Txnrd2 (thioredoxin reductase 2) - Rat Genome Database

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Gene: Txnrd2 (thioredoxin reductase 2) Rattus norvegicus
Analyze
Symbol: Txnrd2
Name: thioredoxin reductase 2
RGD ID: 61960
Description: Exhibits protein homodimerization activity and thioredoxin-disulfide reductase activity. Involved in response to drug; response to hyperoxia; and response to selenium ion. Localizes to several cellular components, including dendrite; mitochondrion; and neuronal cell body. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human TXNRD2 (thioredoxin reductase 2); PARTICIPATES IN pyrimidine metabolic pathway; selenoamino acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC93435; thioredoxin reductase 2, mitochondrial; thioredoxin reductase TR3; Tr3; Trxr2; Trxrd2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,519,996 - 82,568,156 (-)NCBI
Rnor_6.0 Ensembl1186,667,997 - 86,716,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01186,667,994 - 86,716,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01189,762,304 - 89,809,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,513,361 - 84,561,673 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11184,553,962 - 84,602,292 (-)NCBI
Celera1181,297,140 - 81,345,203 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(E)-cinnamyl alcohol  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
aristolochic acid  (ISO)
auranofin  (EXP,ISO)
Aurothioglucose  (ISO)
avobenzone  (ISO)
Bandrowski's base  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
cadmium sulfide  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dithionitrobenzoic acid  (ISO)
elemental selenium  (EXP,ISO)
eugenol  (ISO)
finasteride  (EXP)
folpet  (ISO)
furan  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
isoeugenol  (ISO)
isoniazide  (ISO)
juglone  (ISO)
L-ascorbic acid  (EXP)
lipoamide  (ISO)
lipopolysaccharide  (ISO)
liquiritigenin  (EXP)
liquiritin  (EXP)
mechlorethamine  (ISO)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
metam  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylene blue  (ISO)
methylmercury chloride  (ISO)
monocrotaline  (EXP)
N,N-diethyl-m-toluamide  (EXP)
nickel sulfate  (ISO)
obeticholic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
potassium tellurite  (ISO)
propiconazole  (EXP)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
selenic acid  (ISO)
selenium atom  (EXP,ISO)
selenomethionine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
sodium aurothiomalate  (EXP)
sodium dichromate  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thallium  (EXP)
trans-isoeugenol  (ISO)
triclosan  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
wogonin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
cytoplasm  (IBA,IDA)
cytosol  (IEA,ISO)
dendrite  (IDA)
intracellular membrane-bounded organelle  (ISO)
mitochondrion  (IBA,IDA,IEA,ISO)
neuronal cell body  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10215850   PMID:10721726   PMID:11060283   PMID:12477932   PMID:15485910   PMID:15489334   PMID:16774913   PMID:17291446   PMID:17707404   PMID:18775783   PMID:20126492   PMID:23226354  
PMID:23613536   PMID:24601690   PMID:25055978   PMID:26674287  


Genomics

Comparative Map Data
Txnrd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,519,996 - 82,568,156 (-)NCBI
Rnor_6.0 Ensembl1186,667,997 - 86,716,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01186,667,994 - 86,716,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01189,762,304 - 89,809,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,513,361 - 84,561,673 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11184,553,962 - 84,602,292 (-)NCBI
Celera1181,297,140 - 81,345,203 (-)NCBICelera
Cytogenetic Map11q23NCBI
TXNRD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2219,875,517 - 19,941,820 (-)EnsemblGRCh38hg38GRCh38
GRCh382219,875,522 - 19,941,818 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372219,863,045 - 19,929,341 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,243,040 - 18,309,359 (-)NCBINCBI36hg18NCBI36
Celera223,715,110 - 3,780,635 (-)NCBI
Cytogenetic Map22q11.21NCBI
HuRef223,482,976 - 3,549,921 (-)NCBIHuRef
CHM1_12219,862,754 - 19,929,123 (-)NCBICHM1_1
Txnrd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,245,167 - 18,297,823 (+)NCBIGRCm39mm39
GRCm39 Ensembl1618,245,134 - 18,297,823 (+)Ensembl
GRCm381618,426,417 - 18,479,073 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,426,384 - 18,479,073 (+)EnsemblGRCm38mm10GRCm38
MGSCv371618,426,510 - 18,479,166 (+)NCBIGRCm37mm9NCBIm37
MGSCv361618,339,980 - 18,392,633 (+)NCBImm8
Celera1619,000,768 - 19,053,648 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.41NCBI
Txnrd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544218,152,152 - 18,204,327 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544218,150,060 - 18,205,775 (+)NCBIChiLan1.0ChiLan1.0
TXNRD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12218,310,134 - 18,375,681 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2218,311,714 - 18,375,497 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0222,636,703 - 2,704,082 (-)NCBIMhudiblu_PPA_v0panPan3
TXNRD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,381,823 - 29,430,239 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,381,975 - 29,430,206 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,338,309 - 29,387,889 (+)NCBI
ROS_Cfam_1.02630,783,348 - 30,833,188 (+)NCBI
UMICH_Zoey_3.12628,831,592 - 28,881,196 (+)NCBI
UNSW_CanFamBas_1.02628,456,722 - 28,506,335 (+)NCBI
UU_Cfam_GSD_1.02629,542,394 - 29,592,091 (+)NCBI
Txnrd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118138,906,728 - 138,964,122 (+)NCBI
SpeTri2.0NW_0049366193,789,940 - 3,847,286 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNRD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,354,178 - 51,385,353 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,355,731 - 51,385,096 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,992,386 - 55,021,751 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TXNRD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,803,178 - 5,868,224 (+)NCBI
ChlSab1.1 Ensembl195,813,099 - 5,866,674 (+)Ensembl
Vero_WHO_p1.0NW_0236660851,062,817 - 1,128,610 (-)NCBI
Txnrd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624747485,012 - 569,175 (-)NCBI

Position Markers
D11Mgh1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,566,553 - 82,566,702 (+)MAPPER
Rnor_6.01186,714,483 - 86,714,631NCBIRnor6.0
Rnor_5.01189,808,355 - 89,808,503UniSTSRnor5.0
RGSC_v3.41184,560,092 - 84,560,241RGDRGSC3.4
RGSC_v3.41184,560,093 - 84,560,241UniSTSRGSC3.4
RGSC_v3.11184,600,689 - 84,600,838RGD
Celera1181,343,623 - 81,343,771UniSTS
SHRSP x BN Map1138.1899UniSTS
SHRSP x BN Map1138.1899RGD
FHH x ACI Map1157.2499RGD
Cytogenetic Map11q23UniSTS
D11Wox6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,566,545 - 82,566,718 (+)MAPPER
Rnor_6.01186,714,475 - 86,714,647NCBIRnor6.0
Rnor_5.01189,808,347 - 89,808,519UniSTSRnor5.0
RGSC_v3.41184,560,085 - 84,560,257UniSTSRGSC3.4
Celera1181,343,615 - 81,343,787UniSTS
Cytogenetic Map11q23UniSTS
RH128918  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,520,015 - 82,520,197 (+)MAPPER
Rnor_6.01186,668,014 - 86,668,195NCBIRnor6.0
Rnor_5.01189,762,324 - 89,762,505UniSTSRnor5.0
RGSC_v3.41184,513,381 - 84,513,562UniSTSRGSC3.4
Celera1181,297,160 - 81,297,341UniSTS
RH 3.4 Map11700.2UniSTS
Cytogenetic Map11q23UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112831466586994795Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)113043533986714631Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114309033886714631Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114658320986714631Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115785881090463843Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115994302390463843Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116010984287141948Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)116265336586714475Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116265336586714483Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116449467190463843Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116964970890463843Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117272002986994795Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)118035840887200449Rat
2302043Pia27Pristane induced arthritis QTL 2718.60.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)118671447587444587Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:170
Count of miRNA genes:128
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000002593
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 38 42 33 12 33 3 66 35 31 1
Low 1 5 15 8 7 8 8 8 8 10 10 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002593   ⟹   ENSRNOP00000002593
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1186,667,997 - 86,716,063 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081972   ⟹   ENSRNOP00000073776
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1186,669,069 - 86,716,254 (-)Ensembl
RefSeq Acc Id: NM_022584   ⟹   NP_072106
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,519,996 - 82,568,156 (-)NCBI
Rnor_6.01186,667,994 - 86,716,063 (-)NCBI
Rnor_5.01189,762,304 - 89,809,935 (-)NCBI
RGSC_v3.41184,513,361 - 84,561,673 (-)RGD
Celera1181,297,140 - 81,345,203 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_072106 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD13801 (Get FASTA)   NCBI Sequence Viewer  
  AAH85734 (Get FASTA)   NCBI Sequence Viewer  
  EDL77943 (Get FASTA)   NCBI Sequence Viewer  
  EDL77944 (Get FASTA)   NCBI Sequence Viewer  
  Q9Z0J5 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_072106   ⟸   NM_022584
- Peptide Label: precursor
- UniProtKB: Q9Z0J5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002593   ⟸   ENSRNOT00000002593
RefSeq Acc Id: ENSRNOP00000073776   ⟸   ENSRNOT00000081972
Protein Domains
Pyr_redox_2   Pyr_redox_dim

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698303
Promoter ID:EPDNEW_R8828
Type:multiple initiation site
Name:Txnrd2_1
Description:thioredoxin reductase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01186,716,079 - 86,716,139EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61960 AgrOrtholog
Ensembl Genes ENSRNOG00000001890 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002593 UniProtKB/TrEMBL
  ENSRNOP00000073776 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002593 UniProtKB/TrEMBL
  ENSRNOT00000081972 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.390.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7191992 IMAGE-MGC_LOAD
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/TrEMBL
  FAD/NAD-linked_Rdtase_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_nuc-diS_OxRdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_nucl-diS_OxRdtase_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_nucl-diS_OxRdtase_FAD/NAD UniProtKB/Swiss-Prot
  Pyr_OxRdtase_I_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin/glutathione_Rdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50551 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93435 IMAGE-MGC_LOAD
NCBI Gene 50551 ENTREZGENE
Pfam Pyr_redox_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_redox_dim UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Txnrd2 PhenoGen
PIRSF Mercury_reductase_MerA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PYRIDINE_REDOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP FAD/NAD-linked_reductase_dimer UniProtKB/Swiss-Prot
  SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55424 UniProtKB/TrEMBL
TIGR TC219719
TIGRFAMs TGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K6E2_RAT UniProtKB/TrEMBL
  F1M6X5_RAT UniProtKB/TrEMBL
  Q9Z0J5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Txnrd2  thioredoxin reductase 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization specifically expressed in mitochondria 61776
gene_expression enriched in liver, kidney, adrenal gland, and heart 61776
gene_protein 526 amino acids; dimeric enzyme containing selenocysteine (Secys) as the COOH-terminal penultimate residue 61776