Adgrg7 (adhesion G protein-coupled receptor G7) - Rat Genome Database

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Gene: Adgrg7 (adhesion G protein-coupled receptor G7) Rattus norvegicus
Analyze
Symbol: Adgrg7
Name: adhesion G protein-coupled receptor G7
RGD ID: 1307217
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human ADGRG7 (adhesion G protein-coupled receptor G7); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adhesion G-protein coupled receptor G7; G protein-coupled receptor 128; Gpr128; LOC100911145; LOC304014; probable G-protein coupled receptor 128; probable G-protein coupled receptor 128-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81157,282,904 - 57,345,417 (+)NCBIGRCr8
mRatBN7.21143,808,101 - 43,877,539 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,813,801 - 43,876,316 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1152,590,226 - 52,659,213 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01145,251,834 - 45,320,825 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01144,375,961 - 44,444,935 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01146,103,173 - 46,172,303 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1146,793,777 - 46,856,291 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1146,108,470 - 46,170,929 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01149,975,766 - 50,038,280 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41144,754,925 - 44,817,439 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11144,735,865 - 44,875,052 (+)NCBI
Celera1143,586,173 - 43,648,611 (+)NCBICelera
Cytogenetic Map11q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Adgrg7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81157,282,904 - 57,345,417 (+)NCBIGRCr8
mRatBN7.21143,808,101 - 43,877,539 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,813,801 - 43,876,316 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1152,590,226 - 52,659,213 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01145,251,834 - 45,320,825 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01144,375,961 - 44,444,935 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01146,103,173 - 46,172,303 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1146,793,777 - 46,856,291 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1146,108,470 - 46,170,929 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01149,975,766 - 50,038,280 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41144,754,925 - 44,817,439 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11144,735,865 - 44,875,052 (+)NCBI
Celera1143,586,173 - 43,648,611 (+)NCBICelera
Cytogenetic Map11q12NCBI
ADGRG7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383100,609,601 - 100,695,479 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3100,609,601 - 100,695,479 (+)EnsemblGRCh38hg38GRCh38
GRCh373100,328,445 - 100,414,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363101,811,135 - 101,896,955 (+)NCBINCBI36Build 36hg18NCBI36
Build 343101,811,134 - 101,896,955NCBI
Celera398,719,715 - 98,805,922 (+)NCBICelera
Cytogenetic Map3q12.2NCBI
HuRef397,696,245 - 97,782,237 (+)NCBIHuRef
CHM1_13100,291,475 - 100,377,388 (+)NCBICHM1_1
T2T-CHM13v2.03103,315,353 - 103,401,238 (+)NCBIT2T-CHM13v2.0
Adgrg7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391656,544,972 - 56,616,369 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1656,544,972 - 56,616,218 (-)EnsemblGRCm39 Ensembl
GRCm381656,724,609 - 56,796,006 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1656,724,609 - 56,795,855 (-)EnsemblGRCm38mm10GRCm38
MGSCv371656,724,722 - 56,795,971 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361656,649,560 - 56,720,809 (-)NCBIMGSCv36mm8
Celera1657,056,358 - 57,128,155 (-)NCBICelera
Cytogenetic Map16C1.1NCBI
cM Map1634.22NCBI
Adgrg7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554272,234,866 - 2,300,630 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554272,234,640 - 2,305,510 (+)NCBIChiLan1.0ChiLan1.0
ADGRG7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2298,549,584 - 98,635,619 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1398,554,366 - 98,640,401 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0397,702,101 - 97,788,046 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13104,381,736 - 104,468,487 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3104,381,736 - 104,468,487 (+)Ensemblpanpan1.1panPan2
ADGRG7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1337,156,480 - 7,222,069 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl337,156,835 - 7,221,120 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha337,312,259 - 7,379,216 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0337,296,875 - 7,362,692 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1337,183,678 - 7,250,613 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0337,231,842 - 7,297,132 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0337,561,624 - 7,628,241 (+)NCBIUU_Cfam_GSD_1.0
Adgrg7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602149,670,991 - 149,726,572 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366302,569,513 - 2,624,252 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366302,569,513 - 2,624,252 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADGRG7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13158,338,849 - 158,408,525 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113158,334,535 - 158,402,752 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213167,941,328 - 167,968,352 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADGRG7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12280,202,524 - 80,275,281 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2280,203,710 - 80,273,248 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604186,293,050 - 86,363,694 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adgrg7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478914,189,844 - 14,299,742 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478914,189,844 - 14,299,742 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adgrg7
352 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:18
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000002232, ENSRNOT00000073467
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system integumental system musculoskeletal system renal system reproductive system respiratory system appendage
High
Medium 18
Low 3 14
Below cutoff 15 27 14 111 71 3

Sequence


Ensembl Acc Id: ENSRNOT00000002232   ⟹   ENSRNOP00000002232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1143,813,801 - 43,876,316 (+)Ensembl
Rnor_6.0 Ensembl1146,793,777 - 46,856,291 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000073467   ⟹   ENSRNOP00000066284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1146,108,470 - 46,170,929 (+)Ensembl
RefSeq Acc Id: NM_001107098   ⟹   NP_001100568
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81157,282,904 - 57,345,417 (+)NCBI
mRatBN7.21143,813,801 - 43,876,316 (+)NCBI
Rnor_6.01146,108,243 - 46,171,080 (+)NCBI
Rnor_5.01149,975,766 - 50,038,280 (+)NCBI
RGSC_v3.41144,754,925 - 44,817,439 (+)RGD
Celera1143,586,173 - 43,648,611 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100568 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11043 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002232.5
RefSeq Acc Id: NP_001100568   ⟸   NM_001107098
- UniProtKB: D4AAI8 (UniProtKB/TrEMBL),   A6IQP0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066284   ⟸   ENSRNOT00000073467
Ensembl Acc Id: ENSRNOP00000002232   ⟸   ENSRNOT00000002232
Protein Domains
G-protein coupled receptors family 2 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAI8-F1-model_v2 AlphaFold D4AAI8 1-785 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307217 AgrOrtholog
BioCyc Gene G2FUF-21526 BioCyc
Ensembl Genes ENSRNOG00000001634 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000048134 Ensembl
Ensembl Transcript ENSRNOT00000002232.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.220.50 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro ADGR_G7 UniProtKB/TrEMBL
  GAIN_dom_sf UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/TrEMBL
  GPR128_7tmB2 UniProtKB/TrEMBL
  GPS_dom UniProtKB/TrEMBL
KEGG Report rno:304014 UniProtKB/TrEMBL
NCBI Gene 304014 ENTREZGENE
PANTHER ADHESION G PROTEIN-COUPLED RECEPTOR G7 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
PhenoGen Adgrg7 PhenoGen
PRINTS GPCRSECRETIN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001634 RatGTEx
  ENSRNOG00000048134 RatGTEx
SMART GPS UniProtKB/TrEMBL
UniProt A6IQP0 ENTREZGENE, UniProtKB/TrEMBL
  D4AAI8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-05-24 Adgrg7  adhesion G protein-coupled receptor G7  LOC100911145  probable G-protein coupled receptor 128-like  Data merged from RGD:6494630 737654 PROVISIONAL
2015-03-16 Adgrg7  adhesion G protein-coupled receptor G7  Gpr128  G protein-coupled receptor 128  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911145  probable G-protein coupled receptor 128-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Gpr128  G protein-coupled receptor 128   Gpr128_predicted  G protein-coupled receptor 128 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Gpr128_predicted  G protein-coupled receptor 128 (predicted)      Symbol and Name status set to approved 70820 APPROVED