269(16):11950-5.
55. Yamauchi J, etal., APMIS. 2006 Apr;114(4):270-8.
56. Yeh CN, etal., Oncol Rep. 2009 Jan;21(1):49-56.
57. Zhang J, etal., Curr Eye Res. 2006 Dec;31(12):1011-4.
58. Zhu X, etal., Oncogene. 2000 Sep 7;19(38):4354-61.
Additional References at PubMed
PMID:10880365   PMID:12855694   PMID:15389535   PMID:15672420   PMID:16502470   PMID:17058067   PMID:19190083   PMID:19199708   PMID:19388004   PMID:23533145   PMID:24029230   PMID:29843125  


Genomics

Comparative Map Data
Muc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21168,008,245 - 68,053,229 (-)NCBImRatBN7.2
Rnor_6.01171,242,973 - 71,285,217 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,243,334 - 71,284,939 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,327,777 - 74,369,829 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,830,276 - 69,858,366 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11169,887,864 - 69,915,763 (-)NCBI
Celera1167,453,205 - 67,496,554 (-)NCBICelera
Cytogenetic Map11q22NCBI
MUC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383195,746,771 - 195,811,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3195,746,765 - 195,811,973 (-)EnsemblGRCh38hg38GRCh38
GRCh373195,473,642 - 195,538,800 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363196,959,307 - 197,023,545 (-)NCBINCBI36hg18NCBI36
Build 343196,963,223 - 197,027,458NCBI
Celera3194,080,875 - 194,081,499 (-)NCBI
Celera3193,972,388 - 193,997,732 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3192,745,384 - 192,818,773 (-)NCBIHuRef
CHM1_13195,437,353 - 195,503,105 (-)NCBICHM1_1
T2T-CHM13v2.03198,546,126 - 198,620,098 (+)NCBI
Muc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,555,089 - 32,602,761 (+)NCBIGRCm39mm39
GRCm39 Ensembl1632,555,015 - 32,602,754 (+)Ensembl
GRCm381632,735,886 - 32,782,391 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,735,886 - 32,782,391 (+)EnsemblGRCm38mm10GRCm38
MGSCv371632,735,972 - 32,782,477 (+)NCBIGRCm37mm9NCBIm37
MGSCv361632,656,022 - 32,701,973 (+)NCBImm8
MGSCv361632,523,826 - 32,570,033 (+)NCBImm8
Celera1633,215,985 - 33,261,178 (+)NCBICelera
Cytogenetic Map16B3NCBI
Muc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542012,228,801 - 12,274,840 (-)NCBIChiLan1.0ChiLan1.0
MUC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v03193,050,895 - 193,114,931 (-)NCBIMhudiblu_PPA_v0panPan3
MUC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,061,372 - 29,084,938 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,063,096 - 29,111,802 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3329,083,815 - 29,104,441 (-)NCBI
ROS_Cfam_1.03329,293,733 - 29,314,431 (-)NCBI
UMICH_Zoey_3.13329,089,904 - 29,114,815 (-)NCBI
UNSW_CanFamBas_1.03329,135,982 - 29,160,346 (-)NCBI
UU_Cfam_GSD_1.03329,756,115 - 29,781,034 (-)NCBI
Muc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602125,345,354 - 125,369,724 (+)NCBI
SpeTri2.0NW_004936784515,608 - 539,915 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113134,192,412 - 134,248,435 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213143,786,443 - 143,842,402 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q41NCBI
LOC103242066
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11591,313,060 - 91,345,172 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604165,216,381 - 65,283,540 (+)NCBIVero_WHO_p1.0
Muc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473061,153,753 - 61,176,859 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Muc4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,008,633 - 68,009,770 (+)MAPPERmRatBN7.2
Rnor_6.01171,243,362 - 71,244,498NCBIRnor6.0
Rnor_5.01174,328,166 - 74,329,302UniSTSRnor5.0
RGSC_v3.41169,830,665 - 69,831,801UniSTSRGSC3.4
Celera1167,453,594 - 67,454,730UniSTS
Cytogenetic Map11q22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:219
Count of miRNA genes:151
Interacting mature miRNAs:166
Transcripts:ENSRNOT00000002421
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 7
Low 2 12 8 3 2 11 12 3
Below cutoff 14 12 6 16 6 3 3 12 24 19 8 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002421   ⟹   ENSRNOP00000002421
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1171,243,334 - 71,284,939 (-)Ensembl
RefSeq Acc Id: XM_039088927   ⟹   XP_038944855
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,008,245 - 68,053,229 (-)NCBI
Reference Sequences
RefSeq Acc Id: ENSRNOP00000002421   ⟸   ENSRNOT00000002421
RefSeq Acc Id: XP_038944855   ⟸   XM_039088927
Protein Domains
EGF-like   NIDO   VWFD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63661-F1-model_v2 AlphaFold Q63661 1-2344 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621331 AgrOrtholog
BioCyc Gene G2FUF-21113 BioCyc
Ensembl Genes ENSRNOG00000001777 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002421 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002421 UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NIDO_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_type-D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 303887 ENTREZGENE
Pfam NIDO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Muc4 PhenoGen
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NIDO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NIDO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1M7W8_RAT UniProtKB/TrEMBL
  MUC4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q63655 UniProtKB/Swiss-Prot
  Q63657 UniProtKB/Swiss-Prot
  Q63659 UniProtKB/Swiss-Prot
  Q9JIC4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-08-29 Muc4  mucin 4, cell surface associated  Muc4  mucin 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Muc4  mucin 4      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Muc4  mucin 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a hydrophobic transmembrane domain, a short COOH-terminal cytoplasmic tail, and a large extracellular domain with 24 potential N-glycosylation sites 633414
gene_protein 2172 amino acids 633413
gene_protein sialomucin complex is synthesized as a high M(r) precursor, pre-sialomucin complex (pSMC-1) 633414